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Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi yun Kai yang yu liang Ke Xu Xue Feng zhang yun Kang yu Qin Jin Jun wei Hou Jing zhang Tian yang Salah Hussein Mohamed Saif ElDein Ze Hua lei Hao zhang Shuai Shao Zhao Ming liu Ning liu Xiang zheng Ji Guo Su Sen Sen yang Xiangfeng Cong Yao Tan wenwen lei Xue Jun Gao Zhiwei Jiang Hui wang Meng li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue zhang Chang Qu dan Ying liu Jing zhang Mengjie yang Islam Eltantawy Peng xiao Fu Jie Shen Jin Juan Wu Zi Bo Han li Fang Du Fang Tang Shi Chen Zhi Jing Ma Fan zheng Ya Nan Hou Xin yu li Xin li Zhao Nian wang Jin liang Yin xiao yan Mao Jin zhang liang Qu yun Tao zhang xiao Ming yang Guizhen Wu Qi Ming li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

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Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental Sciences 2021年第1期34卷 9-18页

作者： ZHU yuan yue zhenG Rui Zhi wang Gui Xia CHEN li SHI li Xin SU Qing XU Min XU yu CHEN yu Hong yu Xue Feng yan li wang Tian Ge ZHAO Zhi yun QIN Gui Jun WAN Qin CHEN Gang GAO zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan li Qiang YE zhen zhang Yin Fei liU Chao wang You Min WU Sheng li yanG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu lei HU Ru Ying wang wei Qing NING Guang li Mian LU Jie li BI yu Fang Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China The First Hospital of Jilin University Changchun 130021JinlinChina Qilu Hospital of Shandong University Jinan 250012ShandongChina Affiliated Hospital of Guiyang Medical College Guiyang 550004GuizhouChina Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200092China Tongji Hospital.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The First Affiliated Hospital of zhengzhou University Zhengzhou 450052HenanChina The Affiliated Hospital of Southwest Medical University Luzhou 646099SichuanChina Fujian Provincial Hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central Hospital Dalian 116003LiaoningChina The First Affiliated Hospital of wenzhou Medical University Wenzhou 325000ZhejiangChina The First Affiliated Hospital of Guangxi Medical University Nanning 530021GuangxiChina Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006JiangxiChina The Second Affiliated Hospital of Harbin Medical University Harbin 150086HeilongjiangChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Central Hospital of Shanghai Jiading District Shanghai 201800China Jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The First Affiliated Hospital of Anhui Medical University Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 30,941 men and 62,361 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status

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The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST

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Research in Astronomy and Astrophysics 2019年第11期19卷 33-48页

作者： Bo Chen Hui li Ke-Fei Song Quan-Feng Guo Pei-Jie zhang ling-Ping He Shuang Dai xiao-Dong wang Hai-Feng wang Chun-Long liu Hong-Ji zhang Guang zhang yunqi wang Shi-Jie liu Hong-Xin zhang lei liu Shi-lei Mao yang liu Jia-Hao Peng Peng wang liang Sun yang liu zhen-wei Han yan-Long wang Kun Wu Guang-Xing Ding Peng Zhou Xin zheng Ming-Yi Xia Qing-wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong wang Bo Zhu Chang-Bo Chu wen-Gang yang li Feng yu Huang wei-Qun Gan Ying li Jing-wei li lei Lu Jian-Chao Xue Bei-li Ying Ming-Zhe Sun Cheng Zhu wei-Min Bao lei Deng Zeng-Shan Yin Changchun Institute of Optics FineMechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun 130033China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China Shandong University Weihai 264209China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China

As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,*** maximum exposure time can be up to20 s due to precise pointing and image stabilization *** the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attainers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal *** present the up-to-date design for the LST payload.

关键词： telescopes—instrumentation high angular resolution—Sun flares—Sun coronal mass ejections(CMEs)—Sun UV radiation

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First experimental constraints on WIMP couplings in the effective field theory framework from CDEX

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Science China(Physics,Mechanics & Astronomy) 2021年第8期64卷 15-22页

作者： Yi wang Zhi Zeng Qian yue liTao yang KeJun Kang yuanJing li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen yunHua Chen JianPing Cheng Cheng Yi Chiang wenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo Xuyuan Guo HongJian He li He ShengMing He Jinwei Hu TuChen Huang HanXiong Huang HaiTao Jia liPing Jia Xi Jiang Haubin li JianMin li Jin li MingXuan li RenMingJie li Xia li yuLan li bin liao FongKay lin ShinTed lin ShuKui liu yanDong liu yu liu yuanyuan liu ZhongZhi liu Hao Ma yuCai Mao Qiyuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang weiYou Tang yang Tian GuangFu wang li wang Qing wang yu Chen wang yunXiang wang zhen wang Henry Tsz-King Wong ShiYong Wu yuCheng Wu Haoyang Xing Yin Xu Tao Xue yuLu yan Nan Yi ChunXu yu HaiJun yu JianFeng yue Ming Zeng bingTao zhang lei zhang FengShou zhang zhenyu zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu Key Laboratory of Particle and Radiation Imaging(Ministry of Education) Department of Engineering PhysicsTsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China College of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China Sino-French Institute of Nuclear and Technology Sun Yet-sen UniversityZhuhai 519082China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Department of Physics Banaras Hindu UniversityVaranasi 221005India Department of Physics Beijing Normal UniversityBeijing 100875China School of Physics Nankai UniversityTianjin 300071China

We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region.

关键词： WIMP EFT CDEX dark matter annual modulation

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Chinese Expert Consensus on Clinical Application of Female Contraceptive Methods

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Reproductive and Developmental Medicine 2018年第4期2卷 208-223页

作者： li-Nan Cheng wen Di yan Ding Guang-Sheng Fan Xiang-Ying Gu Min Hao Jing He li-Na Hu Ke-Qin Hua wei Huang li Jin Bei-Hua Kong Jing-He Lang Jin-Hua Leng Jian li Cai-Xia liu Guan-yuan liu lei Song xiao-Ye wang Shang-Chun Wu Min Xue Hui-Xia yang Qing yang Shu-Zhong Yao zhen-yu zhang Ying-Fang Zhou Lan Zhu Shanghai Institute of Planned Parenthood Research ShanghaiChina Department of Obstetrics and Gynecology Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Gynecology The First Affiliated Hospital of Xinjiang Medical UniversityÜrümqiChina Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina Department of Family Planning Tianjin Medical University General HospitalTianjinChina Department of Obstetrics and Gynecology The Second Hospital of Shanxi Medical UniversityTaiyuanChina Department of Obstetrics Zhejiang University School of MedicineHangzhouChina Department of Obstetrics and Gynecology The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghaiChina Department of Obstetrics and Gynecology The West China Second University HospitalSichuan UniversityChengduChina Department of Obstetrics and Gynecology Qilu Hospital of Shandong UniversityJinanChina Department of Family Planning Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijingChina Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyangChina Department of Obstetrics and Gynecology Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Department of Obstetrics and Gynecology PLA General HospitalBeijingChina Department of Obstetrics and Gynecology Peking University Third HospitalBeijingChina Research Institute of National Health Commission of the People's Republic of China BeijingChina Department of Gynecology The Third Xiangya Hospital of Central South UniversityChangshaChina Department of Obstetrics and Gynecology Peking University First HospitalBeijingChina Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Unintended pregnancy is a global issue, with approximately 85,000,000 women around the world having unintended pregnancy annually. The contents of clinical application of women’s contraceptive methods are very wide, involving multiple areas. This consensus deeply discusses the specific contraceptive needs at different statuses, combined with gynecological diseases, postabortion contraception, and postpartum family planning, ensuring the correct use of contraceptive methods under the corresponding status. The top priority of the consensus is the specific contraception consensus section for women combined with gynecological diseases because medical treatment effect as well as side effects should be weighed carefully. The consensus is to make high-efficiency and individual contraceptive strategy for different groups based on multidisciplinary(gynecology, obstetrics, and family planning) and multidimensional aspects, which can provide uniform guidance for medical and health organizations under the condition as relevant global guidance or consensus is still lacking.

关键词： Contraceptive Methods Gynecological Disease Postabortion Contraception Postpartum Family Planning Unintended Pregnancy

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养殖塘CH_(4)通量时空变化特征及其影响因素

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中国环境科学 2021年第6期41卷 2910-2922页

作者：贾磊张弥蒲旖旎赵佳玉王娇谢燕红张圳肖薇石婕邱吉丽南京信息工程大学气候与环境变化国际合作联合实验室大气环境中心江苏南京210044 山西省太原市气象局山西太原030000

本研究基于多通道密闭式动态箱法对亚热带典型养殖塘CH_(4)通量的时空变化特征及其影响因素进行了分析.结果表明:亚热带养殖塘CH_(4)主要排放方式是冒泡,CH_(4)扩散及冒泡通量均呈现明显的季节变化特征.春、夏、秋、冬4个季节CH_(4)扩... 详细信息

本研究基于多通道密闭式动态箱法对亚热带典型养殖塘CH_(4)通量的时空变化特征及其影响因素进行了分析.结果表明:亚热带养殖塘CH_(4)主要排放方式是冒泡,CH_(4)扩散及冒泡通量均呈现明显的季节变化特征.春、夏、秋、冬4个季节CH_(4)扩散通量分别为:0.113,0.830,0.002,0.005μmol/(m^(2)·s),冒泡通量分别为0.923,1.789,0.006,0.007μmol/(m^(2)·s),冒泡通量占总通量的比例分别为89.04%、68.29%、78.95%和60.52%.在冬、春季养殖塘没有人工管理措施的情况下,CH_(4)通量随着离岸距离的增加而增大,冬、春季养殖塘中间区域CH_(4)总通量分别是岸边浅水区的34.70和2.98倍.夏季养殖活跃期CH_(4)通量在空间上呈现出:人工投食区(7.371μmol/(m^(2)·s))>自然生长区(2.151μmol/(m^(2)·s))>人工增氧区(0.888μmol/(m^(2)·s))>岸边浅水区(0.206μmol/(m^(2)·s))的特征.在0.5h尺度上,春季CH_(4)扩散通量与水温呈显著正相关关系,与风速呈负相关关系,秋季CH_(4)扩散通量与水温、风速呈正相关关系,冒泡通量和水温呈正相关关系.在日尺度上,水温是CH_(4)扩散通量和冒泡通量的主控因子,两者均随着水温升高呈指数增加,并且冒泡通量的水温敏感性Q10(12.72)大于扩散通量(7.78).

关键词：养殖塘密闭式动态箱法 CH_(4)扩散通量 CH_(4)冒泡通量时空变化特征影响因素

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Study protocol:A cross-sectional study on psychology and behavior investigation of Chinese residents,PBICR

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Psychosomatic Medicine Research 2022年第3期4卷 30-41页

作者： yu-Jia wang Ayidana Kaierdebieke Si-yuan Fan Rui-Feng zhang Meng-Jie Huang Han li xiao-Nan Sun Qi-yu li wen-Jia Meng wen-yu Wu Zhi lin Jing-Yao liu Xin-Pei wang yun-Chou Wu Jing-Qi Tang Yi-Ke Sun Ke Chen Pu Ge Wai-Kit Ming Casper zhang zheng Feei Ma lei Feng Xin-yue zhang yu-Yao Niu yu-Pei yan Yi-Le Jin Guang-Ze Gao Shuang Dai yu-liu li yue Tan Yi-wei Wu Qi zhang Gui Gui Xian-li Pan yan-Ming liao Xian-Qi Zhao Ya-Ting zhang Hui-Yi Chen yue-wei Qiu xiao-Min Fu Jiang-ling Zhou dan li Ke-Han li Meng-wei Xu Zhe wang yue-Qi wang Yong Ma Xin-Ying Sun Yi-Bo Wu College of Humanities and Social Science Harbin Medical UniversityHarbin150081China School of Public Health Xi'an Jiaotong UniversityXi'an710061China Department of Preventive Medicine Yanjing Medical CollegeCapital Medical UniversityBeijing101300China Preschool Education Guangzhou Huangpu District Phoenix Lake KindergartenGuangzhou510000China School of Public Health Shandong UniversityJinan250012China National Drug Clinical Trial Institute The Second Affiliated HospitalXi'an Jiaotong UniversityXi'an741004China School of Humanities and Health Management Jinzhou Medical UniversityJinzhou121000China School of Arts and Media The University of New South WalesSydneyNSW 2052Australia School of Health Management Harbin Medical UniversityHarbin150081China College of Communication and Art Design University of Shanghai for Science and TechnologyShanghai200093China Medical Equipment Department Peking University First HospitalBeijing100034China School of Philosophy Anhui UniversityHefei230039China College of Integrated Traditional Chinese and Westem Medicine Jining Medical UniversityJining272000China Faculty of Health Sciences University of MacaoMacao999078China Jockey Club College of Veterinary Medicine and life Sciences City University of Hong KongHong KongChina School of Public Health The University of Hong KongHong Kong000000China Centre for Public Health and Wellbeing School of Health and Social WellbeingCollege of HealthScience and SocietyUniversity of the West of EnglandBristol BS161QYUK Centre For life Science National University of Singapore117456Singapore School of Stomatology Zhejiang University School of MedicineHangzhou 310006China Faculty of Arts and Humanities University of MacaoMacao999078China Department of Humanities Arts and MediaChangzhi Medical CollegeChangzhi046013China Baotou Clinical College Inner Mongolia Medical UniversityBaotou010110China Tongliao Clinical College Inner Mongolia Medical UniversityTongliao010110China School of Ima

Objective:This study protocol identifies the basic research route and framework of psychological and behavioral surveys among Chinese residents,aims establishing a database through a multicenter,large-sample cross-sectional survey in China to provide strong data support for research development in various fields and a more comprehensive and systematic understanding of the physical and mental health status of the ***:The study was conducted from June 20,2022 to August 31,2022,using stratified sampling and quota sampling methods,a total of 148 cities,202 districts and counties,390 townships/towns/sub-districts,and 780 communities/villages(excluding Hong Kong,Macao,and Taiwan)from 23 provinces,5 autonomous regions,and 4 municipalities directly under the central government in China were *** questionnaire was distributed one-on-one and face-to-face to the public by trained investigators,and the questionnaire included eight aspects:personal basic information,personal health status,family basic information,social environment in which they were located,psychological level scale,behavioral level scale,other scales,and attitude towards social hot *** analysis will be performed after questionnaire ***:Data collection is *** findings will support physical and mental health research and strategy development in China and even globally,guiding policy-makers and health care organizations to reform their programs to ensure the best interests of residents and their families.

关键词： Chinese residents Psychology Behavior Cross-sectional survey

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Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China

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General Psychiatry 2023年第6期36卷 541-546页

作者： Gangbin Han Guirong Cheng Feifei Hu Chunli li dan liu Juan Zhou Jing liu linya Huang xiaochang liu Qianqian Nie dan Song Deyang Zeng Lang Xu Jinquan li yushan Chen zhen wei Qiong Wu xiaoming He Qingming Wu wei Tan yufei Mei Xingxing Chen yangming Ou Jingjing zhangYafu yu Mengliu yang Pengfei lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue li Junyi wang Cheng Cai Mengdie Pei yuyang Cui Wanying Cai Yiqing li Shiyao Pan Chang Chen yan He Zhaoxia Wu liu Hu liang Tao Hongyan xiao Xinyan Xie yan Zeng Institute of Brain Science and Advanced Technology Wuhan University of Science and TechnologyWuhanHubeiChina Department of Neurology Geriatric Hospital Affiliated to Wuhan University of Science and TechnologyWuhan University of Science and TechnologyWuhanHubeiChina Department of Neurology Tianyou Hospital Affiliated to Wuhan University of Science and TechnologyWuhan University of Science and TechnologyWuhanHubeiChina Institute of Infection Immunology and Tumor MicroenvironmentHubei Province Key Laboratory of Occupational Hazard Identification and ControlMedical CollegeWuhan University of Science and TechnologyWuhanHubeiChina Department of Anesthesiology Zhongnan HospitalWuhan UniversityWuhanHubeiChina Department of Neurology Wuchang Hospital afiliated to Wuhan University of Science and TechnologyWuhan University of Science and TechnologyWuhanHubeiChina Department of neurology Asian Heart HospitalWuhan University of Science and TechnologyWuhanHubeiChina School of Public Health Wuhan University of Science and TechnologyWuhanHubeiChina

To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were *** associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern.

关键词： acute impact consequences

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ROLES OF SOME INFLAMMATORY MEDIATORS IN THE PATHOGENESIS OF EARLY PULMONARY EDEMA IN STEAM RESPIRATORY BURNS

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中华医学杂志(英文版) 1987年第2期100卷 141-141页

作者： li Ao Jiang Kun-yuan yang Zong-cheng Zhu Pei-fang Huang wen-hua Zhou Shan-zhang Dong yan-lin liang yan-Jie Huang yue-hua Yao dan-fan Song yu-nan Chen Fa-ming Feng Hua-fang li yuan-ping Wu zhen-zhong You Zhong-yi wang Tian-yi lian wei-kun Respiratory Burn Research Unit Burn Center Third Military Medical University PLA

The roles of some inflammatory mediators in the pathogenesis of early pulmonary edema by steam inhalation were studied. The experiments were carried out on 36 healthy dogs. The results showed that the pathogenesis of pulmonary edema in severe steam respiratory burns is mainly as follows: direct action by heat leads to organic lesions of pulmonary capillaries and the changes of some inflammatory mediators, i.e., complements, anaphylatoxin, histamine, PGF1 and cAMP, in the left ventricular blood and the lung tissues resulting in increase of permeability of pulmonary capillaries.

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胰腺囊性肿瘤的多层螺旋CT表现与病理对照

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中国临床医学影像杂志 2008年第9期19卷 638-641页

作者：唐平肖立王巍殷于磊吴威岚滑炎卿张国桢复旦大学附属华东医院上海200040

目的:探讨胰腺囊性肿瘤的多层螺旋CT(MSCT)表现和诊断价值。方法:回顾性分析21例经手术病理确诊的胰腺囊性肿瘤MSCT表现,其中浆液性囊腺瘤5例,黏液性囊腺肿瘤10例,导管内乳头状黏液瘤3例,实性假乳头状瘤3例。男5例,女16例,年龄14～78岁... 详细信息

目的:探讨胰腺囊性肿瘤的多层螺旋CT(MSCT)表现和诊断价值。方法:回顾性分析21例经手术病理确诊的胰腺囊性肿瘤MSCT表现,其中浆液性囊腺瘤5例,黏液性囊腺肿瘤10例,导管内乳头状黏液瘤3例,实性假乳头状瘤3例。男5例,女16例,年龄14～78岁,平均52岁。使用4层和16层螺旋CT,平扫21例,同时增强20例。结果:①浆液性囊腺瘤多表现为多房囊性肿块,囊壁及分隔厚薄均匀,无壁结节。②黏液性囊腺肿瘤表现为多房或单房、边界清楚、无壁结节或壁结节小;而黏液性囊腺癌浸润周围组织、边界不清、壁结节较大。③导管内乳头状黏液瘤为多房或葡萄串样囊性肿块,与扩张的胰管相通。④实性假乳头状瘤边界清,可有较厚包膜,囊性成分与实性成分构成比例不一,实性部分逐步强化。结论:MSCT可以展示胰腺囊性肿瘤的病理特征,对诊断与鉴别诊断有较高的价值。

关键词：胰腺肿瘤体层摄影术,螺旋计算机

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