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Corrosion behavior of Q235B carbon steel in simulated seawater pumped storage system under operational conditions

Journal of Oceanology and Limnology 2020年第5期38卷 1537-1547页

作者： YANG dan HUANG Yanliang LI Jianqiu gao Yanming ZHAO Xia XU Weichen CAS Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China CSG Power Generation Co. Ltd.Guangzhou 511400China Open Studio for Marine Corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237Chin a 5 Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Seawater pumped storage systems have bright prospect for energy storage in the coming *** operational conditions of seawater pumped storage system are complex and harsh,where metal materials suff er from severe general and local *** corrosion behavior of Q235B carbon steel in simulated seawater pumped storage system under operational conditions was studied by potentiodynamic polarization,cyclic potentiodynamic polarization,and scanning electron microscope(SEM).The results confi rm that the working pressure aff ected the corrosion resistance of Q235B carbon steel during the whole immersion *** pressure promoted the electrochemical reaction of corrosion process and the corrosion rate increased with pressure at the initial immersion ***,the stable rust layer formed after longtime immersion at diff erent pressures increased the corrosion resistance of carbon steel,and decreased the corrosion degree of carbon ***,the working pressure aff ected the pitting corrosion behavior of Q235B carbon steel during the whole immersion *** pitting corrosion potential was more negative and the tendency of pitting corrosion was higher at 4 MPa during the whole immersion ***,pressure also accelerated the formation rate of protective rust layer on the steel surface.Q235B carbon steel has higher susceptibility to pitting corrosion at 4 MPa in the static seawater.

关键词： seawater pumped storage system seawater pipeline pressure corrosion resistance pitting corrosion

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CoFe_(2)O_(4)nanoparticles anchored on waste eggshell for catalytic oxidation of florfenicol via activating peroxymonosulfate

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Chinese Chemical Letters 2022年第8期33卷 3713-3720页

作者： Yingjie gao Ying Han Bingrui Liu Jianfeng Gou dan Feng Xiuwen Cheng Key Laboratory for Environmental Pollution Prediction and Control College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China College of Chemistry and Environmental Sciences Yili Normal UniversityYining 835000China Key Laboratory of Pollutant Chemistry and Environmental Treatment Yili Normal UniversityYining 835000China

Eggshell-loaded CoFe_(2)O_(4) catalyst was synthesized via a convenient hydrothermal method during our work,then the surface morphology and elemental composition of the composites were systematically *** of CoFe_(2)O_(4)/eggshell-activated peroxymonosulfate(PMS)system was evaluated by selecting florfenicol(FF)as the model pollutant,and effects of operating parameters and water matrices on the FF removal efficiency in this system were *** addition,main radicals involved in FF degradation were identified by EPR tests and radical quenching experiments,and possible mechanism was *** reduction of toxicity during FF degradation was confirmed,and in combination with HP-LC tests,it was found that dehalogenation and defluorination were effectively carried out during FF *** addition,the prepared CoFe_(2)O_(4)polyvinylidene fluoride(PVDF)membrane effectively improved the stability of the material and reduced the precipitation of metals.

关键词： CoFe_(2)O_(4)/eggshell Peroxymonosulfate Florfenicol PVDF membrane

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De novo biosynthesis of liquiritin in Saccharomyces cerevisiae

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Acta Pharmaceutica Sinica B 2020年第4期10卷 711-721页

作者： Yan Yin Yanpeng Li dan Jiang Xianan Zhang Wei gao Chunsheng Liu School of Chinese Pharmacy Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China School of Pharmaceutical Sciences Advanced Innovation Center for Human Brain ProtectionCapital Medical UniversityBeijing 100069China Pharmacy Department Beijing Longfu HospitalBeijing 100010China

Liquiritigenin(LG),isoliquiritigenin(Iso-LG),together with their respective glycoside derivatives liquiritin(LN)and isoliquiritin(Iso-LN),are the main active flavonoids of Glycyrrhiza uralensis,which is arguably the most widely used medicinal plant with enormous demand on the market,including Chinese medicine prescriptions,preparations,health care products and even *** studies have shown that these ingredients have broad medicinal value,including anti-cancer and antiinflammatory *** the biosynthetic pathway of glycyrrhizin,a triterpenoid component from ***,has been fully analyzed,little attention has been paid to the biosynthesis of the flavonoids of this *** obtain the enzyme-coding genes responsible for the biosynthesis of LN,analysis and screening were carried out by combining genome and comparative transcriptome database searches of *** and homologous genes of known flavonoid biosynthesis *** catalytic functions of candidate genes were determined by in vitro or in vivo *** work characterized the complete biosynthetic pathway of LN and achieved the de novo biosynthesis of liquiritin in Saccharomyces cerevisiae using endogenous yeast metabolites as precursors and cofactors for the first time,which provides a possibility for the economical and sustainable production and application of *** flavonoids through synthetic biology.

关键词： Glycyrrhiza uralensis Liquiritin Isoliquiritin Liquiritigenin Isoliquiritigenin Heterologous synthesis Saccharomyces cerevisiae

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An integrated microfluidic chip-mass spectrometry system for rapid antimicrobial resistance analysis of bacteria producingβ-lactamases

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Chinese Chemical Letters 2023年第5期34卷 323-326页

作者： Zhaochen Su Wanting Hu Lizhen Ye dan gao Jin-Ming Lin State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical BiologyTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Chemistry Beijing Key Laboratory of Microanalytical Methods and InstrumentationKey Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China

Bacteria producingβ-lactamases have become a major issue in the global public health *** restrain the development of drug resistance and reduce the abuse of antibiotics,it is very important to rapidly identify bacteria producingβ-lactamases and put forward a reasonable treatment ***,an integrated microfluidic chip-mass spectrometry system was proposed for rapid screening ofβ-lactamaseproducing bacteria and optimization ofβ-lactamase inhibitor dosing *** concentration gradient generator followed by an array of bacterial culture chambers,as well as micro-solid-phase extraction columns was designed for sample pretreatment before mass *** using the combination system,the process of the hydrolysis of antibiotics byβ-lactamase-producing bacteria could be *** validate the feasibility,four antibiotics and two antibiotic inhibitors were investigated using three strains including negative control,SHV-1 and TEM-1 ***-1 and TEM-1 strains were successfully distinguished as theβ-lactamase producing *** the acquired optimal concentrations ofβ-lactamase inhibitors were in accordance with the results by that obtained from the traditional microdilution broth *** total analysis time only needed around 2 h,which was faster than conventional methods that require a few *** technique presented herein provides an easy and rapid protocol forβ-lactamase resistance related studies,which is important for the inhibition of antimicrobial resistance development and the reduction of antibiotics abuse.

关键词： Microfluidics Mass spectrometry β-Lactamases Antimicrobial resistance Inhibitor

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Largeπ-extended donor-acceptor polymers for highly efficient in vivo near-infrared photoacoustic imaging and photothermal tumor therapy

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Science China Chemistry 2021年第12期64卷 2180-2192页

作者： Jiangao Li Hanlin Ou Jing Li Xiaodi Yang Congwu Ge dan Ding Xike gao Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai200032China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin300071China China Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai201203China

Semiconducting polymers(SPs)with intensive near-infrared(NIR)absorption and high photothermal conversion efficiencies have been employed as a new generation of photothermal agents(PTAs)for“all-in-one”theranostic nanoplatforms with integrated photoacoustic imaging(PAI)and photothermal therapy(PTT)***,the lack of facile molecular design principles impedes the development of highly efficient NIR ***,a facile molecular design strategy based on largeπ-extended donor-acceptor(L-π-D-A)structure is reported for achieving SPs(SP1-SP3)with highly efficient in vitro and in vivo PAI and PTT *** adjusting the conjugation length and planarity of the donor units,both SP3 and corresponding nanoparticle(SPN)SPN3 exhibit stronger D-A strength,intensive NIR absorption,enhanced absorption coefficient,and higher photothermal conversion efficiency(up to 61.8%).The excellent photothermal conversion efficiencies make SPN1-SPN3 produce efficient inhibition of tumor growth with excellent biocompatibility and prominent PAI performance with a high contrast manner in living mice at a low systemic injection *** research highlights that the new L-π-D-A molecular design is an effective strategy to obtain highly efficient polymeric NIR PTAs for high desirable cancer phototheranostic nanoplatforms.

关键词： D-A polymers near-infrared photothermal agents photoacoustic imaging photothermal therapy

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Endoplasmic reticulum targeted AIE bioprobe as a highly efficient inducer of immunogenic cell death

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Science China Chemistry 2020年第10期63卷 1428-1434页

作者： Jun Li Heqi gao Ruihua Liu Chao Chen Sheng Zeng Qian Liu dan Ding Key Laboratory of Bioactive Materials Ministry of Education College of Life Sciencesand State Key Laboratory of Medicinal Chemical BiologyNankai UniversityTianjin 300071China Department of Urology Tianjin First Central HospitalTianjin 300192China

Focused oxidative stress of the specific organelles(e.g.,endoplasmic reticulum(ER)and mitochondrion)of cancer cells can boost the immunogenic cell death(ICD)effect for cancer ***,an ER-targeted bioprobe with aggregationinduced emission(AIE)characteristics(TPE-PR-FFKDEL)was rationally designed and synthesized by integrating a new AIE photosensitizer with ER targeting peptide,which has been demonstrated to be able to efficiently induce ER oxidative stress to evoke *** with the photosensitizer hypericin that is well-known as an ER-targeted ICD inducer,TPE-PR-FFKDEL can lead to more robust emission of immunostimulatory damage-associated molecular patterns such as surface-exposed calreticulin,ATP secretion,and high-mobility group protein B1(HMGB1)and heat shock protein 70(HSP 70)***,a range of immune responses are activated to protect mice from the attack of cancer cells in vivo.

关键词： immunogenic cell death endoplasmic reticulum oxidative stress aggregation-induced emission reactive oxygen species

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Reduced microRNA-451 expression in eutopic endometrium contributes to the pathogenesis of endometriosis

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World Journal of Clinical Cases 2019年第16期7卷 2155-2164页

作者： Shan gao Shuang Liu Zi-Ming gao Peng Deng dan-Bo Wang Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110042Liaoning ProvinceChina Department of Surgical Oncology and General Surgery First Affiliated Hospital of China Medical UniversityShenyang 110042Liaoning ProvinceChina Department of Gynecology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042Liaoning ProvinceChina

BACKGROUND Endometriosis (EMs) is a chronic and recurrent,but benign,disease in women of reproductive age,and EMs patients have a high risk of developing gynecological tumors and autoimmune *** etiology of EMs is not *** genetic markers in the eutopic endometrium are key in the pathogenesis of *** (miRNAs) are implicated in several biological processes,such as cell proliferation,differentiation,and ***-451 is interesting,as it acts as a tumor suppressor and is relevant to the poor prognosis of *** To evaluate the expression levels and role of miR-451 in the eutopic endometrium and predict possible targets of miR-451 and related signaling *** Quantitative real-time polymerase chain reaction was used to evaluate miR-451 expression in cultured cell lines as well as in pathologic tissues from 40 patients with EMs and 20 donors with no history of the disease (controls).Cell Counting Kit-8 and flow cytometric assays were performed to determine cell proliferation and survival rates after transfection with miR-451 mimics and ***-451 targets were predicted using miRDB and miRcode target-predicting *** We observed lower miR-451 levels in eutopic endometrial tissues from patients with EMs than in control tissues,and this difference was not related to the American Society for Reproductive Medicine *** overexpression of miR-451 in eutopic cells induced apoptosis and inhibited cell ***-mediated miR-451 knockdown reversed these *** miRDB and miRcode,we identified 12 potential miR-451 target *** hypothesize that the expression of YWHAZ,OSR1,TTN,and CDKN2D may be regulated by miR- 451 and be involved in disease *** Reduced miR-451 expression in the eutopic endometrium contributes to the pathogenesis of EMs by promoting cell proliferation and reducing ***,miR-451 is a novel biomarker for ***,OSR1,TTN,and CDKN2D are potential t

关键词： Endometriosis miR-451 Proliferation Apoptosis Pathogenesis

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Oxidation resistance of nickel-based superalloy Inconel 600 in air at different temperatures

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Rare Metals 2021年第11期40卷 3235-3240页

作者： Dong-Sheng Li Guang Chen dan Li Qi Zheng Pei gao Ling-Ling Zhang School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China

Inconel 600 alloy is widely utilized for high temperature environment application due to the corresponding good oxidation and corrosion resistance *** order to estimate the high temperature oxidation resistance of Inconel 600 alloy at various temperatures,the oxidation weight gain of all specimens was measured and fitted for the curve at the temperatures of 700,800 and 900 ℃ for exposure time of 100 *** surface morphology and the component of the oxide film were analyzed by scanning electron microscopy(SEM),energy-dispersive spectroscopy(EDS) and X-ray diffraction(XRD).The results indicate that the high temperature oxidation resistance of Inconel 600 alloy is excellent blew 800℃ due to the oxidation kinetic curves at different temperatures corresponding to the parabola dynamic *** means that the oxidation film protects the substrate *** dense oxide layer formation containing Cr_(2)O_(3) and NiCr_(2)O_(4) at 700 and 800 ℃ and MnCr_(2)O_(4) at 900 ℃,respectively,is the main reason for the good oxidation *** contrast,the oxide layer peels off easily under applied force as the temperature increases beyond 800℃, on account of the complicated compositions of the oxide film and the binding force between the oxide layer and the substrate *** oxidation mechanism is expected to be understood and the oxidation resistance of Inconel 600 alloy is improved through binding force enhancement.

关键词： Inconel 600 alloy High temperature oxidation Oxide layer Oxidation mechanism

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β-galactosidase responsive AIE fluorogene for identification and removal of senescent cancer cells

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Science China Chemistry 2020年第3期63卷 398-403页

作者： Zhengfeng gao Heqi gao Debin Zheng Tengyan Xu Yaoxia Chen Chunhui Liang Ling Wang dan Ding Zhimou Yang State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy Nankai UniversityTianjin 300071China Key Laboratory of Bioactive Materials Ministry of EducationCollege of Life Sciencesand Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300060China

The selective identification and removal of senescent cells including senescent cancer cells are very important to prolong life and improve the treatment efficacy of cancer *** this study,we integrated the high selectivity of enzyme-instructed selfassembly(EISA)and efficient reactive oxygen species(ROS)generating property of a novel luminogen with aggregationinduced emission(AIE)character to selectively identify and remove senescent He La(s-He La)*** s-He La cells expressed high levels ofβ-galactosidase(β-Gal),which led to the selective accumulation and formation of nanomaterials of Comp.1 in the *** white light irradiation,the nanomaterials efficiently produced ROS and therefore killed s-He La *** study demonstrated a promising strategy to selectively remove senescent cells and improve the treatment efficacy of cancer therapy.

关键词： senescence cancer fluorescence self-assembly aggregation induced emission

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Model Modification and Application on Carrying Capacity of Relative Resources

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Chinese Journal of Population,Resources and Environment 2009年第2期7卷 19-26页

作者： Li Zehong Dong Suocheng gao dan Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Graduate University of Chinese Academy of Sciences Beijing 100049 China College of Resources and Environmental Sciences China Agricultural University Beijing 100193 China

Based on the retrospection of researches on carrying capacity, this article reviewed systematically the research progresses on carrying capacity of relative resources (CCRR). Then the viewpoint was put forward that CCRR is not an appropriate method of appraising the regional sustainability, but a sound way to obtain cognition for coordinating spatial location and flow of population and economy. However, as the most popular computing method of CCRR, the Weighting Linear Sum Model is defective in the random of weight choice and the neglect of matching among different resources. Therefore, this article established the Geometric Model on CCRR based on modifying Weighting Linear Sum Model, which can be used to appraise regions where resources are close matching. Employing the Geometric Model, the article empirically analyzed the population and economic CCRR in Hubei Province from 1978 to 2006. The result indicates that the population in Hubei Province is overloading while the economic carrying capacity is abundant compared to the whole country, and the economic insufficiency restricts the population carrying capacity. In the future, Hubei Province will become one of the core developing zones which are characterized by economic conglomeration.

关键词： carrying capacity CCRR model modification empirical analysis

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