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Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn

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Current Medical Science 2024年第2期44卷 369-379页

作者： Ji luo Jin ZHOU Jing-zeng luo Hai-long WANG Xue-ling ZHAO Ru-dan ZHOU Department of Intensive Care Unit The First People's Hospital of ZiyangZiyang 641300China Department of Orthopedics Kunming Medical University Second Affiliated HospitalKunming 650033China Department of Orthopedics Kunming Medical University First Affiliated HospitalKunming 650032China Department of Orthopedics The Third People's Hospital of Yunnan ProvinceKunming 650200China

Objective:Matrix metalloproteinase 13(MMP13)is an extracellular matrix protease that affects the progression of atherosclerotic plaques and arterial thrombi by degrading collagens,modifying protein structures and regulating inflammatory responses,but its role in deep vein thrombosis(DVT)has not been *** purpose of this study was to investigate the potential effects of MMP13 and MMP13-related genes on the formation of ***:We altered the expression level of MMP13 in vivo and conducted a transcriptome study to examine the expression and relationship between MMP13 and MMP13-related genes in a mouse model of *** screening genes possibly related to MMP13 in DVT mice,the expression levels of candidate genes in human umbilical vein endothelial cells(HUVECs)and the venous wall were *** effect of MMP13 on platelet aggregation in HUVECs was investigated in ***:Among the differentially expressed genes,interleukin 1 beta,podoplanin(Pdpn),and factor VIII von Willebrand factor(F8VWF)were selected for analysis in *** MMP13 was inhibited,the expression level of PDPN decreased significantly in *** HUVECs,overexpression of MMP13 led to an increase in the expression level of PDPN and induced platelet aggregation,while transfection of PDPN-siRNA weakened the ability of MMP13 to increase platelet ***:Inhibiting the expression of MMP13 could reduce the burden of DVT in *** mechanism involves downregulating the expression of Pdpn through MMP13,which could provide a novel gene target for DVT diagnosis and treatment.

关键词： deep vein thrombosis matrix metalloproteinase 13 podoplanin

矿区水文地质勘查与环境地质评价现状及发展形势

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世界有色金属 2024年第1期 157-159页

作者：平措朗加其米多吉旦增罗布西藏自治区地质矿产勘查开发局第五地质大队青海格尔木816000

大气污染和土地污染日趋严重;固体废弃物堆积严重;采空区诱发地裂缝与塌陷等地质灾害越来越频繁。加强对矿区水文地质勘查和环境地质评价已成为保障资源安全和生态安全的重要举措。本文综述了我国矿区水文地质勘查与环境地质评价工作及... 详细信息

大气污染和土地污染日趋严重;固体废弃物堆积严重;采空区诱发地裂缝与塌陷等地质灾害越来越频繁。加强对矿区水文地质勘查和环境地质评价已成为保障资源安全和生态安全的重要举措。本文综述了我国矿区水文地质勘查与环境地质评价工作及取得的成果,分析了其存在问题及面临的形势,指出了矿区水文地质勘查与环境地质评价工作发展方向和主要任务:从矿产开发过程中可能引发环境问题出发,系统开展矿区水文地质勘查与环境地质评价研究工作,并提出相应对策措施。

关键词：矿区水文地质勘查环境地质评价

Pathophysiological changes of muscle after ischemic stroke:a secondary consequence of stroke injury

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Neural Regeneration Research 2024年第4期19卷 737-746页

作者： Hu Qi dan Tian Fei Luan Ruocong Yang Nan zeng State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine School of Pharmacy Chengdu University of Traditional Chinese Medicine Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine

Sufficient clinical evidence suggests that the damage caused by ischemic stroke to the body occurs not only in the acute phase but also during the recovery period,and that the latter has a greater impact on the long-term prognosis of the ***,current stroke studies have typically focused only on lesions in the central nervous system,ignoring secondary damage caused by this *** a phenomenon arises from the slow progress of pathophysiological studies examining the central nervous ***,the appropriate therapeutic time window and benefits of thrombolytic therapy are still controversial,leading scholars to explore more pragmatic intervention *** treatment measures targeting limb symptoms can greatly improve a patient’s quality of life,they have become a critical intervention *** the most vital component of the limbs,skeletal muscles have become potential points of *** this,to the best of our knowledge,there are no comprehensive reviews of pathophysiological changes and potential treatments for post-stroke skeletal *** current review seeks to fill a gap in the current understanding of the pathological processes and mechanisms of muscle wasting atrophy,inflammation,neuroregeneration,mitochondrial changes,and nutritional dysregulation in stroke *** addition,the challenges,as well as the optional solutions for individualized rehabilitation programs for stroke patients based on motor function are discussed.

关键词： inflammation ischemic stroke mitochondria muscle atrophy muscle fiber muscle nutrition quality of life rehabilitation ubiquitin

Aboveground biomass stocks of species-rich natural forests in southern China are influenced by stand structural attributes,species richness and precipitation

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Plant Diversity 2024年第4期46卷 530-536页

作者： Wen-Hao zeng Shi-dan Zhu Ying-Hua luo Wei Shi Yong-Qiang Wang Kun-Fang Cao State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of ForestryGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Forest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China Key Laboratory of National Forestry and Grassland Administration on Biodiversity Conservation in Karst Mountainous Areas of Southwestern China School of Life SciencesGuizhou Normal UniversityHuaxi College TownGui'an DistrictGuiyang 550025China

Forests,the largest terrestrial carbon sinks,play an important role in carbon sequestration and climate change *** forest attributes and environmental factors have been shown to impact aboveground biomass,their influence on biomass stocks in species-rich forests in southern China,a biodiversity hotspot,has rarely been *** this study,we characterized the effects of environmental factors,forest structure,and species diversity on aboveground biomass stocks of 30 plots(1 ha each) in natural forests located within seven nature reserves distributed across subtropical and marginal tropical zones in Guangxi,*** results indicate that forest aboveground biomass stocks in this region are lower than those in mature tropical and subtropical forests in other ***,we found that aboveground biomass was positively correlated with stand age,mean annual precipitation,elevation,structural attributes and species richness,although not with species *** we compared stands with the same basal area,we found that aboveground biomass stock was higher in communities with a higher coefficient of variation of diameter at breast *** findings highlight the importance of maintaining forest structural diversity and species richness to promote aboveground biomass accumulation and reveal the potential impacts of precipitation changes resulting from climate warming on the ecosystem services of subtropical and northern tropical forests in ***,many natural forests in southern China are not fully ***,their continued growth will increase their carbon storage over time.

关键词： Subtropical forest Marginal tropical forest Aboveground biomass Species diversity Forest structural attribute Environment factor

Efficacy of exercise rehabilitation for managing patients with Alzheimer's disease

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Neural Regeneration Research 2024年第10期19卷 2175-2188页

作者： dan Li Jinning Jia Haibo zeng Xiaoyan Zhong Hui Chen Chenju Yi Department of Pathology The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi ProvinceChina Department of Pathology Huichang County People’s HospitalGanzhouJiangxi ProvinceChina School of Life Sciences Faculty of ScienceUniversity of Technology SydneyUltimoNSWAustralia Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research ShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Function and Disease GuangzhouGuangdong ProvinceChina

Alzheimer's disease(AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low-and middle-income countries.

关键词： Alzheimer's disease cerebrovascular function cognitive function epigenetic regulation exercise hippocampal neurogenesis mitochondria neuroinflammation neuronal plasticity

Robustness analysis of O-FDE algorithm for dispersion compensation in coherent fiber optical communications

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Optoelectronics Letters 2024年第5期20卷 289-293页

作者： ZHONG Kun zeng Chenping DONG Jiaqiang WANG Baojiang LI dan School of Information Technology Xichang UniversityXichang 615013China Key Laboratory of Liangshan Agriculture Digital Transformation of Sichuan Provincial Education Department Xichang615013China

The overlapping frequency domain equalization(O-FDE) in digital signal processing(DSP) is frequently employed to provide dispersion compensation in long-distance coherent fiber optical communications. However, the change in overlapping symbol length that occurs during the processing of the O-FDE algorithm will typically be influenced by the decision and zero filling of the last subblock, which is harmful to the robustness of the O-FDE algorithm. In this study, with a thorough robustness analysis on changing overlapping symbol length, we present a novel method for decision and zero filling of the last subblock and examine the correspondingly resulting error vector magnitude(EVM) and symbol error ratio(SER) under different values of optical signal-to-noise ratio(OSNR), chromatic dispersion, and overlapped symbol lengths.

关键词： fiber dispersion symbol

The life-history trait trade-offs mediated by reproduction and immunity in the brown planthopper,Nilaparvata lugens Stål

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Journal of Integrative Agriculture 2024年第6期23卷 2018-2032页

作者： dan Sun Hongfeng Wang Jiahui zeng Qiuchen Xu Mingyun Wang Xiaoping Yu Xuping Shentu Zhejiang Provincial Key Laboratory of Biometrology and Inspection&Quarantine College of Life ScienceChina Jiliang UniversityHangzhou 310018China

Reproduction and immune defense are costly functions,and they are expected to tradeoff with each other to drive *** brown planthopper(BPH),Nilaparvata lugens Stål(Hemiptera,Delphacidae),is a global superpest that mostly damages rice ***-like symbionts(YLS)exist in the abdominal fat body tissue and are tightly associated with the development,growth,and reproduction of *** previous research demonstrated that mating behavior promotes the release of YLS from the fat body into the hemolymph in the BPH,thereby triggering an immune ***,the fitness costs related to life-history traits of BPH(such as survival rate)have a strong dependence on the relative abundance of ***,the possible relationship between reproduction and the immune response in BPH has not been *** this study,an omics-based approach was used to analyze the transcriptome of fat body tissues in mated and unmated BPH at 72 h post-eclosion,from which two antimicrobial peptide genes,NlDefensin A(NlDfA)and NlDefensin B(NlDfB),were selected since they were highly expressed in mated ***,the full-length cDNA sequences of the NlDfA and NlDfB genes were cloned and *** results showed up-regulation of the NlDfA and NlDfB genes in mated BPH when compared to unmated ***-temporal expression analysis indicated that the NlDfA and NlDfB genes were expressed in all tissues and developmental stages,and they were most highly expressed in the fat body at 24 h ***,the symbionts in BPH were significantly inhibited by the in vitro expression of the NlDfA and NlDfB ***,RNA interference(RNAi)-mediated suppression of NlDfA and NlDfB dramatically increased the relative abundance of YLS in the fat body,while YLS in the hemolymph decreased *** BPHs also displayed some fitness disadvantages in survival,fecundity,hatchability,and possibly the vertical transmission of YLS from hemolymph to *** results

关键词： Nilaparvata lugens reproduction immune defense trade-off

Tailoring crystallization zinc hydroxide sulfates growth towards stable zinc deposition chemistry

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Nano Research 2024年第6期17卷 5243-5250页

作者： Kaixin Huang Xianguang zeng dan Zhang Yujie Wang Mu Lan Chengyan Wen Yi Guo College of Materials Science and Engineering Sichuan University of Science and EngineeringZigong 643000China Department of Chemistry College of Resource and EnvironmentBaoshan UniversityBaoshan 678000China College of Optoelectronic Engineering Chengdu University of Information TechnologyChengdu 610225China

The unstable zinc anode/electrolyte interface induced by corrosion,interfacial water splitting reaction,and dendrite growth seriously degrades the performances of metal Zn anode in aqueous ***,the nucleation and growth of zinc hydroxide sulfate(ZHS),an interfacial by-product,has been tailored by Tween 80 in the electrolyte,which thereby assists in in-situ forming a dense solid electrolyte interphase(SEI)with small-sized ZHS and evenly distributed Tween *** SEI has high corrosion resistance and uniform distribution of zinc ions,which not only contributes to blocking the interfacial side reactions but also induces stable and calm zinc plating/***,the modified electrolyte can confer the assembled Zn||Zn symmetric cell with a stable operation life over 1500 h at 1 mA·cm^(−2)and 1 mAh·cm^(−2)as well as the practical Zn||NH4V4O10 full battery with a high-rate capacity of 120 mAh·g^(−1)at the current density of 5 A·g^(−1).This work provides a way for regulating and reusing interfacial by-products,and a new sight on stabilization electrodes/electrolyte interfaces.

关键词： zinc hydroxide sulfides tailoring crystallization in-situ solid electrolyte interphase electrolyte engineering strategy aqueous zinc-ion battery

Role of glucose metabolism and signaling pathways at different stages of ovarian folliculogenesis

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Reproductive and Developmental Medicine 2024年第2期8卷 111-120页

作者： dan Mo Zhong-Hong zeng Xin Sui Rong Li Yi-Hua Yang Guangxi Reproductive Medical Center the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases Nanning 530021China Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology/National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital)Beijing 100191China

The female ovaries are critical for follicle growth and development in the process known as"folliculogenesis".This complex process is regulated by various factors,among which the microenvironment around follicles appears to be *** to previous studies,folliculogenesis is an energy-demanding *** fact,well-balanced follicular energy metabolism is associated with ovarian function and female ***,glucose metabolism has been widely described as the main source of energy during ***,the follicular glucose metabolism profiles change dynamically during follicular *** abnormalities during folliculogenesis are associated with aging,primary ovarian insufficiency,and polycystic ovary syndrome,thereby leading to subfertility and infertility in *** signaling pathways in follicles appear to form a link between glucose metabolism and ***,a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental *** review aimed to describe variations in glucose metabolism at different stages of folliculogenesis,provide new insights into glucose metabolic disorder-related diseases,and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis:phosphatidylinositol 3-kinase,protein kinase B(PI3K-PKB/AKT),and AMP-activated protein kinase(AMPK)signaling pathways.

关键词： Folliculogenesis Glucose metabolism Glycolysis Oxidative phosphorylation Signaling pathway