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Inhibition of Re Du Ning Injection on Enzyme Activities of Rat liver Microsomes Using Cocktail Method

Chinese Herbal Medicines 2016年第3期8卷 231-241页

作者： xiao-qian Xu Ting Geng She-bing zhang dan-yu Kang yan-jing li Gang Ding wen-zhe Huang zhen-zhong wang wei xiao Jiangsu Kanion Modern Chinese Medicine Institute Nanjing 210017China State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine Jiangsu Kanion Pharmaceutical Co.Ltd.Lianyungang 222001China National Enterprise Technology Center National Post-doctoral Research WorkstationJiangsu Enterprise Academician WorkstationLianyungang 222001China China Pharmaceutical University Nanjing 210009China

Objective Re Du Ning Injection （RDN）, a Chinese materia medica injection, is made from the extracts of LoniceraeJaponicae Flos, Gardeniae Fructus, and Artemisiae Annuae Herba. Since last decade, RDN has been widely used in China for the treatment of viral infection, fever, and inflammation. To assess the potential interacting of RDN with co-administered drugs, the inhibitory effects of RDN on the enzyme activities （CYP1A1, CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2） of rat liver microsomes were investigated by a cocktail method. Methods A sensitive and specific LC-MS method capable of simultaneous quantification of five metabolites in rat liver microsomes was developed and validated. Then RDN （0.625%-1.0%） was incubated with rat liver microsomes and specific substrates. The enzyme activities were expressed as the formation rate of the specific metabolites of the substrates （pmol- mg. protein-1 . min-1）. Results RDN competitively inhibited the activities of CYP1A2 and CYP2C11, with inhibition constant （/~） values determined to be 0.18% and 0.63%, respectively. RDN exhibited the mixed inhibition on the activity of CYP2D1, with a K1 value of 0.15%. The activities of CYP1A1 and CYP3A1/2 were not markedly inhibited even by 1.0% RDN. Conclusion RDN could inhibit the rat enzyme activities of CYP1A2, 2Cll, and 2D1 in vitro with different inhibition modes, which is worthy of promoting safety and efficacy of RDN.

关键词： cocktail cytochrome P450 inhibition rat liver microsomes Reduning Injection

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Dynamic single-cell mapping unveils Epstein-Barr virusimprinted T-cell exhaustion and on-treatment response

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4985-4997页

作者： Miao-zhen Qiu Chaye wang Zhiying Wu Qi Zhao Zhibin Zhao Chun-yu Huang wenwei Wu li-Qiong yang Zhi-wei Zhou yu zheng Hong-Ming Pan Zexian liu Zhao-lei Zeng Hui-yan Luo Feng wang Feng-Hua wang Si-yu yang Meng-Xing Huang Zhexiaon lian Haiyan zhang Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center510060 GuangzhouChina Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences510060 GuangzhouChina Department of Experimental Research Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University510060 GuangzhouChina Medical Research Institute Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Endoscopy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University510060 GuangzhouChina Department of Gastric Surgery Sun Yat-sen University Cancer Center510060 GuangzhouChina Department of Internal Medical Oncology Zhejiang University School of MedicineSir Run Run Shaw HospitalHangzhouChina Cancer Centre Faculty of Health SciencesUniversity of MacaoMacao SARChina MOE Frontier Science Centre for Precision Oncology University of MacaoMacao SARChina

Epstein-Barr virus(EBV)-associated gastric cancer(GC)manifests an intriguing immunotherapy ***,the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains *** study aimed to finely characterize the dynamic tumour immune contexture of human EBV(+)GC treated with immunochemotherapy by longitudinal scRNA-seg and paired scTCR/***(+)GC exhibits an inflamed-immune phenotype with increased T-cell and B-cell infiltration.

关键词： chemotherapy treatment EBV

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New hope for esophageal stricture prevention:A prospective singlecentertrial on acellular dermal matrix

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World Journal of Gastrointestinal Endoscopy 2023年第12期15卷 725-734页

作者： Xin-yu Fu zhen-yu Jiang Chen-yang zhang ling-yan Shen xiao-dan yan xiao-Kang li Jia-Ying lin Yi wang Xin-li Mao Shao-wei li Department of Gastr-oenterology Taizhou Hospital of Zhejiang ProvinceWenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical CollegeInner Mongolia University of Science and TechnologyBaotou 014000Inner Mongolia Autonomous RegionChina Department of Gastroenterology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Key Laboratory of Minimally Invasive Techniques&Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Division of Transplantation Immunology National Research Institute for Child Health and DevelopmentTokyo 1540001Japan Institute of Digestive Disease Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina

BACKGROUNDGiven the high incidence of esophageal cancer in China,an increasing number ofpatients there are undergoing endoscopic mucosal dissection(ESD).Although the5-year survival rate after ESD can exceed 95%,esophageal stricture,the mostcommon and serious postoperative complication,affects the long-term prognosisof patients and the quality of *** mucosal grafts have proven to besuccessful in preventing stricture after ESD for early esophageal *** examine the viability of acellular dermal matrix(ADM)as an alternative to autologous mucosa for the prevention of stricture after *** is a prospective,single-center,controlled *** patients who underwent ESD surgery and werewilling to undergo autologous mucosal transplantation were recruited between January 1 and December 31,*** patients who underwent ESD surgery and were willing to undergo ADM transplantation wererecruited between January 1 to December 31,2019.A final three-year follow-up of patients who receivedtransplants was *** on the current incidence of esophageal stricture,the sample size required for both the autologous mucosalgraft group and the ADM group was calculated to be 160 *** to various factors,a total of 20 patients withautologous mucosal grafts and 25 with ADM grafts were *** on the inclusion exclusion andwithdrawal criteria,9 patients ultimately received autologous mucosal grafts and completed the follow-up,while11 patients received ADM grafts and completed the ***,there were 2 cases of stenosis in theautologous mucosal transplantation group with a stenosis rate of 22.22%and 2 cases of stenosis in the ADMtransplantation group with a stenosis rate of 18.18%,with no significant difference noted between the groups(P=0.94).CONCLUSIONIn this prospective,single-center,controlled trial,we compared the effectiveness of autologous mucosatransplantation and ADM for the prevention of esophageal strictur

关键词： Over-the-scope clip Duodenal subepithelial lesion Endoscopic resection Perforation

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Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury

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Protein & Cell 2019年第08期10卷 566-590页

作者： dandan Luo weihong Ge xiao Hu Chen li Chia-Ming Lee liqiang Zhou Zhourui Wu Juehua yu Sheng lin Jing yu wei Xu lei Chen Chong zhang Kun Jiang Xingfei Zhu Haotian li Xinpei Gao yanan Geng Bo Jing zhen wang Changhong zheng Rongrong Zhu Qiao yan Quan lin Keqiang Ye Yi E.Sun liming Cheng Division of Spine Surgery Department of Orthopedics Tongji Hospital Tongji University School of Medicine Institute of Spine and Spine Cord Injury of Tongji University Stem Cell Translational Research Center Tongji Hospital Tongji University School of Medicine Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine University of California Los Angeles Department of Pathology and Laboratory Medicine Center for neurodegeneration disease Emory University School of Medicine

The mammalian central nervous system(CNS) is considered an immune privileged system as it is separated from the periphery by the blood brain barrier(BBB). Yet,immune functions have been postulated to heavily infiuence the functional state of the CNS, especially after injury or during neurodegeneration. There is controversy regarding whether adaptive immune responses are beneficial or detrimental to CNS injury repair. In this study, we utilized immunocompromised SCID mice and subjected them to spinal cord injury(SCI). We analyzed motor function, electrophysiology, histochemistry, and performed unbiased RNA-sequencing. SCID mice displayed improved CNS functional recovery compared to WT mice after SCI. weighted gene-coexpression network analysis(WGCNA) of spinal cord transcriptomes revealed that SCID mice had reduced expression of immune function-related genes and heightened expression of neural transmission-related genes after SCI,which was confirmed by immunohistochemical analysis and was consistent with better functional *** analyses also indicated heightened expression of neurotransmission-related genes before injury in SCID mice, suggesting that a steady state of immune-deficiency potentially led to CNS hyper-connectivity. Consequently, SCID mice without injury demonstrated worse performance in Morris water maze test. Taken together, not only reduced infiammation after injury but also dampened steady-state immune function without injury heightened the neurotransmission program, resulting in better or worse behavioral outcomes respectively. This study revealed the intricate relationship between immune and nervous systems, raising the possibility for therapeutic manipulation of neural function via immune modulation.

关键词： immune deficiency neurotransmision spinal cord injury repair transcriptomic analysis

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Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients

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Cellular & Molecular Immunology 2021年第3期18卷 621-631页

作者： yang li dan-yun La Qing lei Zhao-wei Xu Feng wang Hongyan Hou lingyun Chen Jiaoxiang Wu yan Ren Ming-liang Ma Bo zhang Hong Chen Caizheng yu Jun-biao Xue yun-xiao zheng Xue-ning wang He-wei Jiang Hai-nan zhang Huan Qi Shu-juan Guo yandi zhang xiaosong lin Zongjie Yao Pengfei Pang Dawei Shi wei wang xiao yang Jie Zhou Huiming Sheng Ziyong Sun Hong Shan Xionglin Fan Sheng-ce Tao Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghaiChina Department of Pathogen Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Key Laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhouChina Department of Clinical Laboratory Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina SBGI Education Center University of Chinese Academy of SciencesShenzhen 518083China Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghaiChina BGI-Shenzhenf Shenzhen 518083 China Department of Public Health Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Center for Interventional Medicine The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China National Institutes for Food and Drug Control Beijing 100050China Foshan Fourth Peopled Hospital Foshan 528000China Key Laboratory of RNA Biology Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Serological tests play an essential role in monitoring and combating the COVID-19 *** spike protein(S protein),especially the S1 protein,is one of the major reagents used for serological ***,the high cost of S protein production and possible cross-reactivity with other human coronaviruses pose unavoidable *** taking advantage of a peptide microarray with full spike protein coverage,we analyzed 2,434 sera from 858 COVID-19 patients,63 asymptomatic patients and 610 controls collected from multiple clinical *** on the results,we identified several S protein-derived 12-mer peptides that have high diagnostic *** particular,for monitoring the IgG response,one peptide(aa 1148-1159 or S2-78)exhibited a sensitivity(95.5%,95%CI 93.7-96.9%)and specificity(96.7%,95%CI 94.8-98.0%)comparable to those of the S1 protein for the detection of both symptomatic and asymptomatic COVID-19 ***,the diagnostic performance of the S2-78(aa 1148-1159)IgG was successfully validated by EliSA in an independent sample cohort.A panel of four peptides,S1-93(aa 553-564),S1-97(aa 577-588),S1-101(aa 601-612)and S1-105(aa 625-636),that likely will avoid potential cross-reactivity with sera from patients infected by other coronaviruses was *** peptides identified in this study may be applied independently or in combination with the S1 protein for accurate,affordable,and accessible COVID-19 diagnosis.

关键词： SARS-CoV-2 Spike peptide Antibody Diagnosis

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Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis

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Chinese Medical Journal 2016年第7期129卷 757-762页

作者： Ping liu yan Zhao zhang-lei Mu Qian-Jin Lu Qian-Jin L U li zhang Xu Yao Min zheng Yi-wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun lin yu-zhen li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu wei li wei Lai Hui-Min yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo dan-Qi Deng Tong-Xin Shi Jian-Zhong zhang Department of Dermatology Peking University People's Hospital Beijing 100044 China Department of Dermatology The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China Department of Dermatology The First Hospital of China Medical University Shenyang Liaoning 110001 China Department of Dermatology Institute of Dermatology Chinese Academy of Medical Sciences Nanjing Jiangsu 210042 China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Dermatology Tianjin Changzheng Hospital Tianjin 300120 China Department of Dermatology The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia 010050 China Department of Dermatology Yantai Yuhuangding Hospital Yantai Shandong 264000 China Department of Dermatology The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China Department of Dermatology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Dermatology The Second Hospital of Dalian Medical University Dalian Liaoning 116023 China Department of Dermatology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Dermatology Shanghai Huashan Hospital Shanghai 200040 China Department of Dermatology Xijing Hospital Xi'an Shaanxi 710032 China Department of Dermatology The Third Affiliated Hospital Of Sun Yat-sen University Guangzhou Guangdong 510630 China Department of Dermatology The Second Hospital of Heilongjiang Province Harbin Heilongjiang 150010 China Department of Dermatology Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Dermatology.Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China Department of Dermatology Peking University Third Hospital Beijing 100191 China Department of Dermatology The First Affili

Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczemaJAD and to propose Chinese diagnostic criteria for adult/adolescent AD. Methods： A hospital-based study was performed. Forty-two dermatological centers participated in this study. Adult and adolescent patients （12 years and over） with chronic symmetrical eczema or AD were included in this study. Questionnaires were completed by both patients and-investigators. The valid questionnaires were analyzed using EpiData 3.1 and SPSS 17.0 software. Results： A total of 2662 valid questionnaires were collected （1369 male and 1293 female）. Of all 2662 patients, 2062 （77.5%） patients had the disease after 12 years old, while only 600 （22.5%） patients had the disease before 12 years old, suggesting late-onset eczema/AD is common. Two thousand one hundred and thirty-nine （80.4%） patients had the disease for more than 6 months. One thousand one hundred and forty-four （43.0%） patients had a personal and/or family history of atopic diseases. One thousand five hundred and forty-eight （58.2%） patients had an elevated total serum IgE and/or eosinophilia and/or positive allergen-specific IgE. Based on these clinical and laboratory features, we proposed Chinese criteria for adult/adolescent AD. Of all 2662 patients, 60.3% were satisfied with our criteria, while only 48.2% satisfied with Hanifin Rajka criteria and 32.7% satisfied with Williams criteria, suggesting a good sensitivity of our criteria in adult/adolescent AD patients. Conclusion： Late-onset of eczema or AD is co

关键词： Adolescents and Adults Atopic Dermatitis Clinical Features Diagnostic Criteria Eczema

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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan liU Si Hong FAN Yi Pin WU Gui Hui yanG Pu Ye BAI Jiang Feng CHEN Hong CHEN li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU xiao Mei HU yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao zhen JI liang JIN Hai Hao lei xiao li Chun yan li Min Qing li Qun Tang li Xian Yong liU Hong De liU Jin Ping liU zhang MA yu Ting MAO Ya MO liu Fen NA Hui wang Jing wei SONG Fang li SUN Sheng wang Dong Ting wang Ming Xuan wang xiao yan wang Yin zhen wang yu Dong WU wei WU Lan Ping xiao yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia yanG Chun yanG Kai Jun yuAN Sheng li zhang Gong Qi zhang Jin Bo zhang lin Song ZHAO Shu Sen ZHAO Wan Ying zhenG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing zhang Hua Min wang yan Ping wang Yong yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

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Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-li Luo Hao-Tong zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui Guo-Ping li Yao-Quan Chu Jian-Rong Shi Gang wang Jian-Nan zhang Zhong-Rui Bai xiao-yan Chen Feng-Fei wang yan-Xin Guo Jian-Jun Chen bing Du xiao Kong Ya-Juan lei Yin-Bi li Yi-Han Song yue Wu yan-Xia zhang Xin-lin Zhou Fang Zuo Peng Du lin He wen Hou Yi-Qiao Dong Jian li Guang-wei li Shuang li Jing Song yuan Tian Meng-Xin wang Yong-Hui Hou Zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-wen Hu lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua li Qi li Yin-Dun Mao zheng-Hong Tang Qing-Sheng Tao liang-Ping Tu Da-Qing wang dan wang Jian-Ping wang lei wang Shou-Guan wang Shu-Qing wang Ya-Nan wang You wang yue-Fei wang Ming-Zhi wei Xiang-Xiang Xue xiao-zheng Xing ling-Zhe Xu Xin-Qi Xu yan Xu De-Hua yang Shi-Hai yang zheng-Qiu Yao Yong yu Hui yuan Chao Zhai En-Peng zhang Jing zhang li-Ping zhang weizhang Yong zhang zhen-Chao zhang Ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng xiao-wei liu Yi-Peng Jing Gang wang Hao-Tong zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-Rui Bai yue Wu yan Cai Shu-yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-yuan Chen Jian-Jun Chen Kun-Xin Chen li Chen Xue-lei Chen xiao-yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong bing Du Dong-wei Fan lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-wen Hu Zhi-Ying Huo lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin xiao Kong Xu Kong Ya-Juan lei Ai-Hua li Chang-Hua li Guang-wei li Hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-Nan li yan li Yin-Bi li Ye-Ping li yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu wen-Zhi Lu yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su zheng-Hong Tang Qing-Sheng Tao yuan Tian dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang Jian wang Jia-Ning wang Jian-ling wang Jian-Ping wang Jun-Xian wang lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang yue-Fei wang You-Fen wang Peng wei Ming-Zhi wei Hong Wu Ke-Fei Wu Xue-bing Wu yu-Zhong Wu xiao-zheng Xing ling-Zhe Xu Xin-Qi Xu yan Xu Tai-Sheng yan De-Hua yang Hai-Feng yang Hui-Qin yang Ming yang zheng-Qiu Yao Yong yu Hui yuan Hai-Bo yuan Hai-Long yuan wei-Min yuan Chao Zhai En-Peng zhang Hua-wei zhang Jian-Nan zhang li-Pin zhang wei zhang Yong zhang yan-Xia zhang zheng-Chao zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation

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Nuclear Science and Techniques 2023年第1期34卷 51-85页

作者： Nan‑Shun Huang Zi‑Peng liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua li Tao liu zheng Qi Jia‑wei yan wei zhang Sheng‑wang Xiang yang‑yang lei Ya Zhu Yong‑Zhou He Qi‑bing yuan Fei Gao Rong‑bing Deng Sen Sun Zhi‑Di lei Zhi‑Qiang Jiang Meng‑Qi Duan yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑liang li Shang‑yu Si lian Xue Si Chen Yong‑Fang liu Ya‑Jun Tong Hai‑xiao Deng zhen‑Tang Zhao zhangjiang Laboratory Shanghai 201210China School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China European XFEL Schenefeld 22869Germany ShanghaiTech University Shanghai 201210China

The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic *** general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific *** the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly *** this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE.

关键词： X-ray free-electron laser Free electron laser oscillator Fully coherent X-ray

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