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Effect of nursing on postoperative respiratory function and mental health of lung cancer patients

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World Journal of Clinical Cases 2024年第5期12卷 922-930页

作者： xiang Yang dan Yin Shi-Qing Chen department of Rehabilitation The First People's Hospital of Jiangxia DistrictWuhan(Union Jiangnan Hospital Huazhong University of Science and Technology)Wuhan 430200Hubei ProvinceChina department of Intensive Care The First People's Hospital of Jiangxia DistrictWuhan(Union Jiangnan Hospital Huazhong University of Science and Technology)Wuhan 430200Hubei ProvinceChina department of Neurology The First People's Hospital of Jiangxia DistrictWuhan(Union Jiangnan Hospital Huazhong University of Science and Technology)Wuhan 430200Hubei ProvinceChina

BACKGROUND Both pulmonary rehabilitation training and psychological care have been shown to have a positive effect on the postoperative recovery of patients with lung ***,few studies have combined the two to explore their combined ***,this study aimed to investigate the effects of pulmonary rehabil-itation training combined with psychological care on postoperative respiratory function and mental health in lung cancer *** To investigate effect of nursing on postoperative respiratory function and mental health of lung cancer *** 122 cases of lung cancer patients who underwent surgical treatment in our hospital and were treated in our department from January 2022 to April 2023 were selected and randomly divided into the control group and observation *** control group performed the routine care *** obser-vation group was given pulmonary rehabilitation training and psychological care based on conventional nursing *** expiratory volume,forced vital *** ventilatory volume(MVV)in one second was measured,and the patient's 6-min walking distance and dyspnoea index scale were used to assess the patient's respiratory *** Connor-Davidson resilience scale(CD-RISC),self-rating anxiety scale(SAS),and self-rating depression scale(SDS)were used to evaluate the mental health of the *** There was no difference between the two groups regarding age,gender,education level,surgical procedure,type of pathology,and treatment(P>0.05).After treatment,MVV,6-min walking distance,toughness,strength,optimism,and total CD-RISC scores were significantly higher in the observation group(Pcancer resection could improve lung function,enhance daily activities,e

关键词： Pulmonary rehabilitation training Psychological care Lung cancer Postoperative care Respiratory function

Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： LIU Xiao-rong LI Shuo-fu MEI Wen-ya LIU xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(Pduced the phosphorylation of SRC,ERK,and CREB(Pduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

Lymphangiogenic and angiogenic microvessel density in human primary sporadic colorectal carcinoma

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World Journal of Gastroenterology 2008年第1期14卷 101-107页

作者： Ge Yan, Xiao-Yan Zhou, San-Jun Cai, Gui-Hong Zhang, Jun-Jie Peng, xiang du, department of pathology, cancer hospital of fudan university department of Oncology, Shanghai Medical College, fudan university Colorectal cancer Center, fudan university, 270 Dong’an Road, Shanghai 200032, China department of pathology Cancer Hospital of Fudan University Shanghai 200032 China.

AIM： To investigate the distribution pattern of lymphatic vessels and microvessels in sporadic colorectal carcinoma （SCRC） and their relationship to metastasis and prognosis. METHODS： The lymphatic vessel density （LVD） and microvessel density （MVD） in tumor tissue obtained from 132 patients with primary SCRC, including 74 with metastases and 58 without metastases, were evaluated by immunohistochemistry using antibodies directed against D2-40 and yon Willebrand factor （vWF）. RESULTS：（1） The lymphatic vessels and microvessels at central portions of SCRC often had a reticular architecture with numerous tiny and ill-defined lumina, while those at tumor borders had large and open lumina. The LVD and MVD were both obviously higher in colorectal cancer patients with metastases than in those without （P 〈 0.001）. （2） For each one lymphatic vessel increased, there was a 1.45-fold increase in the risk of metastasis in SCRC. The specificity and sensitivity of LVD in predicting metastasis or non-metastasis in SCRC were 71.62% and 56.90%, respectively, and the corresponding LVD was 5. For each one microvessel increased, there was a 1.11-fold increase in the risk of metastasis in SCRC. The specificity and sensitivity of MVD were 66.22% and 51.72%, respectively. （3） Double labeling immunohistochemistry showed D2-40 immunoreactivity to be specific for lymphatic vessels. （4） Univariate analysis indicated that high LVD, high MVD, as well as co-accounting of high LVD and high MVD were associated with patient＇s poor disease-free survival （Puni 〈 0.05）; multivariate analysis indicated that co-accounting of LVD and MVD was an independent prognostic factor of colorectal cancer, CONCLUSION： D2-40 is a new specific antibody for lymphatic endothelial cells. Lymphogenesis and angiogenesis are commonly seen in SCRC, especially at tumor borders. The detection of LVD and MVD at tumor borders may be useful in predicting metastasis and prognosis in patients with SCRC, and, in particular, coaccount

关键词： Lymphangiogenesis Angiogenesis Lymphaticvessel density Microvessel density Sporadic colorectalcarcinoma Metastasis

Ezrin expression and its translocation in human primary sporadic colorectal carcinoma and prognostic significance

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The Chinese-German Journal of Clinical Oncology 2007年第3期6卷 232-236页

作者： Ge Yan, Xiaoyan Zhou, Xiuying Xiao, Hongfen Lu, xiang du department of pathology, cancer hospital, fudan university department of Oncology, Shanghai Medical College, fudan university Colorectal cancer Center, fudan university, Shanghai 200032, China department of pathology Cancer Hospital Fudan University Shanghai China department of Oncology Shanghai Medical College Fudan University Shanghai China Colorectal cancer Center Fudan University Shanghai China

Objective: The membrane-linking protein Ezrin is highly expressed in several types of human cancers. The cor- relations between its immunoreactivity and histopathological data as well as patient outcome have previously been shown. However, the role played by Ezrin in the carcinogenesis, progression and metastasis of primary sporadic colorectal carcinoma (SCRC) is still under investigation. This study assessed Ezrin protein expression in a series of clinical specimens. Methods: Immunohistochemical analysis was used to characterize patterns of Ezrin expression in 132 cases of SCRC, including 74 metastatic cases and 58 non-metastatic cases and 43 adjacent normal colorectal mucosa. Results: (1) The expression rate of Ezrin in SCRC (79.5%) was significantly higher than in adjacent normal colorectal mucosa (11.6%) (P < 0.001); (2) The total expression rate of Ezrin was 86.5% and 70.7% in metastatic group and non-metastatic group, respectively (P = 0.026); the membrane expression rate of Ezrin was 31.1% and 6.9% in the two groups, respectively (P < 0.01); (3) There was no relation- ship between the expression of Ezrin with age, gender, tumor size, location, degree of differentiation and invasive depth; (4) In the cases with followed-up data, univariate analysis demonstrated that Ezrin expression and its membrane translocation was correlated with worse patient’s disease-free survival (DFS) (Puni < 0.05). Conclusion: Ezrin was expressed in the majority of SCRC and associated with adverse prognostic factors. The increase expression and the switch of Ezrin localization from the cytoplasm to the membrane were closely correlated with metastasis in SCRC. It might be served as an important parameter for determining tumor biological behavior.

关键词： sporadic colorectal carcinoma (SCRC) Ezrin immunohistochemistry metastasis

Germline mutation analysis of hPMS2 gene in Chinese families with hereditary nonpolyposis colorectal cancer

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World Journal of Gastroenterology 2010年第30期16卷 3847-3852页

作者： Xia Sheng, Xiao-Yan Zhou, xiang du, Tai-Ming Zhang, WeiQi Sheng, Da-Ren Shi, department of pathology, Shanghai cancer Center, fudan university, Shanghai 200032, China department of Oncology, Shanghai Medical College, fudan university, Shanghai 200032, China Heng-Hua Zhou, department of pathology, Shanghai Ninth People’s hospital Affi liated to Shanghai Jiao Tong university School of Medicine, Shanghai 200011, China San-Jun Cai, department of Abdominal Surgery, cancer Center, fudan university, Shanghai 200032, China department of pathology Shanghai Cancer Center Fudan University Shanghai 200032 China.

AIM: To study the germline mutation of hPMS2 gene in 26 unrelated Chinese hereditary nonpolyposis colorectal cancer (HNPCC) probands and to fulfill the screening strategy for HNPCC in Chinese. METHODS: Genomic DNA was extracted from the peripheral blood. To avoid the interference of pseudogene in detection of the remaining 11 exons (exon 1-5, 9, 11-15), long-range polymerase chain reaction (PCR) was conducted to amplify the complete coding region of hPMS2 gene firstly. Then 1/8 of the PCR productswere used as template to amplify the individual exon respectively and DNA sequencing was done. Direct DNA sequencing of the conventional PCR products of exon 6, 7, 8 and 10 of hPMS2 gene was performed. The same analysis was made in 130 healthy persons without family histories of HNPCC to further investigate the pathological effects of the detected missense mutation. RESULTS: One HNPCC proband fulf illed Bethesda guidelines and was found to carry the germline mutation of hPMS2 gene, which has not been reported in Chinese HNPCC families. It was a missense mutation at c.1532C>T of exon 11. It was detected in three controls as well with an occurrence rate of 2.3% (3/130). Since it could not be found in the PMS2-single nucleotide polymorphism (SNP) database, this missense mutation is a new SNP unreported up to date. Meanwhile, 260 reported SNPs of hPMS2 gene were detected in the 26 HNPCC probands. The 2nd and 5th exons were probably the hot SNP regions of hPMS2 gene in Chinese HNPCC families involving 53.1% of all reported SNP. CONCLUSION: The germline mutation of hPMS2 gene may be rare in Chinese HNPCC families. The 2nd and 5th exons are hot SNP regions of hPMS2 gene.

关键词： Hereditary nonpolyposis colorectal cancer hPMS2 Missense mutation Single nucleotide polymorphism Colorectal cancer

Knockdown of SIRT2 Rescues YARS-induced Charcot-Marie-Tooth Neuropathy in Drosophila

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Neuroscience Bulletin 2024年第4期40卷 539-543页

作者： Xuedong Li Mengrong Wang xiang Gao Chenyu Li Chunyu Chen Yun Qi Ying Wan Wei Yu State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai200438China School of Basic Medic Science Southwest Medical UniversityLuzhou64600China department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Dear Editor,Charcot-Marie-Tooth disease,the most common inherited peripheral neuropathology,is highly heterogeneous among patients and associated with mutations in~100 different genes at an incidence of at least 1:2,500[1].Over 30 mutated genes have been identified in CMT2,which is characterized by peripheral axon degeneration and distal deficits in motor function[2].The aminoacyl-tRNA synthetase is the largest family in CMT2 and includes tyrosyl-tRNA synthetase(YARS,tyrosyl-tRNA synthetase).

关键词： Marie degeneration pathology

Differences in brain pathological changes between rotenone and 6-hydroxydopamine Parkinson＇s disease models

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Neural Regeneration Research 2018年第7期13卷 1276-1280页

作者： Lan-xiang Liu dan du Zhan-Qiu Wang Yuan Fang Tao Zheng Yan-Chao Dong Qing-Lei Shi Min Zhao Fang Xiao Juan du department of Magnetic Resonance Imaging Qinhuangdao Municipal No. 1 Hospital Qinhuangdao Hebei Province China department of Intervention Qinhuangdao Municipal No. 1 Hospital Qinhuangdao Hebei Province China Siemens Ltd. Beijing China department of pathology Qinhuangdao Municipal No. 1 Hospital Qinhuangdao Hebei Province China Hebei Medical university Shijiazhuang Hebei Province China

Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson＇s disease animal *** not only achieve degenerative changes of dopaminergic neurons in the substantia nigra,but also satisfy the requirements for iron ***,few studies have compared the characteristics of these two models by magnetic resonance *** this study,rat models of Parkinson＇s disease were generated by injection of 3 μg rotenone or 10 μg 6-hydroxydopamine into the right substantia *** 1,2,4,and 6 weeks after injection,coronal whole-brain T2-weighted imaging,transverse whole-brain T2-weighted imaging,and coronal diffusion tensor weighted imaging were conducted to measure fractional anisotropy and T2＊ values at the injury *** fractional anisotropy value on the right side of the substantia nigra was remarkably lower at 6 weeks than at other time points in the rotenone *** the 6-hydroxydopamine group,the fractional anisotropy value was decreased,but T2＊ values were increased on the right side of the substantia nigra at 1 *** findings confirm that the 6-hydroxydopamine-induced model is suitable for studying dopaminergic neurons over short periods,while the rotenone-induced model may be appropriate for studying the pathological and physiological processes of Parkinson＇s disease over long periods.

关键词： nerve regeneration fractional anisotropy T2* rotenone 6-hydroxydopamine Parkinson's disease magnetic resonance imaging diffusion tensor imaging dopaminergic neurons neural regeneration

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165例恶性淋巴瘤中p16基因异常的研究

复旦学报（医学版） 2001年第1期28卷 9-12页

作者：药锦娟李小秋许良中施宗高朱伟萍许越香郑爱华复旦大学附属肿瘤医院病理科上海200032

目的　检测恶性淋巴瘤 (ML)中 p16基因的缺失、甲基化及p16蛋白的表达 ,探讨 p16基因异常在淋巴瘤中的意义。方法　收集淋巴瘤新鲜组织标本 5 0例 ,存档石蜡包埋组织标本 115例 ,均包括T、B非霍奇金淋巴瘤 (NHL)及霍奇金淋巴瘤 (HL)。用... 详细信息

目的　检测恶性淋巴瘤 (ML)中 p16基因的缺失、甲基化及p16蛋白的表达 ,探讨 p16基因异常在淋巴瘤中的意义。方法　收集淋巴瘤新鲜组织标本 5 0例 ,存档石蜡包埋组织标本 115例 ,均包括T、B非霍奇金淋巴瘤 (NHL)及霍奇金淋巴瘤 (HL)。用PCR、甲基化特异的PCR方法检测新鲜组织中的p16基因的等位缺失及 5’CpG岛异常甲基化 ;用免疫组织化学方法检测石蜡标本中p16蛋白的表达情况。另外 ,分别选取 9例反应性增生 (RH)组织的标本作对照。结果　 12 / 5 0例 (2 4.0 % )新鲜标本中检出p16基因纯合性缺失 ,16 / 5 0例 (32 .0 % )检出 p16基因异常高甲基化 ;石蜡包埋标本中p16蛋白的失表达率为 41.6 % ,其中B NHL为 46 .0 % ,T NHL为5 4.5 % ,HL为 31.6 %。恶性程度较高的淋巴瘤类型中 p16蛋白的失表达率也相应较高 ,各类型之间比较 :弥漫性大B细胞淋巴瘤 (DLBCL)和滤泡性淋巴瘤 (FL)的p16失表达率存在组间差异的显著性。所有RH标本均未见 p16基因或蛋白表达的异常。结论　恶性淋巴瘤中 p16基因的异常是一个频发事件。

关键词：恶性淋巴瘤 p16基因甲基化蛋白表达

伴肠母细胞分化的结直肠腺癌8例临床病理学分析

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中华病理学杂志 2024年第4期53卷 370-376页

作者：汪琪张岩谭聪倪淑娟黄丹常彬盛伟琪王磊复旦大学附属肿瘤医院病理科复旦大学上海医学院肿瘤学系上海200032 上海中医药大学附属曙光医院病理科上海201203

目的探讨伴肠母细胞分化的结直肠腺癌(colorectal adenocarcinoma with enteroblastic differentiation,CAED)临床病理学特征。方法收集复旦大学附属肿瘤医院2017年1月至2023年8月8例CAED,对其组织病理学、免疫组织化学及分子特征和预... 详细信息

目的探讨伴肠母细胞分化的结直肠腺癌(colorectal adenocarcinoma with enteroblastic differentiation,CAED)临床病理学特征。方法收集复旦大学附属肿瘤医院2017年1月至2023年8月8例CAED,对其组织病理学、免疫组织化学及分子特征和预后进行分析,并进行文献复习。结果8例CAED中,男性6例,女性2例,平均年龄为58岁(29~77岁,中位年龄61.5岁),其中5例术前血清甲胎蛋白升高(14.0~286.6μg/L)。4例发生于结肠,4例发生于直肠。2例临床分期为Ⅳ期,初诊时已发生远处转移(1例初诊时发现肝脏转移,1例初诊时发现肺、骨和全身多发淋巴结转移),其余6例为局部进展期(Ⅱ~Ⅲ期),3例术后发生远处转移(肝脏1例、肺1例、腹膜1例),2例患者分别于术后9、24个月死亡。肿瘤由不同比例的肠母细胞分化的腺癌成分(30%~100%)和经典管状腺癌成分构成,前者形态类似胚胎发育时期肠黏膜上皮:立方状或柱状肿瘤细胞排列成管状、乳头状、筛状或实性巢状,胞质透亮。免疫组织化学染色结果显示,肿瘤细胞至少表达一种癌胚蛋白(SALL4、Glypican-3、甲胎蛋白)。3例肿瘤细胞伴鳞状分化。与原发灶相比,转移灶中CAED成分及鳞状分化成分所占比例均增高。原发灶和/或转移灶行KRAS、NRAS、BRAF基因突变检测示:5例为野生型,2例显示KRAS基因第2号外显子(G13D)突变。结论CAED是一种罕见的结直肠恶性肿瘤,恶性程度较高,准确的病理诊断具有预后预测价值。肠母细胞分化的组织学特征,血清甲胎蛋白的增高及癌胚蛋白的表达对于该肿瘤的诊断具有重要的价值。

关键词：结直肠肿瘤腺癌甲胎蛋白肠母细胞分化