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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. j., Xiao Teboul, Lydia Wong, Michael D. White, j.cqueline K. Meehan, Terrence F. Weninger, Wolfgang j. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, j.mes M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, j.mes daly, Mark j. Denegre, j.mes M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, j.an Guo, Shiying Horner, Neil R. Hsu, Chih-Wei j.hnson, Sara j. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, j.remy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. j. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas j. Ryder, Edward Samocha, Kaitlin E. Seavitt, j.hn R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, j.nathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. j.stice, Monica j. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David j. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maj. Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada j.ckson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanj.ng Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

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Atraumatic groin pain secondary to an aneurysmal bone cyst:A case report and literature review

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World j.urnal of Orthopedics 2020年第3期11卷 197-205页

作者： Colum Downey Aisling daly Alan P Molloy Brendan j.O’daly Department of Trauma and Orthopaedics Tallaght University HospitalDublin 9Ireland Department of Medicine Trinity College DublinDublin 2Ireland Department of Trauma and Orthopaedics St.Vincent’s University HospitalDublin 4Ireland

BACKGROUND Bone lesions can present the multi-displinary team with a challenge by way of diagnosis as some lesions share many radiological and histological *** cell tumours of the bone(GCTB)are relatively common,benign bone *** bone cysts(ABC)are less common benign osteolytic lesions that are histologically similar to GCTBs but produce blood filled *** GCTBs and ABCs are locally aggressive and are typically found on meta-epiphyseal regions of long bones with pelvic tumours being less *** SUMMARY A 17-year old female presented with atraumatic right groin pain and was initially diagnosed with a GCTB on the right superior pubic ramus of the *** patient was treated successfully with a wide excision,curettage and bone graft and underwent open reduction and internal fixation of the right *** further intra-operative histological investigations,the lesion was diagnosed as an *** This patient has had an uncomplicated post-operative course,has returned to comfortable weight bearing and will be reviewed for minimum 5 yr in the outpatient setting to monitor for reoccurrence.

关键词： Pelvic Tumour Aneurysmal bone cyst Giant cell tumour Open reduction internal fixation of pelvis Case report

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4D imaging of void nucleation,growth,and coalescence from large and small inclusions in steel under tensile deformation

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j.urnal of Materials Science & Technology 2022年第28期123卷 168-176页

作者： Yi Guo Timothy L.Burnett Samuel A.McDonald Michael daly Andrew H.Sherry Philip j.Withers Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Henry Royce Institute Department of MaterialsUniversity of ManchesterM139PLUK European Synchrotron Radiation Facility(ESRF) 6 rue J Horowitz38000 GrenobleFrance National Nuclear Laboratory Chadwick HouseBirchwood ParkWarringtonWA36AEUK

Samples of SA508 grade 3 nuclear pressure vessel ferritic steel were subj.cted to tensile straining whilst being simultaneously imaged in 3D in real time using high resolution,high frame rate time-lapse synchrotron computed tomography(CT).This enabled direct observation of void development from nucleation,through growth to coalescence and final failure validating many inferences made post-mortem or by theoretical models,as well as raising new *** sparse,large inclusions were found to nucleate voids at essentially zero plastic strain(consistent with zero interfacial strength);these became increasingly elongated with *** contrast,a high density of small spherical voids were found to nucleate from the sub-micron cementite particles at larger strains(>200%)only in the centre of the necked(high triaxiality)*** interfacial strength approaching 2100 MPa was inferred and soon after their nucleation,these small voids coalesce to form internal microcracks that lead to the final failure of the *** surprisingly,under these conditions of generally low triaxial constraint the large voids are simply cut across and appear to play no significant role in determining the final *** implications of these results are discussed in terms of ductile fracture behaviour and the Gurson model for ductile fracture.

关键词： Void growth Ductile fracture Synchrotron X-ray tomography 4D imaging Bainitic steel

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Constraining the links between the Himalayan belt and the Central Myanmar Basins during the Cenozoic:An integrated multi-proxy detrital geochronology and trace-element geochemistry study

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Geoscience Frontiers 2021年第2期12卷 657-676页

作者： F.Arboit M.Min D.Chew A.Mitchell K.Drost E.Badenszki j.S.daly Department of Geology Trinity College DublinDublinIreland Department of Geology University of MandalayMandalayMyanmar Myanmar Precious Resources Group and 20 Dale Close OxfordOX11TUUK UCD School of Earth Sciences University College DublinDublinIreland iCRAG(Irish Centre for Research in Applied Geosciences) University College DublinDublinIreland Department of Earth Science Khalifa UniversityAbu DhabiUnited Arab Emirates

Geological and tectonic analysis of the Eastern Himalayan basins has given rise to a decade-long debate on the geodynamic evolution of the Burmese terrane and on the extent of reorganization of the main SE Asia drainage ***,the influence of the Himalayan belt on the Central Myanmar Basin(CMB)system remains poorly documented,although it is key to providing more accurate models for the evolution of the Himalayan-Burmese *** this contribution,we present geochronological,isotopic and geochemical analysis from 2500 zircon,1700 titanite,700 rutile and 850 apatite detrital grains from fifteen Cenozoic siliciclastic samples and one Cretaceous igneous *** samples were collected within the fore-and back-arc basins of the Central Myanmar Basin domain(CMB)to constrain the provenance,maximum depositional ages,and depositional environments of the west Burma *** key lithological units,the Sadwingyi,Ketpanda,Wabo Chaung,Gwegon,Minwun,Padaung,Okmintaung and Irrawaddy formations have detrital age spectra spanning from the Miocene to *** entire data set has common age peaks at ca.20,40,60,90,100 Ma,with about 80%of the U–Pb ages younger than ca.140 Ma and only ca.1%of the grains predating ca.3.0 *** results shed light on the current ambiguities on the transport pathways of Himalayan detritus in the *** show that the fore-arc basin was open to the trench and fed by the unroofing of both the Wuntho Popa volcanic arc to the east and possibly from the Burmese basement and/or from Himalayan-derived Bengal Fan detritus to the west during the Eocene,from at least ca.44 Ma to before ca.39 *** show that the west Burma Terrane was partitioned into pull-apart basins such as the Minwun Basin,which during the Oligocene recorded the first evidence of a new source contribution into the CMB at ca.27 *** new source is characterized by detritus highly compatible with the SE Asia basement rocks,which we suggest corresponds to the initiation of t

关键词： Geochronology Geochemistry Himalaya Indo Burma Range Myanmar Provenance

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STAGE IB, HA AND PROXIMAL IIB, CARCINOMA OF THE UTERINE CERVIX, TREATED BY IRRADIATION ALONE OR IN COMBINATION WITH SURGERY

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Chinese j.urnal of Cancer Research 1990年第1期2卷 73-78页

作者：任传富 j.M Bachaud M Delannes F Izar P Martel N j.daly Division of Radiation Therapy Center Claudius Regaud Toulouse Cedex France Department of Radiation Therapy General Hospital of Tianjin Medical College of Tianjin Division of Radiation Therapy Center Claudius Regaud Toulouse Cedex France Division of Surgery Center Claudius Regaud Toulouse Cedex France Division of Radiation Therapy Center Claudius Regaud Toulouse Cedex Francehis is a report of a nonrandomized comparison of treatment results of 139 patients with stage IB HA and proximal IIB carcinoma of the uterine cervix treated by radiation alone and 113 treated with a combination of radiation and surgery. The five-year tumor free acturial survival for the patients with stage IB either with irradiation alone (RT) or combined with surgery (RS) was approximately 87%. For stage Ⅱ the tumor free actuarial five-year survival 79% with patients of RS and 76% with RT. In the 113 patients treated with RS there were 18 (16%). In the 139 patients treated by RT there were 18 (13%) recurrences of pelvic 4 local recurrences 11 combined with parametrial and free parametrial recurrences. There was no significant difference in the survival and recurrence rate of the patients treated with either method. Major complications were comparable in both groups (RT approximately 25% and RS approximately 10%) but 2/3 of those complications recovered without sequelae. The most frequent minor complication in the patients treated with RT was rectosigmoiditis.

This is a report of a nonrandomized comparison of treatment results of 139 patients with stage IB, HA and proximal IIB carcinoma of the uterine cervix treated by radiation alone and 113 treated with a combination of radiation and surgery. The five-year tumor free acturial survival for the patients with stage IB either with irradiation alone (RT) or combined with surgery (RS) was approximately 87%. For stage Ⅱ the tumor free actuarial five-year survival 79% with patients of RS, and 76% with RT. In the 113 patients treated with RS there were 18 (16%). In the 139 patients treated by RT there were 18 (13%) recurrences of pelvic, 4 local recurrences, 11 combined with parametrial, and free parametrial recurrences. There was no significant difference in the survival and recurrence rate of the patients treated with either method. Maj.r complications were comparable in both groups (RT approximately 25% and RS approximately 10%), but 2/3 of those complications recovered without sequelae. The most frequent minor complication in the patients treated with RT was rectosigmoiditis.

关键词： TREATED BY IRRADIATION ALONE OR IN COMBINATION WITH SURGERY STAGE IB CARCINOMA OF THE UTERINE CERVIX

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Exercise attenuates bone mineral density loss during diet-induced weight loss in adults with overweight and obesity:A systematic review and meta-analysis

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j.urnal of Sport and Health Science 2021年第5期10卷 550-559页

作者： j.kub Mesinovic Paul j.nsons Ayse Zengin Barbora de Courten Alexander j.Rodriguez Robin M.daly Peter R.Ebeling David Scott Department of Medicine School of Clinical Sciences at Monash HealthMonash UniversityClaytonVIA 3168Australia Institute for Physical Activity and Nutrition(IPAN) School of Exercise and Nutrition SciencesDeakin UniversityBurwoodVIA 2134Australia School of Medical and Health Sciences Edith Cowan UniversityPerthWA 6027Australia Department of Medicine and Australian Institute of Musculoskeletal Science Melbourne Medical SchoolWestern CampusUniversity of MelbourneSt AlbansVIA 3021Australia

Background:Weight-loss-induced fat loss improves cardiometabolic health in individuals with overweight and obesity;however,weight loss can also result in bone loss and increased fracture ***-loss-induced bone loss may be attenuated with *** aim was to compare changes in bone mineral density(BMD)in adults with overweight and obesity who undertook diet-induced weight loss alone or in combination with ***:We included randomized controlled trials(RCTs)in adults with overweight or obesity(aged-18 years;body mass index-25 kg/m^(2))that prescribed diet-induced weight loss alone or in combination with supervised exercise,and measured any bone structural *** of bias was assessed using the Cochrane Risk of Bias ***-effects meta-analyses determined mean changes and net mean differences(95%confidence intervals(95%CIs))in the percentage of areal BMD(aBMD)change between ***:We included 9 ***-induced weight loss led to significant losses in femoral neck aBMD(mean change:-1.73%(95%CI:-2.39%to-1.07%),p<0.001)and total hip aBMD(-2.19%(95%CI:-3.84%to-0.54%),p=0.009).Femoral neck aBMD losses were significantly greater in the diet-induced weight loss group compared to the exercise plus diet-induced weight loss group(net difference:-0.88%(95%CI:-1.73%to-0.03%));however,there were no differences in aBMD changes at any other skeletal site:total hip(-1.96%(95%CI:-4.59%to 0.68%))and lumbar spine(-0.48%(95%CI:-1.81%to 0.86%)).aBMD changes did not differ significantly according to exercise modality(resistance exercise,aerobic exercise,or a combination of the two)during diet-induced weight ***:Diet-induced weight loss led to greater femoral neck bone loss compared to diet-induced weight loss plus *** loss at the total hip and lumbar spine was not attenuated by exercise during diet-induced weight *** lack of consistent skeletal benefits may be due to the insufficient duration and/or training intensities

关键词： Bone mass Exercise Obesity Overweight Weight loss

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Damage mechanism identification in composites via machine learning and acoustic emission

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npj.Computational Materials 2021年第1期7卷 852-866页

作者： C.Muir B.Swaminathan A.S.Almansour K.Sevener C.Smith M.Presby j.D.Kiser T.M.Pollock S.daly Materials Department University of California-Santa BarbaraSanta BarbaraCAUSA NASA Glenn Research Center ClevelandOHUSA Materials Scienceand Engineering Department University of Michigan-Ann ArborAnn ArborMIUSA Mechanical Engineering Department University of California-Santa BarbaraSanta BarbaraCAUSA

Damage mechanism identification has scientific and practical ramifications for the structural health monitoring,design,and application of composite *** advances in machine learning uncover pathways to identify the waveform-damage mechanism relationship in higher-dimensional spaces for a comprehensive understanding of damage *** review evaluates the state of the field,beginning with a physics-based understanding of acoustic emission waveform feature extraction,followed by a detailed overview of waveform clustering,labeling,and error analysis *** requirements for damage mechanism identification in any machine learning framework,including those currently in use,under development,and yet to be explored,are discussed.

关键词： composites composite mechanism

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A machine learning framework for damage mechanism identification from acoustic emissions in unidirectional SiC/SiC composites

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npj.Computational Materials 2021年第1期7卷 1326-1335页

作者： C.Muir B.Swaminathan K.Fields A.S.Almansour K.Sevener C.Smith M.Presby j.D.Kiser T.M.Pollock S.daly Materials University of California-Santa BarbaraSanta BarbaraCAUSA Mechanical Engineering University of California-Santa BarbaraSanta BarbaraCAUSA NASA Glenn Research Center ClevelandOHUSA Materials Science and Engineering University of Michigan-Ann ArborAnn ArborMIUSA

In this work,we demonstrate that damage mechanism identification from acoustic emission(AE)signals generated in minicomposites with elastically similar constituents is *** waveforms were generated by SiC/SiC ceramic matrix minicomposites(CMCs)loaded under uniaxial tension and recorded by four sensors(two models with each model placed at two ends).Signals were encoded with a modified partial power scheme and subsequently partitioned through spectral *** cracking and fiber failure were identified based on the frequency information contained in the AE event they produced,despite the similar constituent elastic properties of the matrix and ***,the resultant identification of AE events closely followed CMC damage chronology,wherein early matrix cracking is later followed by fiber breaks,even though the approach is fully domain-knowledge ***,the partitions were highly precise across both the model and location of the sensors,and the partitioning was *** presented approach is promising for CMCs and other composite systems with elastically similar constituents.

关键词： composites damage mechanism

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Resistance analysis of the rice variety Huaidao 5 against root-knot nematode Meloidogyne graminicola

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j.urnal of Integrative Agriculture 2023年第10期22卷 3081-3089页

作者： FENG Hui ZHOU Can-rong ZHU Feng LE Xiu-hu j.NG De-dao Paul daly ZHOU Dong-mei WEI Li-hui Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjing 210014P.R.China Plant Protection and Quarantine Station of j.angsu Province Nanjing 210009P.R.China School of Landscape and Ecological Engineering Hebei University of EngineeringHandan 056038P.R.China Zhenj.ang Institute of Agricultural Science in Hilly Area of j.angsu Province Jurong 212400P.R.China

Meloidogyne graminicola has emerged as one of the most destructive plant-parasitic nematodes affecting rice(Oryza sativa)production *** to *** in rice could be the most effective option for its ***,sources of germplasm with resistance to *** in rice remain ***,we describe the root attraction,gall formation and genetic analysis of the resistance to *** in the rice variety Huidao 5.A nematode attraction assay showed that second-stage j.veniles(j.s)of *** were attracted at the root tip of Huaidao 5 within 8 h without a significant reduction in attraction compared to the susceptible rice variety Nanj.ng *** observation of the infection revealed that the j.s invaded root tissues 12 h after inoculation,but their subsequent movement to the root tip was hindered in Huaidao 5,resulting in decreased nematode number compared to Nanj.ng ***,we used the soil and hydroponic culture systems to simulate upland and flooding conditions in the paddy fields respectively,and found that gall number was significantly reduced,and nematode development was clearly suppressed in Huaidao *** investigate the genetic basis of this resistance,cross breeding was performed between the Huaidao 5 and Nanj.ng 9108 *** was no reduction in the resistance of the F_(1) offspring to *** in the greenhouse or field trials,suggesting that a dominant gene could control resistance in Huaidao *** summary,this study provides a detailed characterization of a novel source of resistance to *** in rice,which is of great potential for use in crop breeding.

关键词： root-knot nematode Meloidogyne graminicola rice resistance

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Are premenstrual symptoms associated with health anxiety in nursing graduates?

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Open j.urnal of Psychiatry 2011年第3期1卷 98-105页

作者： Yinghui Xu Russell Noyes Arthur j. Hartz Barcey T. Levy j.anette M. daly Susan R. j.hnson 不详

Obj.ctive: This study examined retrospectively the relationship between premenstrual symptoms and health anxiety. Methods: Premenstrual symptoms of nursing school graduates were assessed in 1985 and again in 1991 using the Premenstrual Assessment Form (PAF). A total of 571 women completed the survey in 1991, along with items relating to their physical and mental health. The latter included depression, anxiety, and panic attacks. Health anxiety was also assessed using the Whiteley Index (WI). After women who were amenorrheic for any reason were excluded, a final sample of 410 women aged 25 to 52 years was obtained. Factor analyses yielded 57 items that were useful for calculating a total PAF score. A stepwise multivariate linear regression model was used to find the association of PAF scores with various participant characteristics. Results: Thirty-kone of the 410 (7.6%) women had WI scores of ≥5 and were considered to have significant health-related anxiety. The PAF score had statistically significant associations with health anxiety, as well as depression and anxiety. Conclusions: Our results suggest that the premenstrual symptoms often coexist with health anxiety as well as other psychological symptoms. Clinicians should be alert to the fact that PMS may be associated with treatable psychiatric conditions.

关键词： Premenstrual Symptoms PMDD Health Anxiety Hypochondriasis

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