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Gastrointestinal microbiota:A predictor of COVID-19 severity?

World Journal of Gastroenterology 2022年第45期28卷 6328-6344页

作者： maria Adriana Neag damiana-maria vulturar Diana Gherman Codrin-Constantin Burlacu Doina Adina Todea Anca Dana Buzoianu Department of Pharmacology Toxicology and Clinical PharmacologyIuliu Hațieganu University of Medicine and PharmacyCluj-Napoca 400337Romania Department of Pneumology Iuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 400332Romania Department of Radiology Iuliu Hațieganu University of Medicine and PharmacyCluj-Napoca 400347Romania Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca 400347Romania

Coronavirus disease 2019(COVID-19),caused by a severe acute respiratory syndrome coronavirus 2 infection,has raised serious concerns worldwide over the past 3 *** severity and clinical course of COVID-19 depends on many factors(e.g.,associated comorbidities,age,etc)and may have various clinical and imaging findings,which raises management *** microbiota composition is known to influence respiratory disease,and respiratory viral infection can also influence gut *** and lung microbiota and their relationship(gut-lung axis)can act as modulators of *** the intestinal microbiota,by improving its composition and diversity through nutraceutical agents,can have a positive impact in the prophylaxis/treatment of COVID-19.

关键词： Gut microbiota COVID-19 Prognostic biomarkers Gut-lung axis Probiotics Nutraceuticals

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genetic studies in irritable bowel syndrome-status quo

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World Journal of Meta-Analysis 2018年第1期6卷 1-8页

作者： Stefan-Lucian Popa Dan L Dumitrascu Romana vulturar Beate Niesler Department of 2~(nd) Medical "Iuliu Hatieganu" University of Medicine and Pharmacy Department of Cell and Molecular Biology "Iuliu Hatieganu" University of Medicine and Pharmacy Department of Human Molecular Genetics Heidelberg University

AIM To evaluate the most common studied genetic polymorphisms that may have an etiological role in irritable bowel syndrome (IBS).METHODS The data base Pub Med was searched for studies analyzing the association between gene polymorphisms and IBS. All original full papers, written in English, were retained for further analysis. The retrieved papers were further systematized according to those polymorphisms that have been detected in *** Considering these criteria, our literature search found 12 polymorphisms, residing in 10 genes, which were reported to be consistently associated with IBS. The initial search identified 189 articles, out of which 48 potentially appropriate articles were reviewed. Of these 48 articles, 41 articles were included in the review. These articles were published between 2002 and 2016. Out of these 41 studies, 17 reported analysis of the serotonin transporter (SERT) gene (SLC6A4), eight on guanine nucleotide-binding protein subunit beta-3 (GNbeta3), six on the serotonin type 3 receptor genes (HTR3A), four on (HTR3E), three on (HTR2A), three the tumor necrosis factor superfamily member TL1A gene (TNFSF15), and ten on genetic polymorphisms with limited *** Current evidence for the relation between genetic polymorphisms and IBS is limited owing to the fact that high-quality prospective studies and detailed phenotyping of patients suffering from IBS and matched controls were lacking in the past.

关键词： Irritable bowel syndrome Gene Genetic polymorphisms

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