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Ventilator-associated pneumonia(VAP)and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient:A case report

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Infectious Medicine 2023年第2期2卷 143-147页

作者： Rosa Anna Passerotto Francesco Lamanna damiano farinacci Alex Dusina Simona Di Giambenedetto Arturo Ciccullo Alberto Borghetti Dipartimento di Sicurezza e Bioetica-Sezione di Malattie Infettive UniversitàCattolica del Sacro Cuore00168 RomeItaly Dipartimento di Scienze di Laboratorio e Infettivologiche Fondazione Policlinico Universitario Agostino Gemelli IRCCS00168 RomeItaly Infectious Diseases Unit San Salvatore Hospital67100 L’AquilaItaly

We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation,not vaccinated for SARS-COV-2,hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit(ICU).The hospitalization was complicated by bacteraemic ventilator-associated pneumonia(VAP)caused by multidrug-resistant Acinetobacter baumannii(MDR-AB)isolated on pleural fluid culture,treated with colistin and cefiderocol for about 3 *** molecular research of MDR-AB on transtracheal aspirate was negative following this *** aim is to show the safety,efficacy and tolerability of colistin-based combination therapy with cefiderocol for Acinetobacter baumannii infection in HIV-infected patient.

关键词： Acinetobacter baumannii colistin cefiderocol SARS-CoV-2 HIV

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Gsα^(R201C)and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells

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Bone Research 2022年第4期10卷 784-798页

作者： Biagio Palmisano Rossella Labella Samantha Donsante Cristina Remoli Emanuela Spica Ilenia Coletta Giorgia farinacci Michele Dello Spedale Venti Isabella Saggio Marta Serafini Pamela Gehron Robey Alessandro Corsi Mara Riminucci Department of Molecular Medicine Sapienza University of RomeRome 00161Italy Tettamanti Research Center Department of PediatricsUniversity of Milano Bicocca/Fondazione MBBMMonza 20900Italy Department of Biology and Biotechnology Sapienza University of RomeRome 00185Italy Institute of Structural Biology and School of Biological Sciences Nanyang Technological University 639798 SingaporeSingapore CNR Institute of Molecular Biology and Pathology Piazzale Aldo Moro 5Rome 00185Italy Skeletal Biology Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthDepartment of Health and Human ServicesBethesdaMD 20892USA

The Gsα/cAMP signaling pathway mediates the effect of a variety of hormones and factors that regulate the homeostasis of the post-natal ***,the dysregulated activity of Gsαdue to gain-of-function mutations (R201C/R201H)results in severe architectural and functional derangements of the entire bone/bone marrow *** the consequences of gain-of-function mutations of Gsαhave been extensively investigated in osteoblasts and in bone marrow osteoprogenitor cells at various differentiation stages,their effect in adipogenically-committed bone marrow stromal cells has remained *** generated a mouse model with expression of Gsα^(R201C) driven by the Adiponectin(Adq)***-Gsα^(R201C) mice developed a complex combination of metaphyseal,diaphyseal and cortical bone *** the metaphysis,Gsα^(R201C) caused an early phase of bone resorption followed by bone *** bone formation was sustained by cells that were traced by Adq-Cre and eventually resulted in a high trabecular bone mass *** the diaphysis,Gsα^(R201C),in combination with estrogen,triggered the osteogenic activity of Adq-Cre-targeted perivascular bone marrow stromal cells leading to intramedullary bone ***,consistent with the previously unnoticed presence of Adq-Cre-marked pericytes in intraosseous blood vessels,Gsα^(R201C) caused the development of a lytic phenotype that affected both cortical(increased porosity)and trabecular(tunneling resorption)*** results provide the first evidence that the Adq-cell network in the skeleton not only regulates bone resorption but also contributes to bone formation,and that the Gsα/cAMP pathway is a major modulator of both functions.

关键词： estrogen sustained skeleton

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编制铝土矿长期开采计划的计算机辅助过程

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轻金属 1984年第10期 53-54+57页

作者： M.L.farinacci 陈志珍

引言正如大多数生产活动一样,计划职能也是任何采矿工作不可缺少的一部分。一般有两种不同期限的计划:一种是适用于几星期的短期计划,另一种是为确立生产管理的五年或五年以上的长期计划。这种长期计划不仅用于圈定

关键词：编制数学模型试验模型制约条件铝土矿铝矿物矿石品位采区盘区目标函数矿床矿藏计算机辅助机助

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