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Quantitative detection of single amino acid polymorphisms by targeted proteomics

分子细胞生物学报:英文版 2011年第5期3卷 309-315页

作者： Zhi-Duan Su Liang Sun dan-xia yu Rong-xia Li Huai-Xing Li Zhi-Jie yu Quan-Hu Sheng Xu Lin Rong Zeng Jia-Rui Wu Key Laboratory of Systems Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Key Laboratory of Nutrition and Metabolism Institute of Nutritional SciencesShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China SIBS-Novo Nordisk Translational Research Centre for PreDiabetes Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Hefei National Laboratory for Physical Sciences at Microscale and School of Life Science University of Science and Technology of ChinaHefei 230026China

Single-nucleotide polymorphisms(SNPs)are recognized as one kind of major genetic variants in population ***,polymorphisms at the proteome level in population scale remain *** the present study,we named amino acid variances derived from SNPs within coding regions as single amino acid polymorphisms(SAPs)at the proteome level,and developed a pipeline of nontargeted and targeted proteomics to identify and quantify SAP peptides in human *** absolute concentrations of three selected SAP-peptide pairs among 290 Asian individuals were measured by selected reaction monitoring(SRM)approach,and their associations with both obesity and diabetes were further *** work revealed that heterozygotes and homozygotes with various SAPs in a population could have different associations with particular *** addition,the SRM approach allows us for the first time to separately measure the absolute concentration of each SAP peptide in the heterozygotes,which also shows different associations with particular traits.

关键词： single amino acid polymorphism(SAP) proteomics selected reaction monitoring(SRM) diabetes obesity

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Three-dimensional cell-based strategies for liver regeneration

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BIOCELL 2024年第7期48卷 1023-1036页

作者： dan GUO XI xia JIAN YANG Liver Transplant Center Transplant CenterWest China HospitalSichuan UniversityChengdu610041China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu610212China

Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern *** recent years,the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical *** review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver ***,we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver ***,we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical *** collective insights presented herein highlight the signiﬁcance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care.

关键词： Three-Dimensional Liver regeneration Organoids Stem cells Cell therapy

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On Stability Discrimination of Limit Cycles for Piecewise Smooth Systems

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1785-1803页

作者： Mao An HAN xia yu ZHOU School of Mathematical Sciences Zhejiang Normal UniversityJinhua321004P.R.China

This paper is concerned with the problem of stability discrimination of limit cycles for piecewise smooth *** first establish the Poincaré map near a periodic orbit,and deduce the first order derivative of the map for general piecewise smooth systems on the ***,we obtain a sufficient condition for determining the stability of limit cycles for these systems.

关键词： Piecewise smooth system limit cycle stability

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Electronic structure regulation and built-in electric field synergistically strengthen photocatalytic nitrogen fixation performance on Ti-BiOBr/TiO_(2)heterostructure

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Rare Metals 2024年第3期43卷 1125-1138页

作者： Ru-Qi Li yu-Jie Bian Chun-Ming Yang Li Guo Tao-xia Ma Chuan-Tao Wang Feng Fu dan-Jun Wang College of Chemistry and Chemical Engineering Yan’an UniversityYan’an Key Laboratory of Green Catalysis and Quality Improvement and Utilization of Low Rank CoalYan’an716000China

At present,industrial synthetic ammonia was still obtained through the Hubble-Bosch process,with large energy *** is a research hotspot to realize green synthetic ammonia by using solar *** difficulty of photocatalytic ammonia synthesis was that the photo-excited electrons have not enough energy to active N≡*** this study,Ti was doped into BiOBr by one-step hydrothermal method,which was oxidized into TiO_(2)when the doping amount reaches the maximum,in situ forming Ti_(0.31)B_(0.69)OB/TiO_(2)*** from the synergistic effect of Ti doping and S-scheme heterojunction,the synthetic ammonia efficiency of Ti_(0.31)B_(0.69)OB/TiO_(2)-11.96 reached 1.643 mmol·g_(cat)^(-1)at mild conditions and without hole scavenger for up to 7 h,the efficiency of synthetic ammonia is 115 times,10.5 times and 3.3 times of that of BiOBr,Ti_(0.31)B_(0.69)OB and TiO_(2),***,DFT calculation confirms that Ti doping accurately refine the electronic structure of BiOBr,facilitate nitrogen adsorption activation and reduce hydrogenation reaction energy barrier,thus accelerating the reaction kinetics of photocatalytic nitrogen reduction(NRR),Meanwhile,constructing S-scheme heterojunction boosts the separation and transfer of photogenerated electron-hole pairs,improving the reduction ability of electrons in the conduction band of TiO_(2)and the oxidation ability of holes in the valence band of Ti_(0.31)B_(0.69)OB.

关键词： S-scheme heterostructure Electronic structure regulation Built-in electric field Synergistical stren4gthening Photocatalytic nitrogen fixation

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Synthesis Chemistry & Performance Enhancement of Critical Inorganic Functional Materials

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Chemical Research in Chinese Universities 2024年第3期40卷 343-345页

作者： WANG dan yu Ranbo State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China Department of Physical Chemistry School of Metallurgical and Ecological EngineeringUniversity of Science&Technology BeijingBeijing 100083P.R.China

The development of human economy and society relies on the advancement of materials,and the research of advanced materials continuously drives industrial changes,giving rise to a new wave of global scientific and technological *** plays a significant role in the field of materials research and industry,however,the increasing prominence of key strategic materials being controlled by external forces has become a bottleneck issue that hinders national economic and social development as well as national security.

关键词： hinder continuously forces

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Celebrating 40 Years of Chemical Research in Chinese Universities

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Chemical Research in Chinese Universities 2024年第4期40卷 561-563页

作者： yu Jihong WANG dan State Key Laboratory of Inorganic Synthesis and Preparative Chemistry International Center of Future ScienceJilin UniversityChangchun 130012P.R.China State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China

Chemical Research in Chinese Universities was founded in 1984 as a comprehensive academic journal in the field of *** has since become a repository of intellectual treasures,documenting the evolving landscape of chemical science within the academic *** the past 40 years,Chemical Research in Chinese Universities has witnessed the rapid development of chemical research in universities.

关键词： chemistry. landscape journal

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Three-dimensional topological crystalline insulator without spin-orbit coupling in nonsymmorphic photonic metacrystal

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Chinese Physics B 2024年第10期33卷 282-286页

作者： Zhide yu Lingbo xia School of Physics and Electronics Hunan UniversityChangsha 410082China

By including certain point group symmetry in the classification of band topology,Fu proposed a class of threedimensionaltopological crystalline insulators(TCIs)without spin-orbit coupling in *** Fu’s model,surface states(ifpresent)doubly degenerate atГandM when time-reversal and C4 symmetries are *** analogs of Fu’s modelwith surface states quadratically degenerate atM are widely studied,while surface states with quadratic degeneracy atГare rarely *** this study,we propose a three-dimensional TCI without spin-orbit coupling in a judiciously designednonsymmorphic photonic *** surface states of photonic TCIs exhibit quadratic band degeneracy in the(001)surface Brillouin zone(BZ)center(Гpoint).The gapless surface states and their quadratic dispersion are protected by C4and time-reversal symmetries,which correspond to the nontrivial band topology characterized by Z_(2)topological ***,the surface states along lines fromГto the(001)surface BZ boundary exhibit zigzag feature,which is interpretedfrom symmetry perspective by building composite operators constructed by the product of glide symmetries with *** metacrystal array surrounded with air possesses high order hinge states with electric fields highlylocalized at the hinge that may apply to optical *** gapless surface states and hinge states reside in a cleanfrequency *** topological surface states emerge at the boundary of the metacrystal and perfect electric conductor(PEC),which provide a pathway for topologically manipulating light propagation in photonic devices.

关键词： topological crystalline insulator nonsymmorphic photonic metacrystal

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Evolution of inner wall wrinkle defects in the sinking zone of a thick-walled steel tube during radial forging

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Advances in Manufacturing 2024年第2期12卷 396-408页

作者： yu-Zhao Yang Cheng Xu Li-xia Fan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094People’s Republic of China

An axial wrinkle defect was observed in the inner wall of the sinking zone of a thick-wall steel tube processed by cold radial *** can evolve into *** present study focuses on the evolution of wrinkles and the effects of process parameters on them using a three-dimensional radial forging process finite element model,radial forging experiments,and surface morphology *** results indicated that the vertical section angle of the hammer die and the size of the tube blank significantly affect the evolution of *** height-to-width ratioλwas introduced to describe the morphology of *** had an approximately linear relationship with the radius reduction in the sinking *** was a linear correlation between the growth slope ofλand the axial to circumferential strain ratio|εr/εθ|,which can predict theλunder few process *** the 30SiMn2MoVA steel,at the junction of the forging and sinking zones,the threshold ofλof the wrinkle that can evolve into a fissure is approximately 1.123.

关键词： Radial forging Inner wall Wrinkle defects Evolution Sinking zone

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Towards imbalanced motion:part-decoupling network for video portrait segmentation

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Science China(Information Sciences) 2024年第7期67卷 197-210页

作者： Tianshu yu Changqun xia Jia LI State Key Laboratory of Virtual Reality Technology and Systems School of Computer Science and EngineeringBeihang University Peng Cheng Laboratory

Video portrait segmentation(VPS), aiming at segmenting prominent foreground portraits from video frames, has received much attention in recent years. However, the simplicity of existing VPS datasets leads to a limitation on extensive research of the task. In this work, we propose a new intricate large-scale multi-scene video portrait segmentation dataset MVPS consisting of 101 video clips in 7 scenario categories,in which 10843 sampled frames are finely annotated at the pixel level. The dataset has diverse scenes and complicated background environments, which is the most complex dataset in VPS to our best *** the observation of a large number of videos with portraits during dataset construction, we find that due to the joint structure of the human body, the motion of portraits is part-associated, which leads to the different parts being relatively independent in motion. That is, the motion of different parts of the portraits is imbalanced. Towards this imbalance, an intuitive and reasonable idea is that different motion states in portraits can be better exploited by decoupling the portraits into parts. To achieve this, we propose a part-decoupling network(PDNet) for VPS. Specifically, an inter-frame part-discriminated attention(IPDA)module is proposed which unsupervisedly segments portrait into parts and utilizes different attentiveness on discriminative features specified to each different part. In this way, appropriate attention can be imposed on portrait parts with imbalanced motion to extract part-discriminated correlations, so that the portraits can be segmented more accurately. Experimental results demonstrate that our method achieves leading performance with the comparison to state-of-the-art methods.

关键词： video portrait segmentation imbalanced motion unsupervised part decoupling motion correlation inter-frame attention

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Integrating remote sensing and 3-PG model to simulate the biomass and carbon stock of Larix olgensis plantation

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Forest Ecosystems 2024年第4期11卷 543-555页

作者： yu Bai Yong Pang dan Kong Key Laboratory of National Forestry and Grassland Administration on Forestry Remote Sensing and Information System Institute of Forest Resource Information

Accurate estimations of biomass and its temporal dynamics are crucial for monitoring the carbon cycle in forest ecosystems and assessing forest carbon sequestration *** studies have shown that integrating process-based models(PBMs)with remote sensing data can enhance simulations from stand to regional scales,significantly improving the ability to simulate forest growth and carbon stock ***,the utilization of PBMs for large-scale simulation of larch carbon storage distribution is still *** this study,we applied the parameterized 3-PG(Physiological Principles Predicting Growth)model across the Mengjiagang Forest Farm(MFF)to make broad-scale predictions of the biomass and carbon stocks of Larix olgensis *** model was used to simulate average diameter at breast height(DBH)and total biomass,which were later validated with a wide range of observation data including sample plot data,forest management inventory data,and airborne laser scanning *** results showed that the 3-PG model had relatively high accuracy for predicting both DBH and total biomass at stand and regional scale,with determination coefficients ranging from 0.78 to *** on the estimation of total biomass,we successfully produced a carbon stock map of the Larix olgensis plantation in MFF with a spatial resolution of 20 m,which helps with relevant management *** findings indicate that the integration of 3-PG model and remote sensing data can well predict the biomass and carbon stock at regional and even larger *** addition,this integration facilitates the evaluation of forest carbon sequestration capacity and the development of forest management plans.

关键词： 3-PG model Larch Biomass Carbon stock ALS

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