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Treatment strategy and therapy based on immune response in patients with gastric cancers

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2393-2395页

作者： damian jacenik Jakub Fichna Department of Cytobiochemistry Faculty of Biology and Environmental ProtectionUniversity of LodzLodz 90-236Poland Department of Biochemistry Medical University of LodzLodz 92-215Poland

In this editorial,we highlight the significance of a retrospective study“Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis”performed by Liu et *** authors utilized data collected from gastric cancer(GC)patients and assessed immunotherapy effectiveness and survival *** found significant differences in treatment *** immunotherapy seems to be a beneficial strategy for advanced GC patients,strati-fication of the data based on metastasis status may further improve treatment strategies.

关键词： Gastric cancer Metastasis Immunotherapy Treatment strategy

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G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis

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World Journal of Gastroenterology 2019年第30期25卷 4092-4104页

作者： damian jacenik Ellen J Beswick Wanda M Krajewska Eric R Prossnitz Department of Cytobiochemistry Faculty of Biology and Environmental ProtectionUniversity of LodzLodz 90-236Poland Department of Internal Medicine School of Medicineand UNM Comprehensive Cancer CenterUniversity of New MexicoAlbuquerqueNM 87131United States Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineSchool of MedicineUniversity of UtahSalt Lake CityUT 84132United States

Estrogens play important roles in the development and progression of multiple tumor *** evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly *** on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative *** is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC ***,multiple lines of evidence suggest that GPER may play an important role in colorectal *** this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC.

关键词： G protein-coupled estrogen receptor Colorectal cancer Proliferation Migration Colonic motility Inflammatory bowel disease

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