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Stem cell therapy applied for digestive anastomosis: Current state and future perspectives

World Journal of Stem Cells 2022年第1期14卷 117-141页

作者： Jacobo Trébol Tihomir Georgiev-Hristov Isabel Pascual-Miguelañez Hector Guadalajara Mariano garcía-Arranz damian garcía-olmo Servicio de Cirugía General y del Aparato Digestivo Complejo Asistencial Universitario de SalamancaSalamanca 37007Spain Departamento de Anatomía e Histología Humanas Universidad de SalamancaSalamanca 37007Spain Servicio de Cirugía General y del Aparato Digestivo Hospital General Universitario de VillalbaMadrid 28400Spain Servicio de Cirugía General y del Aparato Digestivo Hospital Universitario La PazMadrid 28046Spain Servicio de Cirugía General y del Aparato Digestivo Hospital Universitario Fundación Jiménez DíazMadrid 28040Spain Grupo de Investigación en Nuevas Terapias Instituto de Investigación Sanitaria-Fundación Jiménez DíazMadrid 28040Spain damian garcía-olmo Departamento de CirugíaUniversidad Autónoma de MadridMadrid 28029Spain Servicio de Cirugía General y del Aparato Digestivo Hospital Universitario Fundación Jiménez Díaz y Grupo Quiron-Salud MadridMadrid 28040Spain

BACKGROUND Digestive tract resections are usually followed by an *** leakage,normally due to failed healing,is the most feared complication in digestive surgery because it is associated with high morbidity and *** technical and technological advances and focused research,its rates have remained almost unchanged the last *** the last two decades,stem cells(SCs)have been shown to enhance healing in animal and human studies;hence,SCs have emerged since 2008 as an alternative to improve anastomoses *** To summarise the published knowledge of SC utilisation as a preventative tool for hollow digestive viscera anastomotic or suture *** PubMed,Science Direct,Scopus and Cochrane searches were performed using the key words“anastomosis”,“colorectal/colonic anastomoses”,“anastomotic leak”,“stem cells”,“progenitor cells”,“cellular therapy”and“cell therapy”in order to identify relevant articles published in English and Spanish during the years of 2000 to *** employing SCs,performing digestive anastomoses in hollow viscera or digestive perforation sutures and monitoring healing were finally *** lists from the selected articles were reviewed to identify additional pertinent *** Given the great variability in the study designs,anastomotic models,interventions(SCs,doses and vehicles)and outcome measures,performing a reliable meta-analysis was considered impossible,so we present the studies,their results and *** Eighteen preclinical studies and three review papers were identified;no clinical studies have been published and there are no registered clinical *** studies,mainly in rat and porcine models and occasionally in very adverse conditions such as ischaemia or colitis,have been demonstrated SCs as safe and have shown some encouraging morphological,functional and even clinical *** SCs are mostly employed,and delivery routes are mainly local

关键词： Surgical anastomosis Anastomotic leak Digestive system surgical procedure Cell transplantation Cell therapy Stem cells Tissue engineering

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Recurrent anal fistulae:Limited surgery supported by stem cells

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World Journal of Gastroenterology 2015年第11期21卷 3330-3336页

作者： damian garcia-olmo Hector Guadalajara Ines Rubio-Perez Maria Dolores Herreros Paloma de-la-Quintana Mariano garcia-Arranz Hospital Fundación Jimenez Díaz Colorectal Surgery Unit University Hospital Fundación Jiménez Díaz Colorectal Surgery Unit La Paz University Hospital Cell Therapy Laboratory University Hospital Fundación Jiménez Díaz

AIM:To study the results of stem-cell therapy under a Compassionate-use Program for patients with recurrent anal ***:Under controlled circumstances,and approved by European and Spanish laws,a Compassionate-use Program allows the use of stem-cell therapy for patients with very complex anal *** had previously undergone multiple surgical interventions that had failed to resolve the fistulae,and presented symptomatic *** intervention consisted of limited surgery(with closure of the internal opening),followed by local implant of stem cells in the fistula-tract *** expanded adipose-derived stem cells were the main cell type selected for *** first evaluation was performed on the 8th postoperative week;outcome was classified as response or partial *** one year after the intervention confirmed if complete healing of the fistula was ***:Ten patients(8 male)with highly recurrent and complex fistulae were treated(mean age:49years,range:28-76 years).Seven cases were nonCrohn’s fistulae,and three were Crohn’s-associated *** surgical attempts ranged from 3to *** patients presented with preoperative incontinence(Wexner scores of 12 and 13 points).After the intervention,six patients showed clinical response on the 8th postoperative week,with a complete cessation of suppuration from the *** patients presented a partial response,with an evident decrease in suppuration.A year later,six patients(60%)remained healed,with complete reepithelization of the external *** Wexner Scores were 0 in six *** two patients with previous incontinence improved their scores from12 to 8 points and from 13 to 5 *** adverse reactions or complications related to stem-cell therapy were reported during the study ***:Stem cells are safe and useful for treating anal *** can be achieved in severe cases,sparing fecal incontinence risk,and impr

关键词： Adipose-derived stem cells Cell therapy Compassion

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Control Valve with a Constant Inner Authority Value

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Journal of Thermal Science 2018年第5期27卷 487-495页

作者： MUNIAK damian Piotr Department of Thermal Power Engineering Cracow University of Technology

The aim of the article is to propose the method of designing double regulation control valves used in heating installations, allowing to obtain a constant value of the so-called inner authority and thus the constancy of the valve control characteristic, regardless of the pre-setting value set on the valve. The shape of the valve's regulation characteristics is one of the main factors determining the quality of the quantitative regulation, and thus the stability of the system's operation and overall operating costs. For this reason, the issue discussed in the article is important and can be applied in practical implementations of the valve sizing and the valve selection. The analysis was based on the relations binding the hydraulic resistances occurring inside the control valve, and the corresponding flow factors, using original author's proposal. The experimental verification was performed on a special measuring stand prepared for this purpose, measuring the values of the medium volume flow at a constant differential pressure, and then the results were converted into values of the flow factor, used in the proposed mathematical model. The results confirm the thesis put forward and the proposed mathematical model. High convergence of the results of experimental verification with the proposed mathematical model was obtained.

关键词： control valve valve authority pre-setting heating installation hydraulic balancing

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On Plane Stress State and Stress Free Deformation of Thick Plate with FGM Interface under Thermal Loading

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Journal of Thermal Science 2016年第5期25卷 440-448页

作者： damian Szubartowski Artur Ganczarski Department of Mechanical Engineering Institute of Applied MechanicsCracow University of Technology

This paper demonstrates the plane stress state and the stress free thermo-elastic deformation of FGM thick plate under thermal ***,the Sneddon-Lockett theorem on the plane stress state in an isotropic infinite thick plate is generalized for a case of FGM problem in which all thermo-mechanical properties are optional functions of depth *** proof is based on application of the Iljushin thermo-elastic potential to displacement type system of equations that reduces it to the plane stress state *** an existence of the purely thermal deformation is proved in two ways:first,it is shown that the unique solution fulfils conditions of simultaneous constant temperature and linear gradation of thermal expansion coefficient,second,proof is based directly on stress type system of equations which straightforwardly reduces to compatibility equations for purely thermal deformation if only stress field is homogeneous in domain and at ***,couple examples of application to an engineering problem are presented.

关键词： thick plate with FGM interface plane stress state stress free deformation

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Surgical resection of rectal adenoma:A rapid review

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World Journal of Gastroenterology 2009年第31期15卷 3851-3854页

作者： damian Casadesus Calixto garcia Hospital J and University

Transanal excision （TE）, endoscopic transanal resection （ETAR） and transanal endoscopic microsurgery （TEN） can be used to remove adenomatous polyps. However, their use is limited by the size or location of the tumor. TE is limited to the lower rectum, TEN offers better access to lesions in the middle and upper rectum, and ETAR is used less frequently than it deserves for resection of rectal lesions.

关键词： Adenoma Colorectal surgery Endoscopy Gastrointestinal Microsurgery Rectal neoplasms

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A compartmental model for antibiotic resistant,bacterial infections over networks

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International Journal of Biomathematics 2020年第1期13卷 39-54页

作者： damian AKnopoff Facundo ATrucccd Centro de Investigation y Estudios de Matematica CONICET FaMAF(UNC) CdrdobaArgentina Argentine RedCross CordobaAigentina

This paper presents a compartmental model for bacterial infections in a population distributed over a network of *** each node,individuals interact,bacteria can be transmitted and the disease may be spread;moreover,the acquisition of bacterial antibiotic resistance is *** addition,nodes are connected through weighted edges,and consequently individuals from different nodes may *** a result,the infection may be propagated over the *** perform an analysis on this propagation as well as numerical simulations in order to illustrate the validity of the model.

关键词： Epidemiology compartmental models antibiotic resistance SIR model.

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Quantum Secret Sharing with Error Correction

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Communications in Theoretical Physics 2012年第11期58卷 661-671页

作者： Aziz Mouzali Fatiha Merazka damian Markham Electronic Department National Polytechnic SchoolAlgiersAlgeria Electronic Department National Polytechnic SchoolAlgiersAlgeria 2 Electronic and Computer Enginering FacultyUniversity of Scienceand Technology Houari BoumedineAlgiersAlgeria Laboratoire Traitement et Communication de l'Information CNRS-Tlcom Paris Tech France

We investigate in this work a quantum error correction on a five-qubits graph state used for secret sharing through five noisy channels. We describe the procedure for the five, seven and nine qubits codes. It is known that the three codes always allow error recovery if only one among the sent qubits is disturbed in the transmitting channel. However, if two qubits and more are disturbed, then the correction will depend on the used code. We compare in this paper the three codes by computing the average fidelity between the sent secret and that measured by the receivers. We will treat the case where, at most, two qubits are affected in each one of five depolarizing channels.

关键词： quantum correction graph state quantum secret sharing Feynman program

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Cut stumps vs broken stumps:Does it make any difference in the maintenance of plant and lichen biodiversity in Central European mountain forests?

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Forest Ecosystems 2024年第4期11卷 457-468页

作者： Monika Staniaszek-Kik Jan Zarnowiec damian Chmura Department of Geobotany and Plant Ecology University of Lodz90-237LodzPoland Institute of Nature Protection and Engineering University of Bielsko-BialaWillowa Str 243-309Bielsko-BiałaPoland

Fxcessive forest exploitation significantly contributes to land degradation and the creation of human-made *** are sometimes ignored in studies on the biodiversity of coarse woody *** investigated whether the type of stump,*** stumps(naturally created)and cut stumps(formed during forestry operations)had an impact on the species composition and species diversity as well as due to this fact they can be characterized by plant *** research covered 728 spruce stumps(287 broken and 441 cut stumps)that were inhabited by lichens,liverworts,mosses and vascular plants in mountain forest belt(Karkonosze Mts.,Poland).The following types of microhabitats were included in the research:the upper surface and the lateral surface of a stump with both bark and *** are statistically significant compositional differences between the two types of stumps,which was demonstrated by ordination analyses and indicator species *** to the generalized linear models,the probability of occurrence increases in cut stumps in case of liverworts and vascular plants and also along the decomposition *** generalized linear mixed-effects model showed that there was a higher species richness of liverworts,mosses and vascular plants on the cut stumps and less drier but the reverse situation was in *** generalized additive models for their cover showed similar *** all of the taxonomic groups were affected by altitude both in terms of species composition and total cover on the *** concluded that cut stumps are an important type of deadwood for biodiversity and provide a convenient habitat,especially for many lichens and bryophytes.

关键词： Coarse woody debris Spruce stumps Epixylic flora Plant indicators

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In-vehicle VOCs composition of unconditioned,newly produced cars

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Journal of Environmental Sciences 2014年第5期26卷 1052-1061页

作者： Krzysztof Brodzik Joanna Faber damian Lomankiewicz Anna Golda-Kopek BOSMAL Automotive Research and Development Institute Ltd

The in-vehicle volatile organic compounds （VOCs） concentrations gains the attention of both car producers and users. In the present study, an attempt was made to determine if analysis of air samples collected from an unconditioned car cabin can be used as a quality control measure. The VOCs composition of in-vehicle air was analyzed by means of active sampling on Carbograph 1TD and Tenax TA sorbents, followed by thermal desorption and simultaneous analysis on flame ionization and mass detector （TD-GC/FID-MS）. Nine newly produced cars of the same brand and model were chosen for this study. Within these, four of the vehicles were equipped with identical interior materials and five others differed in terms of upholstery and the presence of a sunroof; one car was convertible. The sampling event took place outside of the car assembly plant and the cars tested left the assembly line no later than 24 hr before the sampling took place. More than 250 compounds were present in the samples collected; the identification of more than 160 was confirmed by comparative mass spectra analysis and 80 were confirmed by both comparison with single/multiple compounds standards and mass spectra analysis. In general, aliphatic hydrocarbons represented more than 60% of the total VOCs （TVOC） determined. Depending on the vehicle, the concentration of aromatic hydrocarbons varied from 12% to 27% of total VOCs. The very short period between car production and sampling of the in-vehicle air permits the assumption that the entire TVOC originates from off-gassing of interior materials. The results of this study expand the knowledge of in-vehicle pollution by presenting information about car cabin air quality immediately after car production.

关键词： volatile organic compounds (VOCs) car interior materials emission

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Using a fluvial archive to place extreme flood sediment(dis)connectivity dynamics in context of a longer-term record

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International Journal of Sediment Research 2022年第4期37卷 447-456页

作者： Kirstie Fryirs Chris Thompson damian Gore School of Natural Sciences Macquarie University Seqwater

The aim of this study was to establish the source and provenance of sediments deposited in a large floodplain sink during extreme floods in the Lockyer Creek catchment, Australia, in 2011 and 2013. We place the sediment source patterns in context of the longer-term record to determine whether coarsegrained sediment sources(i.e., very fine sand to very coarse sand) and the spatio-temporal pattern of(dis)connectivity have changed over time. We do this by matching the geochemical properties and age structure of a sediment profile located in a downstream floodplain sink to the elemental composition of source sediments. One hundred and fifty-seven sediment samples from 20 sites across the catchment are analysed using X-ray fluorescence(XRF) spectrometry to compare the elemental ratio composition of the downstream floodplain sink to its source materials. We use Optically Stimulated Luminescence(OSL)dating to determine the age structure of the sediments in the floodplain sink. The northern tributaries and parts of the Lockyer River trunk stream are the primary sources of coarse sediment. These areas are connected(coupled) to the lower trunk stream and floodplain sediment sink. Southern tributaries are largely disconnected(decoupled) and supply little sediment to the floodplain sediment sink. This pattern of sediment source contribution has remained similar over the last 6.8 ka at least. Sediment sources as observed in the 2011 flood have predominated over the mid-late Holocene whilst those in the 2013 flood are rare.

关键词： Sediment provenance Geomorphology Sediment source Sediment sink Lockyer Valley

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