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Constructing oxygen deficiency-rich V_(2)O_(3)@PEDOT cathode for high-performance aqueous zinc-ion batteries

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Rare Metals 2024年第2期43卷 635-646页

作者： Dong-Fei Sun Zi-Juan Wang Tian Tian Xin yu dan-dan yu Xiao-Zhong Zhou Guo-Fu Ma Zi-Qiang Lei Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceSchool of College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou730070China

Aqueous zinc-ion batteries(AZIBs)have attracted widespread attention due to the advantages of high safety and environmental *** V_(2)O_(3) is a promising cathode,the strong electrostatic interaction between Zn^(2+) and V_(2)O_(3) crystal,and the sluggish reaction kinetics still limit their application in ***,the oxygen defects rich V_(2)O_(3) with conducive poly(3,4-ethylenedioxythiophene)(PEDOT)shell(V_(2)O_(3)-Od@PEDOT)was fabricated for AZIBs by combining the sulfur-assisted thermal reduction and in-situ polymerization *** introduced oxygen vacancies of V_(2)O_(3)–Od@PEDOT weaken the electrostatic interaction between Zn^(2+) and the host material,improving the interfacial electron transport,while the PEDOT coating enhances the structural stability and conductivity of V_(2)O_(3),thus accelerating the reaction *** on the advantages,V_(2)O_(3)–Od@PEDOT electrode delivers a reversible capacity of 495 mAh·g^(−1) at 0.1 A·g^(−1),good rate capability(189 mAh·g^(−1)at 8.0 A·g^(−1)),and an impressive cycling stability with 90.1%capacity retention over 1000 cycles at 8.0 A·g^(−1).The strategy may provide a path for exploiting the other materials for high performance AZIBs.

关键词： Oxygen defects V_(2)O_(3) PEDOT Electrochemical self-optimization Aqueous zinc-ion batteries

Shenqi Fuzheng Injection Ameliorates Radiation-induced Brain Injury

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Current Medical Science 2019年第6期39卷 965-971页

作者： Ling-juan CHEN Rui-guang ZHANG dan-dan yu Gang WU Xiao-rong DONG Cancer Center Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Shenqi Fuzheng injection(SFI)has been confirmed to be able to alleviate brain injury in *** study examined the brain-protective effect of SFI on patients after cranial *** cancer patients with brain metastasis were randomly assigned to two *** SFI group received cranial radiation in combination with *** control group received cranial radiation *** changes in cognitive function were evaluated pre- and post-radiation against the Mini-Mental State Exam(MMSE),Montreal Cognitive Assessement(MoCA),Zung Self-Rating Depression Scale(SDS)and Zung Self-Rating Anxiety Scale(SAS).The changes in inflammatory factors,such as TGF-β1,TNF-α and IL-10,were also detected before,during and after radiation(15Gy/5F).The results showed that 6 months after cranial radiation,the total scores on the MMSE and MoCA scales of the patients decreased,especially memory *** control group experienced a more evident decline,the memory ability being the ***-β1 and TNF-α increased shortly after radiation and decreased one month later,and the change was more conspicuous in SFI group than in control ***-10 increased after radiation and stayed at a high level one month later in both groups,the level being higher in the SFI group than in the control *** study indicated that cognitive functions,especially memory ability,were impaired after cranial *** could alleviate radiation-induced brain injury by regulating inflammatory factors.

关键词： Shenqi Fuzheng injection irradiation-induced brain injury cognitive disorders inflammation

Evodiamine inhibits high-fat diet-induced colitis-associated cancer in mice through regulating the gut microbiota

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Journal of Integrative Medicine 2021年第1期19卷 56-65页

作者： Li-qing Zhu Li Zhang Jia Zhang Guo-lin Chang Gang Liu dan-dan yu Xiao-min yu Mi-sheng Zhao Bin Ye Department of Pathogenic Biology Chongqing Medical UniversityChongqing 400016China Research Center for Molecular Medicine and TumorChongqing Medical UniversityChongqing 400016China Department of Clinical LaboratoryThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325023Zhejiang ProvinceChina Department of PathophysiologyChongqing Medical UniversityChongqing 400016China Department of Clinical LaboratoryWenzhou People’s HospitalWenzhou 325023Zhejiang ProvinceChina Department of EmergencyUniversity-Town Hospital of Chongqing Medical UniversityChongqing 401331China

Objective:High-fat diet is one of the main risk factors that disrupt the balance of gut microbiota,which eventually will induce colorectal cancer(CRC).Evodiamine(EVO)is a wildly used multifunctional traditional Chinese medicine *** this study,we investigated the role of gut microbiota in high-fat dietpropelled CRC and the potential of EVO for CRC ***:Gut microbiota,serum D-lactic acid and endotoxin from 38 patients with colon cancer and 18 healthy subjects were detected by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay(ELISA).In addition,body mass index,phospho-signal transducer and activator of transcription 3(p-STAT3)expression in cancer tissues and paracancerous tissues were detected by immunohistochemistry.A mouse intestinal inflammatory tumor model was established by azomethane/sodium dextran sulfate,followed by treatment with EVO and 5-aminosalicylic acid(ASA).Gut microbiota and inflammatory factors were detected by quantitative polymerase chain reaction,while serum D-lactic acid and endotoxin were detected by ***,cell proliferation,cell apoptosis,and interleukin(IL)-6/STAT3/P65 pathway were evaluated by 5-ethynyl-20-deoxyuridine,terminal-deoxynucleotidyl transferase-mediated nick-end labeling,and Western blot ***:In patients with colon cancer,the numbers of Enterococcus faecalis and Escherichia coli were increased,while those of Bifidobacterium,Campylobacter and Lactobacillus were *** endotoxin and D-lactic acid levels and p-STAT3 levels were significantly *** the mouse model,both EVO and ASA inhibited tumor formation,decreased the proliferation of tumor cells,and induced apoptosis of tumor *** with the control group,the numbers of *** and *** were decreased,while Bifidobacterium,Campylobacter and Lactobacillus numbers were *** the EVO group,serum endotoxin and D-lactic acid levels and inflammatory factors were signifi

关键词： Evodiamine Gut microbiota Colitis-associated cancer Signal transducer and activator of transcription 3

Ocellatuspyrones A‒G,new antibacterial polypropionates from the Chinese mollusk Placobranchus ocellatus

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Marine Life Science & Technology 2023年第3期5卷 373-386页

作者： Song-Wei Li dan-dan yu Ming-Zhi Su Li-Gong Yao Hong Wang Xueting Liu yue-Wei Guo Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals College of Pharmaceutical ScienceZhejiang University of TechnologyHangzhou 310014China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Marine invertebrates serve as rich sources of secondary metabolites with intriguing chemical diversities and a wide spectrum of biological ***,marine shell-less sacoglossan mollusks have attracted much attentions due to the fact that mollusks apply complex metabolites as chemical defense agents against to their *** the purpose of discovering bioactive secondary metabolites to develop marine-derived medicines from the South China Sea,we have conducted a chemical study on the photosynthetic mollusk Placobranchus *** a result,seven newγ-pyrone polypropionates,namely(±)-ocellatuspyrone A(1),(±)-ocellatuspyrone B(2),and ocellatuspyrones C−G(5,9−12),along with fve known polypropionates,have been isolated and characterized from the South China Sea photosynthetic mollusk Placobranchus *** spectroscopic analysis,single crystal X-ray difraction analysis,modifed Mosher’s method,ECD comparison,CD exciton chirality method,TDDFT-ECD calculation,and chemical conversion were used to determine the structures and absolute confgurations of the new compounds and the stereochemistry of undefned known compounds 4,6 and *** these isolated polypropionates were evaluated in bioassays for their biological activities,including antibacterial,neuroprotective efect,anti-infammatory,PTP1B inhibitory,and antiviral *** 7,8 and 11 were found for the frst time to show antibacterial activity against fsh pathogenic bacteria Streptococcus parauberis(the main pathogen causing fsh streptococcal infections and acute death)with MIC values of 35.8,34.2,and 37.4μg/mL,respectively,which might be potential novel antibacterial agents for the treatment of fsh infectious diseases.

关键词： Placobranchus ocellatus γ-pyrone polypropionate Photosynthetic mollusk Antibacterial activity

Comprehensive annotation of the Chinese tree shrew genome by large-scale RNA sequencing and long-read isoform sequencing

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Zoological Research 2021年第6期42卷 692-709页

作者： Mao-Sen Ye Jin-Yan Zhang dan-dan yu Min Xu Ling Xu Long-Bao Lv Qi-yun Zhu yu Fan Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&yunnan Province KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals Primate Facility) Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China 4 State Key Laboratory of Veterinary Etiological BiologyLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhouGansu 730046China

The Chinese tree shrew(Tupaia belangeri chinensis)is emerging as an important experimental animal in multiple fields of biomedical *** reference genome annotation for both mRNA and long non-coding RNA(lncRNA)is crucial for developing animal models using this *** the current study,we collected a total of 234 high-quality RNA sequencing(RNA-seq)datasets and two long-read isoform sequencing(ISO-seq)datasets and improved the annotation of our previously assembled high-quality chromosomelevel tree shrew *** obtained a total of 3514 newly annotated coding genes and 50576 lncRNA *** also characterized the tissuespecific expression patterns and alternative splicing patterns of mRNAs and lncRNAs and mapped the orthologous relationships among 11 mammalian species using the current annotated *** identified 144 tree shrew-specific gene families,including interleukin 6(IL6)and STT3 oligosaccharyltransferase complex catalytic subunit B(STT3B),which underwent significant changes in *** of the overall expression patterns in tissues and pathways across four species(human,rhesus monkey,tree shrew,and mouse)indicated that tree shrews are more similar to primates than to mice at the tissue-transcriptome ***,the newly annotated purine rich element binding protein A(PURA)gene and the STT3B gene family showed dysregulation upon viral *** updated version of the tree shrew genome annotation(KIZ version 3:TS_3.0)is available at http://*** and provides an essential reference for basic and biomedical studies using tree shrew animal models.

关键词： Tree shrew Genome annotation Transcriptome Gene family Virus infection

Chromosomal level assembly and population sequencing of the Chinese tree shrew genome

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Zoological Research 2019年第6期40卷 506-521页

作者： yu Fan Mao-Sen Ye Jin-Yan Zhang Ling Xu dan-dan yu Tian-Le Gu yu-Lin Yao Jia-Qi Chen Long-Bao Lv Ping Zheng Dong-Dong Wu Guo-Jie Zhang Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming Yunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming Yunnan 650204China Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China KIZ–CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China yunnan Key Laboratory of Animal Reproduction Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China

Chinese tree shrews (Tupaia belangeri chinensis) have become an increasingly important experimental animal in biomedical research due to their close relationship to primates. An accurately sequenced and assembled genome is essential for understanding the genetic features and biology of this animal. In this study, we used long-read single-molecule sequencing and high-throughput chromosome conformation capture (Hi-C) technology to obtain a high-qualitychromosome-scale scaffolding of the Chinese tree shrew genome. The new reference genome (KIZ version 2: TS_2.0) resolved problems in presently available tree shrew genomes and enabled accurate identification of large and complex repeat regions, gene structures, and species-specific genomic structural variants. In addition, by sequencing the genomes of six Chinese tree shrew individuals, we produced a comprehensive map of 12.8 M single nucleotide polymorphisms and confirmed that the major histocompatibility complex (MHC) loci and immunoglobulin gene family exhibited high nucleotide diversity in the tree shrew genome. We updated the tree shrew genome database (TreeshrewDB v2.0: http://***) to include the genome annotation information and genetic variations. The new high-quality reference genome of the Chinese tree shrew and the updated TreeshrewDB will facilitate the use of this animal in many different fields of research.

关键词： Tupaia belangeri Chromosomal level assembly genome Population sequencing Database

COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2

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Zoological Research 2020年第5期41卷 517-526页

作者： Ling Xu dan-dan yu yu-Hua Ma yu-Lin Yao Rong-Hua Luo Xiao-Li Feng Hou-Rong Cai Jian-Bao Han Xue-Hui Wang Ming-Hua Li Chang-Wen Ke Yong-Tang Zheng Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming National High-level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academic of SciencesKunmingYunnan 650107China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Department of Respiratory and Critical Care Medicine the Affiliated Drum Tower Hospital of Nanjing UniversityNanjingJiangsu 210008China Medical Key Laboratory for Repository and Application of Pathogenic Microbiology Guangdong Provincial Center for Disease Control and PreventionGuangzhouGuangdong 510440China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 2Q0Q3AChina

Thecoronavirusdisease2019(COVID-19)pandemic continues to pose a global threat to the human population. Identifying animal species susceptible to infection with the SARS-CoV-2/HCoV-19 pathogen is essential for controlling the outbreak and for testing valid prophylactics or therapeutics based on animal model studies. Here,different aged Chinese tree shrews(adult group, 1 year old;old group, 5–6 years old), which are close relatives to primates, were infected with SARS-CoV-2. X-ray, viral shedding, laboratory, and histological analyses were performed on different days postinoculation(dpi). Results showed that Chinese tree shrews could be infected by SARS-CoV-2. Lung infiltrates were visible in X-ray radiographs in most infected animals. Viral RNA was consistently detected in lung tissues from infected animals at 3,5, and 7 dpi, along with alterations in related parameters from routine blood tests and serum biochemistry, including increased levels of aspartate aminotransferase(AST) and blood urea nitrogen(BUN). Histological analysis of lung tissues from animals at 3 dpi(adult group) and 7 dpi(old group) showed thickened alveolar septa and interstitial hemorrhage. Several differences were found between the two different aged groups in regard to viral shedding peak. Our results indicate that Chinese tree shrews have the potential to be used as animal models for SARS-CoV-2 infection.

关键词： SARS-CoV-2/HCoV-19 Treeshrews Animal model Susceptibility COVID-19

Comprehensive Treatment Uncertainty Analysis and PTV Margin Estimation for Fiducial Tracking in Robotic Liver Stereotactic Body Radiation Therapy

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Current Medical Science 2023年第3期43卷 572-578页

作者： Zhi-wen LIANG Meng-lan ZHAI Biao TU Xin NIE Xiao-hui ZHU Jun-ping CHENG Guo-quan LI dan-dan yu Tao ZHANG Sheng ZHANG Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective This study aims to quantify the uncertainties of CyberKnife Synchrony fiducial tracking for liver stereotactic body radiation therapy(SBRT)cases,and evaluate the required planning target volume(PTV)*** A total of 11 liver tumor patients with a total of 57 fractions,who underwent SBRT with synchronous fiducial tracking,were enrolled for the present *** correlation/prediction model error,geometric error,and beam targeting error were quantified to determine the patient-level and fraction-level individual composite treatment *** composite uncertainties and multiple margin recipes were compared for scenarios with and without rotation correction during *** The correlation model error-related uncertainty was 4.3±1.8,1.4±0.5 and 1.8±0.7 mm in the superior-inferior(SI),left-right,and anterior-posterior directions,*** were the primary contributors among all uncertainty *** geometric error significantly increased for treatments without rotation *** fraction-level composite uncertainties had a long tail ***,the generally used 5-mm isotropic margin covered all uncertainties in the left-right and anterior-posterior directions,and only 75%of uncertainties in the SI *** order to cover 90%of uncertainties in the SI direction,an 8-mm margin would be *** scenarios without rotation correction,additional safety margins should be added,especially in the superior-inferior and anterior-posterior *** The present study revealed that the correlation model error contributes to most of the uncertainties in the *** patients/fractions can be covered by a 5-mm *** with large treatment uncertainties might need a patient-specific margin.

关键词： CyberKnife fiducial tracking liver cancer stereotactic body radiation therapy margin expansion

A virtual 3D interactive painting method for Chinese calligraphy and painting based on real-time force feedback technology

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Frontiers of Information Technology & Electronic Engineering 2017年第11期18卷 1843-1853页

作者： Chao GUO Zeng-xuan HOU You-zhi SHI Jun XU dan-dan yu School of Mechanical Engineering Dalian University of Technology Dalian 116024 China

A novel 3D interactive painting method for Chinese calligraphy and painting based on force feedback technology is proposed. The relationship between the force exerted on the brush and the resulting brush deformation is analyzed and a spring-mass model is used to build a model of the 3D Chinese brush. The 2D brush footprint between the brush and the plane of the paper or object is calculated according to the deformation of the 3D brush when force is exerted on the 3D brush. Then the 3D brush footprint is obtained by projecting the 2D brush footprint onto the surface of the 3D object in real time, and a complete 3D brushstroke is obtained by superimposing 3D brush footprints along the painting direction. The proposed method has been suc- cessfully applied in a virtual 3D interactive drawing system based on force feedback technology. In this system, users can paint 3D brushstrokes in real time with a Phantom Desktop haptic device, which can effectively serve as a virtual reality interface to the simulated painting environment for users.

关键词： 3D brush model 3D brushstroke 3D interactive painting Real-time force feedback technology