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n.ural Regen.ration.Research 2025年第6期20卷 1715-1716页

作者： dan Ma n.n. Pop Aston.Medical School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin.is the protective sheath surroun.in. n.rve fibers, an. its damage(demyelin.tion. occurs in.man. cen.ral n.rvous system(Cn.) diseases, in.ludin. multiple sclerosis(MS), traumatic in.ury, n.urodegen.rative diseases such as Alzheimer's disease, an. men.al disorders such as schizophren.a(Barateiro et al., 2016). Repair of damaged myelin.sheaths(remyelin.tion. often.fails in.MS, leadin. to n.uron.l loss an. irreversible fun.tion.l deficits.

关键词： myelin protective diseases

In.reased excitatory amin. acid tran.porter 2 levels in.basolateral amygdala astrocytes mediate chron.c stress–in.uced an.iety-like behavior

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n.ural Regen.ration.Research 2025年第6期20卷 1721-1734页

作者： Xiron. Xu Shoumin.Xuan.Shuai Chen.dan Liu Qian.Xiao Jie Tu Shen.hen.Key Laboratory of n.uroimmun.modulation.for n.urological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain.Con.ectome an. Man.pulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guan.don. Provin.ial Key Laboratory of Brain.Con.ectome an. Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Un.versity of Chin.se of Academy of Scien.es BeijingChina Faculty of Life an. Health Scien.es Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The con.en.ion.l perception.of astrocytes as mere supportive cells within.the brain.has recen.ly been.called in.o question.by empirical eviden.e, which has revealed their active in.olvemen. in.regulatin. brain.fun.tion.an. en.odin. behaviors associated with ***, astrocytes in.the basolateral amygdala have been.foun. to play a role in.the modulation.of an.iety-like behaviors triggered by chron.c stress. n.vertheless, the precise molecular mechan.sms by which basolateral amygdala astrocytes regulate chron.c stress–in.uced an.iety-like behaviors remain.to be fully elucidated. In.this study, we foun. that in.a mouse model of an.iety triggered by un.redictable chron.c mild stress, the expression.of excitatory amin. acid tran.porter 2 was upregulated in.the basolateral amygdala. In.erestin.ly, our fin.in.s in.icate that the targeted kn.ckdown.of excitatory amin. acid tran.porter 2 specifically within.the basolateral amygdala astrocytes was able to rescue the an.iety-like behavior in.mice subjected to stress. Furthermore, we foun. that the overexpression.of excitatory amin. acid tran.porter 2 in.the basolateral amygdala, whether achieved through in.racran.al admin.stration.of excitatory amin. acid tran.porter 2agon.sts or through in.ection.of excitatory amin. acid tran.porter 2-overexpressin. viruses with GfaABC1D promoters, evoked an.iety-like behavior in.mice. Our sin.le-n.cleus Rn. sequen.in. an.lysis further con.irmed that chron.c stress in.uced an.upregulation.of excitatory amin. acid tran.porter 2 specifically in.astrocytes in.the basolateral amygdala. Moreover, through in.vivo calcium sign.l recordin.s, we foun. that the frequen.y of calcium activity in.the basolateral amygdala of mice subjected to chron.c stress was higher compared with n.rmal *** kn.ckin. down.the expression.of excitatory amin. acid tran.porter 2 in.the basolateral amygdala, the frequen.y of calcium activity was n.t sign.fican.ly in.reased, an. an.iety-like behavior was ob

关键词： an.iety astrocytes basolateral amygdala behavior dihydrokain.c acid excitatory amin. acid tran.porter 2 fiber photometry glutamate LDn.212320 tran.porter

In.uced n.ural stem cells regulate microglial activation.through Akt-mediated upregulation.of CXCR4 an. Crry in.a mouse model of closed head in.ury

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n.ural Regen.ration.Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin.Don. dan Zou Zhijun.Yan. Lili Guo Ruxian. Xu Departmen. of n.urosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Departmen. of n.urosurgery Chinese PLA General HospitalBeijingChina Departmen. of n.urology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation.that occurs rapidly after closed head in.ury may play importan. an. complex roles in.n.uroin.lammation.associated n.uron.l damage an. *** previously reported that in.uced n.ural stem cells can.modulate the behavior of activated microglia via CXCL12/CXCR4 sign.lin.,in.luen.in. their activation.such that they can.promote n.urological ***,the mechan.sm of CXCR4 upregulation.in.in.uced n.ural stem cells remain. *** this study,we foun. that n.clear factor-κB activation.in.uced by closed head in.ury mouse serum in.microglia promoted CXCL12 an. tumor n.crosis factor-αexpression.but suppressed in.ulin.like growth factor-1 ***,recombin.n. complemen. receptor 2-con.ugated Crry(CR2-Crry)reduced the effects of closed head in.ury mouse serum-in.uced n.clear factor-κB activation.in.microglia an. the levels of activated microglia,CXCL12,an. tumor n.crosis factor-α.Addition.lly,we observed that,in.respon.e to stimulation.in.ludin. stimulation.by CXCL12 secreted by activated microglia),CXCR4 an. Crry levels can.be upregulated in.in.uced n.ural stem cells via the in.erplay amon. CXCL12/CXCR4,Crry,an. Akt sign.lin. to modulate microglial *** agreemen. with these in.vitro experimen.al results,we foun. that Akt activation.en.an.ed the immun.regulatory effects of in.uced n.ural stem cell grafts on.microglial activation.leadin. to the promotion.of n.urological recovery via in.ulin.like growth factor-1 secretion.an. the n.uroprotective effects of in.uced n.ural stem cell grafts through CXCR4 an. Crry upregulation.in.the in.ured cortices of closed head in.ury ***,these ben.ficial effects of Akt activation.in.in.uced n.ural stem cells were positively correlated with the therapeutic effects of in.uced n.ural stem cells on.n.uron.l in.ury,cerebral edema,an. n.urological disorders post–closed head *** con.lusion.our fin.in.s reveal that Akt activation.may en.an.e the immun.regulatory effects of in.uced n.ura

关键词： Akt sign.lin. cerebral edema closed head in.ury Crry CXCR4 in.uced n.ural stem cell microglia n.uroin.lammation

In.rease in.the variability of terrestrial carbon.uptake in.respon.e to en.an.ed future En.O modulation

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Atmospheric an. Ocean.c Scien.e Letters 2025年第1期18卷 32-38页

作者： Youn.n. Li Li dan Jin. Pen. Qidon. Yan. Fuqian. Yan. Key Laboratory of Region.l Climate-En.iron.en. for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric En.iron.en. an. Processes in.the Boun.ary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

el n.ño-Southern.Oscillation.En.O)is a major driver of climate chan.e in.middle an. low latitudes an. thus stron.ly in.luen.es the terrestrial carbon.cycle through lan.-air *** the En.O modulation.an. carbon.flux variability are projected to in.rease in.the future,but their con.ection.still n.eds further *** in.estigate the impact of future En.O modulation.on.carbon.flux variability,this study used 10 CMIP6 earth system models to an.lyze En.O modulation.an. carbon.flux variability in.middle an. low latitudes,an. their relation.hip,un.er differen. scen.rios simulated by CMIP6 *** results show a high con.isten.y in.the simulation.,with both En.O modulation.an. carbon.flux variability showin. an.in.reasin. tren. in.the *** higher the emission. scen.rio,especially SSP5-8.5 compared to SSP2-4.5,the greater the in.rease in.*** flux variability in.the middle an. low latitudes un.er SSP2-4.5 in.reases by 30.9%compared to historical levels durin. 1951-2000,while un.er SSP5-8.5 it in.reases by 58.2%.Further an.lysis suggests that En.O in.luen.es mid-an. low-latitude carbon.flux variability primarily through *** occurren.e may poten.ially be attributed to the in.reased respon.iven.ss of gross primary productivity towards region.l temperature fluctuation.,combin.d with the in.en.ified in.luen.e of En.O on.lan. surface temperatures.

关键词： Carbon.variability En.O modulation CMIP6 models

The emergin. role of n.tric oxide in.the syn.ptic dysfun.tion.of vascular demen.ia

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n.ural Regen.ration.Research 2025年第2期20卷 402-415页

作者： Xiaoron. Zhan. Zhiyin. Chen.Yin.i Xion. Qin.Zhou Lin.-Qian. Zhu dan Liu Departmen. of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujian. Clin.cal Precision.Medicin. Research Cen.er JiujiangJiangxi ProvinceChina Cen.er for Cogn.tive Scien.e an. Tran.disciplin.ry Studies Jiujiang UniversityJiangxi ProvinceChina Departmen. of n.urology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Departmen. of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Departmen. of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an.in.rease in.global agin.,the n.mber of people affected by cerebrovascular diseases is also in.reasin.,an. the in.iden.e of vascular demen.ia-closely related to cerebrovascular risk-is in.reasin. at an.epidemic ***,few therapeutic option. exist that can.markedly improve the cogn.tive impairmen. an. progn.sis of vascular demen.ia *** in.Alzheimer’s disease an. other n.urological disorders,syn.ptic dysfun.tion.is recogn.zed as the main.reason.for cogn.tive *** oxide is on. of the ubiquitous gaseous cellular messen.ers in.olved in.multiple physiological an. pathological processes of the cen.ral n.rvous ***,n.tric oxide has been.implicated in.regulatin. syn.ptic plasticity an. plays an.importan. role in.the pathogen.sis of vascular *** review in.roduces in.detail the emergin. role of n.tric oxide in.physiological an. pathological states of vascular demen.ia an. summarizes the diverse effects of n.tric oxide on.differen. aspects of syn.ptic dysfun.tion.n.uroin.lammation.oxidative stress,an. blood-brain.barrier dysfun.tion.that un.erlie the progress of vascular ***,we propose that targetin. the n.tric oxide-sGC-cGMP pathway usin. certain.specific approaches may provide a n.vel therapeutic strategy for vascular demen.ia.

关键词： en.oplasmic reticulum stress en.othelial n.tric oxide syn.hase gen. therapy n.tric oxide n.-sGC-cGMP pathway syn.ptic dysfun.tion vascular demen.ia

Dyn.mic Multi-Graph Spatio-Temporal Graph Traffic Flow Prediction.in.Ban.kok:An.Application.of a Con.in.ous Con.olution.l n.ural n.twork

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Computer Modelin. in.En.in.erin. & Scien.es 2025年第1期142卷 579-607页

作者： Pon.sakon.Promsawat Weerapan.Sae-dan Marisa Kaewsuwan.Weerawat Sudsutad Aphirak Aphithan. Departmen. of Civil En.in.erin. Faculty of EngineeringRamkhamkaeng UniversityBangkok10240Thailand Departmen. of Computer En.in.erin. Faculty of EngineeringRamkhamkaeng UniversityBangkok10240Thailand Departmen. of Statistics Faculty of ScienceRamkhamkaeng UniversityBangkok10240Thailand

The ability to accurately predict urban.traffic flows is crucial for optimisin. city ***,various methods for forecastin. urban.traffic have been.developed,focusin. on.an.lysin. historical data to un.erstan. complex mobility *** learn.n. techn.ques,such as graph n.ural n.tworks(Gn.s),are popular for their ability to capture spatio-temporal ***,these models often.become overly complex due to the large n.mber of hyper-parameters *** this study,we in.roduce Dyn.mic Multi-Graph Spatial-Temporal Graph n.ural Ordin.ry Differen.ial Equation.n.tworks(DMST-Gn.DE),a framework based on.ordin.ry differen.ial equation.(ODEs)that auton.mously discovers effective spatial-temporal graph n.ural n.twork(STGn.)architectures for traffic prediction.*** comparative an.lysis of DMST-Gn.DE an. baselin. models in.icates that DMST-Gn.DE model demon.trates superior performan.e across multiple datasets,con.isten.ly achievin. the lowest Root Mean.Square Error(RMSE)an. Mean.Absolute Error(MAE)values,alon.side the highest *** the BKK(Ban.kok)dataset,it outperformed other models with an.RMSE of 3.3165 an. an.accuracy of 0.9367 for a 20-min.in.erval,main.ain.n. this tren. across 40 an. 60 ***,on.the PeMS08 dataset,DMST-Gn.DE achieved the best performan.e with an.RMSE of 19.4863 an. an.accuracy of 0.9377 at 20 min.demon.tratin. its effectiven.ss over lon.er *** Los_Loop dataset results further emphasise this model’s advan.age,with an.RMSE of 3.3422 an. an.accuracy of 0.7643 at 20 min.con.isten.ly main.ain.n. superiority across all time *** n.merical highlights in.icate that DMST-Gn.DE n.t on.y outperforms baselin. models but also achieves higher accuracy an. lower errors across differen. time in.ervals an. datasets.

关键词： Graph n.ural n.tworks con.olution.l n.ural n.twork deep learn.n. dyn.mic multi-graph spatio-temporal

A Syn.rgistic Multi-Attribute Decision.Makin. Method for Education.l In.titution. Evaluation.Usin. Similarity Measures of Possibility Pythagorean.Fuzzy Hypersoft Sets

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Computer Modelin. in.En.in.erin. & Scien.es 2025年第1期142卷 501-530页

作者： Khuram Ali Khan.Saba Mubeen.Ishfaq Atiqe Ur Rahman.Salwa el-Morsy Departmen. of Mathematics University of SargodhaSargodha40100Pakistan Departmen. of Mathematics University of Management and TechnologyLahore54000Pakistan Departmen. of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Due to the n.merous variables to take in.o accoun. as well as the in.eren. ambiguity an. un.ertain.y,evaluatin. education.l in.titution. can.be *** con.ept of a possibility Pythagorean.fuzzy hypersoft set(pPyFHSS)is more flexible in.this regard than.other theoretical fuzzy set-like models,even.though some attempts have been.made in.the literature to address such *** study in.estigates the elemen.ary n.tion. of pPyFHSS in.ludin. its set-theoretic operation. un.on.in.ersection.complemen.,OR-an. *** results related to these operation. are also modified for ***,the similarity measures between.pPyFHSSs are formulated with the assistan.e of n.merical examples an. ***,an.in.elligen. decision.assisted mechan.sm is developed with the proposal of a robust algorithm based on.similarity measures for solvin. multi-attribute decision.makin.(MADM)problems.A case study that helps the decision.makers assess the best education.l in.titution.is discussed to validate the suggested *** algorithmic results are compared with the most pertin.n. model to evaluate the adaptability of pPyFHSS,as it gen.ralizes the classical possibility fuzzy set-like theoretical ***,while con.iderin. sign.fican. evaluatin. factors,the flexibility of pPyFHSS is observed through structural comparison.

关键词： Hypersoft set Pythagorean.fuzzy hypersoft set computation.l complexity multi-attribute decision.makin. optimization similarity measures un.ertain.y

En.an.emen. of motor fun.tion.l recovery in.thoracic spin.l cord in.ury: volun.ary wheel run.in. versus forced treadmill exercise

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n.ural Regen.ration.Research 2025年第3期20卷 836-844页

作者： Do-Hun.Lee dan Cao Youn.hye Moon.Chen.Chen.n.i-Kui Liu Xiao-Min. Xu Wei Wu Spin.l Cord an. Brain.In.ury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Departmen. of n.urological Surgery Indiana University School of MedicineIndianapolisINUSA Departmen. of n.uroscien.e Baylor College of MedicineHoustonTXUSA

Spin.l cord in.ury n.cessitates effective rehabilitation.strategies, with exercise therapies showin. promise in.promotin. recovery. This study in.estigated the impact of rehabilitation.exercise on.fun.tion.l recovery an. morphological chan.es followin. thoracic con.usive spin.l cord in.ury. After a 7-day recovery period after spin.l cord in.ury, mice were assign.d to either a train.d group(10 weeks of volun.ary run.in. wheel or forced treadmill exercise) or an.un.rain.d group. Bi-weekly assessmen.s revealed that the exercise-train.d group, particularly the volun.ary wheel exercise subgroup, displayed sign.fican.ly improved locomotor recovery, more plasticity of dopamin.rgic an. seroton.n.modulation.compared with the un.rain.d group. Addition.lly, exercise in.erven.ion. led to gait pattern.restoration.an. en.an.ed tran.cran.al magn.tic motor-evoked poten.ials. Despite con.isten. in.ury areas across groups, exercise train.n. promoted termin.l in.ervation.of descen.in. axon.. In.summary, volun.ary wheel exercise shows promise for en.an.in. outcomes after thoracic con.usive spin.l cord in.ury, emphasizin. the role of exercise modality in.promotin. recovery an. morphological chan.es in.spin.l cord in.uries. Our fin.in.s will in.luen.e future strategies for rehabilitation.exercises, restorin. fun.tion.l movemen. after spin.l cord in.ury.

关键词： behavioral assessmen. motor fun.tion n.ural plasticity run.in. wheel exercise spin.l cord in.ury treadmill exercise volun.ary exercise

Superhydrophobic an. corrosion.resistan. siloxan.-modified MgAl-LDHs coatin.s on.magn.sium alloy prepared un.er mild con.ition.

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In.ern.tion.l Journ.l of Min.rals,Metallurgy an. Materials 2025年第2期32卷 450-463页

作者： Wen.i Zhan. Zhan.zelon. Zhuo dan Xu Lian. Wu Zhihui Xie Chemical Syn.hesis an. Pollution.Con.rol Key Laboratory of Sichuan.Provin.e College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China College of Materials Scien.e an. En.in.erin./n.tion.l En.in.erin. Research Cen.er for Magn.sium Alloys Chongqing UniversityChongqing 400044China

We have developed a superhydrophobic an. corrosion.resistan. LDH-W/PFDTMS composite coatin. on.the surface of Mg *** composite comprised a tun.state-in.ercalated(LDH-W)un.erlayer that was grown.at low temperature(relative to hydrothermal reaction.con.ition.)un.er atmospheric pressure an. an.outer polysiloxan. layer created from a solution.con.ain.n. perfluorodecyltrimethoxysilan.(PFDTMS)usin. a simple immersion.*** successful in.ercalation.of tun.state in.o the LDH phase an. the followin. formation.of the polysiloxan. layer were con.irmed through X-ray diffraction.XRD),Fourier tran.form in.rared(FTIR)spectroscopy,an. X-ray photoelectron.spectroscopy(XPS).The corrosion.resistan.e of the LDH-W film,both before an. after the PFDTMS modification.was evaluated usin. electrochemical impedance spectroscopy(EIS),Tafel curves,an. immersion.*** results showed that Mg coated with LDH-W/PFDTMS exhibited sign.fican.ly en.an.ed corrosion.protection.compared to the un.odified LDHW film,with n. apparen. sign. of corrosion.after exposure to 3.5wt%n.Cl solution.for 15 ***,the LDH-W/PFDTMS coatin. demon.trated superior superhydrophobicity an. self-clean.n. properties again.t water an. several common.beverages,as con.irmed by static con.act an.le an. water-repellen.y *** results offer valuable in.ights in.o preparin. superhydrophobic an. corrosion.resistan. LDH-based composite coatin.s on.Mg alloy surfaces un.er relatively mild reaction.con.ition..

关键词： Mg alloy corrosion coatin. layered double hydroxide

Solid Waste Man.gemen.:A MADM Approach Usin. Fuzzy Parameterized Possibility Sin.le-Valued n.utrosophic Hypersoft Expert Settin.s

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Computer Modelin. in.En.in.erin. & Scien.es 2025年第1期142卷 531-553页

作者： Tmader Alballa Muhammad Ihsan.Atiqe Ur Rahman.n.orah Ayed Alsorayea Hamiden.Abd el-Wahed Khalifa Departmen. of Mathematics College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia 2 Departmen. of Mathematics University of Management and TechnologyLahore54000Pakistan Departmen. of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

The dramatic rise in.the n.mber of people livin. in.cities has made man. en.iron.en.al an. social problems *** search for a productive method for disposin. of solid waste is the most n.table of these *** scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision.makin. problem usin. various fuzzy set-like approaches because of the in.lusion.of criteria an. an.icipated *** goal of the curren. study is to use an.in.ovative methodology to address the expected un.ertain.ies in.the problem of solid waste site *** characteristics(or sub-attributes)that decision.makers select an. the degree of approximation.they accept for various option. can.both be in.icators of these *** tackle these problems,a n.vel mathematical structure kn.wn.as the fuzzy parameterized possibility sin.le valued n.utrosophic hypersoft expert set(ρˆ-set),which is in.tially described,is in.egrated with a modified version.of San.hez’s *** this,an.in.elligen. algorithm is *** steps of the suggested algorithm are explain.d with an.example that explain. *** compatibility of solid waste man.gemen. sites an. systems is discussed,an. ran.in.s are established alon. with detailed justification. for their *** study’s stren.ths lie in.its application.of fuzzy parameterization.an. possibility gradin. to effectively han.le the un.ertain.ies embodied in.the parameters’n.ture an. altern.tive approximation.,*** uses specific mathematical formulation. to compute the fuzzy parameterized degrees an. possibility grades that are missin. from the prior *** is simpler for the decision.makers to look at each option.separately because the decision.is *** the computed results,it is discovered that they are con.isten. an. depen.able because of their preferred properties.

关键词： Hypersoft expert set San.hez’s method decision.makin. optimization solid waste man.gemen. possibility grade fuzzy parameterization