检索结果-南通市图书馆

人源间充质干细胞药物的研发和转化应用（英文）

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2023年第9期 860-863页

作者：刘怡 dana t.graves 王松灵 Laboratory of tissue Regeneration and Immunology and Department of Periodontics Beijing Key Laboratory of Tooth Regeneration and Function ReconstructionSchool of Stomatology Capital Medical University Beijing Laboratory of Oral Health Capital Medical University Department of Periodontics School of Dental Medicine University of Pennsylvania Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Capital Medical University

In recent years, mesenchymal stem cells(MSCs) have been widely applied in the treatment of various clinical diseases because of multiple advantages and significant therapeutic effects. Despite the long research time and complicated approval procedures, MSC therapy has been gradually progressing and gaining popularity worldwide, including in China.

关键词：

Diabetes mellitus related bone metabolism and periodontal disease

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2015年第2期7卷 63-72页

作者： Ying-Ying Wu E Xiao dana t.graves State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan University School of Dental Medicine University of Pennsylvania Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology

Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide.Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus.Alveolar bone loss is one of the main outcomes of periodontitis,and diabetes is among the primary risk factors for periodontal disease.In this review,we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects,focusing on alveolar bone loss.Bone remodelling begins with osteoclasts resorbing bone,followed by new bone formation by osteoblasts in the resorption lacunae.therefore,we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts.

关键词： periodontal metabolism osteoclast alveolar gingival inflammation populations attachment superoxide macrophages

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

糖尿病对骨的影响

中华口腔医学杂志 2009年第Z1期44卷 95-96页

作者： dana t.graves BostonUniversitySchoolofDentalMedicine MA PeriodontologyandOralBilolgy USA

RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2018年第1期10卷 27-35页

作者： Chia-Ying Yang Hyeran Helen Jeon Ahmed Alshabab Yu Jin Lee Chun-Hsi Chung dana t. graves Department of Orthodontics School of Dental Medicine University of Pennsylvania Philadelphia PA USA Department of Pedodontics School of Dental Medicine University of Pennsylvania Philadelphia PA USA

the bone remodeling process in response to orthodontic forces requires the activity of osteoclasts to allow teeth to move in the direction of the force applied. Receptor activator of nuclear factor-κB ligand(RANKL) is essential for this process although its cellular source in response to orthodontic forces has not been determined. Orthodontic tooth movement is considered to be an aseptic inflammatory process that is stimulated by leukocytes including t and B lymphocytes which are presumed to stimulate bone resorption. We determined whether periodontal ligament and bone lining cells were an essential source of RANKL by tamoxifen induced deletion of RANKL in which Cre recombinase was driven by a 3.2 kb reporter element of the Col1α1 gene in experimental mice(Col1α1.CreERtM+.RANKLf/f) and compared results with littermate controls(Col1α1.CreERtM-.RANKLf/f). By examination of Col1α1.CreERtM+.ROSA26 reporter mice we showed tissue specificity of tamoxifen induced Cre recombinase predominantly in the periodontal ligament and bone lining cells. Surprisingly we found that most of the orthodontic tooth movement and formation of osteoclasts was blocked in the experimental mice, which also had a reduced periodontal ligament space. thus, we demonstrate for the first time that RANKL produced by periodontal ligament and bone lining cells provide the major driving force for tooth movement and osteoclastogenesis in response to orthodontic forces.

关键词： DEPENDENt UP-REGULAtION OStEOCLASt DIFFERENtIAtION ALKALINE-PHOSPHAtASE MECHANICAL VIBRAtION PDL FIBROBLAStS GENE-tRANSFER B-CELLS EXPRESSION tISSUE COMPRESSION

维普期刊数据库

成骨细胞系NF-κB在实验性糖尿病合并牙周炎中的作用机制研究

在线全文

学校读者我要写书评

暂无评论

成骨细胞系NF-κB在实验性糖尿病合并牙周炎中的作用机制研究