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Plasma-Induced Interfacial Processes in Metal Halides FTIR Gas Cell Windows

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Journal of Analysis and Testing 2023年第4期7卷 392-404页

作者： Jaka olenik Vasyl Shvalya Martina Modic Jernej Ekar Janez Kovac Uros Cvelbar James L.Walsh York Plasma Institute School of PhysicsEngineering and TechnologyUniversity of YorkYork YO105DDUK Department for Gaseous Electronics F6 Jozef Stefan Institute1000 LjubljanaSlovenia Department of Surface Engineering F4 Jozef Stefan Institute1000 LjubljanaSlovenia Jozef Stefan International Postgraduate School 1000 LjubljanaSlovenia

Fourier transform infrared spectroscopy(FTIR)is one of the most widely used vibrational diagnostic techniques to investigate gas-phase reactive oxygen and nitrogen species(RONS).However,the technique carries intrinsic challenges,particularly in relation to interfering peaks in the spectral *** study explores the interfacial processes that occur when reactive oxygen and nitrogen species generated by a non-equilibrium air plasma interact with the metal halide windows of an FTIR gas cell,leading to the appearance and evolution of spurious absorption peaks which complicate spectral *** spectroscopy,X-ray photoelectron spectroscopy,time of flight secondary ion mass spectrometry and attenuated total reflectance-FTIR spectroscopy were used to elucidate the origin of spurious absorption peaks spanning the 1400-1300 cm^(-1)spectral range as a result of KBr exposure to plasma generated *** was found that plasma exposed KBr contained a lower atomic fraction of Br which was replaced by the NO3nitrate group,the main absorbance peak of which progressively evolved with plasma exposure and affected the window transparency over the corresponding FTIR region.A correlation was revealed between KNO_(3)formation,plasma power and exposure time to a growth and change in molecular vibrational energies corresponding to asymmetric NO3stretching vibrations in the KNO_(3)structure.

关键词： Cold atmospheric-pressure plasma Gas-phase FTIR RONS IR windows Surface functionalisation KBr

Gastrointestinal microbiota:A predictor of COVID-19 severity?

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World Journal of Gastroenterology 2022年第45期28卷 6328-6344页

作者： Maria Adriana Neag damiana-Maria Vulturar Diana Gherman Codrin-Constantin Burlacu Doina Adina Todea Anca Dana Buzoianu Department of Pharmacology Toxicology and Clinical PharmacologyIuliu Hațieganu University of Medicine and PharmacyCluj-Napoca 400337Romania Department of Pneumology Iuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 400332Romania Department of Radiology Iuliu Hațieganu University of Medicine and PharmacyCluj-Napoca 400347Romania Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca 400347Romania

Coronavirus disease 2019(COVID-19),caused by a severe acute respiratory syndrome coronavirus 2 infection,has raised serious concerns worldwide over the past 3 *** severity and clinical course of COVID-19 depends on many factors(e.g.,associated comorbidities,age,etc)and may have various clinical and imaging findings,which raises management *** microbiota composition is known to influence respiratory disease,and respiratory viral infection can also influence gut *** and lung microbiota and their relationship(gut-lung axis)can act as modulators of *** the intestinal microbiota,by improving its composition and diversity through nutraceutical agents,can have a positive impact in the prophylaxis/treatment of COVID-19.

关键词： Gut microbiota COVID-19 Prognostic biomarkers Gut-lung axis Probiotics Nutraceuticals

Anticancer drug screening of natural products:In vitro cytotoxicity assays,techniques,and challenges

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Asian Pacific Journal of Tropical Biomedicine 2022年第7期12卷 279-289页

作者： Agustina Setiawati damiana Sapta Candrasari F.D.Erika Setyajati Vincentia Krisnina Prasetyo Dewi Setyaningsih Yustina Sri Hartini Faculty of Pharmacy Sanata Dharma UniversityPainganMaguwoharjoDepokSlemanYogyakarta 55282Indonesia

Natural products include several diverse compounds that have been found to be effective against *** anticancer compounds in nature is a multistep and complex process that requires pre-clinical and clinical *** a few of the available natural products are used to treat cancer since most of them have very high complexity and low ***,the process of anticancer drug discovery requires a straightforward and effective method to assess anticancer activity using in vitro *** review summarizes various cell-based assays and techniques used to measure cell viability,migration,and apoptosis,focusing in particular on the principles,mechanisms,advantages,and disadvantages of each assay to provide a preliminary platform for cancer drug discovery.

关键词： Drug discovery Cancer Natural products Screening In vitro assay Cytotoxicity Migration Apoptosis

Novel translational rat models of dopamine transporter deficiency

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Neural Regeneration Research 2018年第12期13卷 2091-2093页

作者： damiana Leo Ilya Sukhanov Raul R.Gainetdinov Department of Neurosciences University of Mons Institute of Pharmacology Pavlov Medical University Institute of Translational Biomedicine St. Petersburg State University

Dopamine （DA） is one of the brain＇s fundamental neurotransmitters. Despite the fact that the dopaminergic synapses constitute less than 1% of all brain synapses, DA is implicated in a number of critical physiological functions and in the pathogenesis of important psychiatric diseases such as schizophrenia, attention-deficit/hyperactivity disorder （ADHD）, Parkinson＇s disease （PD） and others.

关键词： DAT KO Novel translational rat models of dopamine transporter deficiency

Evidence for accuracy of pain assessment and painkillers utilization in neuropsychiatric symptoms of dementia in Calabria region,Italy

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Neural Regeneration Research 2018年第9期13卷 1619-1621页

作者： damiana Scuteri Maria Roberta Garreffa Stefania Esposito Giacinto Bagetta Maria Diana Naturale Maria Tiziana Corasaniti Preclinical and Translational Pharmacology Department of Pharmacy Health Science and NutritionUniversity of Calabria Pharmacy Unit "Mater Domini" University Hospital Department of Health Sciences University "Magna Graecia" of Catanzaro

During the clinical course of dementia,beside cognitive impairment and memory loss,a very complex challenge is posed by the neuropsychiatric symptoms（NPSs）.Accurate evaluation and treatment of pain impacts positively the agitation of demented patients aged ≥ 65 *** gather information on the utilization of pain killers in demented patients a preliminary survey has been conducted in collaboration with the Calabrian Pharmacovigilance Territorial Service of the health district of Catanzaro（Italy）.The study has taken into consideration the prescriptions of acetylcholinesterase inhibitors and memantine during the period ranging from July 2015 to June 2016 and the percentage of patients treated against pain with non steroidal antinflammatory drugs,opioids,and anticonvulsants have been *** latter have been evaluated statistically for difference between the treatment before（pre） and after（post） the settlement of acetylcholinesterase inhibitors（ACh EI） or memantine *** results do support accuracy in painkillers utilization in the course of dementia in the regional population of Calabria（Italy）.

关键词： Alzheimer's disease dementia neuropsychiatric symptoms pain appropriate prescriptions aromatherapy opioids α2δ-1 ligands

Youth Emotional Intelligence as Related to Adaptive Coping with Stress Encounters

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Psychology Research 2017年第1期7卷 1-19页

作者： Dorit olenik Shemesh The Open University of Israel Raanana Israel

Low threshold random lasing in dye-doped and strongly disordered chiral liquid crystals

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Photonics Research 2020年第5期8卷 642-647页

作者： SHAOHUA GAO JIAYI WANG WENHUA LI XUANYI YU XINZHENG ZHANG XIAO SONG ANDREY ILJIN IRENA DREVENSEK-olenik ROMANO A.RUPP JINGJUN XU The MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Institute of Applied Physics and School of PhysicsNankai UniversityTianjin 300457China Institu te of Optoelectronic Engineering College of Physics&OptoelectronicsTaiyuan University of TechnologyTaiyuan 030024China Synergetic Innovation Center of Chemical Science and Engineering Tianjin 300071China Institute of Physics National Academy of Sciences of UkraineProspect Nauki 46Kiev 03028Ukraine Faculty of Mathematics and Physics University of Ljubljana and Department of Complex MatterJ.Stefan InstituteLjubljanaSlovenia Faculty of Physics Vienna UniversityBoltzmanngasse 5A-1090 WienAustria

Random lasing was experimentally investigated in pyrromethene 597-doped strongly disordered chiral liquid crystals (CLCs) composed of the nematic liquid crystal SLC1717 and the chiral agent CB15. The concentration of the chiral agent tuned the bandgap, and disordered CLC microdomains were achieved by fast quenching of the mixture from the isotropic to the cholesteric phase. Random lasing and band edge lasing were observed synchronously, and their behavior changed with the spectral location of the bandgap. The emission band for band edge lasing shifted with the change of the bandgap, while the emission band for random lasing remained practically constant. The results show that the threshold for random lasing sharply decreases if the CLC selective reflection band overlaps with the fluorescence peak of the dye molecules and if the band edge coincides at the same time with the excitation wavelength.

关键词： lasing random dye

Neurodegenerative diseases as proteinopathies-driven immune disorders

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Neural Regeneration Research 2020年第5期15卷 850-856页

作者： Fausta Ciccocioppo Giuseppina Bologna Eva Ercolino Laura Pierdomenico Pasquale Simeone Paola Lanuti damiana Pieragostino Piero Del Boccio Marco Marchisio Sebastiano Miscia Department of Medicine and Aging Science University “G. d’Annunzio” of Chieti-PescaraChietiItaly Centre on Aging Sciences and Translational Medicine (Ce.S.I-MeT) University “G. d’Annunzio” of Chieti-PescaraChietiItaly Department of Medical Oral and Biotechnological SciencesUniversity “G. d’Annunzio” of Chieti-PescaraChietiItaly

In the pathophysiology of neurodegenerative disorders,the role of misfolded protein deposition leading to neurodegeneration has been primarily *** the last decade,however,it has been proposed a parallel involvement of innate immune activation,chronic inflammation and adaptive immunity in the neurodegeneration mechanisms triggered by *** insights in the neurodegenerative field strongly suggest a role for the immune system in the pathophysiology of neurodegenerative ***,the hypothesis underlining the modulation of the innate and the adaptive immune system in the events linked to brain deposition of misfolded proteins could open new perspectives in the setting of specific immunotherapeutic strategies for the treatment of neurodegenerative ***,we have reviewed the pathogenic hypothesis in neurodegenerative pathologies,underling the links between the deposition of misfolded protein mechanisms and the immune activation.

关键词： adaptive immunity choroid plexus immunotherapy innate immunity neurodegenerative diseases neuroinflammation proteinopathies

Diabetic retinopathy and age-related macular degeneration: a survey of pharmacoutilization and cost in Calabria, Italy

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Neural Regeneration Research 2019年第8期14卷 1445-1448页

作者： damiana Scuteri Ada Vero Mariacristina Zito Maria Diana Naturale Giacinto Bagetta Carlo Nucci Paolo Tonin Maria Tiziana Corasaniti Preclinical and Translational Pharmacology Department of Pharmacy Health Science and Nutrition University of Calabria Rende (Cosenza) Italy Pharmacy Unit "Mater Dominf* University Hospital Catanzaro Italy Department of Health Sciences University "Magna Graecia" of Catanzaro Catanzaro Italy Ophtalmology Unit Department of Experimental Medicine Univers 让 y of Rome "Tor Vergata" Rome Italy S. Anna Institute Regional Center for Serious Brain Injuries Crotone Italy

The aged population is constantly growing, thus fostering an increase in age-dependent diseases. Among these, diabetic retinopathy (DR) along with age-related macular degeneration entails progressive vision loss. Since such conditions are associated with the proliferation of novel vessels, their pharmacotherapeutic management consists of the intravitreal injection of anti-vascular endothelial growth factor drugs, able to hinder the driving of vascular proliferation prompted by vascular endothelial growth factor. The humanized anti-vascular endothelial growth factor monoclonal antibody ranibizumab provided evidence for efficacy in several trials, hence earning approval by the US Food and Drug Administration for therapeutic use in all the stages of DR. Due to the lack of epidemiologic and pharmacoeconomic evaluation in the local Calabria Region context, the present retrospective observational study focused on prevalence of DR and age-related macular degeneration, treatment and cost of therapy with ranibizumab in 870 patients arriving to clinical observation at the "Mater Domini” University Hospital in Calabria, Italy from January 2014 to June 2017. Data were extracted from the database of ophthalmology ward and subjected to statistical analysis. The results suggest that the most frequent retinal diseases are age-related macular degeneration and DR and that the use of ranibizumab has been decreasing over the 4-year study period together with the associated cost per patient which was similar for both disorders. Therefore, appropriateness of treatment with drugs other than ranibizumab needs to be assessed in this setting and deep monitoring of pharmacologic treatment for retinal diseases is necessary to prevent or delay visual acuity decrease and complete vision loss. Study procedures were performed in accordance with the "Mater Domini” University Hospital ethical standards of the responsible committee on human experimentation.

关键词： age-related macular degeneration diabetic retinopathy pharmacovigilance ranibizumab anti-VEGFs retrospective study