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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.pears. W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Neuronal and endothelial transglutaminase-2 expression in experimental autoimmune encephalomyelitis and multiple sclerosis

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Neural Regeneration Research 2022年第7期17卷 1471-1472页

作者： damien d.pears. Mousumi Ghosh Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA department of Neurological Surgery University of Miami Miller School of MedicineMiamiFLUSA Neuroscience Program Interdisciplinary Stem Cell InstituteUniversity of Miami Miller School of MedicineMiamiFLUSA department of Veterans Affairs Veterans Affairs Medical CenterMiamiFLUSA

Multiple sclerosis(MS)is a neurological condition characterized by the disruption of the blood-brain barrier,immune system activation,and infla mmation that is accompanied by glial reactivity,neuronal cell death,axon demyelination,and *** changes result in functional loss including paralysis,migraine,vision problems,spasticity,and neuropathic pain.

关键词： sclerosis paralysis autoimmune

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Multiple origin of the lichenicolous life habit in Helotiales,based on nuclear ribosomal sequences

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Fungal diversity 2015年第1期70卷 55-72页

作者： Ave Suija damien Ertz James d.Lawrey Paul diederich Institute of Ecology and Earth Sciences University of Tartu40 Lai st.EE-51005 TartuEstonia département Bryophytes et Thallophytes Jardin botanique national de BelgiqueDomaine de BouchoutB-1860 MeiseBelgium department of Environmental Science and Policy George Mason UniversityMSN 5G810900 University BoulevardManassasVA 20110-2203USA Musée national d’historie naturelle 25 rue MunsterL-2160 LuxembourgLuxembourg

The Helotiales are an ecologically and morphologically highly diverse group of ascomycetes that also includes lichen-inhabiting(lichenicolous)*** generated sequence data of three rdNA regions(nuSSU,nuLSU,5.8S of ITS)from 28 lichenicolous specimens representing nine genera in order to determine their phylogenetic *** on the most complete dataset of helotialean fungi to date,the analyses were performed using Maximum Likelihood(ML)and Bayesian *** results suggest that 1)the lichen-inhabiting life-style in Helotiales was subjected to gains or losses at least three times;2)Thamnogalla,previously tentatively included in Ostropales,is shown to belong to Helotiales;3)ascomata found intermixed with pycnidia of the asexual diplolaeviopsis ranula and possessing the same pigments are tentatively considered as the sexual morph of this taxon,and are shown to belong to Helotiales;4)the lichenicolous species of ***,Llimoniella,Rhymbocarpus,Skyttea,Thamnogalla and Unguiculariopsis form a well-supported clade together with non-lichenicolous encoelioid fungi from the genera Ionomidotis,Cordierites and Encoelia;5)Geltingia associata forms a highly supported clade with the fungicolous asexual fungus Eleutheromyces subulatus,whereas Pezizella epithallina clusters with an aquatic asexual fungus Tetracladium sp.;6)Phaeopyxis punctum belongs to Ostropomycetidae(Lecanoromycetes),but its deep relationships to other groups remain unresolved based on rdNA sequences.

关键词： Convergence Helotiales rdNA Taxonomy diplolaeviopsis Geltingia Llimoniella Pezizella Phaeopyxis Rhymbocarpus Skyttea Thamnogalla Unguiculariopsis

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Carbamylated lipoproteins in diabetes

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World Journal of diabetes 2023年第3期14卷 159-169页

作者： damien denimal department of Biochemistry University Hospital of DijonDijon 21079France INSERM LNC UMR1231 University of BurgundyDijon 21078France

diabetic dyslipidemia is characterized by quantitative and qualitative abnormalities in *** addition to glycation and oxidation,carbamylation is also a post-translational modification affecting lipoproteins in *** with type 2 diabetes(T2d)exhibit higher levels of carbamylated low-density lipoproteins(cLdL)and high-density lipoproteins(cHdL).Accumulating evidence suggests that cLdL plays a role in atherosclerosis in *** levels have been shown to predict cardiovascular events and all-cause *** facilitates immune cell recruitment in the vascular wall,promotes accumulation of lipids in macrophages,and contributes to endothelial dysf-unction,endothelial nitric oxide-synthase(eNOS)inactivation and endothelial repair ***,cLdL induces thrombus formation and platelet *** the other hand,recent data have demonstrated that cHdL serum level is independently associated with all-cause and cardiovascular-related mortality in T2d *** relationship may be causative since the atheroprotective properties of HdL are altered after ***,cHdL loses the ability to remove cholesterol from macrophages,to inhibit monocyte adhesion and recruitment,to induce eNOS activation and to inhibit *** together,it seems very likely that the abnormalities in the biological functions of LdL and HdL after carbamylation contribute to atherosclerosis and to the elevated cardiovascular risk in diabetes.

关键词： Carbamylation Lipoprotein diabetes Low-density lipoprotein High-density lipoprotein Myeloperoxidase

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Gym-ANM: Reinforcement learning environments for active network management tasks in electricity distribution systems

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Energy and AI 2021年第3期5卷 171-193页

作者： Robin Henry damien Ernst School of Engineering Sanderson BuildingThe University of EdinburghEdinburgh EH93FBUK department of Electrical Engineering and Computer Science Montefiore InstituteUniversity of LiegeLiege B-4000Belgium

Active network management(ANM)of electricity distribution networks include many complex stochastic sequential optimization *** problems need to be solved for integrating renewable energies and distributed storage into future electrical *** this work,we introduce Gym-ANM,a framework for designing reinforcement learning(RL)environments that model ANM tasks in electricity distribution *** environments provide new playgrounds for RL research in the management of electricity networks that do not require an extensive knowledge of the underlying dynamics of such *** with this work,we are releasing an implementation of an introductory toy-environment,ANM6-Easy,designed to emphasize common challenges in *** also show that state-of-the-art RL algorithms can already achieve good performance on ANM6-Easy when compared against a model predictive control(MPC)***,we provide guidelines to create new Gym-ANM environments differing in terms of(a)the distribution network topology and param-eters,(b)the observation space,(c)the modeling of the stochastic processes present in the system,and(d)a set of hyperparameters influencing the reward ***-ANM can be downloaded at https://***/robinhenr y/gym-anm.

关键词： Gym-ANM Reinforcement learning Active network management distribution networks Renewable energy

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Molecular data resolve a new order of Arthoniomycetes sister to the primarily lichenized Arthoniales and composed of black yeasts, lichenicolous and rock-inhabiting species

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Fungal diversity 2014年第3期66卷 113-137页

作者： damien Ertz James d.Lawrey Ralph S.Common Paul diederich Jardin botanique national de Belgique Domaine de BouchoutB-1860 MeiseBelgium department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA 534 Fenton St LansingMI 48910USA P.Diederich Musée national d’histoire naturelle 25 rue MunsterL-2160 LuxembourgLuxembourg

Lichenicolous fungi belonging to the anamorphtypified genus Phaeosporobolus and to the teleomorph-typified genus Lichenostigma were isolated in pure culture or sequenced directly,with nuLSU and mtSSU sequences *** analyses place the species of Phaeosporobolusin a strongly supported clade with the generic type of Lichenostigma(***),the genus Phaeococcomyces and several melanized rock-inhabiting *** strongly supported nonlichenized lineage is sister to the primarily lichenized Arthoniales in the Arthoniomycetes and is here described as the *** new order is characterized by cells multiplying by budding,either representing black yeasts,or species in which conidiomata and ascomata are entirely made of an organised agglomeration of spherical yeast-like *** way of life is not only very different from all other Arthoniomycetes that exist only in the mycelial stage,but ascomata and conidiomata representing a dense and organised agglomeration of yeast cells might be unique amongst fungi.A further difference with the Arthoniales is the absence of *** results suggest that Phaeosporobolus usneae is the asexual stage of Lichenostigma *** species of Phaeosporobolus are transferred to the genus Lichenostigma except ***,for which the new genus Etayoa is *** genus diederimyces is reduced into synonymy with *** other members of Lichenostigma are placed in the dothideomycetes and are intermixed with Lichenothelia species.

关键词： Anamorphic fungi Arthoniomycetes dothideomycetes Lichenostigmatales Phaeococcomycetaceae Yeasts

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dismantling Melaspileaceae:a first phylogenetic study of Buelliella,Hemigrapha,Karschia,Labrocarpon and Melaspilea

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Fungal diversity 2015年第2期71卷 141-164页

作者： damien Ertz Paul diederich department Bryophytes-Thallophytes(BT) Botanic Garden MeiseNieuwelaan 38B–1860 MeiseBelgium Musée national d’histoire naturelle 25 rue MunsterL–2160 LuxembourgLuxembourg

Melaspileaceae is a heterogeneous group of Ascomycota including lichenized,lichenicolous and saprobic fungi.A first phylogenetic study of Melaspileaceae is presented and is based on mtSSU and nuLSU sequence *** obtained 49 new sequences for 28 specimens representing 15 *** genera Buelliella,Hemigrapha,Karschia,Labrocarpon and Melaspilea *** included in a molecular phylogeny for the first *** is recovered as polyphyletic,with members placed in two main lineages of *** *** included in *** is placed in synonymy with *** genus Encephalographa is placed in *** genera Buelliella,Karschia,Labrocarpon and several members of Melaspilea are demonstrated to belong to Asterinales,while Hemigrapha is confirmed in this *** genera Melaspileella,Melaspileopsis,Stictographa are reinstated for former Melaspilea species now placed in *** cezannei is described as new,and the new combinations Melaspilea costaricensis,***,***,Melaspileella proximella and Melaspileopsis diplasiospora are *** as newly defined includes lichenized and saprobic *** lichenicolous and saprobic life styles form different intermixed lineages in Asterinales that do not include lichenized *** phylogenetic data provide a first framework for dismantling further the genus Melaspilea for which most of the species are expected to belong to Asterinales.

关键词： Asterinales Eremithallales Lichenicolous fungi Phylogeny Taxonomy

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Mixed-species aggregations in arthropods

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Insect Science 2019年第1期26卷 2-19页

作者： Julien Boulay Cindy Aubernon Graeme d.Ruxton Valery Hedouin Jean-Louis deneubourg damien Charabidze CHU Lille Universite Lille 2EA 7367-UTML-Unite de Taphonomie Medico-LegaleLilleFrance School of Biology University of St. AndrewsDyers Brae HouseSt.AndrewsFifeUK Unit of Social Ecology-CP 231 Universite Libre de Bruxelles (ULB)Campus de la PlaineBoulevard du TriompheBrusselsBelgium

This review offers the first synthesis of the research on mixed-species groupings of arthropods and highlights the behavioral and evolutionary questions raised by such ***-species groups are commonly found in mammals and *** groups are also observed in a large range of arthropod taxa independent of their level of sociality. Several examples are presented to highlight the mechanisms underlying such groupings, particularly the evidence for phylogenetie proximity between members that promotes cross-species *** advantages offered by such aggregates are described and *** advantages can be attributed to the increase in group size and could be identical to those of nonmixed groupings,but competition-cooperation dynamics might also be involved,and such effects may differ between homo-and heterospecific *** discuss three extreme cases of interspecific recognition that are likely involved in mixed-species groups as vectors for cross-species aggregation:tolerance behavior between two social species,one-way mechanism in which one species is attractive to others and two-way mechanism of mutual *** shown in this review,the study of mixed-species groups offers biologists an interesting way to explore the frontiers of cooperation-competition, including the process of sympatric speciation.

关键词： collective behavior complex system cross-species recognition self-organization sociality

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Molecular data place the hyphomycetous lichenicolous genus Sclerococcum close to dactylospora (Eurotiomycetes) and S. parmeliae in Cladophialophora (Chaetothyriales)

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Fungal diversity 2013年第1期58卷 61-72页

作者： Paul diederich damien Ertz James d.Lawrey Masoumeh Sikaroodi Wendy A.Untereiner Musée national d’histoire naturelle 25 rue MunsterL-2160LuxembourgLuxembourg Jardin botanique national de Belgique Département bryophytes-thallophytesDomaine de BouchoutB-1860MeiseBelgium department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA department of Biology Brandon UniversityBrandonMB R7A 6A9Canada

The lichenicolous anamorphic fungus Sclerococcum parmeliae was isolated in pure culture,and ITS,nuLSU and mtSSU sequences were obtained from these *** comparison,sequences from ***,the generic type,were obtained directly from freshly collected *** analyses place *** with species of dactylospora and an unidentified lichen-inhabiting isolate in a strongly supported clade that is sister to a lineage comprising members of the Chaetothyriales and *** contrast,*** is inferred as a member of the Herpotrichiellaceae(Chaetothyriales)and belongs to a robustly supported clade that also includes species of Cladophialophora,Capronia semiimmersa,and Phialophora *** the Herpotrichiellaceae,*** most closely resembles members of the anamorph genus ***,we propose the transfer of *** and the morphologically similar species ***,*** and *** to Cladophialophora.A new lichenicolous species,***,collected twice on Megalospora in Florida and Papua New Guinea,is also described.

关键词： Anamorphic fungi Capronia Conidial fungi Hyphomycetes Parasitic fungi

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Thermal characterization of bio-based phase changing materials in decorative wood-based panels for thermal energy storage

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Green Energy & Environment 2019年第1期4卷 56-65页

作者： damien Mathis Pierre Blanchet Véronic Landry Philippe Lagière NSERC Industrial Research Chair on Ecoresponsible Wood Construction(CIRCERB) Laval University Engineering and Mechanics Institute University of Bordeaux Avenue D'Aquitaine

decorative wood panels containing pouches of bio-based phase changing materials(PCMs) were prepared. Three different PCM mixtures were used: a blend of capric and lauric acids as well as two commercial products, Puretemp?20 and Puretemp?23(Puretemp). The panels consist of engraved Medium density Fiberboard(MdF) filled with a plastic pouch filled with PCM. High density fiberboard(HdF) was used on top of the panels to enclose the PCM pouches. PCM mixtures were first tested by differential scanning calorimetry(dSC). Phase change temperature and total heat storage of the panels were measured for both fusion and solidification with a dynamic Heat-Flow Meter Apparatus(dHFMA). dSC and dHFMA results were compared, allowing a better understanding of results gathered from these two techniques. dSC calibration has been revealed important when assessing PCMs. The panels present a phase change temperature and a latent heat storage suitable for buildings applications. The panel made with Puretemp?23 presented the highest energy, with 57.1 J g^(-1). Thermal cycling was conducted on the panels to investigate thermal reliability, which revealed small modifications of thermal properties for two products. For all cases, latent heat was found stable. Hygro-mechanical behavior of the panels was also evaluated as these where designed to be esthetic decorative panels. This study exposes the potential of a new type of wood-based panels loaded with PCM for thermal energy storage and brings overall knowledge about PCM products thermal characterization.

关键词： PCM Wood Biosourced Fatty acids dHFMA

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