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Micromechanism and mathematical model of stress sensitivity in tight reservoirs of binary granular medium

Petroleum Science 2024年第3期21卷 1780-1795页

作者： Jian-Bang Wu Sheng-Lai Yang Qiang Li Kun Yang Can Huang Dao-ping lv Wei Zhou State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China Laboratoire de G eologie Ecole Normale Sup erieure/CNRS UMR8538PSL Research UniversityParis75005France Research Institute of Exploration and Development Xinjiang Oilfield CompanyKaramay834000XinjiangChina

Research on reservoir rock stress sensitivity has traditionally focused on unary granular structures,neglecting the binary nature of real reservoirs,especially tight *** the stresssensitive behavior and mathematical characterization of binary granular media remains a challenging *** this study,we conducted online-NMR experiments to investigate the permeability and porosity evolution as well as stress-sensitive control mechanisms in tight sandy conglomerate *** results revealed stress sensitivity coefficients between 0.042 and 0.098 and permeability damage rates ranging from 65.6%to 90.9%,with an average pore compression coefficient of 0.0168—0.0208 MPa ***-scale compression occurred in three stages:filling,compression,and compaction,with matrix pores playing a dominant role in pore *** stress sensitivity of binary granular media was found to be influenced by the support structure and particle *** stress sensitivity was associated with small fine particle size,high fines content,high uniformity coefficient of particle size,high plastic deformation,and low Young's ***-supported samples exhibited a high irreversible permeability damage rate(average=74.2%)and stress sensitivity coefficients(average=0.089),with pore spaces more *** contrast,grain-supported samples showed low stress sensitivity coefficients(average=0.021)at high stress *** on the experiments,we developed a mathematical model for stress sensitivity in binary granular media,considering binary granular properties and nested interactions using Hertz contact deformation and Poiseuille *** describing the change in activity content of fines under stress,we characterized the non-stationary state of compressive deformation in the binary granular structure and classified the reservoir into three *** model was applied for production prediction using actual data from the Mahu reservoir in China,showing that the e

关键词： Stress sensitivity Binary granular medium Tight reservoir Online-NMR Reservoir energy retention rate

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Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

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World Journal of Diabetes 2024年第6期15卷 1226-1233页

作者： Jie Pang Lin-Yan Qian ping lv Xiao-Ru Che Heart Center Department of Cardiovascular MedicineZhejiang Provincial People’s Hospital(The Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular *** To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December *** NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were *** receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of *** correlation between NLR and RDW with the presence or absence of cardiac events was also *** Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of ***,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac *** NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic ***,NLR and RDW values were directly proportional to patient outcomes.

关键词： Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis

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METTL9-catalyzed histidine methylation of S100A9 suppresses the anti-Staphylococcus aureus activity of neutrophils

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Protein & Cell 2024年第3期15卷 223-229页

作者： dan Cao Mengyue lv Chi Hu Shukai Li Siwen Wang Chao Xu Wen Pan Department of Digestive Disease The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technologyof ChinaHefei230001China Division of Life Sciences and Medicine The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesInstitute of ImmunologyUniversity of Science and Technology of ChinaHefei 230027China Division of Life Sciences and Medicine MOE Key Laboratory for Cellular DynamicsHefei National Center for Cross-Disciplinary SciencesUniversity of Science and Technology of ChinaHefei 230027China

Dear Editor,Protein histidine methylation has been found to be a widespread post-translational modification(PTM)in mammalian cells and represents more than 13%of all protein methylation events in the human methylome(Ning et al.,2016;Kapell and Jakobsson,2021).Recently,we and other groups independently identified METTL9 as the first broad-specificity histidine N1 methyltransferase in mammals(Davydova et al.,2021;lv et al.,2021).METTL9 methylates a variety of substrates with a common x-His-x-His motif(His is for histidine;the second x is preferably small amino acids:A/C/G/S)and catalyzes methyl transfer to the last histidine.

关键词： S100A9 specificity

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Enhancing CO_(2)capture of an aminoethylethanolamine-based non-aqueous absorbent by using tertiary amine as a proton-transfer mediator:From performance to mechanism

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Journal of Environmental Sciences 2024年第6期140卷 146-156页

作者： Xiaobin Zhou danWang Chao Liu Guohua Jing Bihong lv Dunqiu Wang College of Environmental Science and Engineering Guilin University of TechnologyGuilin 541004China The Guangxi Key Laboratory of Theory and Technology for Environmental Pollution Control Guilin University of TechnologyGuilin 541004China College of Chemical Engineering Huaqiao UniversityXiamen 361021China

Non-aqueous absorbents(NAAs)have attracted increasing attention for CO_(2)capture because of their great energy-saving *** diamines which can provide high CO_(2)absorption loading are promising candidates for formulating NAAs but suffer disadvantages in *** this study,a promising strategy that using tertiary amines(TAs)as proton-transfer mediators was proposed to enhance the regenerability of an aminoethylethanolamine(AEEA,diamine)/dimethyl sulfoxide(DMSO)(A/D)***,some employed TAs such as N,N-diethylaminoethanol(DEEA),N,N,N’,N’’,N’’-pentamethyldiethylenetriamine(PMDETA),3-dimethylamino-1-propanol(3DMA1P),and N,N-dimethylethanolamine(DMEA)enhanced not only the regenerability of the A/D NAA but also the CO_(2)absorption ***,the CO_(2)absorption loading and cyclic loading were increased by about 12.7%and 15.5%-22.7%,*** TA-enhanced CO_(2)capture mechanism was comprehensively explored via nuclear magnetic resonance technique and quantum chemical *** CO_(2)absorption,the TA acted as an ultimate proton acceptor for AEEA-zwitterion and enabled more AEEA to form carbamate species(AEEACOO-)to store CO_(2),thus enhancing CO_(2)*** CO_(2)desorption,the TA first provided protons directly to AEEACOO-as a proton donor;moreover,it functioned as a proton carrier and facilitated the low-energy step-wise proton transfer from protonated AEEA to AEEACOO-.Consequently,the presence of TA made it easier for AEEACOO-to obtain protons to decompose,resulting in enhanced CO_(2)*** a word,introducing the TA as a proton-transfer mediator into the A/D NAA enhanced both the CO_(2)absorption performance and the regenerability,which was an efficient way to“kill two birds with one stone”.

关键词： Carbon dioxide capture Non-aqueous absorbent Tertiary amine Proton-transfer mediator Enhanced mechanism

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Polysulfide modified PtCu intermetallic nanocatalyst with enrichment realizes efficient electrooxidation ethanol to CO_(2)

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Nano Research 2024年第4期17卷 2320-2327页

作者： Shuanglong Zhou Zheng lv Liang Zhao dan Zhang Zuocao Wang Yu Dai Bin Li Olga Starostenko Jianping Lai Lei Wang Key Laboratory of Eco-chemical Engineering Ministry of EducationTaishan scholar advantage and characteristic discipline team of Eco-chemical process and technologyLaboratory of Inorganic Synthesis and Applied ChemistryCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China College of Foreign Languages Qingdao City UniversityQingdao 266106China College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine Kyiv 02160Ukraine Shandong Engineering Research Center for Marine Environment Corrosion and Safety Protection College of Environment and Safety EngineeringQingdao University of Science and TechnologyQingdao 266042China

The main problem faced by ethanol oxidation reaction(EOR)includes low activity,poor selectivity,and *** the study,we found that polysulfide modified on the surface of PtCu intermetallic(IM)/C can simultaneously enrich hydroxyl and ethanol,which could effectively improve the catalytic activity,CO_(2) selectivity,and durability of *** mass activity and the specific activity of the product in 1 M KOH electrolyte reached 17.83 A·mgPt^(-1) and 24.67 mA·cm^(-2).The CO_(2) selectivity of polysulfide modified product achieved 93.5%,which was 30 folds higher than Pt/*** addition,the catalyst showed high catalytic *** mechanism study demonstrates that the surface modified polysulfide could significantly boost the enrichment effect of ethanol and hydroxyl species,accelerating C–C bond cleavage and CO oxidation.

关键词： Pt CO_(2) selectivity enrichment effect ethanol oxidation reaction(EOR) electrocatalyst

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Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia

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Virologica Sinica 2024年第1期39卷 31-43页

作者： Dongyan Zhang Xiulin Wu Xing Xue Wenshi Li ping Zhou Zhao lv Kexin Zhao Fan Zhu State Key Laboratory of Virology and Department of Medical Microbiology School of Basic Medical SciencesWuhan UniversityWuhan430071China Hubei Province Key Laboratory of Allergy&Immunology Wuhan UniversityWuhan430071China

Human endogenous retroviruses(HERVs)are remnants of retroviral infections in human germline cells from millions of years *** these,ERVW-1(also known as HERV-W-ENV,ERVWE1,or ENVW)encodes the envelope protein of the HERV-W family,which contributes to the pathophysiology of ***,neuropathological studies have revealed cell death and disruption of iron homeostasis in the brains of individuals with ***,our bioinformatics analysis showed that differentially expressed genes in the human prefrontal cortex RNA microarray dataset(GSE53987)were mainly related to ferroptosis and its associated *** data demonstrated significantly lower expression levels of ferroptosis-related genes,particularly Glutathione peroxidase 4(GPX4)and solute carrier family 3 member 2(SLC3A2),in schizophrenia patients compared to normal *** in-depth analyses revealed a significant negative correlation between ERVW-1 expression and the levels of GPX4/SLC3A2 in *** indicated that ERVW-1 increased iron levels,malondialdehyde(MDA),and transferrin receptor protein 1(TFR1)expression while decreasing glutathione(GSH)levels and triggering the loss of mitochondrial membrane potential,suggesting that ERVW-1 can induce *** research has shown that ERVW-1 reduced the expression of GPX4 and SLC3A2 by inhibiting their promoter ***,Ferrostatin-1(Fer-1),the ferroptosis inhibitor,reversed the iron accumulation and mitochondrial membrane potential loss,as well as restored the expressions of ferroptosis markers GSH,MDA,and TFR1 induced by *** conclusion,ERVW-1 could promote ferroptosis by downregulating the expression of GPX4 and SLC3A2,revealing a novel mechanism by which ERVW-1 contributes to neuronal cell death in schizophrenia.

关键词： ERVW-1 Glutathione peroxidase 4(GPX4) Solute carrier family 3 member 2(SLC3A2) Ferroptosis Schizophrenia

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Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer

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World Journal of Gastroenterology 2024年第16期30卷 2195-2208页

作者： Xiao-Jun Zhang Yan Yu He-ping Zhao Lei Guo Kun Dai Jing lv Department of Clinical Laboratory Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Department of Spinal Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Department of Clinical Laboratory Yanliang Railway Hospital of Xi’anXi’an 710089Shaanxi ProvinceChina

As a highly invasive malignancy,esophageal cancer(EC)is a global health issue,and was the eighth most prevalent cancer and the sixth leading cause of cancerrelated death worldwide in *** to its highly immunogenic nature,emerging immunotherapy approaches,such as immune checkpoint blockade,have demonstrated promising efficacy in treating EC;however,certain limitations and challenges still *** addition,tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment(TIME);thus,understanding the TIME is urgent and crucial,especially given the importance of an immunosuppressive microenvironment in tumor *** aim of this review was to better elucidate the mechanisms of the suppressive TIME,including cell infiltration,immune cell subsets,cytokines and signaling pathways in the tumor microenvironment of EC patients,as well as the downregulated expression of major histocompatibility complex molecules in tumor cells,to obtain a better understanding of the differences in EC patient responses to immunotherapeutic strategies and accurately predict the efficacy of ***,personalized treatments could be developed to maximize the advantages of immunotherapy.

关键词： Esophageal cancer Esophageal squamous cell carcinoma Esophageal adenocarcinoma Tumor immune microenvironment Immunosuppression Immunotherapy

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High-pressure capacity expansion and water injection mechanism and indicator curve model for fractured-vuggy carbonate reservoirs

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PETROLEUM 2024年第3期10卷 511-519页

作者： Chen, Lixin Jia, Chengzao Zhang, Rujie Yue, ping Jiang, Xujian Wang, Junfang Su, Zhou Xiao, Yun lv, Yuan China Univ Petr Inst Unconvent Oil & Gas Sci & Technol Beijing 102249 Peoples R China Southwest Petr Univ State Key Lab Reservoir Geol & Dev Chengdu 610500 Peoples R China Tarim Oil field Co PetroChina Korla 841000 Peoples R China

Water injection for oil displacement is one of the most effective ways to develop fractured-vuggy carbonate reservoirs. With the increase in the number of rounds of water injection, the development effect gradually fails. The emergence of high-pressure capacity expansion and water injection technology allows increased production from old wells. Although high-pressure capacity expansion and water injection technology has been implemented in practice for nearly 10 years in fractured-vuggy reservoirs, its mechanism remains unclear, and the water injection curve is not apparent. In the past, evaluating its effect could only be done by measuring the injection-production volume. In this study, we analyze the mechanism of high-pressure capacity expansion and water injection. We propose a fluid exchange index for high-pressure capacity expansion and water injection and establish a discrete model suitable for high-pressure capacity expansion and water injection curves in fractured-vuggy reservoirs. We propose the following mechanisms: replenishing energy, increasing energy, replacing energy, and releasing energy. The above mechanisms can be identified by the high-pressure capacity expansion and water injection curve of the well HA6X in the Halahatang Oilfield in the Tarim Basin. By solving the basic model, the relative errors of Reservoirs I and II are found to be 1.9% and 1.5%, respectively, and the application of field examples demonstrates that our proposed high-pressure capacity expansion and water injection indicator curve is reasonable and reliable. This research can provide theoretical support for high-pressure capacity expansion and water injection technology in fracture-vuggy carbonate reservoirs.

关键词： Fractured-vuggy carbonate reservoirs High-pressure capacity expansion and water injection Mechanism Water injection indicator curve ENHANCED OIL-RECOVERY STRESS SENSITIVITY TARIM BASIN FIELD

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The Short-Term Prediction ofWind Power Based on the Convolutional Graph Attention Deep Neural Network

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Energy Engineering 2024年第2期121卷 359-376页

作者： Fan Xiao Xiong ping Yeyang Li Yusen Xu Yiqun Kang dan Liu Nianming Zhang State Grid Hubei Electric Power Research Institute Wuhan430077China College of Energy and Electrical Engineering Hohai UniversityNanjing210098China

The fluctuation of wind power affects the operating safety and power consumption of the electric power grid and restricts the grid connection of wind power on a large ***,wind power forecasting plays a key role in improving the safety and economic benefits of the power *** paper proposes a wind power predicting method based on a convolutional graph attention deep neural network with multi-wind farm *** on the graph attention network and attention mechanism,the method extracts spatial-temporal characteristics from the data of multiple wind ***,combined with a deep neural network,a convolutional graph attention deep neural network model is ***,the model is trained with the quantile regression loss function to achieve the wind power deterministic and probabilistic prediction based on multi-wind farm spatial-temporal data.A wind power dataset in the *** taken as an example to demonstrate the efficacy of the proposed *** with the selected baseline methods,the proposed model achieves the best prediction *** point prediction errors(i.e.,root mean square error(RMSE)and normalized mean absolute percentage error(NMAPE))are 0.304 MW and 1.177%,*** the comprehensive performance of probabilistic prediction(i.e.,con-tinuously ranked probability score(CRPS))is ***,the significance of multi-wind farm data and spatial-temporal feature extraction module is self-evident.

关键词： Format wind power prediction deep neural network graph attention network attention mechanism quantile regression

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Adaptive Predefined-Time Backstepping Control for Grid Connected Photovoltaic Inverter

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Energy Engineering 2024年第8期121卷 2065-2083页

作者： Jiarui Zhang dan Liu Kan Cao ping Xiong Xiaotong Ji Yanze Xu Yunfei Mu Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin300072China State Grid Hubei Electric Power Research Institute Wuhan430077China State Grid Hubei Electric Power Co. Ltd.Wuhan430077China

The system performance of grid-connected photovoltaic(PV)has a serious impact on the grid *** improve the control performance and shorten the convergence time,a predefined-time controller based on backstepping technology and dynamic surface control is formulated for the inverter in the grid-connected *** time-varying tuning functions are introduced into state-tracking errors to realize the predefined-time control *** address the“computational explosion problem”in the design process of backstepping control,dynamic surface control is adopted to avoid the analytical calculations of virtual *** disturbances of the PV system are estimated and compensated by adaptive *** control parameters are chosen and the global stability of the closed-loop is ensured by Lyapunov *** results confirm the effectiveness of the proposed controller and ensure the predefined time control in the photovoltaic inverter.

关键词： Photovoltaic inverter system backstepping technology predefined-time control adaptive control

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