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Protein & Cell 2024年第6期15卷 403-418页

作者： Song Xue Yuru han Fan Wu Qiao Wang Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecurityShanghai Frontiers Science Center of Pathogenic Microorganisms and InfectionSchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China

Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation *** mutations,particularly those within the receptor binding domain(RBD)of SARS-CoV-2 spike(S)protein,lead to the functional alteration in both receptor engagement and monoclonal antibody(mAb)***,we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune *** single amino acid substitutions within RBD epitopes crucial for the antibody evasion capacity may conversely weaken ACE2 binding ***,this weakened effect could be largely compensated by specific epistatic mutations,such as N501Y,thus maintaining the overall ACE2 affinity for the spike protein of all major *** predominant direction of SARS-CoV-2 evolution lies neither in promoting ACE2 affinity nor evading mAb neutralization but in maintaining a delicate balance between these two ***,this review interprets how RBD mutations efficiently resist antibody neutralization and meanwhile how the affinity between ACE2 and spike protein is maintained,emphasizing the significance of comprehensive assessment of spike mutations.

关键词： ACE2 affinity maintained

Fiber optic monitoring of an anti-slide pile in a retrogressive landslide

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 333-343页

作者： Lei Zhang Honghu Zhu Heming han Bin Shi School of Water Resources and Environment China University of GeosciencesBeijing100084China State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing100084China School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China School of Civil and Environmental Engineering Nanyang Technological University639798Singapore

Anti-slide piles are one of the most important reinforcement structures against landslides,and evalu-ating the working conditions is of great significance for landslide *** widely adopted analytical methods of pile internal forces include cantilever beam method and elastic foundation beam ***,due to many assumptions involved in calculation,the analytical models cannot be fully applicable to complex site situations,*** with multi-sliding surfaces and pile-soil interface separation as discussed *** view of this,the combination of distributed fiber optic sensing(DFOS)and strain-internal force conversion methods was proposed to evaluate the working conditions of an anti-sliding pile in a typical retrogressive landslide in the Three Gorges reservoir area,*** optical time domain reflectometry(BOTDR)was utilized to monitor the strain distri-bution along the ***,by analyzing the relative deformation between the pile and its adjacent inclinometer,the pile-soil interface separation was ***,the internal forces of the anti-slide pile were derived based on the strain-internal force conversion *** to the ratio of calculated internal forces to the design values,the working conditions of the anti-slide pile could be *** results demonstrated that the proposed method could reveal the deformation pattern of the anti-slide pile system,and can quantitatively evaluate its working conditions.

关键词： Anti-slide pile Multi-sliding surface Pile-soil interface Brillouin optical time domain reflectometry (BOTDR) Geotechnical monitoring Reservoir landslide

An Interpolation Method for Karhunen-Loève Expansion of Random Field Discretization

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工程与科学中的计算机建模(英文) 2024年第1期138卷 245-272页

作者： Zi han Zhentian Huang Department of Engineering Mechanics Hohai UniversityNanjing211100China College of Civil and Transportation Engineering Shenzhen UniversityGuangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and UtilizationInstitute of Deep Earth Sciences and Green EnergyShenzhenChina

In the context of global mean square error concerning the number of random variables in the representation,the Karhunen–Loève(KL)expansion is the optimal series expansion method for random field *** computational efficiency and accuracy of the KL expansion are contingent upon the accurate resolution of the Fredholm integral eigenvalue problem(IEVP).The paper proposes an interpolation method based on different interpolation basis functions such as moving least squares(MLS),least squares(LS),and finite element method(FEM)to solve the *** with the Galerkin method based on finite element or Legendre polynomials,the main advantage of the interpolation method is that,in the calculation of eigenvalues and eigenfunctions in one-dimensional random fields,the integral matrix containing covariance function only requires a single integral,which is less than a two-folded integral by the Galerkin *** effectiveness and computational efficiency of the proposed interpolation method are verified through various one-dimensional ***,based on theKL expansion and polynomial chaos expansion,the stochastic analysis of two-dimensional regular and irregular domains is conducted,and the basis function of the extended finite element method(XFEM)is introduced as the interpolation basis function in two-dimensional irregular domains to solve the IEVP.

关键词： Random field discretization KL expansion IEVP MLS FEM stochastic analysis

Aggregation-regulated bioreduction process of graphene oxide by Shewanella bacteria

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Chinese Journal of Chemical Engineering 2024年第5期69卷 56-62页

作者： Kaixin han Yibo Zeng Yinghua Lu Ping Zeng Liang Shen Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Chinese Research Academy of Environmental Sciences Beijing 100012China

The bioreduction of graphene oxide(GO)using environmentally functional bacteria such as Shewanella represents a green approach to produce reduced graphene oxide(rGO).This process differs from the chemical reduction that involves instantaneous molecular *** bioreduction,the contact of bacterial cells and GO is considered the rate-limiting *** reveal how the bacteria-GO integration regulates rGO production,the comparative experiments of GO and three Shewanella strains were carried ***-transform infrared spectroscopy,X-ray photoelectron spectroscopy,Raman spectroscopy,and atomic force microscopy were used to characterize the reduction degree and the aggregation *** results showed that a spontaneous aggregation of GO and Shewanella into the condensed entity occurred within 36 h.A positive linear correlation was established,linking three indexes of the aggregation potential,the bacterial reduction ability,and the reduction degree(ID/IG)comprehensively.

关键词： Graphene oxide Reduced graphene oxide Bioreduction Aggregation Shewanella

Galerkin-based quasi-smooth manifold element(QSME)method for anisotropic heat conduction problems in composites with complex geometry

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 137-154页

作者： Pan WANG Xiangcheng han Weibin WEN Baolin WANG Jun LIANG School of Civil Engineering Central South UniversityChangsha 410083China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China School of Science Harbin Institute of TechnologyShenzhen 518055Guangdong ProvinceChina

The accurate and efficient analysis of anisotropic heat conduction problems in complex composites is crucial for structural design and performance evaluation. Traditional numerical methods, such as the finite element method(FEM), often face a trade-off between calculation accuracy and efficiency. In this paper, we propose a quasi-smooth manifold element(QSME) method to address this challenge, and provide the accurate and efficient analysis of two-dimensional(2D) anisotropic heat conduction problems in composites with complex geometry. The QSME approach achieves high calculation precision by a high-order local approximation that ensures the first-order derivative *** results demonstrate that the QSME method is robust and stable, offering both high accuracy and efficiency in the heat conduction analysis. With the same degrees of freedom(DOFs), the QSME method can achieve at least an order of magnitude higher calculation accuracy than the traditional FEM. Additionally, under the same level of calculation error, the QSME method requires 10 times fewer DOFs than the traditional FEM. The versatility of the proposed QSME method extends beyond anisotropic heat conduction problems in complex composites. The proposed QSME method can also be applied to other problems, including fluid flows, mechanical analyses, and other multi-field coupled problems, providing accurate and efficient numerical simulations.

关键词： anisotropic heat conduction quasi-smooth manifold element(QSME) composite with complex geometry numerical simulation finite element method(FEM)

Electrolyte-gated SrCoO_(x) FET sensor for highly sensitive detecting pH in extreme alkalinity solution

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Nano Research 2024年第4期17卷 3079-3086页

作者： han Zhou Gaocan Qi Wenbin Li Yuhang Wang Zhihao Yuan School of Materials Science and Engineering Tianjin Key Lab of Photoelectric Materials&Devicesand Key Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)Tianjin University of TechnologyTianjin 300384China

The pH monitoring is significantly important in chemical industry,biological process,and pollution ***,it remains a great challenge to measure pH in extreme alkalinity ***,we employ an electrolyte-gated field-effect-transistor(FET)strategy using non-stoichiometric SrCoO_(x) with rich oxygen-vacancy defects as channel materials for detecting extreme *** corresponding channel can provide effective oxygen-ion-migration sites for reversible transformation of OH-↔O_(2)-+H^(+)driven by electric *** resultant electrolyte-gated FET sensor exhibits a sensitive linear response to high concentrations of alkaline solution,1–20 ***,the sensor has the ability to directly indicate the pH values ranging from 14.0 to 17.0 in consideration of ion-activity coefficient *** work offers a great possibility for directly detecting base concentration as well as pH values in extreme alkaline solutions.

关键词： field-effect-transistor(FET) pH sensor extreme alkaline solution SrCoO_(x) oxygen-ion migration

Ballistic target recognition based on multiple data representations and deep-learning algorithms

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Chinese Journal of Aeronautics 2024年第6期37卷 167-181页

作者： Lixun han Cunqian FENG Xiaowei HU Sisan HE Xuguang XU Air and Missile Defense College Air Force Engineering UniversityXi’an 710051China College of Information and Communication National University of Defense TechnologyWuhan 430010China

Target recognition is a significant part of a Ballistic Missile Defense System(BMDS).However,most existing ballistic target recognition methods overlook the impact of data representation on recognition *** paper focuses on systematically investigating the influences of three novel data representations in the Range-Doppler(RD)***,the Radar Cross Section(RCS)and micro-Doppler(m-D)characteristics of a cone-shaped ballistic target are ***,three different data representations are proposed:RD data,RD sequence tensor data,and RD trajectory *** accommodate various data inputs,deep-learning models are designed,including a two-Dimensional Residual Dense Network(2D RDN),a three-Dimensional Residual Dense Network-Gated Recurrent Unit(3D RDN-GRU),and a Dynamic Trajectory Recognition Network(DTRN).Finally,an Electromagnetic(EM)computation dataset is collected to verify the performances of the networks.A broad range of experimental results demonstrates the effectiveness of the proposed ***,several key parameters of the proposed networks and datasets are extensively studied in this research.

关键词： Ballistic target Micro-Doppler Deep learning Range-Doppler Radar target recognition

Melt flow,heat transfer and solidification in a flexible thin slab continuous casting mold with vertical-combined electromagnetic braking

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Journal of Iron and Steel Research International 2024年第2期31卷 401-415页

作者： Lin Xu Ze-feng han Christian Karcher En-gang Wang Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang110819LiaoningChina Key Laboratory of Liaoning Province for Clean Combustion Power Generation and Heating Technology Shenyang Institute of EngineeringShenyang110136LiaoningChina Institute of Thermodynamics and Fluid Mechanics Technische Universität IlmenauIlmenau98684Germany

During continuous casting of steel slabs,the application of electromagnetic braking technology(EMBr)provides an effective tool to influence solidification by controlling the pattern of melt flow in the ***,the quality of the final product can be improved considerably.A new electromagnetic braking(EMBr)method,named vertical-combined electromagnetic braking(VC-EMBr),is proposed to be applied to a flexible thin slab casting(FTSC)*** evaluate the beneficial effects of the VC-EMBr,the melt flow,heat transfer,and solidification processes in the FTSC mold are studied by means of numerical *** detail,a Reynolds-averaged Navier–Stokes turbulence model together with an enthalpy-porosity approach was *** numerical findings are compared with respective simulations using the traditional *** results demonstrate that the application of the VC-EMBr contributes significantly to preventing relative slab *** contrast to the Ruler-EMBr,the additional vertical magnetic poles of the VC-EMBr preferentially suppress the direct impact of jet flow on the narrow face of FSTC mold and considerably diminish the level fluctuation near the meniscus *** instance,by applying a magnetic flux density of 0.3 T,the maximum amplitude of meniscus deflection reduces by about 80%.Moreover,the braking effect of the VC-EMBr effectively improves the homogeneity of temperature distribution in the upper recirculation region and increases the solidified shell thickness along the casting *** this basis,the newly proposed VC-EMBr shows a beneficial effect in preventing relative slab defects for FTSC thin slab continuous casting.

关键词： Electromagnetic braking Mold Melt flow Heat transfer Solidification

A non-probabilistic reliability topology optimization method based on aggregation function and matrix multiplication considering buckling response constraints

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 321-336页

作者： Lei WANG Yingge LIU Juxi HU Weimin CHEN Bing han Institute of Solid Mechanics School of Aeronautic Science and EngineeringBeihang UniversityBeijing 100191China Aircraft and Propulsion Laboratory Ningbo Institute of TechnologyBeihang UniversityNingbo 315100Zhejiang ProvinceChina State Key Laboratory of Navigation and Safety Technology Shanghai Ship and Shipping Research InstituteShanghai 200135China National Engineering Research Center of Ship&Shipping Control System Shanghai Ship and Shipping Research InstituteShanghai 200135China

A non-probabilistic reliability topology optimization method is proposed based on the aggregation function and matrix *** expression of the geometric stiffness matrix is derived,the finite element linear buckling analysis is conducted,and the sensitivity solution of the linear buckling factor is *** a specific problem in linear buckling topology optimization,a Heaviside projection function based on the exponential smooth growth is developed to eliminate the gray *** aggregation function method is used to consider the high-order eigenvalues,so as to obtain continuous sensitivity information and refined structural *** cyclic matrix programming,a fast topology optimization method that can be used to efficiently obtain the unit assembly and sensitivity solution is *** maximize the buckling load,under the constraint of the given buckling load,two types of topological optimization columns are *** variable density method is used to achieve the topology optimization solution along with the moving asymptote optimization *** vertex method and the matching point method are used to carry out an uncertainty propagation analysis,and the non-probability reliability topology optimization method considering buckling responses is developed based on the transformation of non-probability reliability indices based on the characteristic ***,the differences in the structural topology optimization under different reliability degrees are illustrated by examples.

关键词： buckling topology optimization aggregation function uncertainty propagation analysis non-probabilistic reliability

Evolution Mechanism of Carbon Covalent Bond during Coal Activation Using Mixed Atmosphere of H_(2)O and CO_(2)

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Journal of Thermal Science 2024年第5期33卷 1961-1973页

作者： WANG Mingyue ZhanG Siyuan han Shaobo ZhanG Chi REN Qiangqiang Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Coal Conversion Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China

Adequate destruction of the aromatic structure in coal is key to further reducing the emission of *** this research,activation reactions of Shenmu coal powder were carried out in a vertical tube *** study investigated the evolution mechanism of carbon covalent bonds during the activation process by altering the ratio of H_(2)O to CO_(2)in the activation *** theoretical validation was conducted through density functional *** two gas molecules follow different pathways to increase the reactivity of ***_(2)mainly participates in the cross-linking reaction by intensifying branching,while H_(2)O and char have lower adsorption energy barriers and are more likely to generate oxygen-containing functional *** molecules partially compete for active sites in a mixed gas atmosphere,but there is a synergism between the two *** synergism can be attributed to two *** inclusion of H_(2)O mitigates the generation of five-membered rings to a limited extent,while concurrently enhances the development of oxygen-containing functional *** oxygen-containing functional groups can effectively diminish the adsorption energy barrier associated with the interaction between gas molecules and char,consequently leading to a reduction in the energy demand for subsequent bond cleavage.

关键词： activation reaction carbon structure char CO_(2)/H_(2)O atmosphere density functional theory