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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： dan ma Nona Pop Aston Medical School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseases such as Alzheimer's disease, and mental disorders such as schizophrenia(Barateiro et al., 2016). Repair of damaged myelin sheaths(remyelination) often fails in MS, leading to neuronal loss and irreversible functional deficits.

关键词： myelin protective diseases

Role of toll-like receptor 4/mutant myeloid differentiation primary response 88/nuclear factor kappa-B mediated inflammation in diabetes mellitus with Northwest dryness syndrome

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Journal of Traditional Chinese Medicine 2024年第5期44卷 963-973页

作者： DENG Deqiang XIAO Yan ma dan QIU Jinling HAO Congli WANG Di ZHANG Miao State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaXinjiang Medical University Department of Endocrinology Traditional Chinese Medicine Hospital of Urumqi

OBJECTIVE: To investigate the role of toll-like receptor 4(TLR4)/mutant myeloid differentiation primary response 88(MyD88)/nuclear factor kappa-B(NF-κB) signaling pathway-mediated inflammation in diabetes mellitus with Northwest dryness ***: Rats were randomly divided into the normal control, type 2 diabetes(T2DM) model, Northwest dryness syndrome + T2DM(Northwest dryness), and simple internal dampness + T2DM(internal dampness)groups. Enzyme-linked immunosorbent assay was used to detect biochemical indexes and inflammatory *** histopathological observation was *** real-time polymerase chain reaction and Western blot analysis were used to detect the mRNA and protein expression levels, ***: Compared with the T2DM group, the glycosylated hemoglobin A1c, insulin, glucose tolerance,the homeostasis model assessment of insulin resistance,tumor necrosis factor-α, interleukin 1β, interleukin 16,malondialdehyde, blood lipid, alanine aminotransferase,and aspartate aminotransferase were significantly elevated in the internal dampness group. Their levels were significantly elevated in the Northwest dryness group than in the T2DM and internal dampness *** superoxide dismutase, glutathione peroxidase, liver glycogen, and organ-to-weight ratio were significantly declined in the internal dampness group and the Northwest dryness group than in the T2DM ***, these levels were elevated in the Northwest dryness group than in the internal dampness ***, the mRNA expression levels of interferon regulatory factor 5 and NF-κB p65, and the protein expression levels of TLR4, MyD88, and NF-κB were significantly higher in the internal dampness and the Northwest dryness groups than the T2DM ***, the mRNA and protein levels were significantly higher in the Northwest dryness group than in the internal dampness ***: Northwest dryness syndrome-mediated TLR4/MyD88/NF-κB pathway and chronic i

关键词： NF-kappa B Northwest dryness syndrome diabetes mellitus inflammation myeloid differentiation factor 88 toll-like receptor 4

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Anti-asynchrony output regulation for switched systems under switching-Q-learning event-triggering against DoS attacks

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Science China(Information Sciences) 2024年

作者： Lili LI Yalin CHEN dan ma Qingjun GUO College of marine Electrical Engineering Dalian Maritime University State Key Laboratory of Synthetical Automation for Process Industries Northeastern University College of Information Science and Engineering Northeastern University

This paper proposes a secure output regulation (SOR) scheme for network switched systems(NSSs) experiencing severely unstable dynamics (SUDs). This scheme aims to address the complex consecutive asynchrony caused by long-duration denial-of-service (LDDoS) attacks. When the denial-of-service(DoS) attack lasts longer than the dwell time of each subsystem, switching to a new subsystem is necessary to manage the unstable dynamic behavior caused by SUDs. The controller cannot immediately obtain information about the new modality. However, owing to the delayed access to new modality information by the controller, consecutive asynchrony occurs. To tackle this, we propose a resilient switching rule that mitigates the impact of consecutive asynchrony by choosing the optimal subsystem once the minimum dwell time is met. Multi-stage event-triggering mechanisms (METMs) are proposed to coordinate with switching signals by incorporating modality matching conditions and a switching-Q-learning algorithm. These mechanisms reduce asynchronous durations by aligning modality matching conditions and terminating attacks using attack parameters. This control scheme for SOR of NSSs with SUDs disturbed by LDDoS attacks provides a detailed analysis of dynamic switching behavior, leveraging the resilient switching rule and METMs. Finally,the feasibility of the proposed methodology is substantiated through simulations with an F-18 aircraft model.

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Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin Chen Shui-dan Xu Min-Hua Deng Shi-Hui Hao Jie-Wei Chen Xiao-dan ma Wei-Tao Zhuang Jing-Hua Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao dan Xie Feng-Wei Wang Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in ***,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inhibits autophagy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the ***,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC ***,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

Perioperative outcomes of transvaginal specimen extraction laparoscopic total gastrectomy and conventional laparoscopicassisted total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1527-1536页

作者： Zhi-Cao Zhang Wen-Sheng Wang Jiang-Hong Chen Yuan-Hang ma Qi-Fa Luo Yun-Bo Li Yang Yang dan ma Department of General Surgery Xinqiao Hospital of Army Medical UniversityChongqing 400037China

BACKGROUND Natural orifice specimen extraction surgery(NOSES)has emerged as a promising alternative compared to conventional laparoscopic-assisted total gastrectomy(LATG)for treating gastric cancer(GC).However,evidence regarding the efficacy and safety of NOSES for GC surgery is *** study aimed to compare the safety and feasibility,in addition to postoperative complications of NOSES and *** Dual circular staplers were used in Roux-en-Y digestive tract reconstruction for transvaginal specimen extraction LATG,and its outcomes were compared with LATG in a cohort of 51 GC patients with tumor size≤5 *** study was conducted from may 2018 to September 2020,and patients were categorized into the NOSES group(n=22)and LATG group(n=29).Perioperative parameters were compared and analyzed,including patient and tumor characteristics,postoperative outcomes,and anastomosis-related complications,postoperative hospital stay,the length of abdominal incision,difference in tumor type,postoperative complications,and postoperative *** Postoperative exhaust time,operation duration,mean postoperative hospital stay,length of abdominal incision,number of specific staplers used,and Brief Illness Perception Questionnaire score were significant in both groups(Pmally invasive incision that met aesthetic *** were no significant differences in gender,age,tumor type,postoperative complications,and postoperative survival between the two *** The application of dual circular staplers in Roux-en-Y digestive tract reconstruction combined with NOSES gastrectomy is safe and *** approach offers better short-term outcomes compared to LATG,while long-term survival

关键词： Gastric cancer Circular stapler Natural orifice specimen extraction surgery Laparoscopic-assisted total gastrectomy

A meta-analysis on the clinical efficacy of fire dragon cupping in the treatment of lumbar disc herniation

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Integrative Medicine Discovery 2024年第11期8卷 1-7页

作者： Hai-Xia ma dan ma Bin Lin Juan-Xia Zheng Department of Rehabilitation Shenzhen Bao’an Traditional Chinese Medicine HospitalGuangzhou University of Chinese MedicineShenzhen 518000China Department of Rheumatology and Immunology Shenzhen University Affiliated South China HospitalShenzhen 518000China Department of Nutrition Shenzhen Hospital of Southern Medical UniversityShenzhen 518000China.

Background:The incidence of lumbar disc herniation(LDH)is notably *** among experts highlights non-surgical treatments as the primary therapeutic approach for *** medicine frequently employs pharmacotherapy and epidural injections in such treatments,which are associated with numerous adverse *** use can severely impair the liver and kidney functions of ***,the role of safe and effective traditional Chinese medicine techniques becomes *** various traditional Chinese medicine approaches for treating LDH,fire dragon cupping,renowned for its remarkable efficacy,cost-effectiveness,and ease of application,is extensively utilised in clinical settings for managing ***,there is a scarcity of systematic and standardised evidence from evidence-based medicine ***,conducting a meta-analysis is ***:A comprehensive computerised search was conducted in databases including China National Knowledge Infrastructure,WanFang Data,VIP,China Biology Medicine disc,PubMed,EMbase,The Cochrane Library,Web of Science,and *** search aimed to gather randomised controlled trials on fire dragon cupping therapy for LDH,spanning from the inception of these databases until December *** researchers independently screened the literature according to inclusion and exclusion criteria,extracted data,and assessed the methodological quality of the studies included,utilising Revman 5.3 software for ***:The results show that the fire dragon cupping therapy group had better clinical effectiveness(relative risk=1.23,95%confidence interval(CI)(1.14,1.33),P<0.00001),less pain(standardized mean difference=–1.33,95%CI(–1.49,–1.16),P<0.00001),and some improvement in lumbar function(Japanese Orthopaedic Association scores:mean difference=3.37,95%CI(2.31,4.43),P<***:The fire dragon cupping therapy significantly alleviates LDH,warranting its extensive ***,consid

关键词： fire dragon cupping therapy lumbar disc herniation lumbar spine meta-analysis randomized controlled trial

互助、组织化与承认:劳动实践中志愿服务的多维动力机制研究以自雇卡车司机为例

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社会 2024年第3期44卷 27-56页

作者：马丹北京市社会科学院社会学所

本文以我国自雇卡车司机的志愿服务为例,结合其劳动实践探讨志愿服务的多维动力机制。研究发现,卡车司机志愿服务的动力机制是一个由微观劳动体制、中观组织化过程与宏观社会地位感知推动的多维框架,展现出从职业群体内部的互助救援扩... 详细信息

本文以我国自雇卡车司机的志愿服务为例,结合其劳动实践探讨志愿服务的多维动力机制。研究发现,卡车司机志愿服务的动力机制是一个由微观劳动体制、中观组织化过程与宏观社会地位感知推动的多维框架,展现出从职业群体内部的互助救援扩展至外部社会公益的动态社会过程。其中,原子化劳动的“孤岛效应”与互帮互助是该机制的客观基础,公益组织内外的组织化过程与互动为之提供了制度保障和文化支撑,底层地位感知以及由其引发的承认需求则构成了持续的价值驱动。本文认为,只有从多维、动态的过程性视角出发,并使用纵贯性的研究方法,才能理解志愿服务的发端与持续。

关键词：卡车司机志愿服务多维动力机制原子化劳动承认

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铸牢中华民族共同体意识的国家仪式机制探析

北方民族大学学报（哲学社会科学版） 2024年第3期 88-97页

作者：马丹丹南开大学马克思主义学院天津300350

国家仪式是中华民族共同体意识的外化景观和铸牢载体。它以国家为单元,是内蕴文化、历史、理论的共同体凝聚机制。具体而言,国家仪式通过可观、可感、可触的仪式空间、仪式符号、仪式主题,激活集体记忆、搭建象征体系、传输民族精神,呈... 详细信息

国家仪式是中华民族共同体意识的外化景观和铸牢载体。它以国家为单元,是内蕴文化、历史、理论的共同体凝聚机制。具体而言,国家仪式通过可观、可感、可触的仪式空间、仪式符号、仪式主题,激活集体记忆、搭建象征体系、传输民族精神,呈现出铸牢中华民族共同体意识的仪式图景。以国庆仪式为实证案例,全国各族人民在“知情意行”的逻辑中,确认民族身份、聚合爱国情感、凝聚价值共识、践行复兴伟业。新征程的国家仪式供给,需撷取历史时空资源、丰富中华符号操演、询唤现实行动自觉,以提升仪式内容的认同合力、话语的传播张力和样态的作用效力,实现有形、有感、有效地铸牢中华民族共同体意识。

关键词：铸牢中华民族共同体意识国家仪式中华民族共同体礼仪文化民族记忆

特大城市新质生产力群体的主观幸福感与社区治理

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深圳大学学报（人文社会科学版） 2024年第4期41卷 17-27页

作者：马丹袁浩中共上海市委党校社会学教研部上海200233 上海大学社会学院上海200444

新质生产力群体是推动生产力向更高级、更先进质态演进的力量。基于2019年中国10个特大城市的入户调查数据,运用分层线性回归模型和倾向值匹配模型,探讨社区治理状况、个体社会交往对新质生产力群体主观幸福感的影响,研究发现:新质生产... 详细信息

新质生产力群体是推动生产力向更高级、更先进质态演进的力量。基于2019年中国10个特大城市的入户调查数据,运用分层线性回归模型和倾向值匹配模型,探讨社区治理状况、个体社会交往对新质生产力群体主观幸福感的影响,研究发现:新质生产力群体趋于迈向后物质主义幸福观,其主观幸福感显著高于非新质生产力群体,并更多地受到个体人际交往状况的积极影响。在社区治理方面,社区层面的社会信任对新质生产力群体的主观幸福感不但具有直接的提升作用,还会强化个体的边缘社交对该群体主观幸福感的消极影响程度;社区层面的社会参与对该群体的主观幸福感没有直接的影响,但却会强化个体的边缘社交和精英社交对主观幸福感的影响程度。对非新质生产力群体而言,社区层面的社会参与对该群体的主观幸福感甚至会产生直接的负面影响。在城市培育和吸引新质生产力群体的过程中,需通过构建互信、包容的社区软环境来推动不同社会群体之间的交流,营造良好的创新氛围。

关键词：新质生产力群体主观幸福感特大城市社区治理社会交往

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区域数字贸易规则与全球数字价值链

统计研究 2024年第6期41卷 30-43页

作者：马丹杨钰涵西南财经大学统计学院中国社会经济统计研究中心

数字贸易规则体系是国际贸易规则领域的核心议题,也是新一轮国际竞争的焦点。区域数字贸易规则在推动全球价值链向数字化转型的过程中,可能会对全球价值链倡导的多边贸易体系产生影响。本文基于区域数字贸易规则条款特征构建数字贸易规... 详细信息

数字贸易规则体系是国际贸易规则领域的核心议题,也是新一轮国际竞争的焦点。区域数字贸易规则在推动全球价值链向数字化转型的过程中,可能会对全球价值链倡导的多边贸易体系产生影响。本文基于区域数字贸易规则条款特征构建数字贸易规则指标,研究其对全球数字价值链的影响。研究发现,区域数字贸易规则通过降低贸易成本、减少贸易壁垒和完善数字贸易网络机制显著提高了各经济体参与全球数字价值链的增加值。进一步分析发现,区域数字贸易规则具有显著的区域主义特征,呈现邻近偏好,更有利于发达国家和新兴经济体参与全球数字价值链。本研究对我国加快推动构建兼顾效率与公平的新型数字贸易规则体系,提升我国在全球数字价值链的竞争力具有重要的参考作用。

关键词：区域数字贸易规则全球数字价值链贸易网络