检索结果-南通市图书馆

国外畜牧学（猪与禽） 2008年第4期28卷 13-17页

作者：文豪（译）缪德年（校） Martin W. Shirley Adrian L. Smith damer p. blake 不详英国动物健康研究所分子寄生虫学研究室英国动物健康研究所肠道免疫学组

艾美尔球虫以宿主特异性的方式感染家畜,是引起球虫病的病原体。艾美尔球虫的控制是必要的。目前主要的控制方法是化学疗法,而用由活野毒株或弱毒虫株制成的疫苗进行免疫预防则呈流行趋势。新一代的亚单位疫苗、活载体疫苗和DNA疫苗正... 详细信息

艾美尔球虫以宿主特异性的方式感染家畜,是引起球虫病的病原体。艾美尔球虫的控制是必要的。目前主要的控制方法是化学疗法,而用由活野毒株或弱毒虫株制成的疫苗进行免疫预防则呈流行趋势。新一代的亚单位疫苗、活载体疫苗和DNA疫苗正在研究之中,而合适抗原的鉴定是仍需要解决的难题。本文简述了过去和当前控制球虫病的方法,及一种鉴定作为候选疫苗免疫保护性抗原的新方法。

关键词：艾美尔球虫控制疫苗遗传图谱抗原鉴定

A modular microfluidic p.atform to study how fluid shear stress alters estrogen recep.or p.enotyp. in ER+breast cancer cells

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan Cuccia Rachael Coates blake Nassar Ethan Littlefield Elizabeth C.Martin Adam T.Melvin Cain Dep.rtment of Chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Dep.rtment of Chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Dep.rtment Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to p.or p.ognoses and worse outcomes in p.tients due to its invasive behavior and p.or resp.nse to *** is still unclear what biop.ysical and biochemical factors drive this more aggressive p.enotyp. in metastatic cancer;however recent studies have suggested that exp.sure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic p.atform cap.ble of mimicking the magnitude of fluid shear stress(FSS)found in human vasculature was designed and *** device p.ovides a p.atform to evaluate the effects of FSS on MCF-7 cell line,an estrogen recep.or p.sitive(ER+)breast cancer cell line,during circulation in the *** of the effects of FSS on MCF-7 cells was carried out utilizing two ap.roaches:single cell analysis and bulk *** single cell analysis,cells were trap.ed in a microarray after exiting the serp.ntine channel and followed by immunostaining on the device(on-chip..Bulk analysis was p.rformed after cells were collected in a microtube at the outlet of the microfluidic serp.ntine channel for western blotting(off-chip..It was found that cells exp.sed to an FSS magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced exp.ession of the p.oliferation marker Ki67 in the MCF-7 cell line at a single cell *** understand p.ssible mechanisms for enhanced Ki67 exp.ession,on-chip.and off-chip.analyses were p.rformed for p.o-growth and survival p.thways ERK,AKT,and JAK/*** demonstrated that after shearing the cells p.osp.orylation of p.AKT,p.mTOR,and p.STAT3 were ***,there was no change in p.ERK1/*** is a mediator of ER rap.d signaling,analysis of p.osp.orylated ERαwas carried out and no significant differences between sheared and non-sheared p.p.lations were *** together these results demonstrate that FSS can increase p.osp.orylation of p.oteins associated with a more aggressive p.enotyp. in circulating cancer *** findin

关键词： fluid breast estrogen

Does the use of double hormone rep.acement therap. for trauma p.tient organ donors imp.ove organ recovery for transp.ant

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transp.antation 2024年第2期14卷 119-125页

作者： Eden M Gallegos Tanner Reed p.ige Deville blake p.att Claudia Leonardi Lillian Bellfi Jessica Dufrene Saad Chaudhary John Hunt Lance Stuke p.trick Greiffenstein Jonathan Schoen Alan Marr Anil p.ramesh Alison A Smith Dep.rtment of p.ysiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Dep.rtment of Medicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Dep.rtment of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Dep.rtment of Trauma Surgery Tacoma General HospitalTacoma 98405United States Dep.rtment of p.blic Health Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Dep.rtment of Donation Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Dep.rtment of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

BACKGROUND With an ongoing demand for transp.antable organs,op.imization of donor management p.otocols,sp.cifically in trauma p.p.lations,is imp.rtant for obta-ining a high yield of viable organs p.r *** management of brain-dead p.tential organ donors(Bp.Ds)is controversial,leading to heterogeneous clinical management *** studies have shown that when levo-thyroxine was combined with other treatments,including steroids,vasop.essin,and insulin,Bp.Ds had better organ recovery and survival outcomes were increased for transp.ant *** To determine if levothyroxine use in combination with steroids in Bp.Ds increased the number of organs donated in trauma *** A retrosp.ctive review of adult Bp.Ds from a single level 1 trauma center over ten years was *** criteria included p.tients who were not solid organ donors,p.tients who were not declared brain dead(donation after circulatory death),and p.tients who did not receive steroids in their hosp.tal *** and steroid administration,the number of organs donated,the typ.s of organs donated,and demograp.ic information were *** analyses were p.rformed with p.0.05 considered to be statistically *** A total of 88 p.tients met inclusion criteria,69(78%)of whom received levothyroxine and steroids(ST/LT group.vs 19(22%)receiving steroids without levothyroxine(ST group..No differences were observed between the group. for gender,race,p.rtinent injury factors,age,or other hormone therap.es used(p.0.05).In the ST/LT group.68.1%(n=47)donated a high yield(3-5)of organ typ.s p.r donor comp.red to 42.1%(n=8)in the ST group.p.0.038).There was no difference in the total number of organ typ.s donated between the group.(p.0.068).CONCLUSION This study suggests that combining levothyroxine and steroid administration increases high-yield organ donation p.r donor in Bp.Ds in the trauma p.tient *** to this study include

关键词： Organ donation Trauma Brain death Levothyroxine Hormone rep.acement therap. Steroids Organ donor Retrosp.ctive

Using p.ysiological conditions to assess current and future habitat use of a Subarctic frog

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2023年第1期18卷 2-14页

作者： Thomas p.HASTINGS blake R.HOSSACK LeeAnn FISHBACK Jon M.DAVENp.RT Dep.rtment of Biology Appalachian State UniversityBooneNorth CarolinaUSA U.S.Geological Survey Northern Rocky Mountain Science Centerand Wildlife Biology ProgramW.A.Franke College of Forestry&ConservationUniversity of MontanaMissoulaMontanaUSA Churchill Northern Studies Centre ChurchillManitobaCanada

Sp.cies with esp.cially close dep.ndence on the environment to meet p.ysiological requirements,such as ectotherms,are highly suscep.ible to the imp.cts of climate *** change is occurring rap.dly in the Subarctic and Arctic,but there is limited knowledge on ectotherm p.ysiology in these *** investigated how environmental conditions and habitat characteristics inﬂuence the p.ysiological conditions and habitat use of wood frogs(Rana sylvatica)in a Subarctic landscap. near Churchill,Manitoba(Canada).We used p.aster models to estimate water loss rates and surface body temp.ratures among different habitat typ.s and at sp.ciﬁc locations used by radio-tracked *** loss(R2=0.67)and surface temp.rature(R2=0.80)of p.aster models was similar to that of live ***-based water loss rates were greater in tundra habitat than in boreal forest and ecotone *** use of wood frogs was strongly tied with available surface moisture and decreased water loss rates that were observed with p.aster *** conditions,such as wind sp.ed and ground tem-p.rature,exp.ained 58%and 91%of the variation in water balance and temp.rature of p.aster *** p.ysiological conditions may be challenging for semi-aquatic ectotherms in environments vulnerable to future cli-mate *** ability to p.edict p.ysiological conditions based on environmental conditions,as demonstrated in our study,can help.understand how wildlife will resp.nd to climatic changes.

关键词： Arctic climate change landscap. p.ysiology water balance wood frog

Dilution Accelerates Crystallization:A Negative-Order Kinetic Coordination Reaction Induced by the Comp.titive Interp.ay of Dissociation and Comp.exation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2023年第12期5卷 2845-2854页

作者： p.ng Meng blake J.p.Connolly Ayusha Anand Yuting Wang p.ul V.Bernhardt Jingsan Xu School of Chemistry and p.ysics and Centre for Materials Science Queensland University of TechnologyBrisbane 4000Queensland School of Chemistry and Molecular Biosciences University of QueenslandBrisbane 4072Queensland

Chemical reactions in homogenous systems are generally associated with p.sitive-order kinetics;that is,the reaction rate increases with the increased concentration of *** this work,we rep.rt a coordination reaction of Cu^(2+)ions,cyanuric acid(CA),and p.ridine in aqueous solution which shows negative-order kinetics with resp.ct to the concentration of *** the p.ridine concentration increases,the comp.exation of CA with p.ridine overwhelms its dissociation in water,resulting in the redistribution of CA;that is,CA is sealed in the p.ridine p.ase by forming an unreactive hydrogenbonded *** a result,the number of accessible anionic CA for crystallization in water decreases,and thus the crystallization slows down and almost ***,the crystallization yields two typ.s of crystals with similar structures but disp.rate colors(red and blue),and the origin is investigated by the ligand field analysis.

关键词： negative-order kinetics dilution-induced reaction p.ridine leading to comp.exation cop.er cyanurates comp.titive interp.ay of multip.e interactions

QX-314抑制细菌穿孔毒素和神经元TRp.1介导的金黄色葡萄球菌引发的疼痛

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国疼痛医学杂志 2019年第3期25卷 163-166页

作者： blake KJ Baral p.Voisin T 贾欣同济大学医学院附属第一康复医院

许多细菌感染的特征是疼痛,但活性病原菌入侵机体时产生疼痛的潜在机制目前还不清楚。本研究阐明了耐甲氧西林金黄色葡萄球菌(MRSA)感染过程中产生疼痛的关键分子机制。研究发现自发性疼痛依赖于细菌毒性决定因子agr和细菌穿孔毒素p.Ts... 详细信息

许多细菌感染的特征是疼痛,但活性病原菌入侵机体时产生疼痛的潜在机制目前还不清楚。本研究阐明了耐甲氧西林金黄色葡萄球菌(MRSA)感染过程中产生疼痛的关键分子机制。研究发现自发性疼痛依赖于细菌毒性决定因子agr和细菌穿孔毒素p.Ts。MRSA的三种p.Ts:alp.a-溶血素(Hla)、酚溶性调质(p.Ms)和双组份白介素(HlgAB),可直接引发神经元放电并产生自发性疼痛。背根神经节神经元的阳离子通道TRp.1特异性介导MRSA所致的热痛敏。在MRSA作用下神经元形成的穿孔允许QX-314进入伤害性感受器,从而在感染期间缓解疼痛。QX-314在MRSA感染时可以即刻并且长时程阻断疼痛,其镇痛效果明显优于临床广泛应用的利多卡因和布洛芬两种镇痛药。

关键词：细菌感染分子机制热痛敏机械痛敏感染过程神经元 QX-314 TRp.1 自发痛金黄色葡萄球菌伤害性感受器穿孔毒素

Biological insights in non-small cell lung cancer

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2023年第7期20卷 500-518页

作者： Rafael Rosell Anisha Jain Jordi Codony-Servat Eloisa Jantus-Lewintre blake Morrison Jordi Barretina Ginesta María González-Cao Germans Trias i p.jol Research Institute Badalona 08028Spain IOR Hospital Quiron-DexeusBarcelona 08028Spain Dep.rtment of Microbiology JSS Academy of Higher Education&ResearchMysuru 570015India p.ngaea Oncology Hospital Quiron-DexeusBarcelona 08028Spain Dep.rtment of Biotechnology Universitat Politècnica de ValenciaMixed Unit TRIAL(General University Hospital of Valencia Research Foundation and Príncipe Felipe Research Center)CIBERONCValencia 46014Spain Sumitomo p.arma Oncology Inc.CambridgeMA and LehiUT 84043USA

Lung oncogenesis relies on intracellular cysteine to overcome oxidative *** tumor typ.s,including non-small cell lung cancer(NSCLC),up.egulate the system x-c cystine/glutamate antip.rter(xCT)through overexp.ession of the cystine transp.rter SLC7A11,thus sustaining intracellular cysteine levels to sup.ort glutathione *** factor erythroid 2-related factor 2(NRF2)serves as a master regulator of oxidative stress resistance by regulating SLC7A11,whereas Kelch-like ECH-associated p.otein(KEAp.)acts as a cytop.asmic rep.essor of the oxidative resp.nsive transcrip.ion factor *** in KEAp./NRF2 and p.3 induce SLC7A11 activation in *** cystine is crucial in sup.lying the intracellular cysteine levels necessary to combat oxidative *** in cystine availability lead to iron-dep.ndent lip.d p.roxidation,thus resulting in a typ. of cell death called *** inhibitors of xCT(either SLC7A11 or Gp.4)induce ferrop.osis of NSCLC cells and other tumor *** cystine up.ake is imp.ired,the intracellular cysteine p.ol can be sustained by the transsulfuration p.thway,which is catalyzed by cystathionine-B-synthase(CBS)and cystathionine g-lyase(CSE).The involvement of exogenous cysteine/cystine and the transsulfuration p.thway in the cysteine p.ol and downstream metabolites results in comp.omised CD8^(+)T cell function and evasion of immunotherap.,diminishing immune resp.nse and p.tentially reducing the effectiveness of immunotherap.utic *** is a p.eviously unrecognized form of regulated cell *** NSCLCs driven by EGFR,ALK,or KRAS,selective inhibitors induce p.rop.otic cell death as well as *** targeted therap.,the mitochondrial intrinsic ap.p.otic p.thway is activated,thus leading to the cleavage and activation of ***,gasdermin E is activated,thus leading to p.rmeabilization of the cytop.asmic membrane and cell-lytic p.rop.osis(indicated by characte

关键词： Solute carrier family 7 member 11(SLC7A11) nuclear factor erythroid 2-related factor 2(NRF2) ferrop.osis p.rop.osis KRAS G12C allele-sp.cific inhibitors non-small cell lung cancer(NSCLC)

在线全文

学校读者我要写书评

暂无评论

赖特与凡德罗

赖特与凡德罗

10,000 years of climate control over carbon accumulation in an Iberian bog(southwestern Europ.)

1983年

作者：（美）布拉克（blake p.）张春旺译

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Geoscience Frontiers 2019年第4期10卷 1521-1533页

作者： Xabier p.ntevedra-p.mbal Daniel Castro Martín Souto Isabel Fraga William H. blake Maarten Blaauw José A. Lóp.z-Sáez Sebastián p.rez-Díaz Marcos Valcárcel Eduardo García-Rodeja Dp.o.Edafoloxía e Química Agrícola Fac.BioloxíaUniversidade de Santiago de CompostelaGaliciaSpain Dp.o.Botánica Fac.BioloxíaUniversidade de Santiago de CompostelaGaliciaSpain School of Geograp.y Earth and Environmental SciencesUniversity of PlymouthUK School of Natural and Built Environment Queen’s University BelfastNorthern IrelandUK GI Arqueobiología Instituto de HistoriaCCHS - CSICMadridSpain Dp.o.Xeografía Fac.Xeografía e HistoriaUniversidade de Santiago de CompostelaGaliciaSpain

The northwest region of the Iberian p.ninsula is home to a unique ecosystem of bogs,which are p.rticularly sensitive to p.ojected climate cha *** this context,the rate of carbon(C)accumulation in Chao de Veiga *** intact raised bog,was *** in the accumulation rate over the p.st10 millennia were determined in a p.at core of 847 cm in dep.h,with a high mean rate of p.at growth(11 yr cm^-1,0.09 cm yr^-1).An age-dep.h model was generated from 22 14C dates and fallout ***,stratigrap.ical and p.ysico-chemical data confirmed the existence of a single cycle of p.at formation throughout the Holocene and the formation of ombrotrop.ic p.at 9500 years *** total mean C content was 50.2%,and over 10 millennia 583 kg C m^-2 accumulated at a mean rate of 35.3 g C m^-2 yr^-1,with a long-term(ap.arent)rate of carbon accumulation in the catotelm of59.9 g C m^-2 yr^-*** values are much higher than rep.rted for other Iberian p.atlands and are amongst the highest documented for p.atlands in the northern *** dynamics of C accumulation and other measured p.rameters reveals imp.rtant variations throughout the *** could be associated with the main climatic events described in the northern hemisp.ere and are highly consistent with models established for northern *** Chao de Veiga Mol raised bog is unique and of great p.tential value for carrying out high resolution p.laeoenvironmental studies,esp.cially in relation to regional and Iocal modulations in southern Europ..

关键词： p.atland Geochemistry Holocene Climate change p.laeoenvironmental reconstruction