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Asian Pacific Journal of Tropical Medicine 2012年第12期5卷 966-969页

作者： Bang-Xing Han dan-zhao guo Jun Chen Jian Mao Research Center of Plant Cell Engineering of Anhui Province School of Pharmacy Jiangsu University School of Food Science and Technology Jiangnan University

Objective:To explore the effect of AIBL on Oncomelania hupensis,the intermediate snail host of Schistosoma ***:The enzyme histochemical profiles of cholineslerase, cytochrome oxidase,lactate dehydrogenase,nitric oxide synthase,and succinate dehydrogenase in the soft tissues of Oncomelania hupensis,the intermediate host snail of Schistosoma japonicum, were analyzed before and after treatment with the active ingredient of Buddleia lindleyana(AIBL), a potent and safe plant ***:Treatment with AIBL induced a notable decrease in the activities of the five enzymes(P<0.01).Conclusions:The results indicate that AIBL impairs the activities of the enzymes,thereby influencing the transfer of neurotransmitter and energy supply in Oncomelania hupensis and ultimately harming their various physiological functions, which are considered to cause death of the species.

关键词： Oncomelania hupensis Snail control Schistosomiasis Active ingredient Enzyme histochemistry

Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang Yu Jingxiao zhao Xuelin Wang Hui guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong dan Zou Zhijun Yang Lili guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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涠洲岛客运班线船舶安全风险研究

西部交通科技 2017年第8期 123-125页

作者：王丹赵新果钦州学院广西钦州535011

文章结合涠洲岛客运现状,从船员管理、交通环境、气象及旅客管理等方面分析了影响涠洲岛客运班线船舶航行安全的风险因素,并提出了相应的安全管理对策。

关键词：涠洲岛水上客运航行安全风险分析

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu Qiu Xiaohan Chen Yinkun zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu dan Xiao zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu zhao Hang Ma Conghui Zhang Yongxin Yang Shuyuan Yu Haiye Zhu Yongjiang Sun Hong guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： dan Hu Yue Li Hua Zhang Lian-Lian Wang Wen-Wen Liu Xin Yang Ming-zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

Temperature Difference and Stack Plate Spacing Effects on Thermodynamic Performances of Standing-Wave Thermoacoustic Engines Driven by Cryogenic Liquids and Waste Heat

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Journal of Thermal Science 2022年第5期31卷 1434-1451页

作者： guo Lixian zhao dan BECKER Sid Department of Mechanical Engineering College of EngineeringUniversity of CanterburyPrivate Bag 4800Christchurch8041New Zealand

The standing-wave thermoacoustic engines(TAE)are applied in practice to convert thermal power into acoustic one to generate electricity or to drive cooling *** there is a number of existing numerical researches that provides a design tool for predicting standing-wave TAE performances,few existing works that compare TAE driven by cryogenic liquids and waste heat,and optimize its performance by varying the stack plate *** present work is primarily concerned with the numerical investigation of the performance of TAEs driven by cryogenic liquids and waste *** this,three-dimensional(3-D)standing-wave TAE models are ***-and time-independence studies are conducted *** validations are then performed by comparing with the numerical results available in the *** validated model is then applied to simulate the standing-wave TAEs driven by the cryogenic liquids and the waste heat,as the temperature gradientΔT is *** is found that limit cycle oscillations in both systems are successfully generated and the oscillations amplitude is increased with increasedΔ*** is identified with acoustic streaming and the flow reversal occurring through the *** studied are then conducted between the cryogenic liquid-driven TAE and that driven by waste heat in the presence of the same temperature gradientΔ*** is shown that the limit cycle frequency of the cryogenic liquid system is 4.72%smaller and the critical temperatureΔT_(cri)=131 K is lower than that of the waste heat system(ΔT_(cri)=187 K).Furthermore,the acoustic power is increased by 31%and the energy conversion efficiency is found to increase by 0.42%.Finally,optimization studies on the stack plate spacing are conducted in TAE system driven by cryogenic *** is found that the limit cycle oscillation frequency is increased with the decreased ratio between the stack plate spacing and the heat penetration *** the ratio is set to between 2 and

关键词： thermoacoustic engine standing-wave cryogenic thermodynamics acoustical energy plate spacing heat transfer acoustic streaming

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金银花不同提取方法的绿原酸比较研究

天然产物研究与开发 2003年第2期15卷 124-126页

作者：林丹赵国玲刘佳佳中南大学化学化工学院湖南长沙410083

本文采用了水提法、水提醇沉法、酶解法、醇提法对金银花进行提取 ,并用紫外分光光度法来测定提取物中绿原酸的含量 ,依此来比较各种方法的优劣。由实验结果可得 :以绿原酸作为指标来考察各种方法的优劣 ,尤以醇提法较好 ,绿原酸的含量... 详细信息

本文采用了水提法、水提醇沉法、酶解法、醇提法对金银花进行提取 ,并用紫外分光光度法来测定提取物中绿原酸的含量 ,依此来比较各种方法的优劣。由实验结果可得 :以绿原酸作为指标来考察各种方法的优劣 ,尤以醇提法较好 ,绿原酸的含量可达到 15 2 8% ;以提取物的得率作为指标来考察 ,以酶解法为最好 ,提取物的得率可达到 37 91%。

关键词：金银花提取方法绿原酸比较研究含量测定水提法水提醇沉法酶解法醇提法得率药用植物

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天山假狼毒的化学成分研究(Ⅱ)

中草药 2017年第1期48卷 58-61页

作者：石磊岭赵丹马国需杨峻山古丽娜.沙比尔张晶新疆维吾尔自治区中药民族药研究所新疆乌鲁木齐830002 吉林农业大学中药材学院吉林长春130118 中国医学科学院北京协和医学院药用植物研究所北京100193

目的系统研究天山假狼毒Stelleropsis tianschanica的化学成分。方法采用柱色谱技术对天山假狼毒的甲醇提取物进行分离纯化,用波谱技术结合化学方法进行结构鉴定。结果从天山假狼毒甲醇提取物中分离得到了12个化合物,包括5个木脂素类,3... 详细信息

目的系统研究天山假狼毒Stelleropsis tianschanica的化学成分。方法采用柱色谱技术对天山假狼毒的甲醇提取物进行分离纯化,用波谱技术结合化学方法进行结构鉴定。结果从天山假狼毒甲醇提取物中分离得到了12个化合物,包括5个木脂素类,3个二苯基戊醇衍生物,分别鉴定为kusunokinin(1)、pluviatolide(2)、邻苯二甲酸二丁酯(3)、邻苯二甲酸二丙酯(4)、对二苯酚(5)、瑞香酮(6)、2(S)-hydroxy-1-(4-hydroxy phenyl)-5-phcnyl-1-pentanone(7)、(2R,3R)-1,5-diphenylpentane-2,3-diol(8)、落叶松树脂醇(9)、异落叶松树脂醇(10)、马台树脂醇(11)、4α,5βH-guai-9,7(11)-dien-12,8-olide-12,8α-diol(12)。结论化合物1~12均为首次从该属植物中分离得到。

关键词：天山假狼毒木脂素类二苯基戊醇类 kusunokinim pluviatolide邻苯二甲酸二丁酯落叶松树脂醇