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Efficacy of Qizi Yusi Pill on Pregnancy Outcomes in Women of Advanced Reproductive Age:A Multicenter,Randomized,Double-Blind,Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第8期28卷 675-682页

作者： ZHANG Yi QIAO Yan LI Li gao dan-dan SONG Jing-yan SUN Zhen-gao College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan250355China The First Clinical College Shandong University of Traditional Chinese MedicineJinan250014China Reproductive and Genetic Center of Integrated Medicine The Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan250011China

Objective:To evalvate efficacy of Qizi Yusi Pills(QYP),a Chinese medicine compound preparation,on in vitro fertilization-embryo transfer(IVF-ET)in women of advanced reproductive ***:This multicenter,randomized,double-blind,placebo-controlled trial was conducted from June 2018 to October2019.A total of 124 patients were randomly allocated to either the QYP group or the placebo group using a stratified block randomization design,with 62 patients in each *** patients completed controlled ovarian stimulation using a standard gonadotropin-releasing hormone agonist(GnRH-a)long *** the QYP group,QYP was administered while the control group received *** and placebo were administered for a total of 24 to 30 days from the day of GnRH-a pituitary downregulation to transvaginal oocyte *** medications were taken orally at doses of 10 g three times each *** primary outcome was cumulative pregnancy rate,and the secondary outcomes were periodic medication,follicular status,serum hormone and endometrial ***-up continued until 4 weeks after *** and neonatal complications,such as gestational diabetes,were also ***:Overall,119 patients completed the study,60 in the QYP group and 59 in the placebo *** protocol(PP)analysis revealed that 6-month cumulative pregnancy rate in the QYP group was significantly higher than that in the placebo group[43.33%(26/60)vs.25.42%(15/59),P=0.040].Additionally,more oocytes were retrieved from the QYP group than those from the placebo group(8.95±3.12 vs.7.85±1.91,P=0.022).Moreover,the endometrial thickness of HCG day in the QYP group was significantly higher than that in the placebo group(11.78±2.27 mm vs.10.68±2.07 mm,P=0.012).Maternal and neonatal complications between the two groups were not significantly different(P>0.05).Intention-to-treat analysis was in line with PP ***:QYP can enhance ovarian reserve capacity and ovarian response,and possibl

关键词： advanced age Qizi Yusi Pills in vitro fertilization-embryo transfer randomized controlled trial

The structural,electronic and magnetic properties of the 3d TM(V,Cr,Mn,Fe,Co,Ni and Cu) doped ZnO nanotubes:A first-principles study

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Science China(Physics,Mechanics & Astronomy) 2012年第3期55卷 428-435页

作者： ZHANG JianMin gao dan XU KeWei College of Physics and Information Technology Shaanxi Normal UniversityXi’an 710062China Department of Physics Xi’an University of Arts and ScienceXi’an 710065China

We have performed the first-principles calculations onto the structural,electronic and magnetic properties of seven 3d transition-metal(TM=V,Cr,Mn,Fe,Co,Ni and Cu) atom substituting cation Zn in both zigzag(10,0) and armchair(6,6) zinc oxide nanotubes(ZnONTs).The results show that there exists a structural distortion around 3d TM impurities with respect to the pristine *** magnetic moment increases for V-,Cr-doped ZnONTs and reaches maximum for Mn-doped ZnONTs,and then decreases for Fe-,Co-,Ni-and Cu-doped ZnONTs successively,which is consistent with the predicted trend of Hund's rule for maximizing the magnetic moments of the doped TM ***,the values of the magnetic moments are smaller than the predicted values of Hund's rule due to strong hybridization between p orbitals of the nearest neighbor O atoms of ZnONTs and d orbitals of the TM ***,the Mn-,Fe-,Co-,Cu-doped(10,0) and(6,6) ZnONTs with half-metal and thus 100% spin polarization characters seem to be good candidates for spintronic applications.

关键词： ZnO nanotubes transition-metal atoms dilute magnetic semiconductors first-principles

Co-culture of tumor spheroids and monocytes in a collagen matrix-embedded microfluidic device to study the migration of breast cancer cells

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Chinese Chemical Letters 2019年第2期30卷 331-336页

作者： Tianying Yuan dan gao Shangfu Li Yuyang jiang State Key Laboratory of Chemical Oncogenomics The Graduate School at Shenzhen Tsinghua University Key Laboratory of Metabolomics at Shenzhen School of Medicine Tsinghua University

Recapitulating the tumor microenvironment is a major challenge in the development of in vitro tumor model for the study of cancer biology and therapeutic treatments. 3D multicellular tumor spheroids (MCTS) have been used as reliable models of mimicking in vivo solid tumors. Macrophages and extracellular matrix (ECM), regarded as two key factors of the tumor microenvironment, play significant roles in tumor progression and drug resistance. In order to investigate their effects on tumor cell migration, a microfluidic chip-based 3D breast cancer model was developed by co-culturing monodisperse MCTS with monocytes in 3 D collagen matrix. A reversible bonding technique was employed for the fabrication of the microfluidic chip, which made it easier for MCTS formation and tailoring the MCTS co-culture conditions. When co-culturing monocytes with low invasive T47D spheroids or high invasive MD-MBA-231 spheroids, we found that T47 D cells with the stimulation of macrophage colony-stimulating factor (M-CSF) and MD-MBA-231 cells could polarize monocytes into tumor-associated macrophages (TAMs). The increased stiffness via increasing collagen concentration decreased tumor cell migration, whereas the presence of TAMs enhanced the migration ability of ***, M-CSF-activated TAMs promoted the migration of T47 D tumor cells via the regulation of TGFβ1. Overall, this 3D co-culture microfluidic model may be useful for studying tumor progress and may offer a reliable and low-cost method for evaluation of drug efficiency.

关键词： Tumor microenvironment Multicellular tumor spheroids Tumor-associated macrophages Extracellular matrix stiffness Microfluidics

Random forest algorithm for classification of multiwavelength data

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Chinese Journal of Astronomy and Astrophysics 2009年第2期9卷 220-226页

作者： dan gao Yan-Xia Zhang Yong-Heng Zhao National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

We introduced a decision tree method called Random Forests for multiwavelength data classification. The data were adopted from different databases, including the Sloan Digital Sky Survey （SDSS） Data Release five, USNO, FIRST and ROSAT. We then studied the discrimination of quasars from stars and the classification of quasars, stars and galaxies with the sample from optical and radio bands and with that from optical and X-ray bands. Moreover, feature selection and feature weighting based on Random Forests were investigated. The performances based on different input patterns were compared. The experimental results show that the random forest method is an effective method for astronomical object classification and can be applied to other classification problems faced in astronomy. In addition, Random Forests will show its superiorities due to its own merits, e.g. classification, feature selection, feature weighting as well as outlier detection.

关键词： classification-- astronomical databases miscellaneous -- catalogs -- meth- ods data analysis -- methods statistical

A microfluidic photolithography for controlled encapsulation of single cells inside hydrogel microstructures

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Science China Chemistry 2012年第4期55卷 494-501页

作者： JiangJiang Liu dan gao SiFeng Mao Jin-Ming Lin Tsinghua Univ Dept Chem Beijing Key Lab Microanalyt Methods & Instrumenta Beijing 100084 Peoples R China

A microfluidic approach to generate hydrogel microstructures inside microchannels for controlled encapsulation of single cells was developed. The method was based,on a modified microscope projection photolithography which allowed for the photopolymerization of poly（ethylene glycol） diacrylate （PEGDA） inside microchannels. Uniformsized hydrogel microstmctures （-50 pan in diameter） were generated one by one with determined positions to encapsulate single cells without losing the viability. Cells of interest could be identified by any kinds of visible labels to be selectively encapsulated inside the formed hydrogel microstructures. Large-scale encapsulation of single cells was achieved with a relatively high efficiency of 80% and the viability of encapsulated cells could be guaranteed by removing the dead cells identified with Trypan blue. This method is simple, fast and convenient to pattern the microchannels with single cells for a wide range of cell-based applications. For demonstration, two intracellular enzyme assays of carboxylesterase were performed to investigate the distribution of enzyme concentrations and the kinetic information within the encapsulated single HepG2 cells.

关键词： microfluidic single cells hydrogel microstructures HepG2 cells enzyme assay

Weathered and Volcanic Provenance-Sedimentary System and Its Influence on Reservoir Quality in the East of the Eastern Depression, the North Yellow Sea Basin

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Journal of Earth Science 2018年第2期29卷 353-368页

作者： dan gao Rihui Cheng Yanjie Shen Liaoliang Wang Xiaoqiang Hu College of Earth Sciences Jilin University Changchun 130061 China Guangzhou Marine Geological Survey Guangzhou 510075 China

Seismic stratigraphy, core logging and the data from cores are used to identify the development and evolution of the east provenance-sedimentary system and to analyze its influence on the quality of reservoirs in the eastern depression of the North Yellow Sea Basin. The eastern provenance-sedimentary system is a fan delta （delta） and subaqueous fan sedimentary system with volcanic provenance. Its evolution is closely related to internal uplift and coeval volcanic activity. During faulting and volcanic activity, an internal uplift gradually formed and the eastern provenance-sedimentary system began to develop. Clastic materials from the weathered uplift and volcanic activity were the main sources of sediment and were deposited in the Middle Jurassic to the Early Cretaceous. A subaqueous fan sedimentary system developed in the Middle Jurassic, a deltaic to subaqueous fan sedimentary system developed in the Late Jurassic, and a fan delta to subaqueous fan sedimentary system developed in the Early Cretaceous. The volcaniclastic detritus was mainly composed of acidic materials with a small amount of intermediate materials. The reservoir in the eastern sedimentary system is a type of tight sandstone with ultra-low porosity and very low permeability due to the influence of volcanism and diagenesis. The reservoir quality is worse than those of the northern and the western sedimentary systems. However, the high volume of volcanic materials and deep-marine sedimentary conditions resulted in good-quality hydrocarbon source rocks that ensures the exploration potential in the eastern sedimentary system reservoir.

关键词： the eastern depression of the North Yellow Sea Basin provenance-sedimentary system volcanism reservoir.

Fabrication of NiTi Shape Memory Alloys with Graded Porosity to Imitate Human Long-bone Structure

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Journal of Bionic Engineering 2015年第4期12卷 575-582页

作者： dan Zhou Yan gao Ming Lai Hao Li Bin Yuan Min Zhu School of Materials Science and Engineering South China University of Technology Guangzhou 510641 China

Replacement of damaged long bones is still a significant challenge in surgery. In the present study, a NiTi Shape Memory Alloy （SMA） constructed with graded porosity imitating human long bone structure was fabricated via a dedicated moulding procedure. The outer layer （porosity 14 %） and inner layer （porosity 52 %） of the bone-like graded NiTi alloy were found to be co-axial very well with the interface with a good metallurgical bonding. Moreover, the compression strength and elastic modulus of the graded-porosity NiTi SMAs were found to be 360.6 MPa and 6.7 GPa, respectively, which have been improved by its coaxiality compared with the one with poor coaxiality. The graded-porosity NiTi SMAs exhibit resembling mechanical performance as human long-bones, and are considered to be better implant candidates for long bone replacement.

关键词： NiTi SMA graded porosity long bone structure compressive strength recoverable strain

A Particle Filter Based Compressive Sensing Method for Tracking Moving Wideband Sound Sources

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China Communications 2018年第5期15卷 197-210页

作者： Juan Wei Fengli Yue Runyu Li Wenjing Wang dan gao School of Communication Engineering Xidian University

Tracking moving wideband sound sources is one of the most challenging issues in the acoustic array signal processing which is based on the direction of arrival(DOA) estimation. Compressive sensing(CS) is a recent theory exploring the signal sparsity representation, which has been proved to be superior for the DOA estimation. However, the spatial aliasing and the offset at endfire are the main obstacles for CS applied in the wideband DOA estimation. We propose a particle filter based compressive sensing method for tracking moving wideband sound sources. First, the initial DOA estimates are obtained by wideband CS algorithms. Then, the real sources are approximated by a set of particles with different weights assigned. The kernel density estimator is used as the likelihood function of particle filter. We present the results for both uniform and random linear array. Simulation results show that the spatial aliasing is disappeared and the offset at endfire is reduced. We show that the proposed method can achieve satisfactory tracking performance regardless of using uniform or random linear array.

关键词： direction of arrival tracking compressive sensing particle filter wideband sound sources

Experimental study of the dynamics of a single cavitation bubble excited by a focused laser near the boundary of a rigid wall

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Journal of Hydrodynamics 2023年第5期35卷 942-953页

作者： Xiang-qing Zhang Xiao-fei Zhang Xu Qiu dan gao Yu-ning Zhang Key Laboratory of Power Station Energy Transfer Conversion and System(Ministry of Education) School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China China Atomic Energy Publishing and Media Co.LTD Beijing100048China China Institute of Nuclear Industry Strategy Beijing100048China National Institute of Energy Development Strategy North China Electric Power UniversityBeijing102206China

Based on high-speed photographic experiments,this study presents a detailed qualitative and quantitative analysis of the dynamics of a single cavitation bubble near the boundary of a rigid wall in asymmetric *** main findings are reported as follows:(1)The non-sphericity of the bubble interface decreases with increasing spacing between the bubble and the boundary,and the asymmetry of the bubble becomes more significant with increasing asymmetry angle.(2)The motion mode of the bubble cluster in the second oscillation cycle can be divided into two typical modes depending on the direction of movement.(3)The angle between the oblique jet pointing towards the upper wall surface and the horizontal direction in the second oscillation cycle decreases as the dimensionless spacing decreases.

关键词： Asymmetry boundary cavitation bubble high-speed photography jet non-sphericity