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RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement

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International Journal of Oral Science 2018年第1期10卷 27-35页

作者： Chia-Ying Yang Hyeran Helen Jeon Ahmed Alshabab Yu Jin Lee Chun-Hsi Chung dana t. graves Department of Orthodontics School of Dental Medicine University of Pennsylvania Philadelphia PA USA Department of Pedodontics School of Dental Medicine University of Pennsylvania Philadelphia PA USA

the bone remodeling process in response to orthodontic forces requires the activity of osteoclasts to allow teeth to move in the direction of the force applied. Receptor activator of nuclear factor-κB ligand(RANKL) is essential for this process although its cellular source in response to orthodontic forces has not been determined. Orthodontic tooth movement is considered to be an aseptic inflammatory process that is stimulated by leukocytes including t and B lymphocytes which are presumed to stimulate bone resorption. We determined whether periodontal ligament and bone lining cells were an essential source of RANKL by tamoxifen induced deletion of RANKL in which Cre recombinase was driven by a 3.2 kb reporter element of the Col1α1 gene in experimental mice(Col1α***+.RANKLf/f) and compared results with littermate controls(Col1α***-.RANKLf/f). By examination of Col1α***+.ROSA26 reporter mice we showed tissue specificity of tamoxifen induced Cre recombinase predominantly in the periodontal ligament and bone lining cells. Surprisingly we found that most of the orthodontic tooth movement and formation of osteoclasts was blocked in the experimental mice, which also had a reduced periodontal ligament space. thus, we demonstrate for the first time that RANKL produced by periodontal ligament and bone lining cells provide the major driving force for tooth movement and osteoclastogenesis in response to orthodontic forces.

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人源间充质干细胞药物的研发和转化应用

Science Bulletin 2023年第9期68卷 860-863页

作者：刘怡 dana t.graves 王松灵 Laboratory of tissue Regeneration and Immunology and Department of Periodontics Beijing Key Laboratory of Tooth Regeneration and Function ReconstructionSchool of StomatologyCapital Medical UniversityBeijing 100050China Beijing Laboratory of Oral Health Capital Medical UniversityBeijing 100069China Department of Periodontics School of Dental MedicineUniversity of PennsylvaniaPhiladelphia PA 19104USA Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

In recent years,mesenchymal stem cells(MSCs)have been widely applied in the treatment of various clinical diseases because of multiple advantages and significant therapeutic *** the long research time and complicated ... 详细信息

关键词：间充质干细胞 clinical diseases

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糖尿病对骨的影响

中华口腔医学杂志 2009年第Z1期44卷 96-96页

作者： dana t.graves BostonUniversitySchoolofDentalMedicine MA PeriodontologyandOralBilolgy USA

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成骨细胞系NF-κB在实验性糖尿病合并牙周炎中的作用机制研究

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成骨细胞系NF-κB在实验性糖尿病合并牙周炎中的作用机制研究

Aggressive surgical approach in patients with adrenal-only metastases from hepatocellular carcinoma enables higher survival rates than standard systemic therapy

第十一次全国牙周病学学术会议

作者：陈珊珊郑嘉宝 dana t.graves 赵蕾吴亚菲四川大学华西口腔医院牙周科口腔疾病研究国家重点实验室宾夕法尼亚大学牙学院

目的:研究NF-κB对成骨细胞系功能的调控作用,分析其在糖尿病状态下,对牙周骨组织改建的影响机制,为糖尿病与牙周炎的相关性提供新的理论支持,同时为牙周炎治疗提供新靶点。方法:采用2.3Col1a1-IKKDN转基因小鼠和野生型小鼠,构建小鼠实...

目的:研究NF-κB对成骨细胞系功能的调控作用,分析其在糖尿病状态下,对牙周骨组织改建的影响机制,为糖尿病与牙周炎的相关性提供新的理论支持,同时为牙周炎治疗提供新靶点。方法:采用2.3Col1a1-IKKDN转基因小鼠和野生型小鼠,构建小鼠实验性糖尿病合并牙

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 28-33页

作者： Sorin t Alexandrescu Adina E Croitoru Razvan t Grigorie dana R tomescu Gabriela Droc Mugur C Grasu Irinel Popescu Dan Setlacec Centre of General Surgery and Liver transplantation Fundeni Clinical InstituteBucharest 022328Romania Carol Davila University of Medicine and Pharmacy Bucharest 020021Romania Department of Oncology Fundeni Clinical InstituteBucharest 022328Romania Faculty of Medicine Titu Maiorescu UniversityBucharest 031593Romania Dan tulbure Centre of Anesteziology and Intensive Care Fundeni Clinical InstituteBucharest 022328Romania Department of Radiology Fundeni Clinical InstituteBucharest 022328Romania

Background:Although guidelines recommend systemic therapy even in patients with limited extrahepatic metastases from hepatocellular carcinoma(HCC),a few recent studies suggested a potential benefit for resection of extrahepatic ***,the benefit of adrenal resection(AR)for adrenal-only metastases(AOM)from HCC was not proved *** is the first study to compare long-term outcomes of AR to those of sorafenib in patients with AOM from ***:the patients with adrenal metastases(AM)from HCC were identified from the electronic records of the institution between January 2002 and December *** who presented AM and other sites of extrahepatic disease were ***,the patients with AOM who received other therapies than AR or sorafenib were ***:A total of 34 patients with AM from HCC were *** of these,22 patients had AOM,6 receiving other treatment than AR or ***,8 patients with AOM underwent AR(AR group),while 8 patients were treated with sorafenib(SOR group).the baseline characteristics of the two groups were not significantly different in terms of age,sex,number and size of the primary tumor,timing of AM diagnosis,Child-Pugh and ECOG *** a median follow-up of 15.5 months,in the AR group,the 1-,3-,and 5-year overall survival rates(85.7%,42.9%,and 0%,respectively)were significantly higher than those achieved in the SOR group(62.5%,0%and 0%at 1-,3-and 5-year,respectively)(P=0.009).the median progression-free survival after AR(14 months)was significantly longer than that after sorafenib therapy(6 months,P=0.002).Conclusions:In patients with AOM from HCC,AR was associated with significantly higher overall and progression-free survival rates than systemic therapy with *** results could represent a starting-point for future phase II/III clinical trials.

关键词： Adrenal metastases Hepatocellular carcinoma Adrenal resection Sorafenib Survival

Physical aspects of f(R,G_(μν)t^(μν))modified gravity theories

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Chinese Physics C 2023年第10期47卷 237-248页

作者： Mihai Marciu dana Maria Ioan Faculty of Physics University of Bucharest405 AtomistilorPOB MG-11RO-077125Bucharest-MagureleRomania

the paper extends basic Einstein–Hilbert action by incorporating an invariant derived from a specific contraction between the Einstein tensor and energy momentum *** represents a non–minimal coupling between the space–time geometry and matter *** fundamental Einstein–Hilbert action is extended by considering a generic function f(R,Gμνtμν).this function is subsequently dissected into its primary components:a geometric part reliant on the scalar curvature,and another segment encapsulating the interaction between geometry and matter *** cosmological models are formulated at the backdrop of these dynamics,rooted in specific associations between the matter energy-momentum tensor and Einstein *** deriving the consequent field equations,the cosmological model's physical implications are explored through a dynamical system analysis applied to diverse coupling *** exploration reveals that the current model aligns with various phases in the Universe's evolution,potentially elucidating several late-time historical epochs.

关键词： dark energy cosmology modified gravity theories

High human disturbance decreases individual variability in skink escape behavior

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Current Zoology 2020年第1期66卷 63-70页

作者： dana M.WILLIAMS Phat-tan NGUYEN Kemal CHAN Madeleine KROHN Daniel t.BLUMStEIN Department of Ecology&Evolutionary Biology University of California621 Young Drive SouthLos AngelesCA90095-1606USA

Animals living around people may modify their antipredator behavior as a function of proximity to humans,and this response has profound implications for whether or not a population can coexist with *** asked whether inland blue-tailed skinks Emoia impar modified their individual antipredator behavior as a function of differential exposure to *** conducted multiple consecutive flushes and recorded 2 measures of antipredator response:flight initiation distance(FID),the distance from a threatening stimulus at which an individual flees,and distance fled,the distance an individual fled after a *** used a multiple model comparison approach to quantify variation in individual escape behavior across multiple approaches and to test for differences in between-individual variation among *** found that individuals tolerated closer approach and fled shorter distances at locations with relatively less human disturbance than at locations with medium and high human disturbance,*** addition,skinks living at high human disturbance sites had less variable FIDs than at low human disturbance *** theories may explain these *** against less favorable phenotypes has reduced behavioral variation in urban habitats and behavioral plasticity allows individuals to flexibly adjust their behavioral patterns in response to human *** results highlight the importance of studying variation within populations,at the individual level,which may better elucidate the impact that human disturbance has on the behavioral composition of populations.

关键词： distance fled Emoia impar flight initiation distance habitat sorting habituation urbanization

the effect of white noise on behavioral and flight responses of blue-tailed skinks

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Current Zoology 2021年第1期67卷 125-126页

作者： Connor KELLIGREW Sarah tIAN Marcus WeISS dana M.WILLIAMS Daniel t.BLUMStEIN Department of Ecology and Evolutionary Biology University of CaliforniaLos AngelesCA90095-1606USA

As human development expands,environments are increasingly exposed to anthropogenic noise which may disrupt animals in a variety of *** noise can be disruptive both as a source of auditory masking,which prevents animals from acquiring acoustic information(Brumm and Slabbekoorn 2005),or as a source of distraction,reallocating an individual's attention and impairing an animal's ability to engage in critical behaviors such as prey risk assessment(Chan et al.2010).

关键词： locating effect critical

Mining diversity of the natural biorefinery housed within tipula abdominalis larvae for use in an industrial biorefinery for production of lignocellulosic ethanol

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Insect Science 2010年第3期17卷 303-312页

作者： dana M. Cook Joy Doran-Peterson Microbiology Department University of Georgia Athens Georgia USA

Although they are the largest taxonomic group of animals, relatively few insects have been examined for symbiotic relationships with micro-organisms. However, this is rapidly changing because of the potential for examination of the natural insectmicrobe-lignocellulose interactions to provide insights for biofuel technology. Micro-organisms associated with lignocellulose-consuming insects often facilitate the digestion of the recalcitrant plant diet; therefore these microbial communities may be mined for novel lignocellulose-degrading microbes, or for robust and inexpensive biocatalysts necessary for economically feasible biofuel production from lignocellulose. these insect-microbe interactions are influenced by the ecosystem and specific lignocellulose diet, and appre- ciating the whole ecosystem-insect-microbiota-lignocellulose as a natural biorefinery provides a rich and diverse framework from which to design novel industrial processes. One such natural biorefinery, the tipula abdominalis larvae in riparian ecosystems, is reviewed herein with applications for biochemical processes and overcoming challenges involved in conversion of lignocellulosic biomass to fuel ethanol. From the dense and diverse t. abdominalis larval hindgut microbial community, a cellulolytic bacterial isolate, 27C64, demonstrated enzymatic activity toward many model plant polymers and also produced a bacterial antibiotic. 27C64 was co-cultured with yeast in fermentation of pine to ethanol, which allowed for a 20% reduction of commercial enzyme. In this study, a micro-organism from a lignocellulose-consuming insect was successfully applied for improvement of biomass-to-biofuel technology.

关键词： ethanol hydrolytic enzymes insect-associated microorganisms lignocellulose