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Journal of Biosciences and Medicines 2015年第11期3卷 33-41页

作者： Motoki Sakai daming wei Faculty of Policy Informatics Chiba University of Commerce Chiba Japan Tohoku University Graduate School of Medicine Miyagi Japan

Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder. It has been reported that approximately 40% of patients with moderate or severe OSAS die within the first eight years of disease. In hospitals, OSAS is inspected using polysomnography, which uses a number of sensors. Because of the cumbersome nature of this polysomnography, an initial OSAS screening is usually conducted. In recent years, OSAS screening techniques using Holter electrocardiogram (ECG) have been reported. However, the techniques so far reported cannot perform an OSAS severity assessment. The present study presents a new method to distinguish the obstructive sleep apnea (OSA) and non-OSA epochs at one-second intervals based on the Apnea Hypopnea Index assessment, defined as the duration of continuous apnea. In the proposed method, the time-frequency components of the heart rate variability and three ECG-derived respiration signals calculated by the complex Morlet wavelet transformation are adopted as features. A support vector machine is employed for classification. The proposed method is evaluated using three eight-hour ECG recordings containing OSA episodes from three subjects. As a result, the sensitivity and specificity of classification are found to reach approximately 90%, a level suitable for OSAS screening in clinical settings.

关键词： Obstructive Sleep Apnea Syndrome Heart Rate Variability ECG-Derived Respiration Complex Morlet Wavelet Transformation Support Vector Machine

Gamma-ray Bursts:Progresses at Purple Mountain Observatory

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Bulletin of the Chinese Academy of Sciences 2011年第3期25卷 192-194页

作者： wei daming FAN Yizhong Purple Mountain Observatory CAS Nanjing 210008 Key Laboratory of Dark Matter and Space Astronomy CAS Nanjing 210008

A gamma-ray burst （GRB） is an extremely luminous flash of gamma rays that occurs as the result of an explosion, and is thought to be associated with the formation of a black hole. Most GRBs are billions of light years away from Earth, implying that the explosions are both extremely energetic （a typical burst releases as much energy in a few seconds as the Sun will in its entire 10-billion-year lifetime） and extremely rare （a few per galaxy per million years）. Researches on GRBs have attracted wide attention. For experts on accretion disks,

关键词：伽玛射线爆发紫金山天文台 GRB Sun 吸积盘爆炸黑洞光年

TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation

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Oncology Research 2025年第1期33卷 161-169页

作者： XIUWANG wei JIANBO LIANG HUANWEN HUANG daming YANG XINXIN WANG XIUJIA WANG CHANGSHENG CHEN KAIQIANG LI TAISEN PANG BIN HU FENGNING WU Department of Urology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530000China Department of Rehabilitation The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530000China

Background:Transmembrane emp24 trafficking protein 3(TMED3)is associated with the development of several tumors;however,whether TMED3 regulates the progression of prostate cancer remains *** and Methods:Short hairpin RNA was performed to repress TMED3 in prostate cancer cells(DU145 cells)and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in ***:In the present study,we found that TMED3 was highly expressed in prostate cancer *** vitro,shTMED3 treatment suppressed the proliferation,invasion,and migration and promoted the apoptosis of DU145 ***,the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed a strong correlation between TMED3 and forkhead box O transcription factor(FOXO)***,TMED3 inhibition efficiently decreased FOXO1a and FOXO3a *** vivo,TMED3 downregulation suppressed the apoptosis,growth,and metastasis of prostate cancer cells via FOXO1a and ***:The present findings show that TMED3 participates in the regulation of prostate cancer progression via FOXO1a and FOXO3a phosphorylation,thereby revealing a novel mechanism underlying prostate cancer development and suggesting that TMED3 inhibition may serve as a novel strategy for prostate cancer treatment.

关键词： Prostate cancer Transmembrane emp24 trafficking protein 3(TMED3) forkhead box O transcription factor(FOXO) Proliferation Apoptosis

基于全国耕地消纳的畜禽粪便特征分布与环境承载力预警分析

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中国生态农业学报（中英文） 2020年第5期28卷 745-755页

作者：张藤丽焉莉韦大明吉林农业大学资源与环境学院长春130118 生态环境部环境规划院总量控制与排放交易研究中心北京100012

为加快畜禽养殖行业粪污资源化利用,促进畜牧业可持续发展,及时掌握畜禽粪便的特征分布,对有效防控养殖区域环境的污染尤为重要。目前多数畜禽粪便污染研究都是基于省市区域尺度,而进行全国尺度的研究相对较少。本文运用排污系数法,以... 详细信息

为加快畜禽养殖行业粪污资源化利用,促进畜牧业可持续发展,及时掌握畜禽粪便的特征分布,对有效防控养殖区域环境的污染尤为重要。目前多数畜禽粪便污染研究都是基于省市区域尺度,而进行全国尺度的研究相对较少。本文运用排污系数法,以中国畜牧年鉴数据为计算基础,估算出2016年全国31个省份畜禽粪便的产生量、污染物产生量及污染物流失量。在此基础上,分析全国2016年畜禽粪便的排放分布特征,并将不同畜种的粪尿产生量统一换算为猪粪当量,计算出单位耕地面积猪粪当量承载负荷及预警值,参照相关标准得到2016年全国各省所对应的预警级别。结果表明:2016年全国畜禽粪便总产生量为246836万t,其中牛粪产量最多,家禽粪产生量最少;所研究的31个省份中四川省、河南省、山东省的粪便产生量较多。假设产生的粪便可以利用当年的有效耕地消纳,则2016年31个省份畜禽粪便平均单位耕地面积猪粪当量承载力负荷为19.55,单位耕地面积猪粪当量预警均值为0.49。本文所测算的31个省份中大部分省份预警值处于无环境威胁预警级别(Ⅰ级),但北京市处于有环境威胁预警级别(Ⅲ级),西藏自治区处于很严重环境威胁预警级别(Ⅵ级),青海处于严重环境威胁预警级别(Ⅴ级)。根据计算得出的预警级别,各省应根据自身情况充分利用畜禽粪便资源,尤其是在预警值较高地区应及时做好畜禽养殖总量控制及污染防控。

关键词：畜禽粪污猪粪当量排污系数法耕地负荷负荷预警

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不同造水工艺参数对产水品质的影响研究

核动力工程 2018年第S2期39卷 135-137页

作者：杨松唐远辉雷超魏大明陈庆旭中国核动力研究设计院成都610213

反应堆对造水系统产水品质有严格的要求,而产水pH值和电导率是反映产水品质的重要指标。基于反应堆现有造水工艺,通过改变工造水艺参数来控制进水pH值,研究不同造水工艺参数对产水pH值及电导率的影响,由此分析并提出产水品质最优的工艺... 详细信息

反应堆对造水系统产水品质有严格的要求,而产水pH值和电导率是反映产水品质的重要指标。基于反应堆现有造水工艺,通过改变工造水艺参数来控制进水pH值,研究不同造水工艺参数对产水pH值及电导率的影响,由此分析并提出产水品质最优的工艺参数,有效保障了反应堆用水品质需求。

关键词：工艺参数电导率 pH值

基于结构分解技术的内蒙古自治区规模化畜禽养殖业减排机制研究

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环境污染与防治 2016年第5期38卷 105-109页

作者：韦大明刘雅玲陈岩环境保护部环境规划院北京100012

运用结构分解技术(SDA),构建了内蒙古自治区规模化畜禽养殖业减排机制分析模型,将规模化畜禽养殖业COD和氨氮减排分解为规模效应、结构效应和技术效应,并根据模型测算了2011—2013年各种效应的数值。测算结果表明:COD和氨氮减排总效应... 详细信息

运用结构分解技术(SDA),构建了内蒙古自治区规模化畜禽养殖业减排机制分析模型,将规模化畜禽养殖业COD和氨氮减排分解为规模效应、结构效应和技术效应,并根据模型测算了2011—2013年各种效应的数值。测算结果表明:COD和氨氮减排总效应分别为50.95%和63.41%,畜禽养殖污染排放增长趋势仍未改变;规模效应分别为77.10%和79.96%,即养殖规模扩张增加COD和氨氮的排放;结构效应分别为-0.51%和7.53%,说明养殖结构调整对COD减排有利,但未促进氨氮减排;技术效应分别为-25.64%和-24.08%,是COD和氨氮减排的主要驱动力;从养殖种类看,生猪、奶牛养殖技术减排是影响整体技术效应的关键,肉鸡养殖的污染物去除率有所降低,需要推动减排工程并加强监管。

关键词：结构分解技术规模化畜禽养殖业减排机制

一维水质模型结合改进的输出系数法在流域非点源污染负荷估算中的应用

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吉林大学学报（地球科学版） 2021年第2期51卷 505-515页

作者：周睿王博林豪栋杨继洲韦大明吉林大学新能源与环境学院长春130021 生态环境部环境规划院北京100012

非点源污染是导致流域水体水质恶化的关键污染来源之一,为了估算流域非点源污染负荷,本文提出将一维水质模型应用于分离监测断面点源污染负荷和非点源污染负荷的方法,并结合了改进的输出系数法,以CODMn和NH3-N为代表性指标,将该模型应... 详细信息

非点源污染是导致流域水体水质恶化的关键污染来源之一,为了估算流域非点源污染负荷,本文提出将一维水质模型应用于分离监测断面点源污染负荷和非点源污染负荷的方法,并结合了改进的输出系数法,以CODMn和NH3-N为代表性指标,将该模型应用于潮河下游流域,并与传统的水文分割法结合改进的输出系数法估算非点源污染负荷的结果进行对比。结果表明,一维水质模型结合改进的输出系数法估算流域非点源CODMn和NH3-N污染负荷模拟值的纳什系数均在0.800以上,具有良好的模拟精度,同时避免了水文分割法无法较好地模拟枯水期非点源污染负荷的弊端。该方法在运用SWAT (soil and water assessment tool)模型预测得到水文数据的情况下,能够预测流域非点源污染负荷,作为SWAT模型对COD模拟的补充。

关键词：非点源污染一维水质模型水文分割法输出系数法 SWAT

罗哌卡因联合针刺下髎、长强穴治疗混合痔患者术后肛门坠胀及并发症临床研究

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辽宁中医杂志 2024年第1期51卷 176-178页

作者：赵艳魏大明戴红杨永晖安徽省中西医结合医院安徽合肥230000

目的探讨低浓度罗哌卡因与针刺下髎穴、长强穴用于混合痔术后对患者肛门坠胀和并发症的影响。方法选取医院2020年7月—2021年7月收治的混合痔患者160例,随机均分为两组,对照组给予低浓度罗哌卡因麻醉,观察者在此基础上针刺下髎穴和长强... 详细信息

目的探讨低浓度罗哌卡因与针刺下髎穴、长强穴用于混合痔术后对患者肛门坠胀和并发症的影响。方法选取医院2020年7月—2021年7月收治的混合痔患者160例,随机均分为两组,对照组给予低浓度罗哌卡因麻醉,观察者在此基础上针刺下髎穴和长强穴,观察者术后两组患者症状消退时间、肛门坠胀程度、炎性因子和疼痛因子水平及并发症的发生率。结果观察组患者疼痛、肛门坠胀及水肿消退时间明显低于对照组(P<0.05);不同时间的肛门坠胀评分有差异(P<0.05),与对照组比较,观察组肛门坠胀评分较低(P<0.05),观察组肛门坠胀评分变化趋势有差异(P<0.05);观察组患者肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)、P物质(SP)、5-羟色胺(5-HT)水平明显低于对照组(P<0.05);观察组并发症的发生率明显低于对照组(P<0.05)。结论混合痔患者低浓度罗哌卡因麻醉术后采用与针刺下髎穴、长强穴联合治疗能有效调节机体炎性因子和疼痛因子水平,缓解肛门坠胀,缩短症状消退时间,并有助于降低术后并发症的发生率。

关键词：混合痔罗哌卡因针刺治疗肛门坠胀长强穴下髎穴

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Science with the 2.5-meter Wide Field Survey Telescope(WFST)

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Science China(Physics,Mechanics & Astronomy) 2023年第10期66卷 155-202页

作者： Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang daming wei Junjie wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao Department of Astronomy University of Science and Technology of ChinaHefei 230026China Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230026China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China National Astronomical Observatory of Japan National Institutes of Natural SciencesTokyo 181-8588Japan

The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky.

关键词： optical telescope time domain astronomy photometric survey supernovae multi-messenger events tidal disruption event

基于SWAT模型对武烈河流域不同水期的水环境治理项目效益分析研究

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环境污染与防治 2016年第7期38卷 99-103,109页

作者：赵翠平白辉赵琰鑫韦大明陈岩环境保护部环境规划院北京100012

基于SWAT模型,以武烈河流域为例,研究流域不同类型水环境治理项目在不同水期的环境效益净值,为流域优化管理提供技术支持。结果表明:水环境治理对考核断面水质的改善情况,在不同水期存在一定的差异性。丰水期的COD和氨氮是枯水期的2~16... 详细信息

基于SWAT模型,以武烈河流域为例,研究流域不同类型水环境治理项目在不同水期的环境效益净值,为流域优化管理提供技术支持。结果表明:水环境治理对考核断面水质的改善情况,在不同水期存在一定的差异性。丰水期的COD和氨氮是枯水期的2~16倍,是平水期的1~3倍;平水期的COD和氨氮是枯水期的1~8倍。在枯水期和平水期,城镇生活污染治理项目对雹神庙断面COD和氨氮的改善贡献程度最大;在丰水期,农村面源污染治理项目对雹神庙断面COD和氨氮的改善贡献程度最大。

关键词： SWAT模型武烈河流域水期环境效益