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Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence

Emergency and Critical Care Medicine 2024年第1期4卷 4-15页

作者： Haiying Rui Huaxiang Yu dan Zou Kai Chi Ping Xu Xiaoshuai Song lulu liu Xuting Wu Jinxin Wang li Xue Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinanShandongChina Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu Hospital of Shandong UniversityJinanShandongChina Key laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinanShandongChina The Key laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu Hospital of Shandong UniversityJinanShandongChina.

Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin *** studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and ***,it remains unclear whether vaspin exerts specific effects on pathological cardiac ***:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57Bl/6 and vaspin-ko *** was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce *** vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic ***:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ***,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and ***,vaspin significantly potentiated the ISO-induced decrease in *** rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated ***,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and *** data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4l-mediated ubiquitination ***:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hyper

关键词： Autophagic flux Myocardial senescence Pathological cardiac hypertrophy Ubiquitination Vaspin

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Simultaneous determination of five plant hormones in cotton leaves using QuEChERS combined with HPlC‒MS/MS

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Journal of Cotton Research 2024年第2期7卷 163-176页

作者： WANG Wenhao SONG Xianpeng WANG dan MA Yajie SHAN Yongpan REN Xiangliang HU Hongyan WU Changcai YANG Jun MA Yan National Key laboratory of Cotton Biobreeding and Integrated Utilization Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000China College of Agriculture Hebei Agricultural UniversityBaodingHebei 071000China Zhengzhou Research Base National Key Laboratory of Cotton Biobreeding and Integrated UtilizationZhengzhou UniversityZhengzhouHenan 450001China Western Agricultural Research Center Chinese Academy of Agricultural SciencesChangjiXinjiang 831100China

Background Plant hormones profoundly influence cotton growth,development,and responses to various ***,there is a pressing need for an efficient assay to quantify these hormones in *** this groundbreaking study,we have established QuEChERS-HPlC‒MS/MS method,for the simultaneous detection of multiple plant hormones in cotton leaves,allowing the analysis and quantification of five key plant *** Sample extraction and purification employed 0.1%acetic acid in methanol and C18 for optimal recovery of plant *** method applied to cotton demonstrated excellent linearity across a concentration range of 0.05–1 mg・l−1,with linear regression coefficients exceeding *** limits of quantification(lOQs)were 20μg・kg−1 for GA3 and 5μg・kg−1 for the other four plant *** rates for the five plant hormones matrix spiked at levels of 5,10,100,and 1000μg・kg−1 were in the range of 79.07%to 98.97%,with intraday relative standard deviations(RSDs)ranging from 2.11%to 8.47%.The method was successfully employed to analyze and quantify the five analytes in cotton leaves treated with plant growth *** The study demonstrates that the method is well-suited for the determination of five plant hormones in *** exhibits excellent selectivity and sensitivity in detecting field samples,thus serving as a robust tool for indepth research into cotton physiology.

关键词： Cotton Plant hormones QuEChERS HPlC‒MS/MS

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Neural-network-based fully distributed formation control for nonlinear multi-agent systems with event-triggered communication

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Science China(Technological Sciences) 2024年第1期67卷 209-220页

作者： ZHU Guoliang lIU KeXin GU HaiBo lÜJinHu School of Automation Science and electrical Engineering Beihang UniversityBeijing 100191China Zhongguancun laboratory Beijing 100094China

This paper investigates the consensus-based formation control problem for multi-agent systems with unknown nonlinear *** achieve the desired formation,we propose two formation controllers to achieve the desired formation,one based on system states and the other on system *** proposed controllers utilize adaptive gains to avoid global information and neural networks to estimate and compensate for *** proposed event-triggered schemes avoid continuous communication among agents and exclude the Zeno *** analysis reveals that formation errors are bounded,and numerical simulations are used to validate the effectiveness of the proposed approaches.

关键词： formation control neural network adaptive control event-triggered communication multi-agent systems

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HAMON电除尘器故障分析及应对措施

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炼油技术与工程 2024年第4期54卷 25-28页

作者：王丹中国石油化工股份有限公司石家庄炼化分公司河北省石家庄市050000

HAMON电除尘器可用于处理催化裂化烟气中的催化剂粉尘。由于催化裂化装置四年一修,电除尘器不能随时停运检修,因此针对HAMON电除尘器的运行情况进行研究,对于保障电除尘器及催化裂化装置的长周期稳定运行具有重要意义。在运行过程中,电... 详细信息

HAMON电除尘器可用于处理催化裂化烟气中的催化剂粉尘。由于催化裂化装置四年一修,电除尘器不能随时停运检修,因此针对HAMON电除尘器的运行情况进行研究,对于保障电除尘器及催化裂化装置的长周期稳定运行具有重要意义。在运行过程中,电除尘器出现电流和电压降低的问题。对故障原因进行分析,并在电除尘器停运后进行检查,发现:腐蚀泄漏导致电除尘器内部烟气湿度大。制定了检查、检修项目,更换了配件,同时结合冷态试验结果,调整了电除尘器的电流、电压、振打周期和振打力度。检修开工后,电除尘器入口粉尘质量浓度53.3 mg/m^(3),出口粉尘质量浓度4.8 mg/m^(3),远低于设计值(30 mg/m^(3))。检修开工至今超过2 a,电除尘器运行平稳,未出现任何故障,实现了长周期稳定运行。

关键词： HAMON 电除尘器电流电压烟气湿度粉尘浓度电晕线振打周期

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Infantile bacterial meningitis combined with sepsis caused by Streptococcus gallolyticus subspecies pasteurianus:A case report

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World Journal of Clinical Cases 2024年第31期12卷 6472-6478页

作者： dan Zou Fen li Shu-li Jiao Jin-Rong Dong Yao-Yao Xiao Xiao-ling Yan Yan li dan Ren Department of Pediatrics Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000Sichuan ProvinceChina Department of Clinical laboratory Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000Sichuan ProvinceChina

BACKGROUND Streptococcus gallolyticus subspecies pasteurianus(SGSP)is a rare pathogen responsible for infant sepsis and meningitis and is potentially overlooked because it is not included in routine group B streptococcal ***,we present a case of SGSP-induced infant meningitis and sepsis,accompanied by bronchopneumonia induced by multidrug-resistant Staphylococcus aureus(MRSA),providing insights into the identification,management,and prognosis of this bacterial *** SUMMARY A 45-day-old female infant presented with two episodes of high fever(maximum temperature:39.5°C)and two generalized grand mal seizure episodes that lasted over ten seconds and self-resolved without concomitant ***,the patient’s C-reactive protein level was 40.73 mg/l,white blood cell count was 13.42×10^(9)/l,neutrophil ratio was 78.4%,procalcitonin level was 7.89μg/l,cerebrospinal fluid(CSF)white cell count was 36×10^(6)/l,multinucleated cell ratio was 95.2%,and protein concentration was 0.41 g/*** and CSF culture revealed that the pathogen was *** bacterium was sensitive to ampicillin,furazolidone,penicillin,lincomycin,moxifloxacin,rifampicin,vancomycin,and levofloxacin but resistant to clindamycin and *** culture revealed the presence of MRSA,which was sensitive to *** patient was diagnosed with meningitis and sepsis caused by SGSP,accompanied by bronchopneumonia induced by ***(100 mg/kg/d)combined with vancomycin(10 mg/kg/dose,q6h)was given as an anti-infective treatment *** 12 days of treatment,the infant was discharged from the hospital with normal CSF,blood culture,and routine blood test results,and no complications,such as subdural effusion,were observed on cranial computed *** growth retardation or neurological sequelae occurred during *** SGPSP-induced infant bacterial meningitis and sepsis should be treated with prompt blood and CSF cultures,and a sensitiv

关键词： Streptococcus gallolyticus subspecies pasteurianus Rare pathogen Bacterial meningitis Sepsis Multidrugresistant Staphylococcus aureus Bronchopneumonia Infant Case report

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Four late-type Galaxies with Double Radio lobes and Properties of Such Galaxies

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Research in Astronomy and Astrophysics 2024年第4期24卷 84-90页

作者： Z.S.Yuan X.Y.Gao Z.l.Wen J.l.Han National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanism for radio lobes from late-type galaxies is not fully *** samples are desired for a thorough investigation and *** utilizing the optical data from the newly released Dark Energy Spectroscopic Instrument imaging surveys and the radio sources from the NRAO VlA Sky Survey and the Faint Images of the Radio Sky at Twenty-centimeter,we identify four late-type Galaxies with double Radio lobes(la GRls):J0217-3645,J0947+6220,J1412+3723 and J1736+*** previously known la GRls,we confirm the correlation between radio power P_(1.4GHz)and stellar mass M_(*)of host ***(25/35)la GRls belong to the blue cloud galaxies,while the newly identified cases in this work are located within the region of the red *** find a clear correlation between the differential radio power,i.e.,the offset from the P_(1.4GHz)-M_(*)relation,and the galaxy color,indicating that bluer galaxies at a fixed M_(*)tend to host more powerful radio ***,the majority(31/36)of la GRls are either located in a galaxy group or displaying a disturbed *** suggest that all of the galaxy mass,color and surrounding environment could play important roles in triggering radio lobes in late-type galaxies.

关键词： galaxies:active galaxies:jets galaxies:spiral radio continuum:galaxies

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Research of surface-enhanced Raman scattering on Ag@PMBA@C@Au hybrid nanoparticles

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Optoelectronics letters 2024年第2期20卷 65-69页

作者： TAN Enzhong lÜ Suye liberal Study College Beijing Institute of Petrochemical TechnologyBeijing 102617China

Monodispersed, biocompatible, and readily-functionalized hybrid reporter-embedded core-shell nanopartilces(NPs) have been prepared in a simple route. This composite offers a potential platform for immunochemical detection using surface-enhanced Raman scattering(SERS) due to their high sensitivity, good stability and biocompatiblity. This also provides a new platform for insight into SERS enhancement mechanism.

关键词： mechanism. readily SERS

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lE DEMI-SIClE, DE MOÏSE AU FISCUS IUDAICUS. HISTOIRE D’UNE TÉlÉOlOGIE

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Journal of Ancient Civilizations 2024年第1期39卷 73-98,124页

作者： Michaël Girardin Universitédu littoral-Côte d’Opale

Many sources are brought together in scholarship in order to write the linear story of a specific tax,the half shekel tax paid each year by the Jews to the Temple of Jerusalem and,then,confiscated by the fiscus Iudaicus in Roman *** do these sources refer to the same tax?In this paper,I defend the idea that the linearity of this story is a *** taxes were levied and justified by the memory of a Biblical tax,but they are all different in meaning,in administration and sometimes even in *** story is a political one:how to justify a tax in ancient Judaism?

关键词： didrachm fiscus Iudaicus half shekel Jerusalem Temple Roman Judea taxation teleology

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A landscape persistence-based methodological framework for assessing ecological stability

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Environmental Science and Ecotechnology 2024年第1期17卷 31-39页

作者： Da lü Yihe lü Guangyao Gao Siqi Sun Yi Wang Bojie Fu State Key laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesPO Box 2871Beijing100085China University of Chinese Academy of Sciences Beijing100049China

Ecological stability is a critical factor in global sustainable development,yet its significance has been *** we introduce a landscape-oriented framework to evaluate ecological stability in the Qingzang Plateau(QP).Our findings reveal a medium-high stability level in the QP,with minimal changes over recent *** driving factors vary across landscape types,with climate and anthropogenic factors emerging as crucial *** anthropogenic factors are strong but unstable due to policy changes and economic development,climatic factors exert a consistent *** on our results,we propose site-specific ecological conservation and restoration *** ecological stability assessment framework provides a practical tool to understand the link between environmental conditions and ecosystems.

关键词： Ecological stability assessment framework landscape changes Nature conservation and ecological restoration Nature-based solutions Qingzang Plateau

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Optimal Control of Service Rates of Discrete-Time(s,Q)Queueing-Inventory Systems with Finite Buffer

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Journal of Systems Science and Systems Engineering 2024年第3期33卷 261-280页

作者： l.Iniya B.Sivakumar G.Arivarignan School of Mathematics Madurai Kamaraj UniversityMaduraiTamilnaduIndia Department of Statistics Manonmaniam Sundaranar UniversityTirunelveliTamilnaduIndia

This article,we develop an optimal policy to control the service rate of a discrete time queueing-inventory system with finite *** customers arrive according to a Bernoulli process and the service time for the customers are *** the buffer size attains its maximum,any arriving new customers are considered to be *** customers are served one by one according to FCFS rule and each customers request random number of *** inventory is replenished according to a(s,Q)inventory policy with geometric lead *** main objectives of this article are to determine the service rates to be employed at each slot so that the long run expected cost rate is minimized for fixed inventory level and fixed buffer size and to minimize the expected waiting time for a fixed inventory level and fixed buffer *** problems are modelled as Markov decision *** establish the existence of a stationary policy and employ linear programming method to find the optimal service *** provide some numerical examples to illustrate the behaviour of the model.

关键词： Queueing-inventory system discrete time batch demand-Markov decision process

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