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氯吡格雷片联合丹红注射液对急性脑梗死患者神经功能及凝血功能的影响

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辽宁医学杂志 2024年第2期38卷 38-41页

作者：熊丹熊执波江西省抚州市东乡区中医院江西抚州331800

目的探讨氯吡格雷片联合丹红注射液对急性脑梗死(ACI)患者神经功能及凝血功能的影响。方法选取医院2020年3月~2021年6月收治的ACI患者85例,将其随机分成对照组(n=42)、试验组(n=43)。对照组予氯吡格雷片治疗,于此基础上,试验组联用丹红... 详细信息

目的探讨氯吡格雷片联合丹红注射液对急性脑梗死(ACI)患者神经功能及凝血功能的影响。方法选取医院2020年3月~2021年6月收治的ACI患者85例,将其随机分成对照组(n=42)、试验组(n=43)。对照组予氯吡格雷片治疗,于此基础上,试验组联用丹红注射液治疗。治疗2周后,对比两组疗效、神经功能[改良爱丁堡⁃斯堪的纳维亚评分(MESSS)]、凝血功能[纤维蛋白原(FIB)、D⁃二聚体(D⁃D)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)]及不良反应率。结果治疗2周后,试验组总有效率显著高于对照组,有统计学差异(P0.05);两组不良发应率相比,无统计学差异(P>0.05)。结论氯吡格雷片联合丹红注射液可改善ACI患者凝血功能,加速其神经功能恢复,提高疗效,且安全性较好。

关键词：急性脑梗死氯吡格雷片丹红注射液神经功能

新工科背景下应用型高校教师教学能力提升路径研究

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创新创业理论研究与实践 2024年第7期7卷 120-123页

作者：熊丹廖大鹏成都工业学院宜宾校区四川宜宾644000

新工科产生于新一轮科技革命与产业转型升级,具有跨界、融合、创新等特点,为以培训卓越工程师与创新科技人才为目标的应用型高校人才培养明确了方向。高校教师的教学能力是人才培养质量的重要保障,新工科建设对高校教师教学能力提出了... 详细信息

新工科产生于新一轮科技革命与产业转型升级,具有跨界、融合、创新等特点,为以培训卓越工程师与创新科技人才为目标的应用型高校人才培养明确了方向。高校教师的教学能力是人才培养质量的重要保障,新工科建设对高校教师教学能力提出了新的要求。该文针对目前应用型高校教师教学能力存在的课程思政教学能力不足、知识整合能力弱、工程实践经验不足等问题,提出打造工程实践平台、发挥教师发展中心功能、组建社群学习团队、优化教师评价体系等提升教师教学能力的路径,为新工科建设以及应用型高校师资队伍建设提供新思路。

关键词：新工科应用型高校教育教学人才培训教学能力提升师资队伍建设

重症肺炎患者外周血CD64指数、NLR及CD14^(+)单核细胞HLA-DR的检测意义分析

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中国医学创新 2024年第21期21卷 166-170页

作者：熊丹邓琼陈婷抚州市第一人民医院检验科江西抚州344000

目的:探讨重症肺炎患者外周血CD64指数、中性粒细胞/淋巴细胞比值(NLR)及CD14^(+)单核细胞人类白细胞DR抗原(HLA-DR)的检测意义。方法:收集2022年1月—2024年3月抚州市第一人民医院收治的80例重症肺炎患者的临床资料进行研究。根据28 d... 详细信息

目的:探讨重症肺炎患者外周血CD64指数、中性粒细胞/淋巴细胞比值(NLR)及CD14^(+)单核细胞人类白细胞DR抗原(HLA-DR)的检测意义。方法:收集2022年1月—2024年3月抚州市第一人民医院收治的80例重症肺炎患者的临床资料进行研究。根据28 d内患者预后情况分组,将死亡患者作为死亡组(n=32),存活患者作为存活组(n=48)。比较两组一般资料及CD64指数、NLR、CD14^(+)单核细胞HLA-DR水平,分析CD64指数、NLR、CD14^(+)单核细胞HLA-DR单独及联合预测重症肺炎预后的价值,以及重症肺炎患者病死的危险因素。结果:两组年龄、入院时急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)比较,差异均有统计学意义(P9.15、NLR>12.19、CD14^(+)单核细胞HLA-DR≤44.60%、年龄≥65岁、入院时APACHEⅡ≥21.69分是重症肺炎患者病死的独立危险因素(P<0.05)。结论:CD14^(+)单核细胞HLA-DR水平偏低,CD64指数、NLR偏高提示重症肺炎患者预后不佳,三者联合检测可为临床预测重症肺炎患者预后提供参考。

关键词：重症肺炎 CD64 指数中性粒细胞/ 淋巴细胞比值 CD14^(+) 单核细胞人类白细胞DR 抗原

应用超声造影及MRI诊断下腔静脉离断伴左髂外静脉半奇静脉异位连接1例

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中国临床医学影像杂志 2024年第5期35卷 373-374页

作者：蒋贤平陈丽羽熊丹蕾浙江中医药大学浙江杭州310053 浙江省肿瘤医院中国科学院基础医学与肿瘤研究所浙江杭州310022

病例女,13岁,因“皮肤弥漫性红斑”到外院就诊,考虑先天性皮肤血管瘤或鲜红血痣,超声示“肝内等回声团,首先考虑肝脏来源,后腹膜来源不排除”,CT示“右上腹部肝脏与上腔静脉间见巨大肿块影,肿瘤性病变考虑”,为求进一步诊治,遂来我院。... 详细信息

病例女,13岁,因“皮肤弥漫性红斑”到外院就诊,考虑先天性皮肤血管瘤或鲜红血痣,超声示“肝内等回声团,首先考虑肝脏来源,后腹膜来源不排除”,CT示“右上腹部肝脏与上腔静脉间见巨大肿块影,肿瘤性病变考虑”,为求进一步诊治,遂来我院。患者一般情况好,无腹痛腹胀、发热畏寒、乏力纳差等不适。饮食可,大小便无殊,体质量无下降。皮肤弥漫性红斑,余无异常。实验室检查消化道肿瘤标志物及生化均为阴性。二维超声显示:肝脏尾状叶区域可见大小约10.6 cm×5.6 cm的等回声团(图1),边界清,内可见脉管结构回声,一条宽约0.7 cm主干及若干分支,在团块内自然延伸,逐渐变细,主干向外似与下腔静脉连通。CDFI及PW显示脉管结构内为入肝静脉血流(图2),肝静脉内为出肝静脉血流。门静脉及其余肝脏扫查未见明显异常。

关键词：腔静脉,下肝疾病超声检查磁共振成像

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空间小管路泄漏率的保压测量方法

航天器环境工程 2024年第4期41卷 509-515页

作者：杨延杰黄奕勇韩伟张翔熊丹中国人民解放军军事科学院国防科技创新研究院北京100071

针对类管路系统密封性检测需求,对基于温度和压力变化的保压法进行研究,分析小管路泄漏率检测的影响因素,提出温度补偿模型;分析满足管路泄漏率的设计指标,管路检漏系统需要的检测时间以及温度和压力传感器的参数要求;通过某型类管路系... 详细信息

针对类管路系统密封性检测需求,对基于温度和压力变化的保压法进行研究,分析小管路泄漏率检测的影响因素,提出温度补偿模型;分析满足管路泄漏率的设计指标,管路检漏系统需要的检测时间以及温度和压力传感器的参数要求;通过某型类管路系统的试验完成了保压法测量小管路泄漏率的验证。试验结果表明,基于温度补偿模型的保压法,具有较好的泄漏率检测精度。研究结果可为解决航天系统工质补给类管路系统的泄漏率检测提供思路。

关键词：泄漏率检测保压法温度补偿工质补给试验验证

Unraveling the 3D Genome Architecture in Plants:Present and Future

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Molecular Plant 2020年第12期13卷 1676-1693页

作者： Weizhi Ouyang dan xiong Guoliang Li Xingwang Li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Agricultural Bioinformatics and Hubei Engineering Technology Research Center of Agricultural Big Data 3D Genomics Research CenterHuazhong Agricultural UniversityWuhan 430070China

The eukaryotic genome has a hierarchicalthree-dimensional(3D)organization with functional implications for DNA replication,DNA repair,and transcriptional *** the past decade,scientists have endeavored to elucidate the spatial characteristics and functions of plant genome architecture using high-throughput chromatin conformation capturing technologies such as Hi-C,ChlA-PET,and ***,we systematically review current understanding of chromatin organization in plants at multiple *** also discuss the emerging opinions and concepts in 3D genome research,focusing on state-of-the-art 3D genome techniques,RNA-chromatin interactions,liquid-liquid phase separation,and dynamic chromatin *** propose the application of single-cell/single-molecule multi-omics,multiway(DNA-DNA,DNA-RNA,and RNA-RNA interactions)chromatin conformation capturing methods,and proximity ligation-independent 3D genome-mapping technologies to explore chromatin organization structure and function in *** methods could reveal the spatial interactions between trait-related SNPs and their target genes at various spatiotemporal resolutions,and elucidate the molecular mecha-nisms of the interactions among DNA elements,RNA molecules,and protein factors during the formation of key traits in plants.

关键词： 3D genomic methods plant 3D genome dynamic chromatin organization liquid-liquid phase separation RNA-chromatin interaction

Tra2βEnhances Cell Proliferation by Inducing the Expression of Transcription Factor SP1 in Cervical Cancer

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Biomedical and Environmental Sciences 2023年第2期36卷 146-159页

作者： LI Mo Juan xiong dan WANG Shuai HUANG Hao Department of The Sixth Affiliated Hospital School of MedicineSouth China University of Technology(Nanhai District People’s Hospital of Foshan)Foshan 528200GuangdongChina Shunde Hospital Southern Medical University(The First People’s Hospital of Shunde)Foshan 528308GuangdongChina

Objective In this study,the role and potential mechanism of transformer 2β(Tra2β)in cervical cancer were *** The transcriptional data of Tra2βin patients with cervical cancer from Gene Expression Profiling Interactive Analysis(GEPIA)and cBioPortal databases were *** functions of Tra2βwere evaluated by using Western blot,MTT,colony formation,Transwell assays,and nude mouse tumor formation *** genes regulated by Tra2βwere studied by ***,representative genes were selected for RT-qPCR,confocal immunofluorescence,Western blot,and rescue experiments to verify their regulatory *** The dysregulation of Tra2βin cervical cancer samples was ***2βoverexpression in Siha and Hela cells enhanced cell viability and proliferation,whereas Tra2βknockdown showed the opposite *** of Tra2βexpression did not affect cell migration and ***,tumor xenograft models verified that Tra2βpromoted cervical cancer ***,Tra2βpositively regulated the mRNA and protein level of SP1,which was critical for the proliferative capability of Tra2β.Conclusion This study demonstrated the important role of the Tra2β/SP1 axis in the progression of cervical cancer in vitro and in vivo,which provides a comprehensive understanding of the pathogenesis of cervical cancer.

关键词： Tra2β Cervical cancer Proliferation SP1 Molecular targeted therapy

Decoding the plant genome: From epigenome to 3D organization

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Journal of Genetics and Genomics 2020年第8期47卷 425-434页

作者： Weizhi Ouyang Zhilin Cao dan xiong Guoliang Li Xingwang Li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan430070China Department of Resources and Environment Henan University of EngineeringZhengzhou451191China Hubei Key Laboratory of Agricultural Bioinformatics and Hubei Engineering Technology Research Center of Agricultural Big Data Huazhong Agricultural UniversityWuhan430070China

The linear genome of eukaryotes is partitioned into diverse chromatin states and packaged into a threedimensional(3D)structure,which has functional implications in DNA replication,DNA repair,and transcriptional *** the past decades,research on plant functional genomics and epigenomics has made great progress,with thousands of genes cloned and molecular mechanisms of diverse biological processes ***,3D genome research has gradually attracted great attention of many plant ***,we briefly review the progress in genomic and epigenomic research in plants,with a focus on Arabidopsis and rice,and summarize the currently used technologies and advances in plant 3D genome organization *** also discuss the relationships between onedimensional linear genome sequences,epigenomic states,and the 3D chromatin *** review provides basis for future research on plant 3D genomics.

关键词： Plant genomics Epigenetic modification Chromatin three-dimensional structures Genomic methods

Ezrin Promotes the Proliferation, Migration, and Invasion of Ovarian Cancer Cells

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Biomedical and Environmental Sciences 2021年第2期34卷 139-151页

作者： LI Mo Juan xiong dan HUANG Hao WEN Zhong Yong Department of Obstetrics and Gynecology Nanhai Hospital Affiliated to Southern Medical UniversityFoshan 528200GuangdongChina Department of Hematology Shunde Hospital of Southem Medical University(The First People's Hospital of Shunde)Foshan 528308GuangdongChina

Objective The underlying mechanism of Ezrin in ovarian cancer(OVCA) is far from being ***, this study aimed to assess the role of Ezrin in OVCA cells(SKOV3 and Ca OV3) and investigate the associated molecular *** We performed Western blotting, reverse transcription-quantitative polymerase chain reaction, MTT, cell colony, cell wound healing, transwell migration and invasion, Rho A and Rac active pull down assays, and confocal immunofluorescence experiments to evaluate the functions and molecular mechanisms of Ezrin overexpression or knockdown in the proliferation and metastasis of OVCA *** The ectopic expression of Ezrin significantly increased cell proliferation, invasiveness, and epithelial–mesenchymal transition(EMT) in OVCA cells. By contrast, the knockdown of endogenous Ezrin prevented OVCA cell proliferation, invasiveness, and EMT. Lastly, we observed that Ezrin can positively regulate the active forms of Rho A rather than Rac-1 in OVCA cells, thereby promoting robust stress fiber *** Our results indicated that Ezrin regulates OVCA cell proliferation and invasiveness by modulating EMT and induces actin stress fiber formation by regulating Rho-GTPase activity, which provides novel insights into the treatment of the OVCA.

关键词： Epithelial ovarian cancer Ezrin Proliferation Invasiveness RhoA Stress fiber