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转子磁钢表贴式永磁同步电机转子初始位置检测

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中国电机工程学报 2011年第18期31卷 48-54页

作者：刘颖周波李帅冯瑛南京航空航天大学自动化学院江苏省南京市210016

针对转子磁钢表贴式永磁同步电机(surface mounted permanent magnet synchronous motor,SPMSM),提出一种无位置传感器转子初始位置检测方法,有效地改善了传统方法中存在的算法执行时间长、实施复杂等缺点。该方法分2步实现,在估算的同... 详细信息

针对转子磁钢表贴式永磁同步电机(surface mounted permanent magnet synchronous motor,SPMSM),提出一种无位置传感器转子初始位置检测方法,有效地改善了传统方法中存在的算法执行时间长、实施复杂等缺点。该方法分2步实现,在估算的同步旋转坐标系中注入高频正弦电压信号,通过闭环调节得出转子位置初次估算值;再利用不同磁极下直轴等效电路时间常数不同的特性,判断出d轴正方向,结合初次估算值,从而得到正确的初始位置信息。运用dSPACE实时仿真系统进行了转子任意初始角度的实验验证。结果表明,所提方法能够快速、准确地检测出SPMSM的初始位置。

关键词：永磁同步电机无位置传感器初始位置检测信号注入磁极判断

Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells

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Acta Pharmaceutica Sinica B 2019年第3期9卷 484-495页

作者： Linlin Chang Yan Hu yingying Fu Tianyi Zhou Jun You Jiamin Du Lin Zheng Ji Cao Meidan ying Xiaoyang Dai dan Su Qiaojun He Hong Zhu Bo Yang Zhejiang Province Key Laboratory of Anti-Cancer Drug Research College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Zhejiang Cancer Hospital Hangzhou310022China

Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastaticassociated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of SKOV3/T4. Further studies showed that slug activated c-Met in a ligand-independent manner due to elevated levels of fibronectin and provoked integrin α V function, which was confirmed by the significant correlation of slug and p-Met levels in 121 ovarian cancer patient samples. Intriguingly,c-Met inhibitor(s) exhibited greatly enhanced anti-cancer effects in slug-positive ovarian cancer models both in vitro and in vivo. Additionally, IHC analyses revealed that slug levels were highly correlated with reduced survival of ovarian cancer patients. Taken together, this study not only uncovers the critical roles of slug in drug resistance in ovarian cancer but also highlights a promising therapeutic strategy by targeting the noncanonical activation of c-Met in slug-positive ovarian cancer patients with poor prognosis.

关键词： Slug c-Met Drug resistance Ovarian cancer XL184

Pharmacokinetics of Clorsulon in Sheep Following Intravenous and Subcutaneous Administration

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Agricultural Sciences in China 2004年第9期3卷 695-699页

作者： HUZhen-ying SHIYan-bin ZHANGXing-guo LIANGJi-lan LUOChao-ying LUOYong-jiang SHANGRuo-feng ZHENGJi-fang GUOFU-cun KeyLaboratoryofNewAnimalMedicineProject MinistryofAgricultrue／LanzhouInstituteofAnimalScienceandVeterinaryPharmaceuticsChineseAcademyofAgriculturalSciencesLanzhou730050P.R.China

The study established a method to analyze clorsulon concentration in sheep plasma byreverse phase-high performance liquid chromatography (RP-HPLC) with an *** plasma, clorsulon concentration within 0.01-1.0gmL-1 and 1.0-20gmL-1 ranges had agood linear relationship (R=0.9991, 0.9958). The average recovery of the method was 98.11±3.52%. The relative standard deviation (RSD)s% of within-day and between-day assayswere less than 7 and 8% respectively. After giving clorsulon to sheep by intravenous (i.v.)or subcutaneous (s.c.) routes at a single dose of 4mgkg-1, drug concentration-time datain plasma were both fitted to a two-compartment open model. The main pharmacokineticparameters were: 1) i.v. administration: T1/2β=10.040.819h, area under the concentrationversus time curve (AUC)=81.8514.24mghL-1; 2) s.c. administration: T1/2ka=1.360.75h,T=71.0314.15%. The results indicated that clorsulon in sheep following a single *** was absorbed rapidly and eliminated slower than that following a single ***, and showed a better bioavailability.

关键词： Clorsulon Sheep Pharmacokinetics

Introduction to minimally invasive endoscopy and“Endos Medical Science and Technology Award”

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中国内镜杂志 2012年第8期18卷 891-893页

作者： CHEN Yu-xiang PENG Wei LI Mu-chun JIN Xing TONG ying-dan WANG Yuan-jing National Hepatobiliary and Enteric Surgery Research Center Ministry of Health of ChinaCentral South UniversityChangshaHunan 41000&P.R.China

Minimally Invasive Endoscopy is a discipline of endoscopic minimally invasive diagnosis of diagnostic techniques and modern science,an emerging discipline in multi-disciplinary field as well *** structure of Minimally... 详细信息

关键词：中国内镜 Endoscopy discipline Endoscopy

Engineering morphologies of yttrium oxide supported nickel catalysts for hydrogen production

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Rare Metals 2023年第1期42卷 176-188页

作者： Rong-Bin Zhang Zi-Ao Tu Shuai Meng Gang feng Zhang-Hui Lu ying-Zhi Yu Tomas Ramirez Reina Fei-Yang Hu Xiao-Han Chen Run-Ping Ye Key Laboratory of Jiangxi Province for Environment and Energy Catalysis Institute of Applied ChemistrySchool of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Chemistry Examination Department Patent OfficeChina National Intellectual Property AdministrationBeijing100088China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang330022China Department of Chemical and Process Engineering University of SurreyGuildfordGU27XHUK Department of Inorganic Chemistry and Materials Sciences Institute University of Seville-CSICSeville41092Spain

The catalytic performance is highly related to the catalyst ***,a series of Ni nanoparticles supported on Y_(2)O_(3) with different morphologies were successfully synthesized via hydrothermal process screening different pH *** Ni/Y_(2)O_(3)catalysts were applied to efficiently produce CO_(x)-free H2through ammonia *** identify a significant impact of Y_(2)O_(3)supports on nickel nanoclusters sizes and *** experimental results show that Ni/Y11 catalyst achieves 100% ammonia decomposition conversion under a gas hour space velocity(GHSV) of 12,000 ml·h^(-1)·gcat^(-1) and temperature of 650℃.Such a high level of activity over Ni/Y11 catalyst was attributed to a large specific surface area,appropriate alkalinity,and small Ni nanoparticles diameter with high dispersion.

关键词： Ammonia decomposition Hydrogen production Yttrium oxide morphology Ni catalysts Hydrothermal method

The Application of English Movies in Higher Vocational English Teaching

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Sino-US English Teaching 2012年第3期9卷 1010-1014页

作者： WANG ying ZHANG Hai-feng Tangshan Vocational and Technical College Tangshan China Hebei University of Science and Technology Tangshan Branch Tangshan China

Since the rapid development of China＇s ecnomy, especially China＇s entry to World Trade Organization, English has become more and more significant. Now in China, College English, an integral part of higher learning, is a required basic course for undergraduate students. In order to deepen teaching reform and improve teaching quality, a wide variety of teaching methods enter the classroom. With the advancement of society and development of modern educational technology, English movies have gained its popularity with more and more advantages recognized in higher vocational English teaching. English movies can not only arouse the students＇ interests to study English but also improve English teaching effect and teaching efficiency. So, this paper aims at how to apply English Movies to higher vocational English teaching.

关键词： English movies higher vocational English English teaching

Coronary heart disease： incidence, risk factors and interventions in Jiaozhou of Shandong province

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Chinese Medical Journal 2014年第12期127卷 2275-2278页

作者： Yu Hua Li dan Chu Xianming An Yi Song Tongxun feng Huixin Lin Peilin Wang Tao Jiang Shaoyan Guo Linlin Xu fengqiang Liu Zhengke Yang Bin Department of Cardiology Affiliated Cardiovascular Hospital of Qingdao UniversityQingdaoShandong 266071China Department of Cardiology Affiliated Hospital of Qingdao UniversityQingdaoShandong 266042China Department of Cardiology Jiaozhou Peoples HospitalQingdaoShandong 266300China Department of Cardiology Jiaozhou Puji Central Health InstituteQingdaoShandong 266326China

Background Coronary heart disease （CHD） is the most common type of heart disease and cause of heart *** study investigated the epidemiological characteristics of CHD and its risk factors in Jiaozhou,Shandong province,to ultimately find a way of reducing the prevalence of cardiovascular disease,and to provide a theoretical basis for establishing a cardiovascular disease management path under the regional medical collaborative *** A questionnaire survey was performed including 1 952 people aged 35 years or older who were questioned by means of stratified,cluster,proportional sampling to investigate the prevalence of CHD and its risk *** data were inputted into SPSS11.0 statistical software for processing and *** advised the local medical institutions to establish health files for the residents with CHD and risk *** were followed up *** risk factors and life-style were monitored,and advice was given as to proper *** channels were established,and the patients were transmitted in a timely manner to superior hospitals for better treatment if the necessary treatments were not available in the local *** control of risk factors was observed after the follow-up for half a *** In Jiaozhou,the rates of coronary artery disease,hypertension,diabetes,hyperlipidemia and overweight were 8.15％,28.54％,11.43％,35.46％,and 18.70％ *** rates of hypertension,diabetes,hyperlipidemia and overweight were higher than the data published in ＂The report of Chinese cardiovascular disease 2012＂; which are 24％,9.7％,18.6％,and 9.7％,*** control of risk factors improved significantly after the guidance of the residents lifestyle and medication for six *** The high prevalence of coronary artery disease in Jiaozhou is closely related to age,gender,diet structure,family history of cardiovascular disease,hypertension,diabetes,hyperlipidemia,overweight,and unhealthy ***

关键词： coronary heart disease risk factors prevalence health file regional medical collaboration

基于情境模拟的儿科临床实践课程设计与实施研究

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临床医学研究与实践 2024年第17期9卷 195-198页

作者：王丹曹珊黄莹郝志艳李剑锋陈应超王玲利朱含上海市浦东医院/复旦大学附属浦东医院儿科上海201399

目的探讨情境模拟教学方式在儿科临床实践课程中的应用效果。方法从河北医科大学2022届临床医学专业的两个班级中各抽取60名学生作为研究对象,将其随机分为试验组和对照组,各60名。对照组采用常规教学方式,试验组采用情境模拟教学方式... 详细信息

目的探讨情境模拟教学方式在儿科临床实践课程中的应用效果。方法从河北医科大学2022届临床医学专业的两个班级中各抽取60名学生作为研究对象,将其随机分为试验组和对照组,各60名。对照组采用常规教学方式,试验组采用情境模拟教学方式。比较两组的综合考试能力评分及教学满意度。结果试验组的课前专业知识准备、情境模拟演练、课后理论考试及平常表现评分高于对照组(P<0.05)。试验组的教学满意度高于对照组(P<0.05)。结论情境模拟教学方式对儿科临床实践课程教学有显著促进作用,能够提高学生的综合考试能力及教学满意度。

关键词：情境模拟儿科临床实践课程课程设计

In situ modifi cation of heavy oil catalyzed by nanosized metal-organic framework at mild temperature and its mechanism

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