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Immunogenicity of a recombinant VSV-Vectored SARS-CoV vaccine induced robust immunity in rhesus monkeys after single-dose immunization

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Virologica Sinica 2022年第2期37卷 248-255页

作者： dan Shan Xiaoyan Tang Renqiang Liu dan pan Xijun Wang Jinying Ge Zhiyuan Wen Zhigao Bu State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin150069China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou UniversityYangzhou225127China

Severe acute respiratory syndrome(SARS)is a highly contagious zoonotic disease caused by SARS coronavirus(SARS-Co V).Since its outbreak in Guangdong Province of China in 2002,SARS has caused 8096 infections and774 deaths by December 31st,2003.Although there have been no more SARS cases reported in human populations since 2004,the recent emergence of a novel coronavirus disease(COVID-19)indicates the potential of the recurrence of SARS and other coronavirus disease among humans.Thus,developing a rapid response SARS vaccine to provide protection for human populations is still needed.Spike(S)protein of SARS-Co V can induce neutralizing antibodies,which is a pivotal immunogenic antigen for vaccine development.Here we constructed a recombinant chimeric vesicular stomatitis virus(VSV)VSVΔG-SARS,in which the glycoprotein(G)gene is replaced with the SARS-Co V S gene.VSVΔG-SARS maintains the bullet-like shape of the native VSV,with the heterogeneous S protein incorporated into its surface instead of G protein.The results of safety trials revealed that VSVΔG-SARS is safe and effective in mice at a dose of 1×10^(6)TCID_(50).More importantly,only a single-dose immunization of 2×10^(7)TCID_(50)can provide high-level neutralizing antibodies and robust T cell responses to non-human primate animal models.Thus,our data indicate that VSVΔG-SARS can be used as a rapid response vaccine candidate.Our study on the recombinant VSV-vectored SARS-Co V vaccines can accumulate experience and provide a foundation for the new coronavirus disease in the future.

关键词： Severe acute respiratory syndrome coronavirus(SARS-CoV) Vesicular stomatitis virus(VSV) Vaccine Immunization

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Targeting the“undruggable”cancer driver genes:Ras,myc,and tp53

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BIOCELL 2023年第7期47卷 1459-1472页

作者： XINGBO WU dan pan SHOUYI TANG YINGQIANG SHEN State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesResearch Unit of Oral Carcinogenesis and ManagementChinese Academy of Medical SciencesWest China Hospital of StomatologySichuan UniversityChengdu610041China

The term“undruggable”is to describe molecules that are not targetable or at least hard to target pharmacologically.Unfortunately,some targets with potent oncogenic activity fall into this category,and currently little is known about how to solve this problem,which largely hampered drug research on human cancers.Ras,as one of the most common oncogenes,was previously considered“undruggable”,but in recent years,a few small molecules like Sotorasib(AMG-510)have emerged and proved their targeted anti-cancer effects.Further,myc,as one of the most studied oncogenes,and tp53,being the most common tumor suppressor genes,are both considered“undruggable”.Many attempts have been made to target these“undruggable”targets,but little progress has been made yet.This article summarizes the current progress of direct and indirect targeting approaches for ras,myc,two oncogenes,and tp53,a tumor suppressor gene.These are potential therapeutic targets but are considered“undruggable”.We conclude with some emerging research approaches like proteolysis targeting chimeras(PROTACs),cancer vaccines,and artificial intelligence(AI)-based drug discovery,which might provide new cues for cancer intervention.Therefore,this review sets out to clarify the current status of targeted anti-cancer drug research,and the insights gained from this review may be of assistance to learn from experience and find new ideas in developing new chemicals that directly target such“undruggable”molecules.

关键词： Ras Myc Tp53 Antineoplastic agents Pharmacology Oncogene proteins Antagonists and inhibitors

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Treatment with sorafenib plus camrelizumab after splenectomy for primary splenic angiosarcoma with liver metastasis:A case report and literature review

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World Journal of Clinical Cases 2022年第9期10卷 2818-2828页

作者： dan pan Tai-Ping Li Jian-Hui Xiong Shu-Bo Wang Yao-Xu Chen Jian-Feng Li Qi Xiao Department of General Surgery The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina The Medical Department 3D Medicines Inc.Shanghai 201114Shanghai ProvinceChina

BACKGROUND Primary splenic angiosarcoma(PSA)is an extremely rare and aggressive mesenchymal malignancy with high metastatic potential and a poor prognosis.There are no established treatment guidelines for PSA,even for adjuvant therapy.This rare case may provide a reliable therapeutic regime for a better prognosis.CASE SUMMARY A 49-year-old female who complained of right-upper quadrant abdominal pain was diagnosed as having PSA with splenic rupture and liver metastasis.After splenectomy and liver tumor resection,she received sorafenib and camrelizumab therapy.After 15 mo of follow-up,she is in good condition,without recurrence or any identified metastasis.CONCLUSION Immunotherapy combined with targeted therapy could be a potential option for the adjuvant therapy of PSA.

关键词： Primary splenic angiosarcoma Immunotherapy Targeted therapy Prognosis Case report

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Emerging roles of circular RNAs in the invasion and metastasis of head and neck cancer:Possible functions and mechanisms

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Cancer Innovation 2023年第6期2卷 463-487页

作者： Shouyi Tang Luyao Cai Zhen Wang dan pan Qing Wang Yingqiang Shen Yu Zhou Qianming Chen State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesChinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and ManagementWest China Hospital of StomatologySichuan UniversityChengduChina State Institute of Drug/Medical Device Clinical Trial West China Hospital of StomatologyChengduChina

Head and neck cancer(HNC)is the seventh most prevalent malignancy worldwide in 2020.Cancer metastasis is the main cause of poor prognosis in HNC patients.Recently,circular RNAs(circRNAs),initially thought to have no biological function,are attracting increasing attention,and their crucial roles in mediating HNC metastasis are being extensively investigated.Existing studies have shown that circRNAs primarily function through miRNA sponges,transcriptional regulation,interacting with RNA-binding proteins(RBPs)and as translation templates.Among these functions,the function of miRNA sponge is the most prominent.In this review,we summarized the reported circRNAs involved in HNC metastasis,aiming to elucidate the regulatory relationship between circRNAs and HNC metastasis.Furthermore,we summarized the latest advances in the epidemiological information of HNC metastasis and the tumor metastasis theories,the biogenesis,characterization and functional mechanisms of circRNAs,and their potential clinical applications.Although the research on circRNAs is still in its infancy,circRNAs are expected to serve as prognostic markers and effective therapeutic targets to inhibit HNC metastasis and significantly improve the prognosis of HNC patients.

关键词： circRNA head and neck cancer invasion metastsais

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多层螺旋CT在宫颈癌FIGO分期及盆腔淋巴结转移诊断中的应用研究

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中国临床医学影像杂志 2024年第5期35卷 347-350,359页

作者：潘丹丹吴磊冯爱平宜昌市妇幼保健院放射科湖北宜昌443000 枝江市人民医院放射科湖北枝江443200

目的:分析多层螺旋CT在宫颈癌FIGO分期及盆腔淋巴结转移诊断中的应用价值。方法:选择2019年12月—2022年12月收治的136例宫颈癌患者作为研究对象,采用64排CT仪进行扫描检查;以手术病理结果作为金标准,绘制受试者工作特征(ROC)曲线对CT... 详细信息

目的:分析多层螺旋CT在宫颈癌FIGO分期及盆腔淋巴结转移诊断中的应用价值。方法:选择2019年12月—2022年12月收治的136例宫颈癌患者作为研究对象,采用64排CT仪进行扫描检查;以手术病理结果作为金标准,绘制受试者工作特征(ROC)曲线对CT扫描评估宫颈癌FIGO分期及盆腔淋巴结转移的诊断价值,依照ROC曲线下面积(AUC)对诊断结果进行评估。结果:利用CT扫描检查诊断评估FIGO分期时Ⅰ~Ⅱ期60例,Ⅲ~Ⅳ期76例,利用CT扫描检查诊断评估盆腔淋巴结转移时未转移69例,转移67例;利用CT扫描方法诊断评估FIGO分期及盆腔淋巴结转移的敏感度、特异度及准确率均高于90%;CT扫描方法诊断评估FIGO分期的AUC为0.951,高于0.9,具有较高的临床诊断价值;CT扫描方法诊断评估盆腔淋巴结转移的AUC为0.933,高于0.9,具有较高的临床诊断价值。结论:多层螺旋CT在宫颈癌诊断和评估FIGO分期及盆腔淋巴结转移时AUC均>0.9,具有较高的应用价值。

关键词：宫颈肿瘤淋巴转移体层摄影术,螺旋计算机

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“双一流”建设背景下中国省域高校办学效率的区域差异及动态演进

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学习与实践 2024年第5期 78-86页

作者：潘丹张曼熊雨萌武汉科技大学管理学院湖北武汉430070 湖北产业政策与管理研究中心

为考察“双一流”建设启动后的中国省域高校办学效率水平、差距及动态演进,研究采用超效率DEA方法对2016-2021年中国省域高校办学效率进行评价,并采用Dagum基尼系数、Kernel密度估计法测算了省域高校办学效率地区差距来源以及分布态势... 详细信息

为考察“双一流”建设启动后的中国省域高校办学效率水平、差距及动态演进,研究采用超效率DEA方法对2016-2021年中国省域高校办学效率进行评价,并采用Dagum基尼系数、Kernel密度估计法测算了省域高校办学效率地区差距来源以及分布态势。研究表明:全国及四大区域平均效率值呈现先降后升的U型变化趋势,最优效率省域数量也呈现先降后升的U型变化趋势。中国省域高校办学效率差距呈现“先下降、后上升、再下降、再上升”的态势,四大区域的区域内差距从大到小依次为东部、西部、中部、东北,区域间差距最大的为东北&东部、东部&西部、东部&中部,区域差异来源主要为超变密度,其次为区域间差距,地区内差距贡献最小。全国范围内高校办学效率空间差距在逐步扩大,东中部、东北地区极化特征明显。

关键词： “双一流”建设高校办学效率高等教育

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农村电子商务发展对林区内部收入差距与共同富裕的影响

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林业科学 2024年第5期60卷 35-50页

作者：潘丹罗璐薏季凯文孔凡斌江西财经大学经济学院南昌330013 江西师范大学政法学院南昌330022 南京林业大学数字林业与绿色发展研究院/经济管理学院南京210037

[目的]在实现全体人民共同富裕的中国式现代化进程中,研究农村电子商务发展对林区内部收入差距与共同富裕的影响及其作用机制,为缩小农村内部收入差距、实现效率和公平有机统一、促进共同富裕提供有益参考。[方法]将“电子商务进农村综... 详细信息

[目的]在实现全体人民共同富裕的中国式现代化进程中,研究农村电子商务发展对林区内部收入差距与共同富裕的影响及其作用机制,为缩小农村内部收入差距、实现效率和公平有机统一、促进共同富裕提供有益参考。[方法]将“电子商务进农村综合示范政策”视为农村电子商务发展的一项“准自然试验”,基于2012-2020年中国家庭追踪调查(CFPS)5期面板数据,采用双重机器学习方法分析农村电子商务发展对宏观层面的林区各村庄内部所有林农家庭收入差距以及微观层面的各村庄内部单个林农家庭之间收入差距的影响及其作用机制,进而回答农村电子商务发展对实现共同富裕的作用。[结果]1)农村电子商务发展能够显著缩小林区各村庄内部所有林农家庭年收入的基尼系数和各村庄内部单个林农家庭之间的收入相对剥夺指数,即缩小林区内部收入差距,经过一系列稳健性检验后该结果仍然稳健。2)农村电子商务发展缩小林区内部收入差距主要通过显著提高低于40分位数和低于均值的低收入林农家庭的收入来实现,从而有利于促进共同富裕。3)促进林农家庭非农就业、提高林农家庭创业和增加林农家庭出售农产品价值是农村电子商务发展缩小林区内部收入差距的主要途径。4)农村电子商务发展对低技能水平、低社会资本和贫困线以下的林农家庭增收效应更大,表明农村电子商务发展具有很好的包容性。[结论]通过大型微观数据库的实证研究,验证农村电子商务作为数字经济的重要表现形式在林区发挥了公平与效率之间的平衡效应。在数字经济发展浪潮下,本研究不仅提供了农村电子商务在缩小林区内部收入差距方面的新经验证据,还为推动共同富裕提供了重要政策启示。

关键词：农村电子商务发展共同富裕收入差距双重机器学习模型

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Primary localized gastric amyloidosis:A scoping review of the literature from clinical presentations to prognosis

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World Journal of Gastroenterology 2021年第12期27卷 1132-1148页

作者： Xin-Yu Lin dan pan Li-Xuan Sang Bing Chang Department of Neurology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Geriatrics The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Gastroenterology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

Localized gastric amyloidosis(LGA)is a rare disease characterized by abnormal extracellular deposition of amyloid protein restricted to the stomach and it is confirmed by positive results of Congo red staining.Over decades,only a few cases have been reported and studies or research focusing on it are few.Although LGA has a low incidence,patients may suffer a lot from it and require proper diagnosis and management.However,the pathology of LGA remains unknown and no overall review of LGA from its presentations to its prognosis has been published.Patients with LGA are often asymptomatic or manifest atypical symptoms,making it difficult to differentiate from other gastrointestinal diseases.Here,we report the case of a 70-year-old woman with LGA and provide an overview of case reports of LGA available to us.Based on that,we conclude current concepts of clinical manifestations,diagnosis,treatment,and prognosis of LGA,aiming at providing a detailed diagnostic procedure for clinicians and promoting the guidelines of LGA.In addition,a few advanced technologies applied in amyloidosis are also discussed in this review,aiming at providing clinicians with a reference of diagnostic process.With this review,we hope to raise awareness of LGA among the public and clinicians.

关键词： Gastroscopy Changes of gastric mucosa Primary localized gastric amyloidosis Clinical presentations Prognosis

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个性化动态集成的阿尔茨海默症辅助诊断模型

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计算机工程与应用 2024年第5期60卷 139-145页

作者：梁浩霖潘丹曾安杨宝瑶 Xiaowei Song 广东工业大学计算机学院广州510006 广东技术师范大学电子与信息学院广州510540 素里纪念医院临床研究中心不列颠哥伦比亚省V3V 1Z2

针对阿尔茨海默症(AD)分类模型大多没有针对输入样本制定特定的策略,导致容易忽略样本间的个性化差异信息的问题,提出个性化动态集成AD分类模型。该模型考虑到输入样本间脑区退化程度的差异性,利用注意力机制评估特定于输入样本的各脑... 详细信息

针对阿尔茨海默症(AD)分类模型大多没有针对输入样本制定特定的策略,导致容易忽略样本间的个性化差异信息的问题,提出个性化动态集成AD分类模型。该模型考虑到输入样本间脑区退化程度的差异性,利用注意力机制评估特定于输入样本的各脑区退化程度,并根据脑区退化程度对脑区特征进行挑选和融合;同时通过重新设计损失函数,解决未被选中脑区无法获得优化梯度的问题,从而提高AD分类性能。实验结果表明,该模型在AD vs.HC(正常组)、MCIc(会向AD转化的轻度认知障碍)vs.HC以及MCIc vs.MCInc(不会向AD转化的轻度认知障碍)中的分类准确率表现分别提升4%、11%以及8%。同时,模型定位到的退化脑区功能与AD临床表现具有高度一致性。

关键词：阿尔茨海默症(AD) 动态集成策略集成学习卷积神经网络

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Probiotic mixture VSL#3:An overview of basic and clinical studies in chronic diseases

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World Journal of Clinical Cases 2020年第8期8卷 1361-1384页

作者： Fang-Shu Cheng dan pan Bing Chang Min Jiang Li-Xuan Sang Department of Dermatology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Class 85 of 101k China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Geriatrics the First Affiliated HospitalChina Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Gastroenterology the First Affiliated HospitalChina Medical UniversityShenyang 110001Liaoning ProvinceChina

Probiotics are known as“live microorganisms”and have been proven to have a health effect on hosts at the proper dose.Recently,a kind of probiotic mixture including eight live bacterial strains,VSL#3,has attracted considerable attention for its combined effect.VSL#3 is the only probiotic considered as a kind of medical food;it mainly participates in the regulation of the intestinal barrier function,including improving tight junction protein function,balancing intestinal microbial composition,regulating immune-related cytokine expression and so on.The objective of this review is to discuss the treatment action and mechanism for the administration of VSL#3 in chronic diseases of animals and humans(including children).We found that VSL#3 has a therapeutic or preventive effect in various systemic diseases per a large number of studies,including digestive systemic diseases(gastrointestinal diseases and hepatic diseases),obesity and diabetes,allergic diseases,nervous systemic diseases,atherosclerosis,bone diseases,and female reproductive systemic diseases.

关键词： VSL#3 Intestinal barrier function Chronic diseases Intestinal microbial balance Cytokines Therapeutic use

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