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Deciphering the role of FSCN family genes in cancer:a pan-cancer bioinformatics study

Medical Data Mining 2024年第4期7卷 10-18页

作者： Wen-Shuai Zhang dan-yang ren Xin Li Department of Pathology Tianjin Cancer Hospital Airport HospitalTianjin 300308China National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and HospitalKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China

Background:The Fascin(FSCN)family,comprising actin-bundling proteins,plays vital roles in cytoskeletal reorganization and cell ***1,FSCN2,and FSCN3 are implicated in cancer progression through cell motility,invasion,and ***,their specific contributions across different cancer types remain ***:We conducted a pan-cancer bioinformatics analysis of FSCN genes using data from The Cancer Genome *** included differential expression patterns,copy number variations(CNVs),mutations,methylation status,and correlations with tumor mutational burden,microsatellite instability,and immune checkpoint molecule *** expression was analyzed using DESeq2,while CNV and mutation analyses utilized GISTIC2.0 and *** data were assessed using the Illumina Human Methylation 450K ***:FSCN1 and FSCN2 showed significant differential expression in multiple cancers,often correlating with poor ***3 exhibited less variability but a protective role in certain *** analysis indicated frequent gene gains in FSCN genes,correlating with increased ***3 had a higher mutation rate,suggesting genetic *** analysis showed hypomethylation of FSCN1 and FSCN2 in tumors compared to normal tissues,whereas FSCN3 had minor *** associations were found between FSCN gene expression and tumor mutational burden,microsatellite instability,and immune checkpoint molecules,suggesting their involvement in tumor immunogenicity and the immune ***:This pan-cancer analysis highlights the multifaceted roles of FSCN genes in cancer biology,emphasizing their potential as biomarkers and therapeutic ***1 and FSCN2 are associated with poor prognosis and aggressive phenotypes,while FSCN3 shows protective roles in specific *** findings offer new avenues for cancer diagnosis and treatment,particularly in personalized *** studie

关键词： Fascin family pan-cancer analysis gene expression copy number variation tumor mutational burden

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Observation of Small-amplitude Electromagnetic Cyclotron Waves in the Solar Wind

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Research in Astronomy and Astrophysics 2023年第4期23卷 94-102页

作者： Hai-Feng yang Guo-Qing Zhao Heng-Qiang Feng Gilbert Pi Qiang Liu Liang Xiang Qiu-Huan Li dan-yang ren Institute of Space Physics Luoyang Normal UniversityLuoyang 471934China Henan Key Laboratory of Electromagnetic Transformation and Detection Luoyang 471934China Faculty of Mathematics and Physics Charles UniversityPrague 12116Czech Republic

Our previous studies on low-frequency electromagnetic cyclotron waves(ECWs)with amplitudes larger than 0.1nT in the solar wind revealed that the left-handed(LH)polarized ECWs are the dominant waves,and these waves preferentially occur in plasma conditions of high proton speed(V_(p)),high proton temperature(T_(p)),low proton density(N_(p)).In the present study,using magnetic field and plasma data from the Wind mission between 2005 and2015,we perform a survey of small-amplitude ECWs with amplitudes smaller than 0.1 *** is revealed for the first time that the small-amplitude right-handed(RH)polarized ECWs tend to frequently occur in plasmas characterized by low V_(p),low T_(p),low N_(p),although the small-amplitude LH ECWs still preferentially occur in plasma conditions similar to the LH ECWs with amplitudes larger than 0.1 *** investigation shows that the occurrences of small-amplitude RH ECWs and long-lasting radial interplanetary magnetic field(lrIMF)share the similar preferential plasma conditions of low T_(p)and low N_(p).During lrIMF events,in particular,the occurrence rates of RH and LH ECWs are comparable,with the occurrence rate of small-amplitude RH ECWs slightly larger than that of small-amplitude LH *** generation mechanism of the small-amplitude ECWs is discussed.

关键词： (Sun:)solar wind-magnetic fields-waves

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Pan-cancer analysis of ORAI family proteins and their genomic alterations

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Medical Data Mining 2024年第4期7卷 41-49页

作者： Zhan-Bo Wu Wen-Shuai Zhang dan-yang ren Xin Li Department of Cancer Immunotherapy Tianjin Cancer Hospital Airport HospitalTianjin 300308China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Pathology Tianjin Cancer Hospital Airport HospitalTianjin 300308China

Background:The ORAI family of proteins,comprising ORAI1,ORAI2,and ORAI3,plays a crucial role in the regulation of intracellular calcium signaling,which is essential for various cellular functions including proliferation,differentiation,and *** of calcium signaling has been implicated in cancer pathogenesis,influencing tumor progression,metastasis,and resistance to *** study aims to provide a comprehensive analysis of the ORAI family members across a broad spectrum of ***:Publicly available datasets from The Cancer Genome Atlas and the Gene Expression Omnibus were *** sequencing data,mutation profiles,copy number variation data,and methylation data across different cancer types were *** expression analysis,survival analysis,copy number variation analysis,mutation analysis,methylation analysis,immune cell infiltration analysis using the Cibersort algorithm,and gene set enrichment analysis were conducted using R ***:ORAI1 and ORAI3 were significantly upregulated in glioblastoma multiforme,whereas ORAI2 was notably downregulated in kidney chromophobe and pancreatic ***2 exhibited higher mutation rates and copy number gains in multiple cancers compared to ORAI1 and *** hypermethylation of ORAI2 in head and neck squamous cell carcinoma,esophageal carcinoma,and glioblastoma multiforme negatively correlated with its gene ***1 and ORAI3 expression positively correlated with regulatory T cells infiltration,whereas ORAI2 showed a negative correlation with CD8^(+)T cell *** set enrichment analysis revealed that ORAI1 and ORAI2 are associated with immune-related pathways,while ORAI3 is linked to MYC targets and oxidative ***:Our pan-cancer analysis reveals significant differential expression,genomic alterations,and epigenetic regulation of ORAI family members across various ***1 and ORAI3 appear to promote an immunosuppr

关键词： ORAI family calcium signaling cancer progression immune cell infiltration gene expression

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民航企业人力成本分析

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天津工业大学学报 2001年第2期20卷 5-10页

作者：程志超杨丹阳任治国中国民航学院管理学院天津300300

通过案例分析 ,从人力成本、工作效率、员工激励状况等角度分析了民航企业工资管理的现状 ,并运用人力资源管理理论以及组织行为学和经济学的相关理论和方法 ,从岗位职务分析、岗位规范、工资率的确定、绩效工资。

关键词：人力成本激励绩效工资工资率民航企业中国人事管理

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Nutation instability of spinning solid rocket motor spacecraft

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Chinese Journal of Aeronautics 2017年第4期30卷 1363-1372页

作者： dan yang Yongliang XIONG Qian ren Xianyong WANG School of Naval Architecture and Ocean Engineering Huazhong University of Science and Technology Wuhan 430074 China Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 China Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment Luoyu Road 1037 Wuhan 430074 China

The variation of mass, and moment of inertia of a spin-stabilized spacecraft leads to concern about the nutation instability. Here a careful analysis on the nutation instability is performed on a spacecraft propelled by solid rocket booster（SRB）. The influences of specific solid propellant designs on transversal angular velocity are discussed. The results show that the typical SRB of End Burn suppresses the non-principal axial angular velocity. On the contrary, the frequently used SRB of Radial Burn could amplify the transversal angular velocity. The nutation instability caused by a design of Radial Burn could be remedied by the addition of End Burn at the same time based on the study of the combination design of both End Burn and Radial *** analysis of the results proposes the design conception of how to control the nutation *** method is suitable to resolve the nutation instability of solid rocket motor with complex propellant patterns.

关键词： Attitude control Nutation dampers Payloads Solid rocket booster Spin stabilization of spacecraft

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The velocity patterns in rigid and mobile channels with vegetation patches

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Journal of Hydrodynamics 2020年第3期32卷 561-569页

作者： Bao-liang ren dan Wang Wen-qi Li Ke-jun yang State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China

The hydraulic characteristics in an open channel with vegetation are very important in controlling the environment pollution and restoring the river ecology. This paper studies the influence of the bed form and the vegetation patch density on the spatial velocity pattern. Rigid fiberglass circular cylinders are used to simulate the vegetation and a 3-D acoustic Doppler velocimeter (ADV) is used to measure the local flow velocities. Two types of bed forms and a series of vegetation patch densities are considered. The experimental results show that the bed form significantly influences the vertical distribution of the streamwise velocity. Besides, the velocity is affected by the bed form while the lateral distribution shape of the streamwise velocity as well as the lateral and longitudinal distribution shapes of the depth-averaged velocity is less affected. When all test conditions but the bed condition remain the same, as a result of the water energy consumption by the sediment movement, the velocity in the mobile bed case is smaller than that in the rigid bed case. The vegetation patch density has a significant effect on the flow velocity. The distributions of the flow velocity at different locations show different trends with the increase of the vegetation patch density. The upstream adjustment length is not affected by the vegetation patch density, but the steady wake length is very much affected.

关键词： Vegetation patch density bed form velocity characteristics sediment

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Maize MS2 encodes an ATP-binding cassette transporter that is essential for anther development

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The Crop Journal 2021年第6期9卷 1301-1308页

作者： Qilong Xu Li yang dan Kang Zhenjing ren Yunjun Liu Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

The anther cuticle and pollen exine play a critical role in male gametophyte development. The sporopollenin precursors and cuticular lipid monomers are transported to the surface of the microspores and the epidermis by lipid transport proteins(LTPs) and ATP-binding cassette G(ABCG) transporters for the formation of the pollen wall and anther cuticle, respectively. However, the function of ABCG transporters in maize anther development is unclear. Here, we cloned the MS2 gene from the maize male sterile2 mutant using map-based cloning and determined that it encodes an ABCG transporter. MS2 protein was experimentally confirmed to be located on the cell membrane. The quantitative real-time PCR(qRT-PCR)results showed that MS2 was ubiquitously expressed in all vegetative and reproductive tissues, whereas a high transcriptional level of MS2 was observed in anthers, especially at the young microspore stage. Gas chromatography-mass spectrometry(GC–MS) analysis showed decreased accumulation of cutin and wax components in ms2 anthers, indicating that MS2 plays a role in the transport of lipid molecules to anther cuticle and pollen exine. To our knowledge, MS2 is the first reported ABCG transporter gene that participates in anther development in maize.

关键词： Zea mays ABCG transporter Male sterility Anther development

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Early intervention with Didang decoction delays macrovascular lesions in diabetic rats through regulating AMP-activated protein kinase signaling pathway

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Chinese Journal of Natural Medicines 2017年第11期15卷 847-854页

作者： ren dan-dan LI Jing CHANG Bai LI Chun-Shen yang Ju-Hong Metabolic Diseases Hospital Tianjin Medical University Tianjin 300070 China Tanggu Dahua Hospital Tianjin Coastal New Area Tianjin 300455 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China

The study aimed to investigate the intervening role of Didang decoction(DDD) at different times in macrovascular endothelial defense function, focusing on its effects on the AMP-activated protein kinase(AMPK) signaling pathway. The effects of DDD on mitochondrial energy metabolism were also investigated in rat aortic endothelial cells(RAECs). Type 2 diabetes were induced in rats by streptozotocin(STZ) combined with high fat diet. Rats were randomly divided into non-intervention group, metformin group, simvastatin group, and early-, middle-, late-stage DDD groups. Normal rats were used as control. All the rats received 12 weeks of intervention or control treatment. Western blots were used to detect the expression of AMP-activated protein kinase α1(AMPKα1) and peroxisome proliferator-activated receptor 1α(PGC-1α). Changes in the intracellular AMP and ATP levels were detected with ELISA. Real-time-PCR was used to detect the m RNA level of caspase-3, endothelial nitric oxide synthase(eNOS), and Bcl-2. Compared to the diabetic non-intervention group, a significant increase in the expression of AMPKα1 and PGC-1α were observed in the early-stage, middle-stage DDD groups and simvastatin group(Prengthening the defense function of large vascular endothelial cells and postpone the development of macrovascular diseases in diabetes.

关键词： Didang decoction Caspase-3 AMPK Endothelial cells PGC-1α

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Hypersonic impact flash characteristics of a long-rod projectile collision with a thin plate target

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Defence Technology（防务技术） 2021年第2期17卷 375-383页

作者： Yi-jiang Xue Qing-ming Zhang dan-yang Liu ren-rong Long yang-yu Lu Tian-fei ren Liang-fei Gong State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Impact flash occurs when objects collide at supersonic speeds and can be used for real-time damage assessment when weapons rely on kinetic energy to destroy ***,the mechanism of impact flash remains unclear.A series of impact flash experiments of flat-head long-rod projectiles impacting thin target plates were performed with a two-stage light gas *** impact flash spectra for 6061 aluminum at 1.3e3.2 km/s collision speeds were recorded with a high-speed camera,a photoelectric sensor,and a time-resolved *** intensity of the impact flash exhibited a pulse characteristic with *** intensity(I)increased with impact velocity(V0)according to IfVn 0,where n?4.41 for V0>2 km/***,for V02 km/s,a continuous spectrum(thermal radiation background)was observed and increased in intensity with ***,for V0<2 km/s,only atomic line spectra were *** was no aluminum spectral lines for V0<2 km/s,which indicated that it had not been *** initial intense flash was emission from excited and ionized ambient gases near the impact surface,and had little relationship with shock temperature rise,indicating a new mechanism of impact flash.

关键词： Hypersonic impact flash Radiation intensity Impact flash mechanism Environmental luminescence

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Ligustilide protects PC12 cells from oxygen-glucose deprivation/reoxygenation-induced apoptosis via the LKB1-AMPK-mTOR signaling pathway

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Neural Regeneration Research 2020年第3期15卷 473-481页

作者： dan-yang Zhao Dong-Dong Yu Li ren Guo-Rong Bi Shengjing Hospital of China Medical University ShenyangLiaoning ProvinceChina The First People’s Hospital of Shenyang ShenyangLiaoning ProvinceChina The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine ShenyangLiaoning ProvinceChina

Autophagy has been shown to have a protective effect against brain ***(LIG)is a bioactive substance isolated from Ligusticum chuanxiong,a traditional Chinese *** has a neuroprotective effect;however,it is unclear whether this neuroprotective effect involves *** this study,PC12 cells were treated with 1×10^-5–1×10^-9 M LIG for 0,3,12 or 24 hours,and cell proliferation was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium(MTS)*** with 1×10^-6 M LIG for 3 hours had the greatest effect on cell proliferation,and was therefore used for subsequent ***12 cells were pre-treated with 1×10^-6 M LIG for 3 hours,cultured in 95%N2/5%CO2 in Dulbecco’s modified Eagle’s medium without glucose or serum for 4 hours,and then cultured normally for 16 hours,to simulate oxygen-glucose deprivation/reoxygenation(OGD/R).Cell proliferation was assessed with the MTS *** was detected by flow *** expression levels of apoptosis-related proteins,Bcl-2 and Bax,autophagy-related proteins,Beclin 1 and microtubule-associated protein l light chain 3B(LC3-II),and liver kinase B1(LKB1)-5′-adenosine monophosphate-activated protein kinase(AMPK)-mammalian target of rapamycin(mTOR)signaling pathway-related proteins were assessed by western blot *** staining was used to detect LC3-II *** formation was observed by electron *** significantly decreased apoptosis,increased Bcl-2,Beclin 1 and LC3-II expression,decreased Bax expression,increased LC3-II immunoreactivity and the number of autophagosomes,and activated the LKB1-AMPK-mTOR signaling pathway in PC12 cells exposed to OGD/*** addition of the autophagy inhibitor 3-methyladenine or dorsomorphin before OGD/R attenuated the activation of the LKB1-AMPK-mTOR signaling pathway in cells treated with *** together,our findings show that LIG promotes autophagy and protects

关键词： AMPK apoptosis autophagy Bax Bcl-2 Beclin 1 LC3-II ligustilide mTOR PC12 cells

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