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Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats

World Journal of Gastroenterology 2013年第19期19卷 2894-2903页

作者： Ibrahim Akyazi Evren Eraslan Ahmet Gülubuk Elif Ergül Ekiz Zeynep L rakli damla haktanir Deniz Aktaran Bala Mete zkurt Erdal Matur Mukaddes zcan Department of Physiology Veterinary FacultyIstanbul University34320 IstanbulTurkey Department of Pathology Veterinary FacultyIstanbul University34320 IstanbulTurkey Department of Biochemistry Bakirkoy Dr.Sadi Konuk Training and Research Hospital34147 IstanbulTurkey Department of Physiology Faculty of MedicineEski ehir Osmangazi University26480 EskisehirTurkey

AIM:To investigate the effects of long term pretreatment with low-,medium-and high-dose aspirin(acetylsalicylic acid,ASA) on a model of acute pancreatitis(AP) induced in ***:Forty male Wistar rats were *** experimental groups,each consisting of eight animals,received low-(5 mg/kg per day),medium-(150 mg/kg per day) and high-dose(350 mg/kg per day) ASA in supplemented pellet chow for 100 *** animals,serving as the AP-control group,and another eight,serving as reference value(RV) group,were fed with standard pellet chow for the same *** pretreatment,AP was induced in the experimental animals by intraperitoneal administration of cerulein(2 × 50 μg/kg),while the RV group received saline in the same *** hours after the second injection,the animals were *** tissue and plasma samples were *** part of the collected pancreatic tissues was used for histopathological evaluation,and the remaining portion was *** levels [tumor necrosis factor,interleukin(IL)1β,IL-6],hemogram parameters,biochemical parameters(amylase and lipase),nuclear factor-κB,aspirin triggered lipoxins and parameters related to the antioxidant system(malondialdehyde,nitric oxide,hemeoxygenase-1,catalase and superoxide dismutase) were ***:Cerulein administration induced mild pancreatitis,characterized by interstitial edema(total histopathological score of 5.88 ± 0.44vs 0.25 ± 0.16,P < 0.001).Subsequent pancreatic tissue damage resulted in an increase in amylase(2829.71 ± 772.48 vs 984.57 ± 49.22 U/L,P = 0.001) and lipase(110.14 ± 75.84 U/L vs 4.71 ± 0.78 U/L,P < 0.001) in plasma,and leucocytes(6.89 ± 0.48 vs 4.36 ± 0.23,P = 0.001) in peripheral ***,IL-1β(18.81 ± 2.55 pg/μg vs 6.65 ± 0.24 pg/μg,P = 0.002) and IL-6(14.62 ± 1.98 pg/μg vs 9.09 ± 1.36 pg/μg,P = 0.04) in pancreatic tissue also *** pretreatment reduced the increase in the aforementioned parameters to a certain degree and partially i

关键词： Aspirin Acute pancreatitis Cerulein Antioxidant Cytokines

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