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Neurodegenerative diseases as proteinopathies-driven immune disorders

Neural Regeneration Research 2020年第5期15卷 850-856页

作者： Fausta Ciccocioppo Giuseppina Bologna Eva Ercolino Laura Pierdomenico Pasquale Simeone Paola Lanuti damiana pieragostino Piero Del Boccio Marco Marchisio Sebastiano Miscia Department of Medicine and Aging Science University “G. d’Annunzio” of Chieti-PescaraChietiItaly Centre on Aging Sciences and Translational Medicine (Ce.S.I-MeT) University “G. d’Annunzio” of Chieti-PescaraChietiItaly Department of Medical Oral and Biotechnological SciencesUniversity “G. d’Annunzio” of Chieti-PescaraChietiItaly

In the pathophysiology of neurodegenerative disorders,the role of misfolded protein deposition leading to neurodegeneration has been primarily *** the last decade,however,it has been proposed a parallel involvement of innate immune activation,chronic inflammation and adaptive immunity in the neurodegeneration mechanisms triggered by *** insights in the neurodegenerative field strongly suggest a role for the immune system in the pathophysiology of neurodegenerative ***,the hypothesis underlining the modulation of the innate and the adaptive immune system in the events linked to brain deposition of misfolded proteins could open new perspectives in the setting of specific immunotherapeutic strategies for the treatment of neurodegenerative ***,we have reviewed the pathogenic hypothesis in neurodegenerative pathologies,underling the links between the deposition of misfolded protein mechanisms and the immune activation.

关键词： adaptive immunity choroid plexus immunotherapy innate immunity neurodegenerative diseases neuroinflammation proteinopathies

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Risk of Upper Extremity Biomechanical Overload in Automotive Facility

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Biomedical and Environmental Sciences 2013年第1期26卷 70-75页

作者： Angela SANCINI Assunta CAPOZZELLA Tiziana CACIAR Francesco TOMEI Nadia NARDONE Barbara SCALA Maria FIASCHETTI Carlotta CETICA Lara SCIMITTO pieragostino GIOFFRè Federica SINIBALDI Claudia Di PASTENA Paola CORBOSIERO Maria Pia SCHIFANO Gianfranco TOMEI Manuela CIARROCCA University of Rome "Sapienza" Department of AnatomyHistologyMedical-Legal and OrthopedicsUnit of Occupational MedicineViale Regina Elena 33600161 RomeItaly University of Rome "Sapienza" Department of Psychiatric and Psychological SciencePiazzale Aldo Moro 500185 RomeItaly

Objective To assess the risk factors for upper extremity-work-related musculoskeletal disorders（UE-WMSD） on 13 prod ucti on lines in an airbag factory using the threshold limit values-American conference of industrial hygienists-hand activity level（TLV-ACGIH-HAL） method and introduce the ergonomic improvement to reduce the repe titi veness and the peak force（Pf）.Methods Professional exposure level on 13 production lines in a automobile factory was measured using the TLV-ACGIH-HAL method and a further risk was assessed according to the ergonomic *** The first assessment of 9 produc tion lines showed that the professional exposure level was above the TLV or HAL *** second assessment showed that the professional exposure level was below the AL limit on all production lines except 1,in which the professional exposure level was between TLV and *** The assessment of UE-WMSD-related risk can ide ntif y the riskiest emplacements and evaluate the reduc tion of risk in professional exposure through interventi ons of structuralorganizati onal type.

关键词： Repe titi ve acti vity Work-related musculoskeletal disorders Assessment of work-related risk Threshold limit values-American conference of industrial hygienists Hand activity level.

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