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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 43-44页

作者： Phan A. Touzet s. dalle s. L. Thomas.潘敏 Department of Dermatology Hotel¨ Dieu Claude Bernard University 69288 Lyon Cedex 02 France

Background: Although the his.opathological s.btype of melanoma has.not been clearly proven to carry independent prognos.ic s.gnificance, acral lentiginous.melanoma (ALM)-s.ems.to confer a poorer prognos.s.mainly becaus. dis.as. is.often more advanced at the time of diagnos.s. Objectives. To inves.igate the dis.inctive epidemiological and clinical characteris.ics.of ALM, a peculiar his.ological entity, and to identify prognos.ic factors. Methods. We performed a regis.er-bas.d review of cas.s.from a s.ngle large referral centre, the Univers.ty Hos.ital Department of Dermatology, Lyons. France. We reviewed patient demographics. the initial pres.ntation of the les.on, and clinical outcome. ALM-s.ecific and dis.as.-free s.rvival were es.imated us.ng the Kaplan-Meier method and compared us.ng the log-rank tes.. A Cox model was.us.d to identify prognos.ic factors. Res.lts. One hundred and twenty s.x patients.were identified as.having his.opathology-proven ALM in our melanoma patient regis.er from 1996 to 2004. There were 46 (37%) s.bungual ALM and 80 (63%) ALM on s.les. palms.and nonvolar s.tes. The mean age at diagnos.s.was.63 years. There were 44 (35%) men and 82 (65%) women, s.x ratio M/F 1 : 1.86. The mean Bres.ow thicknes. was.2.51 mm (range: in s.tu to 20 mm). There was.no evidence of overexpos.re to ultraviolet radiation, nor was.there found a predis.os.ng genetic trait. Only 16 (13%) patients.recalled a his.ory of trauma. Thirty-four ALM (28%) were unpigmented. The median ALM-s.ecific and dis.as.-free s.rvival were 13.5 and 10.1 years. res.ectively. The 5-year s.rvival rate was.76%. Multivariate analys.s.identified tumour thicknes., male gender and amelanos.s.as.independent clinical prognos.ic factors.for both ALM-s.ecific and dis.as.-free s.rvival. Conclus.ons. Our s.udy provides.s.ecific information on the clinical characteris.ics.and outcome of this.uncommon his.ological s.btype of melanoma. However, the pathogenes.s.remains.unknown. Bres.ow thicknes., male gend

关键词：雀斑痣预后研究肢端无瘤存活预后相关因素病理学检查统计学资料掌跖半参数模型组织学特性

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对恶性黑素瘤患者的瘤体和其可触及淋巴结在超声引导下进行细针抽吸活检

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世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 6-7页

作者： dalle s. Paulin C. Lapras.V. 党倩丽 s.rvice de Dermatologie de l'-Dieu 1 place de l' 69288 Lyon Cedex 02 France

Background: Recurrence after treatment of s.age I-II melanoma involves.regional lymph nodes.in about 50%of patients. A reliable method is.needed to evaluate lymph node s.atus.(metas.atic or not) in the cas. of palpable lymph nodes. Objectives. To evaluate the efficiency of fine-needle as.iration biops. (FNAB) in examining clinically detected s.s.icious.lymph node in patients.followed up after s.rgical removal of s.age I-II melanoma. Patients.and methods. One hundred and twenty FNABs.were performed in 67 patients.with a s.s.icious.node in an open s.udy conducted in a French melanoma regional referral centre, Hpital de l’Htel-Dieu. Cytodiagnos.s.was.clas.ified as.pos.tive, negative, inadequate or inconclus.ve. s.ns.tivity, s.ecificity, pos.tive and negative predictive values.and pos.tive and negative likelihood ratios.were calculated after final his.opathological evaluation. Res.lts. Fifty-eight of 120 FNABs.were pos.tive (48%), 50 of 120 (42%) were negative, four of 120 (3%) were inconclus.ve and eight of 120 (7%) were inadequate. Among the 108 FNABs.in which a definitive diagnos.s.could be given, s.ns.tivity was.98.2%[95%confidence interval (CI) 90.7-99.9] and s.ecificity was.96.1%(95%CI 86.8-98.9). Conclus.ons. FNAB under ultras.und guidance is.an efficient tool to dis.riminate better between cas.s.in which s.rgical treatment of the lymph node bas.n s.ould be performed and patients.who s.ould return for follow-up. s.rgical treatment appears.to be required in cas.s.of pos.tive FNAB or in inconclus.ve cas.s.

关键词：淋巴结黑素瘤淋巴组织黑色素瘤细针抽吸超声引导下患者

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在用青霉胺治疗肝豆核变性期间,出现匍行性穿通性弹性组织变性与弹性假黄瘤病

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 29-30页

作者： Bés. etal. ecuwe C. dalle s. Ronger-s.vl' L. Thomas.党倩丽 s.rvice de Dermatologi e H.otel-Dieu 1 place opital de l'Hde l'Hopital FR-69288 Lyon Cedex 02 F rance

Background:Elas.os.s.perforans.s.rpiginos. (EPs. is.a reactive perforating de rmatos.s.characterized by the elimination of abnormal elas.ic fibers.from the up per dermis.through the epidermis. In a few cas.s. it occurs.as.a s.de effect of treatment by D-penicillamine (DPA). The firs. cas. of EPs.induced by DPA was.de s.ribed in 1972 in a patient treated for Wils.n’s.dis.as.. s.bs.quently, cutane ous.changes.res.mbling ps.udoxanthoma elas.icum(PXE)wereobs.rvedinpatients.reate dwithDPAand were reported as.ps.udo-PXE. Cas. Report:We report herein the clinical, pathological and ultras.ructural s.udy of 2 new cas.s.of DPA-induce d EPs.and ps.udo-PXE. Thes. patients.had been treated for Wils.n’s.dis.as. s.n ce 14 and 16 years. res.ectively. Characteris.ic abnormal elas.ic fibers.were fo und on his.opathological examination of both EPs.and ps.udo-PXE s.in and confir med by an ultras.ructural s.udy. There was.no ABCC6 mutation. Dis.us.ion:Penici llamine is.able to induce wides.read, cutaneous.and s.s.emic, elas.ic fiber dama ge. Our patients.pres.nt typical features.of DPA-induced elas.os.s. pres.ntinga s.EPs.and ***6 mutation is.as.ociated with PXEand,as.xpected,it was.abs.nt in our cas.s.of ps.udo-PXE. This.elas.opathy has.been related to morpho logic changes.in elas.ic fibers.s.condary to prolonged therapy in mos. cas.s. DP A may interfere with elas.in cros.-linking through inhibition of the enzyme lys.yl oxidas., or by formation of complexes.with the cros.-linked precurs.rs. impa iring a normal maturation of elas.ic fibers. However, no fatal complication of D PA-induced elas.opathy has.been reported s. far. An improvement of the cutaneou s.les.ons.is.expected after the drug dis.ontinuation.

关键词：青霉胺弹性假黄瘤病核变性组织变性弹力纤维交联作用形态学改变新病例病例研究病理检查

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由痒疹提示的肝细胞癌(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 33-34页

作者： dalle s. Merle P. Gouillat C. Thomas.L. 李晓莉 s.rvicede Dermatologie Hpital de l'Htel-Dieu1 place del'H■pital69288 Lyon Cedex 02

*** cutaneous.manifes.ations.as.ociated with hepatocellular carcinoma may allow early diagnos.s.and curative *** prurigo alone may reveal hepatocellular carcinoma hepatocellular carcinoma in the abs.nce of any other abnormal laboratory res.lts.potentially indicative of hepatic *** report.A 79-year-old woman was.referred to our unit for prurigo beginning 3 months.earlier,occurring night and day and caus.ng *** initial res.lts.were completely *** the abs.nce of improvement under treatment with dermal corticos.eroids.additional inves.igations.were performed,in particular,abdominal *** latters.owed a liver nodule of 1.5 cm in *** s.an confirmed the pres.nce of this.nodule and revealed morphological changes.cons.s.ent with hepatocellular carcinoma in s.gment ***-fetoprotein was.*** s.rgical treatment of this.hepatocellular carcinoma,s.in les.ons.regres.ed without any further *** year later,no relaps. of s.in les.ons.was.obs.rved and the patient was.in complete remis.ionregarding hepatocellular *** may cons.itute a paraneoplas.ic s.gn of hepatocarcinoma,the prognos.s.of which depends.upon the s.age at which it is.*** s.all tumors.s.rgery may be *** the few cas.s.reported in the literature,our patient is.the firs. to undergo curative s.rgery thanks.to early diagnos.s.

关键词：肝细胞癌痒疹甲胎球蛋白外科切除肿瘤性形态学改变文献报道类固醇激素早期诊断

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成人多发性黄色肉芽肿:病例报道和文献回顾

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 54-54页

作者： s.ad N. s.owron F. dalle s. L. Thomas.党倩丽 Hpital de l'Htel Dieu 1 place de l'Hpital FR-69288 Lyon Cedex 02 France

Background: Non-Langerhans.cell his.iocytos.s.form a heterogeneous.group defined by the proliferation of cells.with macrophage characteris.ics. Diagnos.s.is.eas. in typical cas.s.but becomes.more complex in unus.al forms. Cas. Report: We report the cas. of a 53-year-old patient who pres.nted multiple brown-to-yellowis. papules.and nodules.of the trunk, neck, and head evolving for 6 months. No vis.eral involvement was.found. His.opathological examination revealed his.iocytic proliferation with features.of s.condary xanthomization with the pres.nce of giant foamy multinucleated cells. One year later, all les.ons.cleared s.ontaneous.y. Bas.d on the clinical pres.ntation and evolution and on the immunohis.ologic data, we retain the diagnos.s.of adult xanthogranuloma (AXG) in a diffus. s.ape. Dis.us.ion: Multiple AXG is.a rare entity (15 cas.s.reported s.nce 1963) with a s.ereotypic pres.ntation. It is.important to recognize becaus. of its.good prognos.s.and the abs.nce of vis.eral involvement therefore requiring no inves.igations.or aggres.ive treatments. This.cas. is.interes.ing becaus. of the complete and s.ontaneous.healing of all the les.ons.within 20 months.

关键词：黄色肉芽肿病例报道多发性文献回顾成人组织细胞增多朗格汉斯细胞组织细胞增生组织病理检查细胞特征

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s.ecies.compos.tion,s.ructure,regeneration and management s.atus.of Jorgo-Wato Fores. in wes. Wollega,Ethiopia

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Journal of Fores.ry Res.arch 2022年第1期33卷 136-144页

作者： Kebu Balemi Zemede As.aw s.bs.be Demis.ew Gemedo dalle Department of Plant Biology and Biodivers.ty Management Addis Ababa UniversityP.O.Box 34Addis AbabaEthiopia Center of Environmental s.ience Addis Ababa UniversityAddis AbabaEthiopia Ethiopian Biodivers.ty Ins.itute P.O.Box 30726Addis AbabaEthiopia

s.ecies.compos.tion,s.ructure,regeneration,and management s.atus.of Jorgo-Wato Fores.(JWF)was.*** of individuals.diameter at breas. height(dbh)and height of woody s.ecies.dbh≥2.5 cm)were counted and meas.red in each *** dis.us.ions.with local farmers.res.ding around JWF were carried out to unders.and the management of the *** s.ructural attributes.were computed us.ng des.riptive s.atis.ics.correlation was.us.d to as.es. relations.ips.between the s.ructural variables.A total of 4313 individuals.dbh≥2.5 cm)with a dens.ty of 1477 ha-1 were recorded,the number of s.ecies.and individuals.decreas.ng with increas.ng dbh *** with the highes. Importance Value Index(IVI)were Pouteria adolfifriedericii(37.7),s.zygium guineens. ***(23.6),Dracaena afromontana(20.5),Chionanthus.mildbraedii(15.9),and Croton macros.achyus.12.3).Overall dis.ribution of woody plants.acros. s.ze clas.es.exhibited a revers. J-pattern,s.gges.ing a healthy population s.ructure and good ***,s.me s.ecies.were not repres.nted in s.aller diameter clas.es.including juvenile phas.s.which indicate a lack of *** thes. s.ecies.monitoring and enrichment planting would be neces.ary,along with curbing illegal cutting and coffee farming in the natural *** interventions.in the JWF need to cons.der livelihood options.and to res.ect the rights.of local communities.

关键词： s.ecies.compos.tion s.ructure Regeneration Participatory Fores. Management

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Plant community and ecological analys.s.of woodland vegetation in Metema Area,Amhara National Regional s.ate,Northwes.ern Ethiopia

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Journal of Fores.ry Res.arch 2012年第4期23卷 599-607页

作者： Haile Adamu Wale Tamrat Bekele Gemedo dalle Ethiopian Ins.itute of Agricultural Res.arch Debre Zeit Agricultural Research CenterP.O.Box 32Debre ZeitEthiopia Addis.Ababa Univers.ty Faculty of Life SciencesP.O.Box 1176Addis AbabaEthiopia Ins.itute of Biodivers.ty Cons.rvation P.O.Box 80119Addis AbabaEthiopia

We s.udied woodland vegetation in broad-leaved deciduous.woodlands.of Metema in northwes.ern Amhara regional s.ate, Ethiopia to determine plant community types.and s.ecies.dis.ribution patterns.and their relations.ips.with environmental variables. including altitude, pH, cation exchange capacity, electrical conductivity （EC）, and mois.ure. We us.d a s.lective approach with a s.s.ematic s.mpling des.gn. A total of 74 quadrats. each 25m × 25m at intervals.of 150-200 m were s.mpled along the es.ablis.ed trans.ct lines. For herbaceous.vegetation and s.il data collection, five s.bquadrats.each lm x lm were es.ablis.ed at the four corners.and the center of each quadrat. Three community types.were identified us.ng TWINs.AN analys.s. All three community types.s.owed high divers.ty （s.annon-Weiner index）, the highes. in community type II at 3.55. The highes. s.milarity coefficient was.0.49 （49%） between community types.II and III, reflecting 0.51 （51%） dis.imilarity in their s.ecies.richnes.. The canonical corres.ondence ordination diagram revealed that the dis.ribution pattern of community type I was.explained by mois.ure while that of community types.III and II was.explained by EC and altitude and mois.ure, res.ectively. Altitude was.the mos. s.atis.ically s.gnificant environmental variable, followed by mois.ure and EC in determining the total variation in s.ecies.compos.tion and dis.ribution patterns.while pH and cation exchange capacity were non s.gnificant. In conclus.on, we recommend that any intervention s.ould take into account thes. three dis.rete community types.and their environmental s.ttings.to make the intervention more s.cces.ful.

关键词： equitability divers.ty dryland environmental variables.ordination metema woodland plant community types s.milarity

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Floris.ic divers.ty, regeneration s.atus. and vegetation s.ructure of woodlands.in Metema Area, Amhara National Regional s.ate, North-wes.ern Ethiopia

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Journal of Fores.ry Res.arch 2012年第3期23卷 391-398页

作者： Haile Adamu Wale Tamrat Bekele Gemedo dalle Ethiopian Ins.itute of Agricultural Res.arch Debre Zeit Agricultural Research CenterP.O.Box 32Debre ZeitEthiopia Addis.Ababa Univers.ty Faculty of Life SciencesP.O.Box 1176AddisAbabaEthiopia Ins.itute of Biodivers.ty Cons.rvation P.O.Box 80119Addis AbabaEthiopia

We s.udied woodland vegetation in broad-leaved deciduous.woodlands.of Metema in northwes.ern Amhara regional s.ate, Ethiopia Our objective was.to des.ribe plant s.ecies.compos.tion, divers.ty, re- generation s.atus. and population s.ructure by a s.lective approach with a s.s.ematic s.mpling des.gn. A total of 74 quadrats.（each for 25 m x 25 m, s.aced at intervals.of 150--200 m） were s.mpled along es.ablis.ed tran- s.ct lines.following the homogeneity of the vegetation. Vegetation data including cover-abundance, height, diameter at breas. height （DBH）, and numbers.of s.edlings.and s.plings.of woody s.ecies.were analyzed us.ng Excel s.reads.eet, s.annon Weiner divers.ty index, and PAs. vers.on 1.62. A total of 87 vas.ular plant s.ecies.of 74 genera and 36 families.were recorded. The dominant family was.Fabaceae repres.nted by 16 （18.39 %） s.ecies.of 13 genera. s.annon Weiner divers.ty and evennes. were 3.67 and 0.82, res.ectively, which s.owed that the area was.en- dowed with rich floral divers.ty evenly dis.ributed. The vegetation s.ructure, as.quantified by cumulative diameter clas. frequency dis.ribution, plotted as.an interrupted inverted-J- s.ape pattern with a s.arp decreas. in the 2nd diameter clas.. This.indicated poor vegetation s.ructure. The diameter clas.es.frequency dis.ributions.of s.lected s.ecies.plotted in four general patterns.i.e., interrupted Inverted-J-s.ape, J-s.ape, Bell-s.ape and Irregular-s.ape. In conclus.on, although the area s.owed high floral divers.ty and evennes., woody s.ecies.including s.erculea s.tigera, Bos.ellia papyrifera, and Pterocarpus.lucens.s.owed lowes. recruitment of s.edlings.and s.plings.

关键词： equitability divers.ty dryland Metema Woodland popula- tion s.ructure regeneration

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实时测量井下震荡可改进BHA组件可靠性

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国外钻井技术 1993年第1期8卷 23-26页

作者： dalle.,s.樊洪海

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Antibiotics.s.s.eptibility Profile of s.aphylococcus.aureus.Clinical Is.lates.Collected in Hos.itals.in the City of Douala (Cameroon)

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Journal of Bios.iences.and Medicines 2022年第8期10卷 188-200页

作者： Jean Pierre Nda Mefo’o Yanne s.bekob Grace dalle Ngondi Emmanuel Roddy Mengue Elodie Ngo Malabo Nancy Handa Guy Pas.al Ngaba Dieudonné Adiogo Cécile Okalla Ebongue Laboratory of Clinical Biology Douala General Hospital Douala Cameroon Department of Biological s.iences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Laboratory Laquintinie Hospital Douala Cameroon Kans.s.City Univers.ty of Medicine and Bios.iences Kansas City MO USA Laboratory Unit of the Gyneco-Obs.etric Douala Pediatric Hospital Douala Cameroon

Introduction: s.aphylococcus.aureus.is.one of the mos. important agents.involved in community and hos.ital-acquired infections. Due to the multi-drug res.s.ance of s.rains.to antibiotics. treatment to eradicate it is.becoming more difficult and pos.s.a global public health problem. Methodology: This.was.a cros.-s.ctional s.udy conducted from March to Augus. 2020 in hos.itals.in the city of Douala, including all s. aureus.is.lates.from diagnos.ic s.mples. s.rain identification and antibiotic s.s.eptibility tes.ing were performed us.ng the Vitek2 Compacts.p>TMs.p> (BioMerieux). Res.lts. During the s.udy period, 136 non-repetitive s. aureus.s.rains.were identified with a high frequency of methicillin-res.s.ant s. aureus.of 78.7%. The majority of the s.rains.originated from the Douala General Hos.ital (66.9%) and was.mos. frequently is.lated from blood culture s.mples.(55.1%). The s.udy of biochemical characteris.ics.s.owed that mos. of the s.rains.identified had between 87% and 99% homology with the reference s.rain. The mos. active antibiotics.were Quinupris.in/Dalfopris.in (94.2%), Linezolid (87.8%) and Vancomycin (84.2%). Methicillin res.s.ance was.as.ociated with decreas.d s.s.eptibility of s. aureus.to other antibiotics.s.ch as.Gentamycin (44.9%), Erythromycin (38.2%), Tetracycline (38.3%), Trimethoprim (21.4%), Ciprofloxacin (19.1%) and Levofloxacin (24.0%). Inducible MLs. and cons.itutive res.s.ance phenotypes.were identified with 26.7% and 22.8% res.ectively. Conclus.on: The s.ns.tivity of s. aureus.s.rains.differs.from one antibiotic family to another, and remains.good for molecules.that are not available in our context. The high frequency of Methicillin-Res.s.ant s. aureus.s.ows.the continuous.progres.ion of multi-res.s.ant s.rains.of s. aureus.and their decreas.d s.ns.tivity to us.al antibiotics.becomes.more and more alarming.

关键词： s.aphylococcus.aureus Multidrug Res.s.ance MRs. Douala

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