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Retinal vascular morphological characteristics in diabetic retinopathy: an artificial intelligence study using a transfer learning system to analyze ultra-wide field images

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1001-1006页

作者： Xin-Yi Deng Hui Liu Zheng-Xi Zhang Han-Xiao Li jun Wang Yi-Qi Chen Jian-Bo mao Ming-Zhai Sun Li-jun Shen Center for Rehabilitation Medicine Department of OphthalmologyZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina Department of Precision Machinery and Instrumentation University of Science and Technology of ChinaHefei 230026Anhui ProvinceChina Department of Retina Eye Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To investigate the morphological characteristics of retinal vessels in patients with different severity of diabetic retinopathy(DR)and in patients with or without diabetic macular edema(DME).METHODS:The 239 eyes of DR patients and 100 eyes of healthy individuals were recruited for the *** severity of DR patients was graded as mild,moderate and severe non-proliferative diabetic retinopathy(NPDR)according to the international clinical diabetic retinopathy(ICDR)disease severity scale classification,and retinal vascular morphology was quantitatively analyzed in ultra-wide field images using RU-net and transfer learning *** presence of DME was determined by optical coherence tomography(OCT),and differences in vascular morphological characteristics were compared between patients with and without ***:Retinal vessel segmentation using RU-net and transfer learning system had an accuracy of 99%and a Dice metric of *** with the healthy group,the DR group had smaller vessel angles(33.68±3.01 vs 37.78±1.60),smaller fractal dimension(Df)values(1.33±0.05 vs 1.41±0.03),less vessel density(1.12±0.44 vs 2.09±0.36)and fewer vascular branches(206.1±88.8 vs 396.5±91.3),all P<*** the severity of DR increased,Df values decreased,P=*** significant difference between the DME and non-DME groups were observed in vascular morphological ***:In this study,an artificial intelligence retinal vessel segmentation system is used with 99%accuracy,thus providing with relatively satisfactory performance in the evaluation of quantitative vascular *** patients have a tendency of vascular occlusion and *** presence of DME does not compromise the integral retinal vascular pattern.

关键词： diabetic retinopathy vascular morphology deep learning ultra-wide field imaging diabetic macular edema

Octopus-like DNA nanostructure coupled with graphene oxide enhanced fluorescence anisotropy for hepatitis B virus DNA detection

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Chinese Chemical Letters 2024年第6期35卷 531-535页

作者： Jia-Li Xie Tian-Jin Xie Yu-Jie Luo Kai mao Cheng-Zhi Huang Yuan-Fang Li Shu-jun Zhen Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University) Chongqing Science and Technology BureauCollege of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China

Fluorescence Anisotropy(FA)is an effective biochemical detection method based on molecular *** oxide(GO)has been extensively used as an FA ***,the enhancement of FA by GO alone is limited and the strong scattering of GO will easily make the measurement of FA *** order to address these problems,an octopus-like DNA nanostructure(ODN)was designed and coupled with GO to enhance the FA together in this *** mimicking the multi-clawed structure of the octopus,the ODN can be adsorbed on GO tightly,which not only could improve the sensitivity because of the double FA enhancement abilities of GO and ODN,but also could improve the specificity due to the decrease of the nonspecific interaction in complex ***,ODN could maintain a certain distance between the fluorophore and GO to reduce the fluorescence quenching efficiency of GO,which could improve the *** method has been applied for the detection of hepatitis B virus DNA(HBV-DNA)in a range of 1-50 nmol/L and the limit of detection(LOD)was 330 pmol/*** addition,the proposed method has been successfully utilized to detect HBV-DNA in human serum,indicating that this method has a great practical application prospect.

关键词： Fluorescence anisotropy Graphene oxide(GO) Octopus-like DNA nanostructure HBV-DNA

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Spectral matching based remote sensing identification of two main crop rotation patterns in a large irrigation district

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中国水利水电科学研究院学报(中英文) 2024年

作者： DUAN Yuanyuan CHEN Xiuhua LIU jun YE mao LU Wenjing LIU Hongjie China Institute of Water Resources and Hydropower Research Application Center of Remote Sensing Technology Research Center on Flood & Drought Disaster Prevention and Reduction of the Ministry of Water Resources Qingdao Comcore Technologies Co. Ltd Sucheng District Water Resources Bureau

Abstract:The rapid identification of planting patterns for major crops in a large irrigated district has vital importance for irrigation management,water fee collection,and crop yield *** this study,the OTSU algorithm and Mean-Shift algorithm were employed to automatically determine threshold values for mapping two main rotated crop patterns at the pixel scale.A time series analysis was conducted to extract the spatial distribution of rice-wheat and wheat-maize rotations in the Chuanhang irrigation district from 2016 to *** results demonstrate that both threshold segmentation algorithms are reliable in extracting the spatial distribution of the crops,with an overall accuracy exceeding 80%.Additionally,both Kappa coefficients surpass 0.7,indicating better performance by OTSU *** the period from 2016 to 2020,the area occupied by ricewheat rotation cropping ranged from 12 500 to 14 400 hm2;whereas wheat-maize rotation cropping exhibited smaller and more variable areas ranging from 19730 to 34070 *** findings highlight how remote sensing-based approaches can provide reliable support for rapidly and accurately identifying the spatial distribution of main crop rotation patterns within a large irrigation district.

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Engineering CuMn Prussian blue analog-shelled nanobox for efficient electrochemical reduction of nitrate to ammonia

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Tungsten 2024年第4期6卷 833-844页

作者： Zi-Yi Yang Yu-Dong Li dan Liu mao-Sen Song Yang Gao Qing-Ping Wu En-Shan Han Yan-Zhen He Xiao-Hui Yang School of Chemical Engineering and Technology Hebei University of Technology Key Laboratory of Bio-Based Material Science and Technology Northeast Forestry University Institute of Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und Energie Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences

Electrocatalytic nitrate reduction reaction（ENRR） for ammonia synthesis is a promising strategy to relieve nitration contamination,as well as an alternative to the Haber-Bosch *** blue analogs（PBAs） are expected to be an electrocatalytic material with superior performance owing to their abundant active sites and open channel ***,most reported PBA materials possess low nitrate conversion and ammonia yield rates,which has led to a hindrance in their research of ***,CuMn-PBA-shelled nanoboxes（CuMn-PBA SNBs） synthesized through tannic acid etching and cation exchange approaches are demonstrated for efficient ammonia *** optimal CuMn-PBA SNBs electrode achieves a high nitrate conversion of 91.33% and ammonia selectivity of 98.87% in a 0.2 mol·L-1Na2SO4solution with100×10-6NO3--N at-1.4 V ***,the CuMn-PBA SNB s electrode exhibits exceptional stability throughout a 30 h electrocatalytic *** outstanding electrochemical performance is attributed to the unique hollow nanobox structure with abundant active sites and high-throughput transport pathways for ions' aspects.

关键词： Acid etching Ammonia synthesis Cation exchange Electrocatalytic nitrate reduction Nanobox Prussian blue analogs

Predictive model for non-malignant portal vein thrombosis associated with cirrhosis based on inflammatory biomarkers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1213-1226页

作者： Guo-Le Nie jun Yan Ying Li Hong-Long Zhang dan-Na Xie Xing-Wang Zhu Xun Li The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Portal vein thrombosis(PVT),a complication of liver cirrhosis,is a major public health *** prediction is the most effective method for PVT diagnosis and *** To develop and validate a nomogram and network calculator based on clinical indicators to predict PVT in patients with *** Patients with cirrhosis hospitalized between January 2016 and December 2021 at the First Hospital of Lanzhou University were screened and 643 patients with cirrhosis who met the eligibility criteria were *** a 1:1 propensity score matching 572 patients with cirrhosis were screened,and relevant clinical data were *** risk factors were identified using the least absolute shrinkage and selection operator(LASSO)and multivariate logistic regression *** inflation factors and correlation matrix plots were used to analyze multicollinearity among the variables.A nomogram was constructed to predict the probability of PVT based on independent risk factors for PVT,and its predictive performance was verified using a receiver operating characteristic curve(ROC),calibration curves,and decision curve analysis(DCA).Finally,a network calculator was constructed based on the *** This study enrolled 286 cirrhosis patients with PVT and 286 without *** analysis revealed 13 variables as strongly associated with PVT *** logistic regression analysis revealed nine indicators as independent PVT risk factors,including etiology,ascites,gastroesophageal varices,platelet count,D-dimer,portal vein diameter,portal vein velocity,aspartate transaminase to neutrophil ratio index,and platelet-to-lymphocyte *** and correlation matrix plot results revealed no significant multicollinearity or correlation among the variables.A nomogram was constructed based on the screened independent risk *** nomogram had excellent predictive performance,with an area under the ROC curve of 0.821 and 0.829 in the

关键词： Portal vein thrombosis Liver cirrhosis Nomogram Inflammatory markers Aspartate aminotransferase to neutrophil ratio index Platelet-to-lymphocyte ratio

Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Rare Metals 2024年第3期43卷 1207-1221页

作者： Shun Xing Dong-Hui Wang Hai-Feng Zhang Li-dan Liu Cheng-Ce Li Chao Wei jun-Yu Liu Nai-Jian Ge Xuan-Yong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Intervention Center Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai200438China School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjin300130China

Malignant obstruction makes gallbladder cancer have a high mortality ***-titanium alloy(nitinol)stents are commonly used as a local intervention to maximize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary ***-based drugs show good therapeutic promise against gallbladder *** meet clinical *** layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60%after simple heat treatment compared with the conventional anion-exchange *** addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released *** importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the normal tissues,guaranteeing its ***,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic *** short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.

关键词： Nitinol Layered double hydroxides Arsenic Gallbladder cancer

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Synthesis of biheteroaryls via 2-methyl quinoline C(sp^(3))-H functionalization under metal-free conditions

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Green Synthesis and Catalysis 2024年第1期5卷 73-76页

作者： Dahan Wang Yuhan Yang Fuhong Xiao Jinbing Liu Guojiang mao Guo-jun Deng Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education Hunan Province Key Laboratory of Green Organic Synthesis and ApplicationCollege of ChemistryXiangtan UniversityXiangtan 411105China Department of Food and Chemical Engineering Shaoyang UniversityShaoyang 422100China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

An acetic acid-promoted C(sp^(3))-H functionalization of 2-methyl quinoline,enaminoesters and elemental sulfur for the synthesis of 3,4,5-trisubstituted isothiazoles under metal-free conditions has been *** approach provides viable access to various 5-(quinolin-2-yl)isothiazoles in moderate to good yields with good functional group ***,the success of the gram-scale reaction gives this reaction a great potential application.

关键词： C(sp^(3))-H functionalization Multicomponent reactions Biheteroaryls Elemental sulfur Metal-free

Chemoselective synthesis of α-carboline derivatives via hypervalent iodine-catalyzed [3+3] annulation under metal-free conditions

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第2期5卷 112-116页

作者： Shuowen Wang Rong Li Shanping Chen Guojiang mao Wen Shao Guo-jun Deng Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105China Department School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

A strategy for the synthesis ofα-carboline derivatives from indole-3-carboxaldehydes and 3-aminocyclohex-2-enones under metal-free conditions has been *** combination use of phenyliodine(Ⅲ)diacetate(PIDA)and benzoic acid could significantly facilitate the corresponding[3+3]annulation *** newly developed strategy featured unextraordinary chemoselectivity,good functional group tolerance and the preservation of the carbonyl group of the ketone substrates,which offers the possibility for further transformation of the products.

关键词： Hypervalent iodine-catalysis Annulation Metal-free α-Carboline Chemoselectivity

Babao dan Inhibits Gastric Cancer Progression in vivo Through Multiple Signaling Pathways

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 14-21页

作者： Hai-Xia Shang Yi Fang Bin Guan Jian-Hua Guan jun Peng Jin-Yan Zhao Jiu-mao Lin Institute of Oncology of Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhouFujianChina Key Laboratory of Integrative Medicine of Fujian Province University Fujian University of Traditional Chinese MedicineFuzhouFujianChina Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese MedicineFuzhouFujianChina Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhouFujianChina Xiamen Traditional Chinese Medicine Co. Ltd.XiamenFujianChina

Objective:The aim of this study was to explore the effects of Babao dan(BBD),a traditional Chinese medicine,on gastric cancer(GC)progression in *** and Methods:A subcutaneous xenograft mouse model of GC was established using MGC80-3 *** terminal deoxynucleotidyl transferase-mediated dUTP:2'-deoxyuridine 5'-triphosphate-biotin nick-end labeling method was adopted to detect cell apoptosis in *** expression levels of proteins associated with proliferation,apoptosis,and angiogenesis were measured by immunohistochemical staining or western blotting(WB).The activation and protein levels of p-c-jun N-terminal kinase(JNK),p-p38,p-extracellular-regulated kinase 1/2,p-nuclear factor-κB(NF-κB),and p-STAT3 were examined by Bio-plex and ***:BBD significantly inhibited tumor growth in GC mouse models with no adverse effect on body weight or organ *** was also found that BBD significantly suppressed the proliferation of GC tumor cells,induced the apoptosis of tumor cells,and inhibited angiogenesis through inactivating with mitogen-activated protein kinase,NF-κB,and STAT3 ***:BBD exerts suppressive effects on GC tumor growth by regulating multiple pathways in vivo,which may provide a novel treatment option for GC therapy.

关键词： Babao dan gastric cancer multiple signaling pathways proliferation traditional Chinese medicine

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