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Research 2024年第1期2023卷 489-507页

作者： Xiaoping Song Jif.ng Zhang Si Shen dan Liu Jie Zhang Wenming Yin Genlan Ye Leyu Wang Liu Cai Honghao Hou Xiaozhong Qiu Central Laboratory The Fifth Affiliated HospitalSouthern Medical UniversityGuangzhouGuangdong 510910China Department of Anatomy Neuroscience Laboratory for Cognitive and Developmental DisordersMedical College of Jinan UniversityGuangzhou 510630China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical ScienceBiomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhouGuangdong 510515China

The b.omimetic construction of a microstructural–mechanical–electrical anisotropic microenvironment adaptive to the native cardiac tissue is essential to repair myocardial infarction(MI).Inspired by the 3D anisotropic characteristic of the natural fish swim bladder(fSb),a novel flexible,anisotropic,and conductive hydrogel was developed for tissue-specific adaptation to the anisotropic structural,conductive,and mechanical features of the native cardiac extracellular *** results revealed that the originally stiff,homogeneous fSb film was tailored to a highly flexible anisotropic hydrogel,enabling its potential as a functional engineered cardiac patch(ECP).In vitro and in vivo experiments demonstrated the enhanced electrophysiological activity,maturation,elongation,and orientation of cardiomyocytes(CMs),and marked MI repair performance with reduced CM apoptosis and myocardial fib.osis,thereby promoting cell retention,myogenesis,and vascularization,as well as improving electrical *** findings offer a potential strategy for functional ECP and provides a novel strategy to b.onically simulate the complex cardiac repair environment.

关键词： bladder thereby patch

Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing fSP1 to inhibit ferroptosis

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Acta Pharmaceutica Sinica b 2024年第6期14卷 2581-2597页

作者： Hongliang Qiu Sihui Huang Yuting Liu Libo Liu f.ngming Guo Yingying Guo dan Li Xianf.ng Cen Yajie Chen Meng Zhang Yan Che Man Xu Qizhu Tang Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Hubei Key Laboratory of Metabolic and Chronic Diseases Wuhan 430060China

Doxorubicin(DoX)-mediated cardiotoxicity can exacerbate mortality in oncology patients,but related pharmacotherapeutic measures are relatively *** was recently identified as a major mechanism of DoX-induced ***,a novel ferroptosis inhibitor,is a well-described clinical drug widely ***,its role and pathological mechanism in DoX-induced cardiotoxicity are still *** this study,we demonstrated the effects of idebenone on DoX-induced cardiotoxicity and elucidated its underlying mechanism.A single intraperitoneal injection of DoX(15 mg/kg)was administrated to establish DoX-induced *** results showed that idebenone significantly attenuated DoX-induced cardiac dysfunction due to its ability to regulate acute DoX-induced fe^(2+)and RoS overload,which resulted in *** and bLI further revealed that idebenone's anti-ferroptosis effect was mediated by ***,idebenone increased fSP1 protein levels but did not affect fsp1 mRNA levels in the presence of *** could form stable hydrogen bonds with fSP1 protein at K355,which may influence its association with *** results confirmed that idebenone stabilized fSP1 protein levels by inhibiting its ubiquitination *** conclusion,this study demonstrates idebenone attenuated DoX-induced cardiotoxicity by inhibiting ferroptosis via regulation of fSP1,making it a potential clinical drug for patients receiving DoX treatment.

关键词： Idebenone DoX-induced cardiotoxicity ferroptosis fSP1 Ubiquitination Lipid peroxidation Iron overload Clinical translation

Dietary copper improves intestinal structural integrity in juvenile grass carp(Ctenopharyngodon idella)probably related to its increased intestinal antioxidant capacity and apical junction complex

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Animal Nutrition 2024年第3期18卷 96-106页

作者： Rui Ma Lin f.ng Pei Wu Yang Liu Hong Mei Ren Xiao Wan Jin Shu Wei Li Ling Tang Xiao Qiu Zhou Wei dan Jiang Animal Nutrition Institute Sichuan Agricultural UniversityChengdu611130China fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu611130China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu611130China Animal Nutrition Institute Sichuan Academy of Animal ScienceSichuan Animtech Feed Co.Ltd.Chengdu610066China

This research evaluated the effects of copper(Cu)on intestinal antioxidant capacity and apical junctional complex(AJC)in juvenile grass carp.A total of 1080 healthy juvenile grass carp(11.16±0.01 g)were fed six diets including different dosages of Cu,namely 0,2,4,6,8 mg/kg(Cu citrate[CuCit]as Cu source)and 3 mg/kg(CuSo4·5H2o as Cu source).The trial lasted for 9 *** findings revealed that dietary optimal Cu supplementation(2.2 to 4.1 mg/kg)promoted intestinal growth,including intestinal length,intestinal length index,intestinal weight,and intestinal somatic index(P 0.05).on the other hand,optimal Cu increased intestinal tight junction(TJ)proteins(except for claudin 15b)and adherens junction(AJ)proteins(E-cadherin,α-catenin,β-catenin,nectin and afadin)mRNA levels(Pould be connected to the signaling pathway formed by the Ras homolog gene family,member A(RhoA),Rho-associated kinase(RoCK),and myosin light chain kinase(MLCK).finally,based on serum indicator D-lactate and intestinal oxidative damage index(RoS),Cu requirement(CuCit as Cu source)for juvenile grass carp from initial weight to final weight(from 11 to 173 g)was determined to be 4.14 and 4.12 mg/kg diet,*** work may provide a theoretical foundation for identifying putative Cu regulation pathways on fish intestinal health.

关键词： Copper Ctenopharyngodon idella Structural integrity Intestine

Evaluating the performance of genomic selection on purebred population by incorporating crossbred data in pigs

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Journal of Integrative Agriculture 2024年第2期23卷 639-648页

作者： Jun Zhou Qing Lin Xueyan f.ng Duanyang Ren Jinyan Teng Xibo Wu dan Wu Xiaoke Zhang Xiaolong Yuan Zanmou Chen Jiaqi Li Zhe Zhang Hao Zhang College of Animal Science South China Agricultural University/State Key Laboratory of Swine and Poultry Breeding Industry/National Engineering Research Center for Breeding Swine IndustryGuangzhou 510642China Guangxi State farms Yongxin Animal Husbandry Group Co. Ltd.Nanning 530022China

Genomic selection(GS)has been widely used in livestock,which greatly accelerated the genetic progress of complex *** population size was one of the significant factors affecting the prediction accuracy,while it was limited by the purebred *** to directly combining two uncorrelated purebred populations to extend the reference population size,it might be more meaningful to incorporate the correlated crossbreds into reference population for genomic *** this study,we simulated purebred offspring(PAS and PbS)and crossbred offspring(CAb)base on real genotype data of two base purebred populations(PA and Pb),to evaluate the performance of genomic selection on purebred while incorporating crossbred *** results showed that selecting key crossbred individuals via maximizing the expected genetic relationship(REL)was better than the other methods(individuals closet or farthest to the purebred population,CP/fP)in term of the prediction ***,the prediction accuracy of reference populations combining PA and CAb was significantly better only based on PA,which was similar to combine PA and ***,the rank correlation between the multiple of the increased relationship(MIR)and reliability improvement was *** for individuals with low correlation(Cor(Pi,PA or b),the reliability improvement was significantly lower than other *** findings suggested that incorporating crossbred into purebred population could improve the performance of genetic prediction compared with using the purebred population *** genetic relationship between purebred and crossbred population is a key factor determining the increased reliability while incorporating crossbred population in the genomic prediction on pure bred individuals.

关键词： pigs crossbred population genomic selection reference population construction relationship

RbM25 depletion suppresses the growth of colon cancer cells through regulating alternative splicing of MNK2

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Science China(Life Sciences) 2024年第10期67卷 2186-2197页

作者： Lili Zhi Chaoqun Chen Ge Zhang Tian Huang Wenxia He Jinrui Zhang dan Chen Jiayi Liu Jinyao Zhao Yangfan Qi Guiying Wang Wenjing Zhang Yang Wang Sino-US Research Center for Cancer Translational Medicine of the Second Affiliated Hospital of Dalian Medical University&Institute of Cancer Stem Cell Dalian Medical UniversityDalian 116023China Department of Immunology College of Basic Medical SciencesDalian Medical UniversityDalian 116044China Institute of Cancer Stem Cell Dalian Medical UniversityDalian 116044China Department of Pathology the First Affiliated Hospital of Dalian Medical UniversityDalian Medical UniversityDalian 116011China Department of General Surgery the Second Hospital of Hebei Medical UniversityShijiazhuang 050000China The Second Department of General Surgery the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Hebei Key Laboratory of Etiology Tracing and Individualized Diagnosis and Treatment for Digestive System Carcinoma Shijiazhuang 050001China

Increasing evidence suggests that deregulated RNA splicing factors play critical roles in tumorigenesis;however,their specific involvement in colon cancer remains largely *** we report that the splicing factor RbM25 is overexpressed in colon cancer,and this increased expression correlates with a poor prognosis of patients with colon ***,RbM25 ablation suppresses the growth of colon cancer cells both in vitro and in ***,our transcriptome-wide analysis of splicing events revealed that RbM25 regulates a large number of cancer-related alternative splicing events across the human genome in colon ***,RbM25 regulates the splicing of MNK2 by interacting with the poly G rich region in exon 14a,thereby inhibiting the selection of the proximal 3'splice site(ss),resulting in the production of the oncogenic short isoform,*** of RbM25 leads to an increase in the MNK2a isoform and a decrease in the MNK2b ***,re-expression of MNK2b.or b.ocking the 3′ss of the alternative exon 14a with ASo partially reverses the RbM25 knockdown mediated tumor ***,MNK2b levels were significantly increased in colon cancer tissues,which is positively correlated with the expression level of ***,our findings uncover the critical role of RbM25 as a key splicing factor in colon cancer,suggesting its potential as a prognostic marker and therapeutic target.

关键词： RbM25 colon cancer alternative splicing MNK2

Aflatoxin b1 decreased flesh flavor and inhibited muscle development in grass carp(Ctenopharyngodon idella)

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Animal Nutrition 2024年第3期18卷 27-38页

作者： Xiang Ning He Zhen Zhen Zeng Wei dan Jiang Pei Wu Yang Liu Sheng Yao Kuang Ling Tang Shu Wei Li Lin f.ng Xiao Qiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130China fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130China Key Laboratory for Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130China Animal Nutrition Institute Sichuan Academy of Animal ScienceChengdu 610066China

In nature,aflatoxins,especially aflatoxin b1(Afb1),are the common mycotoxins,which cause serious health problems for humans and *** paper aimed to study the effects of Afb1 on flesh flavor and muscle development of grass carp(Ctenopharyngodon idella)and its *** were 1440 individual fish in total,with 6 treatments and each treatment replicated 3 *** 6 treatments were fed a control diet with different doses of Afb1(0.04,29.48,58.66,85.94,110.43 and 146.92μg/kg diet)for 60 ***1 increased myofiber diameter,as well as decreased myofiber density of grass carp muscle(Pontents of free amino acid decreased gradually(Pfb1 increased in the muscle of grass *** levels of reactive oxygen species,malonaldehyde and protein carbonyl(PC)were increased(Pfb1 *** levels of antioxidant enzyme(glutathione peroxidase,glutathione,glutathione reductase,total antioxidant capacity,anti-superoxide anion,and anti-hydroxyl radical)were decreased(Pfb1 *** addition,dietary Afb1 decreased the content of collagen,and downregulated the mRNA and protein levels of transforming growth factor-β(TGf-β)/Smads signaling pathway in grass carp muscle(Potein levels of myogenic regulatory factors were downregulated in grass carp muscle(Pfurthermore,the activities of matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-9(MMP-9)were increased(Potein levels of phosphorylate-38 mitogen-activated protein kinase(p-p38MAPK),phosphorylate-c-Jun N-terminal kinase,urokinase-type plasminogen activator(uPA),MMP-2 and MMP-9 were upregulated(Pbut collagenⅠ,lamininβ1 and fib.onectin were downregulated(Pfb1 increased in the muscle of grass *** on the results of this study,we can draw the following conclusion:dietary Afb1 might damage flesh flavor and inhibit the muscle development through MAPK/uPA/MMP/extrac

关键词： Aflatoxin b1 flesh flavor Muscle development Grass carp

Molecular Characterization of Coxsackievirus b1 Strains Isolated from Patients with Hand foot and Mouth Disease in Yunnan,Southwest China

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b.omedical and Environmental Sciences 2024年第5期37卷 543-548页

作者： XU dan Han ZHAng Ming CHEN Jun Wei f.ng Chang Zeng LIU Yu Han CHU Zhao Yang LIU Wen Jing LI Li MA Shao Hui Institute of Medical b.ology Chinese Academy of Medical Sciencesand Peking Union Medical CollegeKunming 650118YunnanChina Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease Kunming 650118YunnanChina School of Life Sciences Yunnan UniversityKunming 650504YunnanChina School of Medicine Yunnan UniversityKunming 650504YunnanChina Department of Clinical Laboratory Kunming Maternal and Child Health hospital Kunming 650031YunnanChina

Coxsackievirus(CV)b belongs to the species Enterovirus b,genus Enterovirus of the family *** b(EV-b)includes 63 serotypes:CVb1-6;CVA9;echoviruses E1-7,9,11-21,24-27,and 29-33;EV-b69,EV-b 73-75,EV-b77-88,EV-b 93,EV-b 9... 详细信息

关键词： Coxsackievirus Patients belongs

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《互动成分语法》介评

外语教学与研究 2024年第4期56卷 628-632页

作者：黄丹北京外国语大学英语学院北京市100089

1.引言bernd Heine为德国科隆大学荣休教授,兼任欧洲科学院院士、纽约科学院院士等职位,多年来一直致力于语言类型学、语法化、历史语言学及社会语言学研究,是二十世纪最具影响力的功能语言学家之一。

关键词：历史语言学语言类型学功能语言学家社会语言学研究语法化德国科隆大学互动

Pathological progression of osteoarthritis:a perspective on subchondral bone

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frontiers of Medicine 2024年第2期18卷 237-257页

作者： Xuefei Li Wenhua Chen dan Liu Pinghua Chen Shiyun Wang f.ngf.ng Li Qian Chen Shunyi Lv f.ngyu Li Chen Chen Suxia Guo Weina Yuan Pan Li Zhijun Hu Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai200032China Research and Development Center of Chinese Medicine Resources and b.otechnology Shanghai University of Traditional Chinese MedicineShanghai201203China

osteoarthritis(oA)is a degenerative bone disease associated with *** rising global aging population has led to a surge in oA cases,thereby imposing a significant socioeconomic *** have been keenly investigating the mechanisms underlying *** studies have suggested that the disease starts with synovial inflammation and hyperplasia,advancing toward cartilage ***,subchondral-bone collapse,sclerosis,and osteophyte formation *** progression is deemed as“top to bottom.”However,recent research is challenging this perspective by indicating that initial changes occur in subchondral bone,precipitating cartilage *** this review,we elucidate the epidemiology of oA and present an in-depth overview of the subchondral bone’s physiological state,functions,and the varied pathological shifts during oA *** also introduce the role of multifunctional signal pathways(including osteoprotegerin(oPG)/receptor activator of nuclear factor-kappa b ligand(RANKL)/receptor activator of nuclear factor-kappa b(RANK),and chemokine(CXC motif)ligand 12(CXCL12)/CXC motif chemokine receptor 4(CXCR4))in the pathology of subchondral bone and their role in the“bottom-up”progression of *** vivid pattern maps and clinical images,this review highlights the crucial role of subchondral bone in driving oA progression,illuminating its interplay with the condition.

关键词： osteoarthritis subchondral bone oPG/RANKL/RANK CXCL12/CXCR4

拉萨市河谷平原区地下水位动态特征及影响因素

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地质通报 2024年第6期43卷 971-983页

作者：王丹唐蕴中国水利水电科学研究院北京100038 天津华北地质勘查局核工业二四七大队天津301800

为加强拉萨市河谷平原区地下水资源的合理开发和可持续利用,以拉萨市城关区为例,对拉萨市河谷平原区地下水位动态特征及影响因素进行分析。对1996—2015年拉萨城关区地下水位进行了年内与年际变化特征分析,运用反距离加权法(IDW)进行空... 详细信息

为加强拉萨市河谷平原区地下水资源的合理开发和可持续利用,以拉萨市城关区为例,对拉萨市河谷平原区地下水位动态特征及影响因素进行分析。对1996—2015年拉萨城关区地下水位进行了年内与年际变化特征分析,运用反距离加权法(IDW)进行空间插值,得出地下水位空间分布及变幅。利用Pearson相关分析法及灰色关联分析法对城关区地下水位动态的影响因素及各因素影响程度进行了分析。分析结果显示,城关区地下水位具有东高西低,中间高南北低的空间分布特征。1996—2015年间地下水位逐年下降,下降范围为0.2~3.7 m,年均降幅为0.01~0.19 m。地下水位动态受降水量、气温、开采量、建设用地面积的共同影响,影响程度为:气温>降水量>建设用地面积>开采量。

关键词：拉萨市河谷平原区降水量地下水位动态影响因素