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The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang yuan Liang Yixue gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Exploration of Gas-Dependent Self-Adaptive Reconstruction Behavior of Cu₂O for Electrochemical CO₂ Conversion to Multi-Carbon Products

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NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： Zhang, Chaoran gu, Yichuan Jiang, Qu Sheng, Ziyang Feng, Ruohan Wang, Sihong Zhang, Haoyue Xu, Qianqing yuan, Zijian Song, Fang Shanghai Jiao Tong Univ Sch Mat Sci & Engn State Key Lab Met Matrix Composites Shanghai 200240 Peoples R China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO2 reduction reaction (CO2RR), whereas the behavior is by far superficially understood. Here, we report that CO2 accessibility results in a universal self-adaptive structural reconstruction from Cu2O to Cu@CuxO composites, ending with feeding gas-dependent microstructures and catalytic performances. The CO2-rich atmosphere favors reconstruction for CO2RR, whereas the CO2-deficient one prefers that for hydrogen evolution reaction. With the assistance of spectroscopic analysis and theoretical calculations, we uncover a CO2-induced passivation behavior by identifying a reduction-resistant but catalytic active Cu(I)-rich amorphous layer stabilized by *CO intermediates. Additionally, we find extra CO production is indispensable for the robust production of C2H4. An inverse correlation between durability and FECO/FEC2H4 is disclosed, suggesting that the self-stabilization process involving the absorption of *CO intermediates on Cu(I) sites is essential for durable electrolysis. guided by this insight, we design hollow Cu2O nanospheres for durable and selective CO2RR electrolysis in producing C2H4. Our work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO2 reduction reaction Electrocatalysts Cu2O Reconstruction Self-adaptive electrocatalysis

Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities

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Science China Chemistry 2024年第3期67卷 953-962页

作者： yuan-Qing gu Hong-Xin Long dan-dan Zhang Mei-Feng Ruan guo-Kai liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

Metabonomics delineates allergic reactions induced by Shuang-huang-lian injection in rats using ultra performance liquid chromatography-mass spectrometry

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Chinese Journal of Natural Medicines 2018年第8期16卷 628-640页

作者： gu yuan-yuan SHI Lang ZHANG dan-dan HUANG Xin CHEN Da-Zhong Research Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine First Clinical Medical College Heilongjiang University of Chinese Medicine

Shuang-huang-lian Injection(SHLI) is the first successfully developed drug from traditional Chinese medicine(TCM) powder for injection,since its use for the treatment of acute respiratory tract infection,pneumonia,influenza,*** the same time,its allergic reactions have also emerged,which limits clinical ***,few scholars pay attention to the mechanism of allergic *** this present study,metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction;we and analyzed the metabolites,metabolic pathway,and the mechanism which were closely related to the allergic *** levels of serum histamine and tryptase were examined and changes in histomorphology were also *** on the UPLC-Q-TOF/MS metabonomics,we carried out the pattern recognition analysis,selected potential biomarkers associated with allergic reactions,and explored the pathological mechanism for SHLI induced allergic reaction,which laid the foundation for the safety research of *** results showed that SHLI increased the levels of serum histamine and tryptase in rats with allergic reaction;we determined 15 biomarkers in rat allergic reaction model induced by SHLI and found multiple metabolic pathways involved,such as metabolism of linolenic acid,phenylalanine,amino acid,2-oxo acid,and purine and other metabolic pathways.

关键词： Shuang-huang-lian injection Biomarker Metabonomics Allergic mechanism Metabolites

Surface effect induced phase transformation by Mn removal during annealing and its textures in cold-rolled high manganese transformation-induced plasticity steel

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Journal of Iron and Steel Research International 2022年第3期29卷 494-502页

作者： Li-ying liu Ping Yang dan-dan Ma Xin-fu gu School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China

The surface effect induced transformation texture during vacuum annealing of cold-rolled high manganese transformation-induced plasticity(TRIP)steels was *** to Mn removal occurring at the surface layer,γ→δdiffusional phase transformation leads to the formation of hard pancake-shaped ferrite grains due to solution strengthening at the surface and the centre layer remains as austenite+martensite after *** the case of slow heating,{112}/{111}textures for the surface ferrite were strengthened with the increase in temperature and holding time,indicating an inheritance of rolling *** increasing the heating rate of annealing,the rotated cube texture was developed in surface *** kind of multiphase sandwich structure with hard ferrite surface layer and tough austenite dominant centre can increase tensile strength and should also improve deep drawing properties,therefore providing new possibility of controlling properties for the application of high manganese TRIP steel.

关键词： High manganese transformation-induced plasticity steel Surface effect Texture Microstructure Vacuum annealing

Sensitivity of Sample for Simulation-Based Reliability Analysis Methods

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Computer Modeling in Engineering & Sciences 2021年第1期126卷 331-357页

作者： Xiukai yuan Jian gu Shaolong liu School of Aerospace and Engineering Xiamen UniversityXiamen361005China Institute for Risk and Reliability Leibniz Universitat HannoverHannoverGermany

In structural reliability analysis,simulation methods are widely *** statistical characteristics of failure probability estimate of these methods have been well *** this study,the sensitivities of the failure probability estimate and its statistical characteristics with regard to sample,called‘contribution indexes’,are proposed to measure the contribution of *** contribution indexes in four widely simulation methods,i.e.,Monte Carlo simulation(MCS),importance sampling(IS),line sampling(LS)and subset simulation(SS)are derived and *** proposed contribution indexes of sample can provide valuable information understanding the methods deeply,and enlighten potential improvement of *** is found that the main differences between these investigated methods lie in the contribution indexes of the safety samples,which are the main factors to the efficiency of the ***,numerical examples are used to validate these findings.

关键词： Reliability analysis Monte Carlo simulation importance sampling line sampling subset simulation

Recognition of hairpin DNA from coil DNA by electrospray mass spectrometry with annealing strategy

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Chinese Chemical Letters 2012年第4期23卷 500-503页

作者： Bo Zheng Yi Quan liu gu yuan Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationDepartment of Chemical BiologyCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100086China Shanghai Research Institute of Chemical Industry Shanghai 200062China

This research presented an annealing strategy to identify hairpin DNA from coil DNA with the same base composition but different arrangements using electrospray mass spectrometry（ESI-MS）.A series of single-stranded DNA were annealed with their complementary sequences,*** the five pairs of hairpin DNA and coil DNA were unambiguously distinguished by ESIMS with annealing *** research offers a potential method to probe the DNA structure by comparing with mass spectral characteristics.

关键词： Hairpin DNA Annealing Mass spectrometry

Multi-ASV Collision Avoidance for Point-to-Point Transitions Based on Heading-Constrained Control Barrier Functions With Experiment

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IEEE/CAA Journal of Automatica Sinica 2023年第6期10卷 1494-1497页

作者： Yanping Xu Lu liu Nan gu dan Wang Zhouhua Peng the School of Marine Electrical Engineering Dalian Maritime UniversityDalian 116026China

Dear Editor, Collision avoidance is critical for safe operations of multiple autonomous surface vehicles(ASVs). It is a challenging task to design collision-free control laws to ensure safety, especially in a crowded sea environment. This letter presents a collision-free pointto-point transition strategy for multiple ASVs subject to static obstacles, dynamic obstacles and neighboring ASVs based on control barrier functions(CBFs).

关键词： collision Transition obstacles

Morphology-structure diversity of ZnS nanostructures and their optical properties

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Rare Metals 2014年第1期33卷 1-15页

作者： yuan-Peng Zhang Wei liu Bao-dan liu Rong-Ming Wang Department of Physics Beijing University of Aeronautics and Astronautics Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences

ZnS nanostructures with different dimensions and structure-related properties were reviewed in this paper. The crystallization of nanostructures from 0D, 1D to 3D, as well as the heterogonous counterparts, was sum- marized in the aspect of zinc blende, wurtzite structure, and their combinations. Furthermore, the structure-related energy bands and the corresponding photoelectric properties of ZnS nanostructures were also focused, in which we made a brief summary of the co-relations between photoluminescence and crystallography, especially the defectrelated luminescence properties of ZnS nanocrystal.

关键词： ZnS Multi-dimensional nanostructure Photoluminescence Energy band structure