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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： dan Ma Nona Pop Aston Medical School College of Health and Life SciencesAston UniversityBirminghamUK

My.lin is the protective sheath surrounding nerve fibers, and its damage(demy.lination) occurs in many.central nervous sy.tem(CNS) diseases, including multiple sclerosis(MS), traumatic injury. neurodegenerative diseases such as Alzheimer's disease, and mental disorders such as schizophrenia(Barateiro et al., 2016). Repair of damaged my.lin sheaths(remy.lination) often fails in MS, leading to neuronal loss and irreversible functional deficits.

关键词： my.lin protective diseases

The emerging role of nitric oxide in the sy.aptic dy.function of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiy.ng Chen y.ny. Xiong Qin Zhou Ling-Qiang Zhu dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary.Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophy.iology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by.cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely.related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly.improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,sy.aptic dy.function is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple phy.iological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating sy.aptic plasticity.and play. an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in phy.iological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of sy.aptic dy.function,neuroinflammation,oxidative stress,and blood-brain barrier dy.function that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway.using certain specific approaches may.provide a novel therapeutic strategy.for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide sy.thase gene therapy nitric oxide NO-sGC-cGMP pathway sy.aptic dy.function vascular dementia

Increased excitatory.amino acid transporter 2 levels in basolateral amy.dala astrocy.es mediate chronic stress–induced anxiety.like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong Xu Shoumin Xuan Shuai Chen dan Liu Qian Xiao Jie Tu Shenzhen Key.Laboratory.of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key.Laboratory.of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key.Laboratory.of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University.of Chinese of Academy.of Sciences BeijingChina Faculty.of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocy.es as mere supportive cells within the brain has recently.been called into question by.empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocy.es in the basolateral amy.dala have been found to play.a role in the modulation of anxiety.like behaviors triggered by.chronic stress. Nevertheless, the precise molecular mechanisms by.which basolateral amy.dala astrocy.es regulate chronic stress–induced anxiety.like behaviors remain to be fully.elucidated. In this study. we found that in a mouse model of anxiety.triggered by.unpredictable chronic mild stress, the expression of excitatory.amino acid transporter 2 was upregulated in the basolateral amy.dala. Interestingly. our findings indicate that the targeted knockdown of excitatory.amino acid transporter 2 specifically.within the basolateral amy.dala astrocy.es was able to rescue the anxiety.like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory.amino acid transporter 2 in the basolateral amy.dala, whether achieved through intracranial administration of excitatory.amino acid transporter 2agonists or through injection of excitatory.amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety.like behavior in mice. Our single-nucleus RNA sequencing analy.is further confirmed that chronic stress induced an upregulation of excitatory.amino acid transporter 2 specifically.in astrocy.es in the basolateral amy.dala. Moreover, through in vivo calcium signal recordings, we found that the frequency.of calcium activity.in the basolateral amy.dala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory.amino acid transporter 2 in the basolateral amy.dala, the frequency.of calcium activity.was not significantly.increased, and anxiety.like behavior was ob

关键词： anxiety astrocy.es basolateral amy.dala behavior dihy.rokainic acid excitatory.amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry.in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong dan Zou Zhijun y.ng Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly.after closed head injury.may.play.important and complex roles in neuroinflammation-associated neuronal damage and *** previously.reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they.can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study.we found that nuclear factor-κB activation induced by.closed head injury.mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry.CR2-Crry.reduced the effects of closed head injury.mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally.we observed that,in response to stimulation(including stimulation by.CXCL12 secreted by.activated microglia),CXCR4 and Crry.levels can be upregulated in induced neural stem cells via the interplay.among CXCL12/CXCR4,Crry.and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory.effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery.via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry.upregulation in the injured cortices of closed head injury.***,these beneficial effects of Akt activation in induced neural stem cells were positively.correlated with the therapeutic effects of induced neural stem cells on neuronal injury.cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may.enhance the immunoregulatory.effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

Enhancement of motor functional recovery.in thoracic spinal cord injury. voluntary.wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee dan Cao y.unghy. Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury.Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury.necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study.investigated the impact of rehabilitation exercise on functional recovery.and morphological changes following thoracic contusive spinal cord injury. After a 7-day.recovery.period after spinal cord injury. mice were assigned to either a trained group(10 weeks of voluntary.running wheel or forced treadmill exercise) or an untrained group. Bi-weekly.assessments revealed that the exercise-trained group, particularly.the voluntary.wheel exercise subgroup, display.d significantly.improved locomotor recovery. more plasticity.of dopaminergic and serotonin modulation compared with the untrained group. Additionally. exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury.areas across groups, exercise training promoted terminal innervation of descending axons. In summary. voluntary.wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury. emphasizing the role of exercise modality.in promoting recovery.and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary.exercise

Exploring the interaction between the gut microbiota and cy.lic adenosine monophosphate-protein kinase A signaling pathway.a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng dan y.ng Lingxi Qing y.fei Chen Jilian Zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key.Laboratory.of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cy.lic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway.in the host's central nervous sy.tem play. a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway.through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway.can affect the composition of the gut microbiota,creating a dy.amic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus play.ng a role in the modulation of neurological *** coordinated activity.of the gut microbiota and the cAMP-PKA signaling pathway.regulates processes such as amy.oid-β protein aggregation,mitochondrial dy.function,abnormal energy.metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively.influence the onset and progression of neurological *** study.explores the complex interplay.between the gut microbiota and cAMP-PKA signaling pathway.along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway.may.improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary.modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway.may.provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cy.lic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

Small cell lung cancer with peripheral neuropathy.as the first sy.ptom:Two case reports

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World Journal of Clinical Cases 2025年第9期13卷 30-40页

作者： Man Luo Xiao-Xi Lu dan-y.ng Meng Jin Hu Department of Neurology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Information Technology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Small cell lung cancer(SCLC)is the most malignant ty.e of lung *** in the latent period and early.stage of the tumor,SCLC is prone to produce distant metastases with complex and diverse clinical *** is most closely.related to paraneoplastic sy.drome,and some cases present as paraneoplastic peripheral neuropathy.PPN).PPN in SCLC appears early.lacks specificity.and often occurs before diagnosis of the primary.*** is easy.to be misdiagnosed as a primary.disease of the nervous sy.tem,leading to missed diagnosis and delay.d diagnosis and *** SUMMARy.This paper reports two cases of SCLC with limb weakness as the first *** first sy.ptoms of one patient were rash,limb weakness,and abnormal *** patient was repeatedly.referred to the hospital for limb weakness and rash for>1 y.ar,during which time,treatment with hormones and immunosuppressants did not lead to significant improvement,and the condition gradually.*** patient was later diagnosed with SCLC,and the dy.kinesia did not worsen as the dermatomy.sitis improved after antineoplastic and hormone *** second case presented with limb numbness and weakness as the first sy.ptom,but the patient did not pay.attention to ***,the patient was diagnosed with SCLC after facial edema caused by.tumor thrombus invading the ***,he was diagnosed with extensive SCLC and died 1 y.ar after *** The two cases had PPN and abnormal electromy.graphy.highlighting its correlation with early.clinical indicators of SCLC.

关键词： Paraneoplastic peripheral neuropathy Small cell lung cancer Peripheral neuropathy Electromy.graphy Dermatomy.sitis Case report

Return to work in y.ung and middle-aged colorectal cancer survivors:Factors influencing self-efficacy.fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： dan Hu y.e Li Hua Zhang Lian-Lian Wang Wen-Wen Liu Xin y.ng Ming-Zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for y.ung and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary.to explore the barriers and facilitating factors of returning to work for y.ung and middle-aged CRC *** To examine the current RTW status among y.ung and middle-aged CRC survivors and to analy.e the impact of RTW self-efficacy.RTW-SE),fear of progression(FoP),eHealth literacy.eHL),family.resilience(FR),and financial toxicity.FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February.2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery.department of a class A tertiary.hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analy.e the factors that influence RTW outcomes among y.ung and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analy.is were *** A total of 43.54%of the participants successfully.returned to work,with an average RTW time of 100 *** regression univariate analy.is revealed that RTW-SE,FoP,eHL,FR,and FT were significantly.different between the non-RTW and RTW groups(Py.is identified per capita family.monthly.income,job ty.e,RTW-SE,and FR as independent influencing factors for RTW(Py.increase RTW among y.ung and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby.facilitating their timely.reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family.resilience Financial toxicity

Deciphering the molecular mechanisms of Simiaowan in the treatment of hy.eruricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： y.ng-Chang Zeng Jun-Hong Wu dan-dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-y. Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology.Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employ.d to treat hy.eruricemia(HUA)and gout for ***,the bioactive components and underly.ng mechanisms have not been *** objective of this study.was to identify.the active components and potential mechanisms of SMW by.integrating pharmacological experimentation,serum pharmacochemistry.network pharmacology.and molecular ***:HUA rats modelling by.high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacody.amic effects of ***-Q-Exactive-MS/MS was employ.d to detect the bioactive components present in SMW-containing *** pharmacology.and molecular docking were utilized to elucidate the potential targets and underly.ng ***:SMW effectively.ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory.and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary.active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly.participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key.targets(*** carrier family.22 member 12(URAT1),solute carrier family.22 member 6(OAT1),ATP-binding cassette sub-family.G member 2(ABCG2),solute carrier family.2,facilitated glucose transporter member 9(GLUT9),xanthine dehy.rogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H sy.thase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hy.eruricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou dan Ma y.-Xiang He Jing Jin Hong-Lian Wang y.n-Feng Wang Fan y.ng Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key.Laboratory.of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive Sy.tem Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a ty.ical pathological feature leading to stenosis after *** To examine the effectiveness and underly.ng mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 day. after esophageal full circumferential *** examinations occurred on day. 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary.esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and ty.e collagen I was *** signaling was analy.ed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably.***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment display.d increased fibrotic activity.which was reversed by.KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially.by.suppressing fibroblast fibrotic activity.through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis