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NIR-II fluorescence imaging in liver tumor surgery: A narrative review

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 29-44页

作者： Zihao Liu Lifeng yan Qingsong Hu dalong Yin Department of General Surgery Anhui Provincial Hospital Anhui Medical UniversityHefei 230001P.R.China Department of Hepatobiliary Surgery and Centre for Leading Medicine and Advanced Technologies of IHM The First A±liated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui 230001P.R.China Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Soft Matter Chemistry and Department of Chemical Physics University of Science and Technology of China Hefei 230026P.R.China Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230001P.R.China

In liver tumor surgery,the recognition of tumor margin and radical resection of microcancer focis have always been the crucial points to reduce postoperative recurrence of ***,naked-eye inspection and palpation have limited effectiveness in identifying tumor boundaries,and traditional imaging techniques cannot consistently locate tumors in real *** an intraoperative real-time navigation imaging method,NIRfluorescence imaging has been extensively studied for its simplicity,reliable safety,and superior sensitivity,and is expected to improve the accuracy of liver tumor *** recent years,the research focus of NIRfluorescence has gradually shifted from the-rst near-infrared window(NIR-I,700–900 nm)to the second near-infrared window(NIR-II,1000–1700 nm).Fluorescence imaging in NIR-II reduces the scattering effect of deep tissue,providing a preferable detection depth and spatial resolution while signi-cantly eliminating liver autofluorescence background to clarify tumor *** combined with tumor antibodies will further improve the precision offluorescence-guided surgical *** the development of a bunch offluorophores with phototherapy ability,NIR-II can integrate tumor detection and treatment to explore a new therapeutic strategy for liver ***,we review the recent progress of NIR-IIfluorescence technology in liver tumor surgery and discuss its challenges and potential development direction.

关键词： Fluorescence guided-surgery liver cancer near infrared-II optical imaging

基于gdh基因分析云南牛源十二指肠贾第虫感染情况

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中国畜牧兽医 2024年第6期51卷 2644-2652页

作者：汪文雅谢昕言闫大龙魏鹏浩杨建岭毕润李清马君邹丰才云南农业大学动物医学院昆明650201 勐海县畜牧兽医工作站西双版纳666200 罗平县九龙街道农业农村综合服务中心曲靖655800

【目的】了解云南省牛感染十二指肠贾第虫(Giardia duodenalis)的情况和基因型分布,评估贾第虫病的传播风险。【方法】采用巢式PCR方法基于十二指肠贾第虫的谷氨酸脱氢酶(gdh)基因对云南省3个地区采集的258份牛新鲜粪便样品进行检测,计... 详细信息

【目的】了解云南省牛感染十二指肠贾第虫(Giardia duodenalis)的情况和基因型分布,评估贾第虫病的传播风险。【方法】采用巢式PCR方法基于十二指肠贾第虫的谷氨酸脱氢酶(gdh)基因对云南省3个地区采集的258份牛新鲜粪便样品进行检测,计算不同地区、不同年龄、不同品种牛的十二指肠贾第虫阳性率;对阳性样品进行测序,将测序结果提交至NCBI比对进行基因型鉴定;使用MrBayes 3.1程序进行贝叶斯推理法分析,采用普通时间可逆(general time reversible, GTR)替换模型,构建系统进化树。【结果】258份牛粪便样品中有23份呈十二指肠贾第虫阳性,总阳性率为8.91%(23/258)。其中,不同地区牛十二指肠贾第虫阳性率差异极显著(P24月龄)(5.56%,12/216,95%CI=2.48~8.64);不同品种牛十二指肠贾第虫阳性率差异极显著(P<0.01),荷斯坦奶牛十二指肠贾第虫阳性率最高,为20.75%(11/53,95%CI=12.00~39.17),黄牛、西杂牛(西门塔尔牛和本地黄牛的杂交品种)、西门塔尔牛阳性率较低,分别为17.86%(5/28,95%CI=2.73~32.98)、4.38%(6/137,95%CI=0.91~7.85)和2.50%(1/40,95%CI=0~7.56)。基于gdh基因序列分析23份十二指肠贾第虫阳性样品集聚体类型均是E型,但为7种不同基因亚型,其中6种亚型(E1、E12、E20、E30、E36和E38)与已知参考序列相似性为99.8%~100%,另一种亚型与未命名亚型参考序列相似性为99.8%。【结论】云南省牛存在十二指肠贾第虫感染,不同地区、不同年龄、不同品种牛的十二指肠贾第虫阳性率存在一定差异;集聚体主要为E型,且此类型在云南地区遗传多样性较高。

关键词：牛十二指肠贾第虫 gdh基因基因型

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基于移动激光点云的非接触式接触网参数检测方法

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电气化铁道 2024年第3期35卷 48-53页

作者：宋宗莹尹太军张海山闫大龙王文斌曾杉中国神华能源股份有限公司中科吉芯(秦皇岛)信息技术有限公司中国科学院地理科学与资源研究所

针对目前接触网参数检测存在精度低、效率低等问题,提出一种基于移动激光点云的非接触式接触网参数检测方法:基于预处理后的接触网点云实现接触线和接触网支柱要素的分类;基于连通性分析,实现接触网支柱单体化分割,并通过建立kd-tree数... 详细信息

针对目前接触网参数检测存在精度低、效率低等问题,提出一种基于移动激光点云的非接触式接触网参数检测方法:基于预处理后的接触网点云实现接触线和接触网支柱要素的分类;基于连通性分析,实现接触网支柱单体化分割,并通过建立kd-tree数据结构提取定位点;最后根据定位点与轨面关系计算接触网导高、拉出值。结果显示,基于本文方法得到的接触网参数检测精度符合《接触网悬挂状态检测监测装置(4C)暂行技术条件》要求,验证了方法的有效性和准确性。

关键词：移动激光点云接触线接触网支柱定位点导高拉出值

Preparation of Core-Shell Structured Cobalt Coated Tungsten Carbide Composite Powders by Intermittent Electrodeposition

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Journal of Materials Science & Technology 2016年第11期32卷 1171-1178页

作者： Huan Zhong Yuejun Ouyang Gang Yu Bonian Hu dalong yan State Key Laboratory of Chemo/Biosensing and Chemometrics. College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Huaihua Key Laboratory of Functional Inorganic & Polymeric Materials Huaihua University Huaihua 418000 China Department of Materials and Chemical Engineering Hunan Institute of Technology Hengyang 421008 China

Core-shell structured cobalt coated tungsten carbide（WC/Co） composite powders were prepared by intermittent electrodeposition. The influence of process parameters such as current density, single deposition pulse, p H value and surfactants on the formation of WC/Co was investigated and characterized by scanning electron microscopy（SEM）, electrochemical station, acidometer and X-ray diffraction（XRD） *** composite powders with 54% cobalt content were fabricated at a current density of 16 A dm-2, with a load of 10 g dm-3WC powders and a stirring speed of 600 r min-1at an operation temperature of 40 ± 2 °C,and 90% current efficiency was obtained with a single deposition pulse of 1.5 min and single stirring pulse of 2 min during 12 min efficient electrodeposition time. The uniformly distributed WC/Co powders could be obtained in the cobalt electrolyte containing 300 mg dm-3PEG-2000. The spherical cobalt grains coated WC particles were prepared in the p H 4-5 electrolyte at the Co deposition rate of 0.58 g min-1. A practical process for high efficient production of WC/Co powders by electrodeposition was developed in the present work.

关键词： Composite powder Electrodeposition Dispersion Crystal structure

提高6-DZF-20电动助力车用电池的小片极板重量合格率的方法

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蓄电池 2022年第2期59卷 58-63页

作者：闫大龙李娟马洪涛张凯周邦红超威电源集团有限公司浙江长兴313100 广西超威鑫锋能源有限公司广西河池547000

为了提升6-DZF-20电动助力车用电池的小片极板重量合格率,首先通过六西格玛工具找出关键因素—涂板,然后用六西格玛DMAIC对涂板工艺进行参数优化和验证,将小片极板的重量合格率由57.7%提高到75.5%,最后结合TRIZ工具关键难题进行改善,使... 详细信息

为了提升6-DZF-20电动助力车用电池的小片极板重量合格率,首先通过六西格玛工具找出关键因素—涂板,然后用六西格玛DMAIC对涂板工艺进行参数优化和验证,将小片极板的重量合格率由57.7%提高到75.5%,最后结合TRIZ工具关键难题进行改善,使小片极板的重量合格率达到了90%。

关键词：电池极板重量合格率 DMAIC TRIZ 电动助力车涂板六西格玛

The influence of calculation error of hourly marine meteorological parameter on building energy consumption calculation

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Frontiers of Architectural Research 2022年第5期11卷 981-991页

作者： dalong Liu Tian Sun Yufei Han Xiuying yan School of Architecture Xi'an University of Architecture and TechnologyXi'an 710055China

The ocean is a crucial area for future economic *** marine environment has high energy-efficient and ecological requirements for building *** parameters are the key basis for the analysis and design of building energy *** lack of meteorological parameters for energy efficiency,particularly hourly data,under oceanic climatic conditions is a universal *** appropriate calculation methods of hourly meteorological parameters under oceanic climatic conditions are explored in this *** impact of the calculation errors of the hourly meteorological parameters on building energy consumption is also *** key meteorological parameters are selected:temperature,humidity,and wind *** hourly calculations methods,including linear interpolation,cubic spline interpolation,pieceated three-Hermite interpolation,Akima interpolation,and radial basis function interpolation,are selected to calculate the error of the difference method,with Xiamen,Haikou,and Sanya as the locations of meteorological *** interpolation methods are selected for the three parameters,and the seasonal and regional characteristics of the errors of each parameter are *** interpolation methods should be selected for different meteorological parameters in different *** error data of the three parameters of different magnitudes are constructed.A quantitative relationship between the sum of squares due to error of the three meteorological parameters and the rate of change of cooling energy consumption is *** hourly calculation errors of meteorological parameters have an important impact on the calculation of dynamic energy *** energy consumption differences caused by the errors of different parameters are *** regional and seasonal differences also *** research strengthens the research foundation of building energy consumption calculation under oceanic climate c

关键词： Building energy efficiency Oceanic climate Meteorological parameters Interpolation method Calculation error Dynamic energy simulation

近红外二区荧光靶向探针在肝癌体内显像的应用研究

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中华实验外科杂志 2024年第7期41卷 1479-1482页

作者：刘子豪党慧萍闫立峰尹大龙安徽医科大学附属省立医院普外科合肥230001 中国安徽省合肥市中国科学技术大学化学物理系合肥微尺度物质科学国家实验室合肥230026 中国科学技术大学附属第一医院(安徽省立医院)先导医学与前沿技术研究所肝胆外科合肥230036

目的探究半乳糖靶向纳米探针Gal-OH-BDP(GOB)在近红外二区(NIR-Ⅱ)进行原位肝癌荧光成像的可行性和成像效果。方法合成NIR-Ⅱ纳米荧光探针GOB,通过人源HepG2肝癌细胞构建BALB/c裸鼠原位肝癌模型,将12只裸鼠采用简单随机抽样法分为2组,... 详细信息

目的探究半乳糖靶向纳米探针Gal-OH-BDP(GOB)在近红外二区(NIR-Ⅱ)进行原位肝癌荧光成像的可行性和成像效果。方法合成NIR-Ⅱ纳米荧光探针GOB,通过人源HepG2肝癌细胞构建BALB/c裸鼠原位肝癌模型,将12只裸鼠采用简单随机抽样法分为2组,每组各6只。使用GOB瘤内注射法进行NIR-Ⅱ成像的记为NIR-ⅡGOB组,使用吲哚菁绿(ICG)静脉注射法并先后进行近红外一区(NIR-Ⅰ)和NIR-Ⅱ成像,分别记为NIR-ⅠICG组和NIR-ⅡICG组。利用NIR-Ⅰ/Ⅱ相机进行体内成像试验。使用mageJ软件对图片进行荧光图像处理,定量计算肝癌荧光图像的肿瘤-正常组织比(TNR)和肿瘤边缘分辨率,通过石蜡切片及苏木精-伊红染色法进行病理学验证。样本数据采用t检验和方差分析。结果通过病理学成功验证了瘤内注射后GOB在肝癌组织内的靶向积累。NIR-ⅡGOB组的TNR高于NIR-ⅡICG组和NIR-ⅠICG组(5.61±0.98比3.35±0.63比2.01±0.54,F=29.022,P<0.05)。对组成TNR的3项指标(肿瘤区域荧光、正常肝组织背景荧光和环境背景荧光)进行的亚组分析结果表明,在肿瘤区域荧光方面,NIR-ⅡGOB组高于NIR-ⅡICG组(228.04±5.60比207.62±14.86,t=3.149,P<0.05);在正常肝组织背景荧光方面,NIR-ⅡGOB组低于NIR-ⅡICG组(43.22±8.68比63.47±8.88,t=-3.992,P<0.05)。通过计算跨越肿瘤边缘像素点的灰度值变化率来量化肿瘤边缘分辨率,NIR-ⅡGOB组高于NIR-ⅡICG组和NIR-ⅠICG组(170.01±30.92比98.96±23.99比36.82±10.19,F=48.882,P<0.05)。结论通通过瘤内注射Gal-OH-BDP纳米荧光团在NIR-Ⅱ窗口实现优于传统ICG介导的原位肝肿瘤荧光成像。

关键词：近红外二区荧光成像原位肝肿瘤半乳糖靶向

新型负极有机膨胀剂对铅炭动力电池性能的影响

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蓄电池 2020年第2期57卷 67-69,74页

作者：马洪涛李娟闫大龙超威电源集团有限公司浙江长兴313100

通过红外光谱、电化学性能测试和粒径分析,对不同膨胀剂进行分析,并且进一步通过检测实验电池的容量、低温等初期性能及循环性能,对膨胀剂进行优选。

关键词：铅炭动力电池有机膨胀剂负极容量低温木素

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铅酸蓄电池添加4BS晶种配方研究

蓄电池 2020年第4期57卷 160-163页

作者：马洪涛闫大龙李娟超威电源集团有限公司浙江长兴313100

采用高温固化工艺,通过分析固化过程中游离铅、水含量的变化,测试生极板的SEM形貌、XRD物相组成、铅膏内聚力,最终结合电池循环性能,优选添加4BS晶种的正极配方。

关键词：铅酸蓄电池 4BS 晶种正极添加剂高温固化游离铅内聚力