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Journal of Iron and Steel Research International 2020年第2期27卷 141-147页

作者： dan-qing jiang Rui Wang Qiong Zhang Zhen-qiang Zhang Ting-sheng Tu jiang Wang Zhong-ming Ren School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The effect of final electromagnetic stirring on the solidification structure,element segregation,and carbides of GCrl5 bearing steel was *** experiment of continuous casting of the steel was carried out by using a continuous casting physical simulation apparatus with the final electromagnetic *** liquid core profile was revealed by the pour-out method during the solidification *** ingots were produced under different electromagnetic stirring parameters for *** results show that,at the final stage of solidification,intense electromagnetic stirring exacerbates the central carbon segregation,resulting in more serious precipitation of the primary *** is also found that the carbides in the segregation area are dominantly M3C type,together with a small amount of M7C3-type and M3C2-type *** this physical simulation model,the optimal stirring parameters to obtain a fine and homogeneous structure are the liquid pool width of 15 mm,current intensity of 150 A,and stirring frequency of 5 Hz.

关键词： GCrl5 bearing steel Solidification structure Continuous casting Final electromagnetic stirring Segregation Carbide

Melting and floating processes of inorganic materials in molten steel:Visualization physical simulation and mathematical modelling

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China Foundry 2023年第2期20卷 89-98页

作者： Jin-hu Lai Sheng Yu Yang-jian Xu dan-qing jiang San-san Shuai jiang Wang Zhong-ming Ren State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Shaoxing Institute of Technology Shanghai UniversityShaoxing 312000ZhejiangChina

It has been demonstrated that heat absorption method by using the inorganic material rod to cool the molten steel can significantly reduce the macrosegregation level of the large steel ***,owing to the opacity of the molten steel,the physical mechanism of the heat absorption method is not *** this work,a transparent hydraulic physical model with water and paraffin wax was built to simulate the melting and floating processes of inorganic materials in the molten steel.A mathematical simulation was also carried out to analyze the connection between the actual ingot and the physical *** show that it is feasible to simulate the molten steel and inorganic materials with water and paraffin *** the help of the physical model,the process of the melting of paraffin wax and its floating to the surface of water were clearly observed,during which the temperature of water at some characteristic positions in the mold was *** visualization findings demonstrate that the melting and floating processes of paraffin wax can help to bring the heat from the center of the mold to the top surface more quickly,which reduces the superheat and significantly accelerates the cooling rate of *** experimental results show that for the water with a certain superheat,the use of a larger mass of paraffin wax can accelerate the cooling of the water,but there is a risk of incomplete melting of the paraffin wax.A higher superheat of water will lead to a quicker melting rate for a given mass of paraffin wax,while a lower superheat leads to the incomplete melting of paraffin wax as well.

关键词： water and paraffin wax heat absorption method physical simulation superheat large steel ingot

Influence of mechanical reduction amount on internal quality of continuous casting billets by thermal and numerical simulation

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Journal of Iron and Steel Research International 2023年第6期30卷 1234-1243页

作者： dan-qing jiang Shu-jian Sun Han Wu Yang-jian Xu Fu-hai Zhu Zhen-qiang Zhang jiang Wang Zhong-ming Ren School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

With establishment of thermal and numerical simulation models,the influence of reduction amount on solidification structure,segregation and shrinkage porosity of continuous casting(CC)billets was *** thermal–mechanical coupled simulation results indicated that with an increase in reduction amount,the temperature in the central area decreases,and the reduction efficiency firstly increases and then decreases,reaching the maximum value at reduction amount of 6 *** analysis showed that increasing the reduction amount is beneficial for the refinement of central solidification ***,the internal cracks are more likely to appear at higher reduction *** X-ray computerized tomography results revealed that a higher reduction amount can significantly reduce the volume fraction and equivalent diameter of the central shrinkage porosities of CC billets and increase the sphericity of ***,the macrosegregation of carbon along the central line is improved as the reduction amount increases;while the reduction amount exceeds 8 mm,the segregation degree will not change any more.

关键词： Mechanical reduction Solidification structure Porosity Thermal simulation Continuous casting billet

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng dan Yang Lingxi qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu dan-dan Xu Kang He Chang-qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

小檗碱类似物Y53在STZ诱导的糖尿病C57BL/6J小鼠中抗糖尿病肾病的作用研究

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中国药理学通报 2016年第9期32卷 1236-1242页

作者：李峥王灿宋丹青蒋建东孔维佳中国医学科学院医药生物技术研究所北京100050 中国医学科学院药物研究所北京100050

目的研究小檗碱(BBR)类似物假BBR(Y53)在链脲佐菌素(STZ)诱导的糖尿病(DM)小鼠中改善糖尿病肾病(DN)的作用。方法采用腹腔注射STZ 120 mg·kg^(-1)的方法诱发C57BL/6J小鼠的DM。建模成功的动物被分为4组,每天分别灌胃给予生理盐水、BBR ... 详细信息

目的研究小檗碱(BBR)类似物假BBR(Y53)在链脲佐菌素(STZ)诱导的糖尿病(DM)小鼠中改善糖尿病肾病(DN)的作用。方法采用腹腔注射STZ 120 mg·kg^(-1)的方法诱发C57BL/6J小鼠的DM。建模成功的动物被分为4组,每天分别灌胃给予生理盐水、BBR 50 mg·kg^(-1)、Y53 50mg·kg^(-1)或罗格列酮(ROSI)5 mg·kg^(-1)。实验过程中和结束后,收集动物的尿液、全血、血清和肾脏,使用试剂盒检测相关指标。以苏木精-伊红(HE)染色对肾组织进行病理学检验,分别以实时荧光定量反转录-PCR(qRT-PCR)和Western blot检测肾脏中靶基因的mRNA和蛋白的表达水平。结果与DM对照组比较,Y53能够明显降低DM动物的空腹血糖(FBG)和糖化血红蛋白(GHb),改善多食和多尿等DM症状(P<0.01)。与DM对照组比较,Y53还可明显降低血尿素氮(BUN)、血清肌酐(Scr)、24 h尿蛋白、肾指数、血清和肾组织中的晚期糖基化终末产物(AGEs)和一氧化氮(NO)、以及肾脏胆固醇(CHO)和三酰甘油(TG)含量(P<0.05或P<0.01)。在病理检测中,与DM对照组比较,Y53可明显改善DM小鼠肾组织的形态并抑制肾小球硬化(P<0.001)。另外,与DM对照组比较,Y53还能明显下调DM小鼠肾脏中纤维化相关基因,如转化生长因子-β1(TGF-β1)和smad2的表达(P<0.01)。该研究中Y53的肾脏保护效果明显优于BBR和ROSI(P<0.05或P<0.01)。结论BBR类似物Y53在STZ诱导的DM小鼠中具有明显的改善肾脏损伤、恢复肾功能的作用,该化合物在未来有可能被开发成为治疗DN的新型药物。

关键词：糖尿病肾病假小檗碱肾脏保护晚期糖基化终末产物一氧化氮转化生长因子-β1

Maternal and fetal death associated with acute pancreatitis during pregnancy:A case report

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World Journal of Clinical Cases 2025年第10期13卷 53-58页

作者： Jin Li qing-Yan Zhang Mei-Hong Zhang Shan-Yun jiang Department of Anesthesiology Kaihua County People’s HospitalQuzhou 324300Zhejiang ProvinceChina Center for Clinical Inspection and Quarantine Kaihua County Center for Clinical Inspection and QuarantineQuzhou 324300Zhejiang ProvinceChina

BACKGROUND Acute pancreatitis in pregnancy is a rare but serious condition that can lead to high maternal mortality and fetal *** of pregnancy complicated by severe acute pancreatitis,particularly with subsequent respiratory and cardiac arrest,are rarely *** SUMMARY We present the case of a 35-year-old woman,at 36+5 weeks of gestation,who presented with paroxysmal epigastric pain accompanied by low back pain,nausea,and *** to the clinical symptoms,B-ultrasound imaging and biochemical indicators,the patient was diagnosed with acute pancreatitis and initially managed ***,3 hours after admission,the patient experienced respiratory and cardiac arrest,and the fetus *** this case,the adverse outcomes occurred due to the lack of aggressive fluid resuscitation and an active surgical *** Implementing aggressive fluid resuscitation to sustain tissue perfusion,alongside the proactive evaluation of pharmacological agents that suppress gastric acid secretion and inhibit pancreatic enzyme activity,may be beneficial in mitigating the risk of a severely adverse *** management of acute pancreatitis during pregnancy requires careful timing of surgical intervention,a thorough evaluation of the risks and benefits regarding the continuation or termination of pregnancy,and a focus on safeguarding both maternal and fetal health.

关键词： Severe acute pancreatitis Pregnancy Cardiac arrest Fetal death Case report

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina qing-Rui Zhang Xiao-Ge Li Qi-Bao jiang Shi Bai Miao-Miao jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan Zhi-Yuan Liu Zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi Huang Jun-jiang Wang Xue-qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

Quasi-synchronous control of uncertain multiple electrohydraulic systems with prescribed performance constraint and input saturation

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Chinese Journal of Aeronautics 2023年第9期36卷 416-425页

作者： Shuai LI qing GUO Yan SHI Yao YAN dan jiang School of Aeronautics and Astronautics University of Electronic Science and Technology of ChinaChengdu 611731China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

This article focuses on the high accuracy quasi-synchronous control issue of multiple electrohydraulic systems(MEHS).In order to overcome the negative effects of parameter uncertainty and external load interference of MEHS,a kind of finite-time disturbance observer(FTDO)via terminal sliding mode method is constructed based on the MEHS model to achieve fast and accuracy estimation and compensation *** avoid the differential explosion in backstepping iteration,the dynamic surface control is used in this paper to guarantee the follower electrohydraulic nodes synchronize to the leader motion with a better ***,a timevarying barrier Lyapunov function(tvBLF)is adopted during the controller design process to constraint the output tracking error of MEHS in a prescribed performance with time-varying exponential *** the initial state condition is relax by tvBLF,the input saturation law is also adopted during the controller design process in this paper to restrain the surges of input signals,which can avoid the circuit and mechanical structure damage caused by the volatile input *** MEHS experimental bench is constructed to verify the effectiveness of the theoretical conclusions proposed in this paper and the advantages of the proposed conclusions in this paper are illustrated by a series of contradistinctive experimental results.

关键词： Backstepping Dynamic surface Finite-time disturbance observer Input saturation Multiple Electrohydraulic Systems Output error constraint Quasi-synchronous control