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Impact of stage-specific limb function exercises guided by a selfmanagement education model on arteriovenous fistula maturation status

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World Journal of Clinical Cases 2024年第14期12卷 2316-2323页

作者： Yi Li Li-Jun Huang Jian-Wen Hou dan-dan Hu Department of Nursing The People's Hospital of Jianyang CityJianyang 641400Sichuan ProvinceChina Department of Nephrology The People's Hospital of Jianyang CityJianyang 641400Sichuan ProvinceChina Department of Head and Neck Surgery Zhejiang Cancer HospitalHangzhou 310000Zhejiang ProvinceChina School of Nursing Shangqiu Institute of TechnologyShangqiu 476005Henan ProvinceChina

BACKGROUND The exercise of limb function is the most economical and safe method to promote the maturation of arteriovenous fistula(AVF).However,due to the lack of a uni-fied exercise standard in China,many patients have insufficient awareness of the importance of AVF,leading to poor effectiveness of limb function *** self-management education model can effectively promote patients to take pro-active health-related *** study focuses on the characteristics of patients during the peri-AVF period and conducts a phased limb function exercise under the guidance of the self-management education model to observe changes in fac-tors such as the maturity of *** To assess the impact of stage-specific limb function exercises,directed by a self-management education model,on the maturation status of *** This study is a randomized controlled trial involving 74 patients with forearm AVFs from the Nephrology Department of a tertiary hospital in Sichuan Province,*** were randomly divided into an observation group and a control group using a random number table *** observation group underwent tailored stage-specific limb func-tion exercises,informed by a self-management education model which took into account the unique features of AVF at various stages,in conjunction with routine ***,the control group was given standard limb function exercises along with routine *** assessment involves the maturity of AVFs post-intervention,post-operative complications,and the self-management level of the fistula in both groups *** were conducted using SPSS version *** data were represented by frequency and percentage and subjected to chi-square test *** data adhering to a normal distribution were presented as mean±*** independent samples t-test was utilized for inter-group comparisons,while the paired t-test was used for intra-group *** measurement data not fitting a normal distr

关键词： Self-management Education model Stage-specific Limb function exercises Arteriovenous fistula Maturation status

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Three-dimensional cell-based strategies for liver regeneration

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BIOCELL 2024年第7期48卷 1023-1036页

作者： dan GUO XI XIA JIAN YANG Liver Transplant Center Transplant CenterWest China HospitalSichuan UniversityChengdu610041China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu610212China

Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern *** recent years,the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical *** review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver ***,we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver ***,we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical *** collective insights presented herein highlight the signiﬁcance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care.

关键词： Three-Dimensional Liver regeneration Organoids Stem cells Cell therapy

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Induced Absolute Configuration of Achiral Tetradentate Ligands in Metal–Organic Frameworks for Circularly Polarized Luminescence

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Chinese Journal of Chemistry 2024年第11期42卷 1260-1266页

作者： Hong-Ru Fu dan-dan Ren Kun Zhang Hong Chen Xiaoyan Lu Qing-Rong Ding Lu-Fang Ma College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyangHenan471934 China College of Materials&Chemical Engineering China Three Gorges UniversityYichangHubei443002 China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian350002 China

The crystallization of chiral molecules is of great significance to understand the origin and evolution of hierarchical chirality and reveal the relationships between structural chirality and circularly polarized luminescence(CPL)***,we report two pairs of chiral metal–organic frameworks(MOFs)(DCF-17/LCF-17,DCF-18/LCF-18)by utilizing tetradentate ligands tetra(3-imidazoylphenyl)ethylene(TIPE)and 4,4'-[4',5'-bis[4-(4-pyridinyl)phenyl][1,1':2',1”-terphenyl]-4,4”-diyl]bis[pyridine](TPPP)as *** can be observed that the spontaneous resolution of the achiral ligands is converted into the induced resolution,and the ligands form the absolute configuration by using enantiopure camphoric acid(cam)as chiral induced reagent(CIR).As a result,the racemate MOFs can be driven to generate absolute homochiral *** two achiral MOFs[Cd(D-cam)(TPPP)_(0.5)](AF-1,AF=achiral framework)and[Cd(L-cam)(TPPP)_(0.5)](AF-2)were *** position disorder of D/L-cam skeleton causes the generation of nonchiralization,further leading to disappearance of symmetry breaking of *** the perspective of structure,this is the first report which reveals the chiral transfer and nonchiralization between chiral induced agents and tetradentate ***,DCF-17 and LCF-17 show CPL with luminescence dissymmetry factor(glum)of–1.0×10^(-2)and+9.2×10^(–3),*** work provides the useful evidences to reveal the induced chiral crystallization and the construction of CPL-active crystalline materials.

关键词： Metal-organic frameworks Circularly polarized luminescence Chirality induction Spontaneous resolution Chirality transfer

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Impact of thoracic paravertebral block and sufentanil on outcomes and postoperative cognitive dysfunction in thoracoscopic lung cancer surgery

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World Journal of Psychiatry 2024年第6期14卷 894-903页

作者： dan-dan Wang Hong-Yu Wang Yan Zhu Xi-Hua Lu Department of Anesthesiology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008Henan ProvinceChina

BACKGROUND Postoperative pain management and cognitive function preservation are crucial for patients undergoing thoracoscopic surgery for lung cancer(LC).This is achieved using either a thoracic paravertebral block(TPVB)or sufentanil(SUF)-based multimodal ***,the efficacy and impact of their combined use on postoperative pain and postoperative cognitive dysfunction(POCD)remain *** To explore the analgesic effect and the influence on POCD of TPVB combined with SUF-based multimodal analgesia in patients undergoing thoracoscopic radical resection for LC to help optimize postoperative pain management and improve patient *** This retrospective analysis included 107 patients undergoing thoracoscopic radical resection for LC at The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital between May 2021 and January *** receiving SUF-based multimodal analgesia(n=50)and patients receiving TPVB+SUF-based multimodal analgesia(n=57)were assigned to the control group and TPVB group,*** compared the Ramsay Sedation Scale and visual analog scale(VAS)scores at rest and with cough between the two groups at 2,12,and 24 h after *** levels of epinephrine(E),angio-tensin Ⅱ(Ang Ⅱ),norepinephrine(NE),superoxide dismutase(SOD),vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),and S-100 calcium-binding proteinβ(S-100β)were measured before and 24 h after *** Mini-Mental State Examination(MMSE)was administered 1 day before surgery and at 3 and 5 days after surgery,and the occurrence of POCD was monitored for 5 days after *** reactions were also *** There were no significant time point,between-group,and interaction effects in Ramsay sedation scores between the two groups(P>0.05).Significantly,there were notable time point effects,between-group differences,and interaction effects observed in VAS scores both at rest

关键词： Thoracic paravertebral block Sufentanil Thoracoscope Radical resection of lung cancer Postoperative cognitive dysfunction

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A small D-A molecule with highly heat-resisting room temperature phosphorescence for white emission and anti-counterfeiting

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结构化学 2024年第3期43卷 3-9页

作者： Kun Zhang Ni dan dan-dan Ren Ruo-Yu Zhang Xiaoyan Lu Ya-Pan Wu Li-Lei Zhang Hong-Ru Fu Dong-Sheng Li College of Materials and Chemical Engineering China Three Gorges UniversityYichang443002PR China College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyang471934PR China College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyang471934PR China College of Materials and Chemical Engineering China Three Gorges UniversityYichang443002PR China

Achieving high heat-resisting room temperature phosphorescence(RTP)performance and robust white emission from pure small molecules is a meaningful but challenging ***,a simple donor-acceptor(D-A)molecule,9-(1H-benzotriazol-1-ylmethyl)-9H-carbazole(CzBtrz),was *** simple molecule not only exhibits multiple emissions including white light,thermally activated delayed fluorescence(TADF)and ultralong RTP with a lifetime of 988.54 ms at 545 nm,but also shows superhigh heat-resisting phosphorescence property which can maintain stability in a large temperature region from 77 to 350 K(ΔT=273 K),exceeding those of other RTP ***,this molecule shows the time-evolved dynamic *** experimental and theoretical an-alyses from CzBtrz crystal demonstrate that the intramolecular charge transfer(ICT)interaction and molecular stacking play an important role in the generation of ***,this work provides an efficient strategy to design ultrahigh heat-resistant RTP,ultralong RTP and single-phased white-light emitting materials.

关键词： Ultralong RTP TADF D-A molecule Heat-resisting White light

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High-throughput and simultaneous inertial separation of tumor cells and clusters from malignant effusions using spiral-contraction-expansion channels

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Microsystems & Nanoengineering 2024年第2期10卷 91-99页

作者： Zhixian Zhu Hui Ren dan Wu Zhonghua Ni Nan Xiang School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina School of Mechanical Technology Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina Department of Oncology Jiangyin People’s Hospital214400JiangyinChina

Tumor cell clusters are regarded as critical factors in cancer pathophysiology,and increasing evidence of their higher treatment resistance and metastasis compared to single tumor cells has been ***,existing cell separation methods that are designed for single tumor cells cannot be used to simultaneously purify tumor cell *** address this problem,we demonstrated a microfluidic approach for the high-throughput,continuous-flow ternary separation of single tumor cells,tumor cell clusters,and WBCs from clinical pleural or abdominal effusions by coupling slanted spiral channels and periodic contraction-expansion *** first systematically explored the influence of particle size and flow rate on particle *** separation performance indicated that 94.0%of WBCs were removed and more than 97%of MDA-MB-231 tumor cells were recovered at a high flow rate of 3500µL/***,more than 90%of tumor cell clusters were effectively preserved after ***,we successfully applied our device for the ternary separation of single tumor cells,tumor cell clusters,and WBCs from different malignant effusions collected from patients with metastatic ***,our spiral-contraction-expansion device has potential as a sample pretreatment tool for the cytological diagnosis of malignant effusions.

关键词： separation contraction removed

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Unraveling electrolyte solvation architectures for high-performance lithium-ion batteries

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Science China(Technological Sciences) 2024年第3期67卷 958-964页

作者： YANG MengHao SHI Zhe HE ZhiYuan WANG dan School of Materials Science and Engineering Tongji UniversityShanghai 201804China Department of Nuclear Science and Engineering Massachusetts Institute of Technology CambridgeMassachuseis 02139USA School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China

The design of advanced electrolytes hinges critically on a comprehensive comprehension of lithium-ion migration mechanisms within these electrochemical systems. Fluorination generally improves the stability and reduces the reactivity of organic compounds, making them potentially suitable for use in harsh conditions such as those found in a battery electrolyte. However,the specific properties, such as the solvation power, diffusivity, ion mobility, and so forth, would depend on the exact nature and extent of the fluorination. In this work, we introduce a theoretical framework designed to facilitate the autonomous creation of electrolyte molecular structures and craft methodologies to compute transport coefficients, providing a physical interpretation of fluoride systems. Taking fluorinated-1,2-diethoxyethanes as electrolyte solvents, we present and analyze the relationship between the electronic properties and atomic structures, and further correlate these properties to the transport coefficients, resulting in a good alignment with the experimental diffusion behaviors and Li-solvation structures. The insights derived from this research contribute to the methodological basis for high-throughput evaluation of prospective electrolyte systems, and consequently, propose strategic directions for the improvement of electrochemical cycle characteristics. This comprehensive exploration of the transport mechanisms enhances our understanding, offering avenues for further advancements in the field of lithium-ion battery technology.

关键词： Unraveling electrolyte solvation architectures for high-performance lithium-ion batteries

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HTDcr:a job execution framework for high-throughput computing on supercomputers

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Science China(Information Sciences) 2024年第1期67卷 69-85页

作者： Jiazhi JIANG dan HUANG Hu CHEN Yutong LU Xiangke LIAO School of Computer Science and Engineering Sun Yat-sen University School of Software Engineering South China University of Technology

High-throughput computing(HTC) is a computing paradigm that aims to accomplish jobs by easily breaking them into smaller,independent ***,it requires a large amount of computing power for a long *** existing HTC frameworks are job-oriented without support for coscheduling with hardware architecture and task-level ***,most of the frameworks reach a limited scale,and their usability needs further ***,we present HTDcr,a job execution framework for the HTC on *** study aims to improve the throughput,task dispatching,and usability of the *** detail,the throughput optimizations include a sophisticated designed task management system,a hierarchical scheduler,and the co-optimization of the task-scheduling strategy with the application and hardware *** optimizations for usability include a programable execution workflow,mechanisms for more robust and reliable service qualities,and a fine-grained resource allocation system for the colocation of multiple *** to our evaluations,HTDcr can achieve outstanding scalability and high throughput on large-scale clusters for the HTC *** evaluate HTDcr with several microbenchmarks and real-world applications on Tianhe-2 and Sunway TaihuLight to demonstrate its effects on existing design *** instance,the task scheduling for two real-world applications integrated with the application and hardware characteristics achieves 1.7× and 1.9× speedups over the basic task-scheduling strategy.

关键词： high-throughput computing supercomputer task scheduling middleware password guessing

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Constructal design of printed circuit recuperator for S-CO_(2)cycle via multi-objective optimization algorithm

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Science China(Technological Sciences) 2024年第1期67卷 285-294页

作者： dan ZhiSong FENG HuiJun CHEN LinGen LIAO NaiBing GE YanLin Institute of Thermal Science and Power Engineering Wuhan Institute of TechnologyWuhan 430205China College of Power Engineering Naval University of EngineeringWuhan 430033China Hubei Provincial Engineering Technology Research Center of Green Chemical Equipment Wuhan 430205China School of Mechanical&Electrical Engineering Wuhan Institute of TechnologyWuhan 430205China AECC Hunan Aviation Powerplant Research Institute Zhuzhou 412002China

Based on a constructal theory,the structure design of a printed circuit recuperator with a semicircular heat transfer channel for supercritical CO_(2)cycle is carried ***,a complex function composed of weighted sum of the reciprocal of total heat transfer rate and total pumping power consumption is regarded as an optimization objective,and total volumes of the recuperator and heat transfer channel are regarded as *** optimal heat transfer channel radius and minimum complex function of the recuperator are *** turns out that heat transfer rate,pumping power consumption,and complex function under the optimal construct of recuperator are reduced by 15.10%,82.44%,and 32.33%,*** exists the optimal single plate channel number which results in the double minimum complex ***,for the purpose of minimizing the reciprocal of heat transfer rate and pumping power consumption,NSGA-II algorithm is used to achieve multi-objective optimization,and the minimum deviation index derived by the decision-making methods is 0.076,which can be taken as multi-objective optimal design scheme for printed circuit recuperator with semicircular heat transfer *** findings presented here can serve as theoretical recommendations for the structure design of printed circuit recuperator.

关键词： constructal theory supercritical CO_(2)cycle printed circuit heat exchanger heat transfer rate pumping power consumption multi-objective optimization

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The Perturbed Compound Poisson Risk Model with Proportional Investment

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 109-128页

作者： Nai-dan Deng Chun-wei Wang Jia-en Xu School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang471023China

In this paper, the insurance company considers venture capital and risk-free investment in a constant proportion. The surplus process is perturbed by diffusion. At first, the integro-differential equations satisfied by the expected discounted dividend payments and the Gerber-Shiu function are derived. Then, the approximate solutions of the integro-differential equations are obtained through the sinc method. Finally, the numerical examples are given when the claim sizes follow different distributions. Furthermore, the errors between the explicit solution and the numerical solution are discussed in a special case.

关键词： expected discounted dividend payments lognormal distribution proportional investment perturbed risk model sinc numerical method

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