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Olfactory receptors in neural regeneration in the central nervous system

Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni capó Joan serrano-Marín Rafael Rivas-santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain school of Chemistry Universitat de BarcelonaBarcelonaSpain department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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Transparent cap adjusted the stent placed for stenosis after endoscopic injection of esophageal varices:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2614-2620页

作者： Fu-Long Zhang Jing Xu Yuan-Dong Zhu Qian-Neng Wu Yan shi Lei Fang dan Zhou Hai Wang Chao-JunHuang Chun-Hua Zhou Qun Zhu department of Gastroenterology Hangzhou Xixi hospitalHangzhou 310023Zhejiang ProvinceChina department of Hepatopathy Hangzhou Xixi hospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND The stent embedded in the esophageal mucosa is one of the complications after stenting for esophageal *** present a case of stent adjustment with the aid of a transparent cap after endoscopic injection of an esophageal varices *** sUMMARY A 61-year-old male patient came to the hospital with discomfort of the chest after the stent implanted for the stenosis because of endoscopic injection of esophageal *** gastroscopy was performed,and the stent embedded into the esophageal *** first,we pulled the recycling line for shrinking the stent,however,the mucosa could not be removed from the *** a forceps was performed to remove the mucosa in the stent,nevertheless,the bleeding form the mucosa was *** then,we used a transparent cap.to scrape the mucosa along the stent,and the mucosa were removed successfully without *** A transparent cap helps gastroscopy to remove the mucosa embedded in the stent after endoscopic injection of the esophageal varices stent.

关键词： stent Transparent cap stenosis Endoscopic injection Esophageal varices Case report

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Hierarchical Voronoi structure Inspired by Cat Paw Pads substantially Enhances Landing Impact Energy Dissipation

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Journal of Bionic Engineering 2024年第4期21卷 1847-1861页

作者： da Lu Baoqing Pei Yangyang Xu Mengyuan Hu shijia Zhang Le Zhang Xin Huang Yangwei Wang Xueqing Wu Beijing Key Laboratory for design and Evaluation Technology of Advanced Implantable&Interventional Medical devices Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang University100083BeijingChina National Key Laboratory of science and Technology on Materials under shock and Impact Beijing Institute of Technology100081BeijingChina shenzhen Institute of Beihang University 518000ShenzhenChina

When a human lands from a high drop,there is a high risk of serious injury to the lower *** the other hand,cats can withstand jumps and falls from heights without being fatally wounded,largely due to their impact-resistant paw *** aim of the present study was to investigate the biomechanism of impact resistance in cat paw pads,propose an optimal hierarchical Voronoi structure inspired by the paw pads,and apply the structure to bionic cushioning shoes to reduce the impact force of landing for *** microstructure of cat paw pads was observed via tissue section staining,and a simulation model was reconstructed based on CT to verify and optimize the structural cushioning *** distribution pattern,wall thickness of compartments,thickness ratio of epidermis and dermis,and number of compartments in the model were changed and simulated to achieve an optimal composed structure.A bionic sole was 3D-printed,and its performance was evaluated via compression test and a jumping-landing *** results show that cat paw pads are a spherical cap structure,divided from the outside to the inside into the epidermis,dermis,and compartments,each with different cushioning capacities.A finite element simulation of different cushioning structures was conducted in a cylinder with a diameter of 20 mm and a height of 10 mm,featuring a three-layer *** optimal configuration of the three layers should have a uniform distribution with 0.3–0.5 mm wall thickness,a 1:1–2 thickness ratio of epidermis and dermis,and 100–150 compartments.A bionic sole with an optimized structure can reduce the peak impact force and delay the peak arrival *** energy absorption rate is about 4 times that of standard *** jumping 80,100,and 120 cm,the normalized ground reaction force is also reduced by 8.7%,12.6%and 15.1%compared with standard *** study provides theoretical and technical support for effective protection against human lower limb landing injuries.

关键词： Cat paw pads Hierarchical Voronoi structure Landing impact Energy dissipation Bionic sole

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Effects of application date and rate of foliar-applied glyphosate on pine seedlings in Turkey

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Journal of Forestry Research 2018年第3期29卷 583-591页

作者： Mehmet Can cap derya Essn department of Forest Engineering Faculty of ForestryDüzce UniversityKonuralp Yerleskesi81620 DüzceTurkey

Glyphosate is the herbicide most extensively used for site preparation and conifer release. It is a broadspectrum herbicide and therefore crop safety is a critical issue. This study assessed the early effects of 14 different treatments, including no weed control, manual weed control, and 12 foliar-applied herbicide treatments at low,intermediate, high, and highest application rates and application timing on glyphosate phytotoxicity of containerized seedlings of Austrian pine(Pinus nigra ***.), scots pine(P. sylvestris L.) and maritime pine(*** Aiton), conifer species widely used for afforestation and supplementary plantings in Turkish forestry. In general, scots pine seedlings were tolerant to glyphosate compared to the other species. Glyphosate phytotoxicity varied significantly according to the time and rate of application. seedlings were relatively tolerant to glyphosate in April whereas they were intolerant in May. The highest herbicide rate(1.2% v:v) was consistently phytotoxic to all species. Moreover, the effect of herbicide rate on seedling survival and growth varied significantly according to application date(i.e., application rate 9 date interaction). seedlings appeared tolerant to glyphosate at low and intermediate rates(0.2, 0.4% v:v) between midspring and mid-summer, whereas they demonstrated significant sensitivity to the highest rate across all time periods. Glyphosate at the high rate(0.8% v:v) was particularly more phytotoxic when applied in May. Application of glyphosate at rates up to 0.8% could be recommended for weed control without significant pine damage in midspring when the needles presumably have a dense leaf epicuticular wax layer limiting herbicide *** of 0.8 and 1.2% v:v are not recommended during May–June.

关键词： Application date and rate Glyphosate screening Pines seedling tolerance

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海上浮式风机多体系统耦合动力模型研究

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振动工程学报 2024年第1期37卷 20-30页

作者：李书进郑达成孔凡武汉理工大学土木工程与建筑学院湖北武汉430070 合肥工业大学土木与水利工程学院安徽合肥230009

海上浮式风机是近年来随着海上风电的快速发展,为了捕获深海更丰富、更持久的风能而提出的一种风力发电装置,已成为当今风能开发的主要方向。作为一种多体系统,由于海上浮式风机结构特殊,加上环境复杂,对其进行准确的计算和分析尤为重... 详细信息

海上浮式风机是近年来随着海上风电的快速发展,为了捕获深海更丰富、更持久的风能而提出的一种风力发电装置,已成为当今风能开发的主要方向。作为一种多体系统,由于海上浮式风机结构特殊,加上环境复杂,对其进行准确的计算和分析尤为重要。本文对海上浮式风机的耦合动力模型进行了研究,建立了复杂工况下spar型海上浮式风机改进的14-DOF耦合动力模型,包括气动力模块、水动力模块和结构分析模块等,用于扩展其适用范围和准确计算风机的动力响应,并通过数值仿真对所建模型进行了分析和验证。主要的改进有:不对平台和塔架的转动角度作小量近似,扩展其适用范围;考虑角速度和欧拉角速度的换算关系,不作等化处理。此外,所建模型考虑风机叶片扭转角对叶片变形的影响,得到了较为准确的叶片面内外响应。同时采用线性势流理论对水动力进行计算,较之Morison方程适用性更广。仿真分析表明,本文所建模型可以更准确地计算海上浮式风机系统的动力响应,且具有更广的适用范围。

关键词：海上浮式风机多体系统气动力分析水动力分析耦合模型

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sequential Analysis in the Identification of 3rd Order system Tract in the Abidjan Margin

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Open Journal of Applied sciences 2024年第6期14卷 1474-1489页

作者： Blandine Akissi Egoran N’guessan Donald Ahoure Fori Yao Paul Assalé sylvain Mondé Loukou Victor N’da UFR Marine sciences San Pedro University San Pedro Cte dIvoire UFR of sciences and Technologies Alassane Ouattara Bouak Laboratory of Plant Biology and Earth Sciences Bouak Cte dIvoire UFR/sTRM Flix Houphout Boigny de Cocody Abidjan Cte dIvoire PETROCI Consultant at the Center for Analysis and Research Department of Sequential Stratigraphy Abidjan Cte dIvoire

The use of sequential stratigraphy concept, based on well logs, sedimentology, and biostratigraphy, has shed light on the complex mechanisms controlling sedimentary accumulations. Consequently, identifying these mechanisms allows us to predict the hydrocarbon generation potential of source rocks. In the Ivorian offshore sedimentary basin, certain studies have contributed to understanding and characterizing the petroleum system. However, these previous works did not integrate biostratigraphic data to highlight sedimentary facies. This study, conducted on two wells in the Abidjan margin, is crucial as it helps us comprehend the geometry of fossil sediments in relation to sea level variations. It will also aid in reconstructing the basin-filling history and predicting the distribution of rocks capable of trapping oil, determining lowstand systems tracts (reservoir rocks), transgressive systems tracts, and highstand systems tracts (cap rocks). Lithological analysis revealed predominantly clayey sedimentation with sandy layers. Well log data facilitated the delineation of formation boundaries and highlighted reservoirs consisting of sands, sandstones, limestones, and occasionally intercalated shales. Integrating these analysis results with biostratigraphic interpretations based on foraminifera and palynomorphs revealed that the traversed formations were deposited in a transitional environment ranging from Coniacian to Maastrichtian ages. Applying sequential stratigraphy concept from well logging resolved dating issues encountered in microfossil-poor or microfossil-free zones. The results of the Coniacian-Maastrichtian age sequential subdivision were aligned with the chart.

关键词： sequence stratigraphy systems Tracts senonian Côte d’Ivoire

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stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern sichuan Basin,south China

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Petroleum science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang shi Dong-Ge Wang Ke-Ning Qi Yu-Chong Wang da-Wei Qiao Xiao-shuai Chen Li-Zhi Wu Meng Tian Long Chen Yi Wei Liao-Yuan song Jian Li Zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-Qing Chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China state Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological survey Chongqing401122China Key Laboratory of deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DsT),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DsT,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DsT barrier coast *** proposed DsT of the northeastern sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation cap dolomite deglacial and coastal deposits detrital zircon U-Pb dating

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Five-year outcomes of immediate implant placement for mandibular molars with and without chronic apical periodontitis:A retrospective study

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World Journal of Clinical Cases 2023年第22期11卷 5224-5235页

作者： Hua Yang dan Luo Mu-Jie Yuan Jian-Jun Yang da-shan Wang department of Oral and Maxillofacial surgery The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina school of stomatology Qingdao UniversityQingdao 266003Shandong ProvinceChina department of Oral Implantology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND Most physicians consider molars with chronic apical periodontitis(cap)lesions as contraindications for immediate implant *** the patient’s request,we perform immediate implant placement of the mandibular molars with cap in clinical *** To retrospectively analyze and compare the 5-year outcomes of immediate implant placement of the mandibular molars with cap and those without obvious *** The clinical data of patients with immediate implant placement of the mandibular molars in the department of Oral and Maxillofacial surgery,the Affiliated Hospital of Qingdao University,from June 2015 to June 2017 were *** patients were divided into cap(n=52)and no-cap(n=45)*** in bone mineral density and bone mass around implants were analyzed 5 years after implant *** At 5 years after implantation,the peri-implant bone mineral density was 528.2±78.8 Hounsfield unit(HU)in the cap group and 562.6±82.9 HU in the no-cap group(P=0.126).Marginal bone resorption around implants did not differ significantly between the two groups,including buccal(P=0.268)or lingual(P=0.526)resorption in the vertical direction or buccal(P=0.428)or lingual(P=0.560)resorption in the horizontal *** in the peri-implant jump space did not differ significantly between the two groups,including the buccal(P=0.247)or lingual(P=0.604)space in the vertical direction or buccal(P=0.527)or lingual(P=0.707)space in the horizontal *** gray value of cone-beam computed tomography measured using Image J software can reflect the bone mineral *** the cap area,the gray values of the bone tissue immediately and 5 years after implant placement differed significantly from those of the surrounding bone tissue(PsION The results of this study suggest that immediate implant placement of the mandibular molars with cap can achieve satisfactory 5-year clinical results,without significant differences in the complic

关键词： Molar Chronic apical periodontitis dental implantation Bone density Treatment outcome Retrospective study

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Temporal and phenological profiles of open and dense Caatinga using remote sensing:response to precipitation and its irregularities

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Journal of Forestry Research 2021年第3期32卷 1067-1076页

作者： Janisson Batista de Jesus Tatiana Mora Kuplich íkaro daniel de Carvalho Barreto Cristiano Niederauer da Rosa Fernando Luis Hillebrand Postgraduate Program in Remote sensing Federal University of Rio Grande Do SulAv.Bento GoncalvesCEP 91501-970Porto AlegreRio Grande do Sul 9500Brazil National Institute for space Research(INPE)southern Regional Centre(CRs) CEP 97105-970Santa MariaRio Grande do SulBrazil Postgraduate Program in Applied Biometrics and statistics Rural Federal University of PernambucoDom Manuel de Medeiross/nDois IrmaosCEP 52171-900RecifePernambucoBrazil

Caatinga is a typical biome of Brazil's semiarid regions and subject to climate *** is needed on the relation of its features to climate *** study analyzed the infl uence of rainfall and its irregularities in open and dense woody Caatinga *** curves were generated by means of Normalized Difference Vegetation Index(NDVI)time profiles in the Grota do Angico Conservation Unit study area in sergipe *** data from 2000 to 2018 were collected and phenological curves generated using various estimate methods that produced the following variables:[start of season,end of season,peak of season position,length of season,mean growing season and maximum seasonal].Rainfall showed a standard intra-annual behavior,with inter-annual variations related to irregularities infl uencing Caatinga *** Caatinga vegetation had higher values of NDVI in all periods,even in anomalous years compared to open Caatinga,in addition to having longer leaf coverage over the year,with an anticipated start and a more extended seasonal *** analysis of the rainfall regime made it possible to assess its infl uence on the Caatinga and phenological profiles proved to be fundamental to understand periods of physiological change of open and dense *** results indicate that dense Caatinga maintains physiological activity longer,which may be associated with greater moisture maintenance in a semiarid *** addition,because it has a greater leaf cover for longer periods,the soil may be preserved and maintain its characteristics longer,reducing the effects of *** results may be associated with the type of forest management and conservation in this *** total or partial suppression of individual remnants of Caatinga should be avoided,since the most open areas have lower photosynthetic capacity,affected to a considerable extent from the effects of adverse climatic ***,open Caatinga has a reduced cap

关键词： semiarid Tropical dry forest NDVI MODIs Phenopix

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cap morphology after small-incision lenticule extraction and its effects on intraocular scattering

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 456-461页

作者： dan Fu Lin Wang Xing-Tao Zhou Zhi-Qiang Yu Eye and ENT Hospital of Fudan University Shanghai 200031 China Myopia Key Laboratory of the Health Ministry Shanghai 200031 China

AIM： To investigate cap morphology after small-incision lenticule extraction （sMILE） and its effects on intraocular scattering. METHODs： sixty-five eyes of 33 patients undergoing sMILE were enrolled. In addition to regular evaluation, Fourier-domain optical coherence tomography was used to investigate cap thickness at ld, lwk, 1 and 3mo postoperatively. The optical quality including modulation transfer function cutoff frequency, strehl ratio, Optical Quality Analysis system （OQAs） values, and objective scattering index （OsI）, were evaluated using OQAsTM. REsULTs： cap thickness decreased from ld to lwk （P〈0.001）, but remained higher than intended thickness of 120 μm after 3mo （P〈0.001）. cap thickness in central area was thinner than that of in the paracentral and peripheral areas （P〈0.0001）. Total number of microdistortions decreased from ld to 3mo （P〈0.0001）. Pearson analysis revealed a weak correlation between OsI and standard deviation of cap thickness at ld and lmo, as well as between range of cap thickness and OsI at 1mo. No correlation was found between microdistortion and OsI, but a negative correlation existed between microdistortion and range at ld and lmoafter surgery. CONCLUsION： The corneal cap tends to be more accurate and regular with time lapse. Better cap morphology tends to contribute less intraocular scattering in the eyes undergoing sMILE.

关键词： corneal cap intraocular scattering microdis-tortion small-incision lenticule extraction

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