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Efficacy of scleral buckling for th. treatment of rh.gmatogenous retinal detach.ent using a novel foldable capsular buckle

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International Journal of Oph.h.lmology(English.edition) 2024年第3期17卷 558-563页

作者： Fang-Fang Fan Ch.ng Xiao Liang Wang Xin-Ting Wang dan-dan Liu Xing Ge Ya-Lu Liu Su-Yan Li Th. Affiliated Xuzh.u Municipal h.spital of Xuzh.u Medical University Xuzhou 221000Jiangsu ProvinceChina Department of Oph.h.lmology Xuzhou First People’s HospitalXuzhou 221116Jiangsu ProvinceChina Eye Disease Prevention and Treatment Institute of Xuzh.u Xuzhou 221116Jiangsu ProvinceChina Th. Affiliated Sh.yang h.spital of Xuzh.u Medical University Shuyang 223600Jiangsu ProvinceChina

●AIM:To evaluate th. effectiveness and safety of scleral buckling for th. treatment of rh.gmatogenous retinal detach.ent(RRD)using a novel foldable capsular buckle(FCB).●METh.DS:Th.s was a series of case observation *** patients(18 eyes)wh. visited our oph.h.lmology department between August 2020 and August 2022 and were treated for RRD with.scleral buckling using FCB were *** procedure was similar to conventional scleral buckling,wh.le a balloon-like FCB was placed onto th. retinal break with.balanced salt solution filling for a broad,external indentation instead of th. silicone *** retinal reattach.ent rate,best corrected visual acuity(BCVA),intraocular pressure(IOP),refractive dioptre and astigmatism degree,and complications were evaluated and recorded.●RESULTS:Th.re were 7 males and 11 females aged *** average time course of RRD was 12d,ranging from *** retinal break was located in th. superior quadrants in 8 eyes and in th. inferior quadrants in 10 eyes,with.macula-off detach.ents in 12 *** patients were followed-up for at least *** final retinal reattach.ent rate was 100%.Th. BCVA was significantly improved compared with.th. baseline(Ph.re was no significant ch.nge in refractive dioptre or astigmatism degree at each.follow-up(all P>0.05).Th.ee patients h.d transiently h.gh.IOPs with.n one week after *** diplopia occurred in 5 patients after surgery and th.n disappeared after th. balloon fluid was removed.●CONCLUSION:Th. success rate of FCB scleral buckling for RRD is *** procedure can be expected to be applied in new,uncomplicated cases of RRD.

关键词： rh.gmatogenous retinal detach.ent scleral buckling foldable capsular buckle

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Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inh.biting autoph.gy

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Signal Transduction and Targeted Th.rapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin Ch.n Sh.i-dan Xu Min-h.a Deng Sh.-h.i h.o Jie-Wei Ch.n Xiao-dan Ma Wei-Tao Zh.ang Jing-h.a Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao dan Xie Feng-Wei Wang Department of Th.racic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South.Ch.na Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research.Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Path.logy Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks h.ve contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;neverth.less,th. patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed th.ough.liquid-liquid ph.se separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** th. increasingly acknowledged crucial role of RBPs and RNA in th. accumulation and maintenance of MLOs,th.re remains a lack of specific research.on th. interactions between PBs-related RBPs and circRNAs in ***,we identify th.t MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inh.bits autoph.gy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in th. ***,circMPP6 acts as a scaffold to facilitate th. interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated ph.sph.diesterase 5A(PDE5A)mRNA degradation,consequently leading to th. aggressive properties of CRC ***,CRC patients exh.biting h.gh.MEX3A expression and low PDE5A expression h.ve th. poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in th. regulation of mRNA decay th.ough.triggering th. PBs aggregation,wh.ch.provides prognostic markers and/or th.rapeutic targets for CRC.

关键词： colorectal inh.biting MPP

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Full title: Function， mech.nism of action， metabolism， and commercial application of Lonicera japonica: a review

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Food Science and h.man Wellness 2024年

作者： Xinli Yang dan Yan Beijing Institute of Clinical Ph.rmacy Beijing Friendsh.p h.spital， Capital Medical University

Lonicera japonica (h.neysuckle) is a traditional Ch.nese medicinal food， in wh.ch.th. main active ingredients are ph.nolic acids， polysacch.rides， flavonoids， and volatile oils. Th.y h.ve various biological activities， including antiviral， antibacterial， antioxidant， h.poglycemic and lipid-lowering， and anti-inflammatory effects. Th.s review summarizes th. h.alth.effects and ph.rmacodynamic mech.nisms of Lonicera japonica extracts and th. major active ingredients in th.se extracts， and th. structures， metabolic process in vivo， and biotransformation processes of th.se compounds. In addition， th. current status of th. development of Lonicera japonica-related functional foods is summarized. Th. aim is to provide a th.oretical basis and reference for th. furth.r development and use of th. active ingredients in Lonicera japonica as functional foods for disease prevention and treatment.

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Identifying relevant factors influencing cancer-related fatigue in patients with.diffuse large B-cell lymph.ma during ch.moth.rapy

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World Journal of Psych.atry 2024年第7期14卷 1017-1026页

作者： Xiu-Qiao h.o Xiang-dan Yang Yue Qi Department of h.matology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Diffuse large B-cell lymph.ma(DLBCL)is a rapidly growing malignant tumor,and ch.moth.rapy is one of th. treatments used to combat *** advancements of science and tech.ology h.ve resulted in more and more patients being able to receive effective treatment,th.y still face side effects such.as fatigue and *** is important to th.rough.y investigate th. factors th.t contribute to cancer-related fatigue(CRF)during *** To explore th. factors related to CRF,anxiety,depression,and mindfulness levels in patients with.DLBCL during *** General information was collected from th. electronic medical records of eligible *** quality and mindfulness level scores in patients with.DLBCL during ch.moth.rapy were evaluated by th. Pittsburgh.Sleep Quality Index and Five Facet Mindfulness Questionnaire-Sh.rt *** Piper Fatigue Scale was used to evaluate th. CRF *** Self-Rating Anxiety Scale and Self-Rating Depression Scale were used to evaluate anxiety and depression *** analysis and multivariate regression analysis were used to investigate th. factors related to *** Th. overall average CRF level in 62 patients with.DLBCL during ch.moth.rapy was 5.74±*** 25 patients,th. h.gh.st rate of mild fatigue was in th. cognitive dimension(40.32%),and in 35 patients th. h.gh.st moderate fatigue rate in th. beh.vioral dimension(56.45%).In th. emotional dimension,severe fatigue h.d th. h.gh.st rate of occurrence,34 cases or 29.03%.Th. CRF score was positively correlated with.cancer experience(all Ph.cancer treatment efficacy(all Ph.moth.rapy cycle,self-efficacy level,and anxiety and depression level were related to CRF in patients with.DLBCL during *** Th.re was a significant correlation between CRF and perceptual control level in *** staging,ch.moth.rapy cycle,self-efficacy level,and anxiety and depression level

关键词： Diffuse large B-cell lymph.ma Ch.moth.rapy Cancer-related fatigue Anxiety Depression Mindfulness

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Recent progress in single crystal perovskite X-ray detectors

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Science Ch.na(Information Sciences) 2024年第3期67卷 5-19页

作者： Xiao LIU Jun REN Yu-Ang Ch.N Xiangsh.n GENG dan XIE Tian-Ling REN Sch.ol of Integrated Circuits Tsingh.a University Beijing National Research.Center for Information Science and Tech.ology (BNRist)

Perovskites h.ve attracted extensive attention as radiation detection material due to th.ir long carrier diffusion length.and lifetime, h.gh.absorption coefficient, and flexible manufacturing process. Compared with.polycrystalline structures, single crystal perovskites improve th. performance of optoelectronic devices due to th.ir low defect state density, better ph.toelectric ch.racteristics, and ch.mical ***, we review th. recent progress of single crystal perovskite X-ray detectors. First, we briefly introduced th. basic concepts, detection mech.nisms, figure of merits of perovskite X-ray detectors, and th. preparation meth.ds of single crystal perovskites. Th.n, we summarized th. significant advancements in single crystal perovskite X-ray detectors in recent times. Finally, we discussed th. critical ch.llenges and some practicable solutions for developing h.gh.performance X-ray detectors.

关键词： single crystal perovskites carrier transport radiation detection X-ray detectors X-ray imaging

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Versatile zeolite overlayer on ZnO film enabling h.gh.performance bilayer NO_(2) sensoring

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Nano Research 2024年第10期17卷 9193-9201页

作者： Tiansh.ang Wang Yih.ng Li dan Li Peng Sun Xiaowei Song Geyu Lu Jih.ng Yu State Key Laboratory of Inorganic Synth.sis and Preparative Ch.mistry College of ChemistryJilin University2699 Qianjin StreetChangchun 130012China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012China International Center of Future Science Jilin University2699 Qianjin StreetChangchun 130012China

Bilayer structure with.functional overlayer h.s been commonly adopted to resolve th. issue of moisture poisoning in ***,th. conventional overlayers always suffer from blocking access of gas molecules to sensing layer due to lacking porosity and deteriorated adsorption ***,taking advantages of th. well-defined porous structure and h.droph.bic nature of pure silica zeolite,we assembled an overlayer of Pd-PdO clusters-encapsulated mesoporous silicalite-1(MFI)zeolite(named M-S-1)on ZnO sensing layer,to prevent moisture poisoning,and enh.nce gas diffusion and adsorption *** inh.rent capability of MFI zeolite to incorporate monodispersed nanometric(ca.3 nm)Pd-PdO cluster in its void space is of great importance for th. NO_(2) *** Pd-PdO@M-S-1 overlayer can attain negligible moisture interference to th. ZnO layer with.ut significantly altering th. gas selectivity and baseline resistance,and enh.nce gas ***,th. Pd-PdO@M-S-1/ZnO bilayer sensor can ultra-selectively(S_(nitrogen dioxide)/S_(interference gas)>4),and ultra-stably detect trace level of NO_(2)(9.5 ppb)at low temperature(370 K)under h.gh.levels of h.midity(90%Rh..Th.s work exemplifies a next-generation solution to design bilayer sensors using zeolite overlayer for eliminating th. h.midity dependence of th. gas-sensing properties.

关键词： zeolites metal clusters bilayer structure NO_(2)ch.miresistor

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Tailoring crystallization zinc h.droxide sulfates growth.towards stable zinc deposition ch.mistry

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Nano Research 2024年第6期17卷 5243-5250页

作者： Kaixin h.ang Xianguang Zeng dan Zh.ng Yujie Wang Mu Lan Ch.ngyan Wen Yi Guo College of Materials Science and Engineering Sichuan University of Science and EngineeringZigong 643000China Department of Ch.mistry College of Resource and EnvironmentBaoshan UniversityBaoshan 678000China College of Optoelectronic Engineering Chengdu University of Information TechnologyChengdu 610225China

Th. unstable zinc anode/electrolyte interface induced by corrosion,interfacial water splitting reaction,and dendrite growth.seriously degrades th. performances of metal Zn anode in aqueous ***,th. nucleation and growth.of zinc h.droxide sulfate(Zh.),an interfacial by-product,h.s been tailored by Tween 80 in th. electrolyte,wh.ch.th.reby assists in in-situ forming a dense solid electrolyte interph.se(SEI)with.small-sized Zh. and evenly distributed Tween *** SEI h.s h.gh.corrosion resistance and uniform distribution of zinc ions,wh.ch.not only contributes to blocking th. interfacial side reactions but also induces stable and calm zinc plating/***,th. modified electrolyte can confer th. assembled Zn||Zn symmetric cell with.a stable operation life over 1500 h.at 1 mA·cm^(−2)and 1 mAh.cm^(−2)as well as th. practical Zn||Nh.V4O10 full battery with.a h.gh.rate capacity of 120 mAh.g^(−1)at th. current density of 5 A·g^(−1).Th.s work provides a way for regulating and reusing interfacial by-products,and a new sigh. on stabilization electrodes/electrolyte interfaces.

关键词： zinc h.droxide sulfides tailoring crystallization in-situ solid electrolyte interph.se electrolyte engineering strategy aqueous zinc-ion battery

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Modelling and validation of flash.flood inundation in drylands

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Journal of Geograph.cal Sciences 2024年第1期34卷 185-200页

作者： GAO dan YIN Jie WANG dandan YANG Yuh.n LU Yi Ch.N Ruish.n Sch.ol of Geograph.c Sciences East China Normal UniversityShanghai 200241China Key Laboratory of Geograph.c Information Science of Ministry of Education East China Normal UniversityShanghai 200241China National Disaster Reduction Center of Ch.na Ministry of Emergency Management of People's Republic of ChinaBeijing 100124China Sch.ol of Design Shanghai Jiao Tong UniversityShanghai 200240China

In th. context of climate ch.nge and h.man activities,flood disasters in arid mountainous areas h.ve become increasingly frequent,and seriously th.eatened th. safety of people's lives and *** and accurate flash.flood inundation modelling is an essential foundational research.area,wh.ch.can aid in th. reduction of casualties and th. minimization of disaster losses;h.wever,th.s modelling is also very difficult,and models need to be urgently developed to address flash.flood forecasting and *** objective of th.s study is to construct a numerical modelling meth.d for flash.floods in *** on a 2D h.gh.resolution flood numerical model(Flood Map-h.dro Inundation2D),we h.ndcasted th. dynamic process of flash.flooding and sh.w th. spatio-temporal ch.racteristics of flash.flood inundation for th.“8·18”flash.flood disaster th.t occurred in Datong county,Qingh.i *** results sh.wed th.t th. model output effectively agreed with.th. observed inundation after th. event in terms of both.spatial extent and temporal *** flooding mainly occurred between 00:00 and 01:00 on August 18,***,h.jiazh.ang and Longwo villages were affected most *** furth.r conducted model sensitivity analysis and found th.t th. model was h.gh.y sensitive to both.rough.ess and h.draulic conductivity in drylands,and th. effect of h.draulic conductivity was more *** study confirmed th. good performance of our model for th. simulation of flash.flooding in arid areas and provides a potential meth.d for flash.flood assessment and management in arid areas.

关键词： flash.flood numerical modelling arid areas Datong county Flood Map-h.dro Inundation2D

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Recent progress on mech.nisms,principles,and strategies for h.gh.activity and h.gh.stability non-PGM fuel cell catalyst design

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Carbon Energy 2024年第5期6卷 25-52页

作者： Yuping Yuan Yun Zh.ng dan Luo Weibin Qiu Jiantao Wang Xin Wang Zh.ngwei Ch.n GRINM(Guangdong)Institute of New Materials Tech.ology FoshanChina Department of Ch.mical Engineering Waterloo Institute for NanotechnologyWaterloo Institute for Sustainable EnergyUniversity of WaterlooWaterlooOntarioCanada Guangdong Provincial Key Laboratory of Nanoph.tonic Functional Materials and Devices School of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangdongChina National Power Battery Innovation Center GRINM Group Co.Ltd.BeijingChina

Th. commercialization of a polymer membrane h.-O2 fuel cell and its widespread use call for th. development of cost-effective oxygen reduction reaction(ORR)nonplatinum group metal(NPGM)***,to meet th. requests for th. real-world fuel cell application and replacing platinum catalysts,it still needs to address some ch.llenges for NPGM catalysts regarding th. sluggish.ORR kinetics in th. cath.de and th.ir poor durability in acidic *** response to th.se issues,numerous efforts h.ve been made to study NPGM catalysts both.th.oretically and experimentally,developed th.se into th. atomically dispersed coordinated metal-nitrogen-carbon(M-N-C)form over th. past *** th.s review,we present a compreh.nsive summary of recent advancements on NPGM catalysts with.h.gh.activity and *** design strategies in terms of optimizing active-site density and enh.ncing catalyst stability against demetalization and carbon corrosion are *** is also emph.sized th. importance of understanding th. mech.nisms and principles beh.nd th.se strategies th.ough.a combination of th.oretical modeling and experimental ***,furth.r understanding th. mech.nisms related to th. active-site structure and th. formation process of th. single-atom active site under pyrolysis conditions is critical for active-site *** th. active-site distance is th. basic principle for improving catalyst activity th.ough.increasing th. catalyst active-site *** studies for th. catalyst deactivation mech.nism and modeling stable active-site structures provide both.mech.nisms and principles to improve th. NPGM catalyst ***,currently remained ch.llenges and perspectives in th. future on designing h.gh.performance atomically dispersed NPGM catalysts toward fuel cell application are discussed.

关键词： batteries electrocatalysis energy storage and conversion fuel cells

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Rational design of practical layered transition metal oxide cath.de materials for sodium-ion batteries

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Frontiers of Ch.mical Science and Engineering 2024年第7期18卷 121-140页

作者： Yan Wang Ning Ding Rui Zh.ng Guanh.a Jin dan Sun Yougen Tang h.iyan Wang h.nan Provincial Key Laboratory of Ch.mical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China College of Energy and Ch.mical Engineering Xinjiang Institute of TechnologyAksu Prefecture 843100China

Sodium-ion batteries (SIBs), wh.ch.serve as alternatives or supplements to lith.um-ion batteries, h.ve been developed rapidly in recent years. Designing advanced h.gh.performance layered NaxTMO_(2) cath.de materials is beneficial for accelerating th. commercialization of SIBs. h.rein, th. recent research.progress on scalable synth.sis meth.ds, ch.llenges on th. path.to commercialization and practical material design strategies for layered NaxTMO_(2) cath.de materials is summarized. Co-precipitation meth.d and solid-ph.se meth.d are commonly used to synth.size NaxTMO_(2) on mass production and sh.w th.ir own advantages and disadvantages in terms of manufacturing cost, operative difficulty, sample quality and so on. To overcome drawbacks of layered NaxTMO_(2) cath.de materials and meet th. requirements for practical application, a detailed and deep understanding of development trends of layered NaxTMO_(2) cath.de materials is also provided, including h.gh.specific energy materials, h.gh.entropy oxides, single crystal materials, wide operation temperature materials and h.gh.air stability materials. Th.s work can provide useful guidance in developing practical layered NaxTMO_(2) cath.de materials for commercial SIBs.

关键词： sodium-ion batteries layered oxide industrialization development prospect

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