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Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats

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World Journal of Gastroenterology 2016年第16期22卷 4136-4148页

作者： dan-dan gao Jia Fu Bo Qin Wen-Xiang Huang Chun Yang Bei Jia Chongqing Key Laboratory of Infectious Diseases and Parasitic Diseases Department of Infectious Diseases The First Affiliated Hospital of Chongqing Medical University

AIM: To investigate the protective efficacy of recombinant adenovirus containing hyper-interleukin-6 (Hyper-IL-6, HIL-6) and hepatocyte growth factor (HGF) (Ad-HGF-HIL-6) compared to that of recombinant adenovirus containing either HIL-6 or HGF (Ad-HIL-6 or Ad-HGF) in rats with acute-on-chronic liver failure (ACLF).METHODS: The recombinant adenoviruses containing HIL-6 and/or HGF were constructed. We established an ACLF model, and rats were randomly assigned to control, model, Ad-GFP, Ad-HIL-6, Ad-HGF or Ad-HGF-HIL-6 group. We collected serum and liver tissue samples to test pathological changes, biochemical indexes and molecular biological ***: Attenuated alanine aminotransferase, prothrombin time, high-mobility group box 1 (HMGB1), endotoxin, tumour necrosis factor (TNF)-α and interferon-γ were observed in the Ad-HGF-, Ad-HIL-6- and Ad-HGF-HIL-6-treated rats with ACLF. Likewise, reduced hepatic damage and apoptotic activity, as well as reduced HMGB1 and Bax proteins, but raised expression of Ki67 and Bcl-2 proteins and Bcl-2/Bax ratio were also observed in the Ad-HGF-, Ad-HIL-6- and Ad-HGF-HIL-6-treated rats with ACLF. More significant changes were observed in the Ad-HGF-HIL-6 treatment group without obvious side effects. Furthermore, caspase-3 at the protein level decreased in the Ad-HIL-6 and Ad-HGF-HIL-6 treatment groups, more predominantly in the latter ***: This study identifies that the protective efficacy of Ad-HGF-HIL-6 is more potent than that of Ad-HGF or Ad-HIL-6 in ACLF rats, with no significant side effects.

关键词： Acute-on-chronic liver failure Recombinant adenovirus Hyper-interleukin-6 Hepatocyte growth factor Inflammatory cytokines

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Network toxicology and LC-MS-based metabolomics:New approaches for mechanism of action of toxic components in traditional Chinese medicines

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Chinese Herbal Medicines 2019年第4期11卷 357-363页

作者： Xin-yu Li Xin Jin Ya-zhuo Li dan-dan gao Rui Liu Chang-xiao Liu College of Pharmaceutical Engineering of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300193China Military Medicine Section Logistics University of Chinese People's Armed Police ForceTianjin 300309China Center for Drug Evaluation Research Tianjin Institute of Pharmaceutical ResearchTianjin 300193China Research Center of Traditional Chinese Medicine Quality Markers Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese MedicineTianjin Institute of Pharmaceutical ResearchTianjin 300193China

Network toxicology combined with metabonomics is of great significance for the study of the toxic mechanism and prediction of toxicity of traditional Chinese medicines(TCMs).In this study,we reviewed the application of network toxicology based on LC-MS metabolomics,mainly in the study of toxic components and the toxicity mechanism of TCMs,which provides new ideas and methods for the further study of the toxicity mechanism of TCMs.

关键词： LC-MS-based metabolomics network toxicology toxicity of traditional Chinese medicines

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DNA methylation clocks for estimating biological age in Chinese cohorts

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Protein & Cell 2024年第8期15卷 575-593页

作者： Zikai Zheng Jiaming Li Tianzi Liu Yanling Fan Qiao-Cheng Zhai Muzhao Xiong Qiao-Ran Wang Xiaoyan Sun Qi-Wen Zheng Shanshan Che Beier jiang Quan Zheng Cui Wang Lixiao Liu Jiale Ping Si Wang dan-dan gao Jinlin Ye Kuan Yang Yuesheng Zuo Shuai Ma Yun-GuiYang Jig Qu Feng Zhang Peilin Jia Guang-Hui Liu Weiqi Zhang CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Computational Biology Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China Division of Orthopaedics Quzhou Affliated Hospital of Wenzhou Medical UniversityQuzhou 324000China The Joint Innovation Center for Engineering in Medicine Quzhou Affliated Hospital of Wenzhou Medical UniversityQuzhou 324000China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerXuanwu HospitalCapital Medical UniversityBeijing 100053China Aging Biomarker Consortium Beijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China nstitute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China

Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation(DNAm)at specific CpG ***,a systematic comparison between DNA methylation data and other omics datasets has not yet been ***,available DNAm age predictors are based on datasets with limited ethnic *** address these knowledge gaps,we generated and analyzed DNA methylation datasets from two independent Chinese cohorts,revealing age-related DNAm ***,a DNA methylation aging clock(iCAS-DNAmAge)and a group of DNAm-based multi-modal clocks for Chinese individuals were developed,with most of them demonstrating strong predictive capabilities for chronological *** clocks were further employed to predict factors influencing aging *** DNAm aging clock,derived from multi-modal aging features(compositeAge-DNAmAge),exhibited a close association with multi-omics changes,lifestyles,and disease status,underscoring its robust potential for precise biological age *** findings offer novel insights into the regulatory mechanism of age-related DNAm changes and extend the application of the DNAm clock for measuring biological age and aging pace,providing the basis for evaluating aging intervention strategies.

关键词： DNA methylation aging clock aging age prediction

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou gao Qin Dong dan Zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao gao Wenlong Liu dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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果蝇在药理学研究中的应用

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中国药学杂志 2016年第19期51卷 1638-1642页

作者：段丹丹高丽秦雪梅周玉枝杜冠华山西大学中医药现代研究中心太原030006 山西大学化学化工学院太原030006 中国医学科学院北京协和医学院药物研究所北京100050

果蝇作为一种模式生物,具有生命周期短、繁殖力强、基因保守性高等特点。目前,果蝇已广泛应用于药理学和疾病机制研究中,涵盖衰老、神经退行性疾病、失眠、肿瘤等领域,在加快药物筛选速度和靶点发现等方面显示出潜在的应用价值。笔者就... 详细信息

果蝇作为一种模式生物,具有生命周期短、繁殖力强、基因保守性高等特点。目前,果蝇已广泛应用于药理学和疾病机制研究中,涵盖衰老、神经退行性疾病、失眠、肿瘤等领域,在加快药物筛选速度和靶点发现等方面显示出潜在的应用价值。笔者就果蝇作为模式生物的优势、在药理学研究中的应用及局限性3个方面展开综述。

关键词：果蝇衰老神经退行性疾病失眠肿瘤药物发现

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海口市老年人口腔健康KAP调查分析

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中国健康教育 2017年第3期33卷 269-271页

作者：刘晓晶王小丹薄丹丹高允锁中南大学湘雅医学院附属海口医院口腔中心.海南省口腔医学中心海南海口570102 海南医学院海南海口571101 海南省人民医院海南海口570311

目的探讨老年人口腔健康知识、态度、行为(KAP)的影响因素,为深入开展老年人群社区口腔健康教育工作提供参考依据。方法采用自制的老年人口腔健康知识、态度、行为调查表对海口市4个城区的800名65~74岁的老年人进行问卷调查。结果海口... 详细信息

目的探讨老年人口腔健康知识、态度、行为(KAP)的影响因素,为深入开展老年人群社区口腔健康教育工作提供参考依据。方法采用自制的老年人口腔健康知识、态度、行为调查表对海口市4个城区的800名65~74岁的老年人进行问卷调查。结果海口市老年人口腔健康知识调查显示,"保持口腔卫生是防治牙病的关键"的认知度最高,有83.2%;"爱牙日是哪一天"的知晓率最低,仅5.5%;态度调查显示,78.2%的老年人认为老年掉牙是必然的。32.3%的老年人认为牙好坏是天生的,与自身保护关系不大;行为调查显示,73.8%的老年人有饭后漱口的习惯,66.4%的老年人会早晚刷牙,28%的老年人过去1年内有没有看过牙;KAP总平均分为(16.23(4.94)分,不同性别间KAP总平均分差异无统计学意义(F=1.18,P=0.277),不同文化程度和城乡间均有统计学意义(P<0.05)。结论应采取有针对性的措施,建立以社区为基础的老年人口腔健康KAP保健模式,改变口腔不良习惯,提高老年人的生活质量。

关键词：口腔健康知识口腔健康态度口腔健康行为老年人

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大学生公益精神培育的路径选择

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安徽工业大学学报（社会科学版） 2016年第3期33卷 116-117页

作者：王萌刘丹丹高敏安徽工业大学商学院安徽马鞍山243002 安徽工业大学马克思主义学院安徽马鞍山243002

公益精神是当代大学生不可或缺的内在品质。高校可以通过突出思想政治理论课的主渠道作用,激发个人情感的内在驱动力,重视网络新媒体的推动作用,注重校园文化的熏陶作用,坚持社会实践培育的积极作用等路径培育大学生的公益精神。

关键词：大学生公益精神培育路径

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高校思想政治理论教师教学与科研的关系论析

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吉林工程技术师范学院学报 2017年第8期33卷 47-50页

作者：梁丹丹高维义东北师范大学马克思主义学部吉林长春130024 农安县职业教育中心吉林农安130200

教学与科研是高校的两大职能,高校依靠教师实现教学与科研的职能。思想政治理论课教师是高校教师队伍的组成部分,承担教学和科研双重任务,其中教学是主要任务。为此,思想政治理论课教师需正确处理二者的关系,明确教育任务,将教书育人置... 详细信息

教学与科研是高校的两大职能,高校依靠教师实现教学与科研的职能。思想政治理论课教师是高校教师队伍的组成部分,承担教学和科研双重任务,其中教学是主要任务。为此,思想政治理论课教师需正确处理二者的关系,明确教育任务,将教书育人置于中心地位。同时,在科研过程中不忘教育初心,坚持以科研辅助教学。此外,改革教师评价机制,树立教师科学工作观念,合理设置班额等举措,将有利于更好地发挥思想政治理论课教师的育人职能。

关键词：高校思想政治理论课教师教学科研

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索非布韦联合达卡他韦治疗慢性丙型肝炎的临床观察

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广东医科大学学报 2017年第5期35卷 542-544页

作者：华丹丹高文军高齐明张倩华广东省中山市第二人民医院肝病科广东中山528400

目的观察索非布韦(SOF)联合达卡他韦(DCV)治疗慢性丙型肝炎的治疗效果。方法 100例慢性丙型肝炎患者随机分为SD组(40例)和PR组(60例)。SD组采用SOF联合DCV治疗,PR组采用聚乙二醇干扰素联合利巴韦林治疗。观察并比较两组治疗后肝功能、HC... 详细信息

目的观察索非布韦(SOF)联合达卡他韦(DCV)治疗慢性丙型肝炎的治疗效果。方法 100例慢性丙型肝炎患者随机分为SD组(40例)和PR组(60例)。SD组采用SOF联合DCV治疗,PR组采用聚乙二醇干扰素联合利巴韦林治疗。观察并比较两组治疗后肝功能、HCV-RNA转阴率、病毒学应答率及不良反应等指标。结果与治疗4周比较,治疗48周后两组的丙氨酸转氨酶、门冬氨酸转氨酶及总胆红素异常发生率明显降低,且以SD组更为显著(P<0.05);治疗12周,SD组非Ⅰ型HCV-RNA转阴率高于PR组(P<0.05);SD组不良反应发生率明显低于PR组(P<0.05)。结论 SOF联合DCV方案可有效改善慢性丙型肝炎患者肝功能,降低不良反应。

关键词：丙型肝炎索非布韦达卡他韦干扰素

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