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Unique immunological profile in patients with COVID-19

Cellular & Molecular Immunology 2021年第3期18卷 604-612页

作者： Stefania Varchetta dalila mele Barbara Olivier Stefania Mantovani Serena Ludovisi Antonella Cerino Raffaele Bruno Alberto Castelli Mario Mosconi Marco Vecchia Silvia Roda Michele Sachs Catherine Klersy Mario U.Mondelli Division of Infectious Diseases Ⅱ and Immunology Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Internal Medicine and Therapeutics University of PaviaPaviaItaly Division of Infectious Diseases I Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Clinical SurgicalDiagnosticand Pediatric SciencesUniversity of PaviaPaviaItaly Division of Orthopaedics and Traumatology Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Clinical-Surgical Diagnostic and Pediatric SciencesUniversity of PaviaPaviaItaly Clinical Epidemiology&Biometry Unit IRCCS Fondazione Polidinico San MatteoPaviaItaly

The relationship between severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)and host immunity is poorly *** performed an extensive analysis of immune responses in 32 patients with severe COVID-19,some of whom succumbed A control population of healthy subjects was *** with COVID-19 had an altered distribution of peripheral blood lymphocytes,with an increased proportion of mature natural killer(NK)cells and low T-cell *** cells and CD8^(+)T cells overexpressed T-cellimmunoglobulin and mucin domain-3(TIM-3)and *** cell exhaustion was attested by increased frequencies of programmed cell death protein 1(PD-1)positive cells and reduced frequencies of natural killer group 2 member D(NKG2D)-,DNAX accessory molecule-1(DNAM-1)-and sialic acid-binding Ig-like lectin 7(Siglec-7)-expressing NK cells,associated with a reduced ability to secrete interferon(IFN)γ.Patients with poor outcome showed a contraction of immature CD56^(bright) and an expansion of mature CD57^(+)F_(CEI)Rlγ^(eng) adaptive NK cells compared to *** serum levels of IL-6 were also more frequently identified in deceased patients compared to *** note,monocytes secreted abundant quantities of IL-6,IL-8,and IL-1β which persisted at lower levels several weeks after recovery with concomitant normalization of CD69,PD-1 and TIM-3 expression and restoration of CD8^(+)T cell numbers.A hyperactivated/exhausted immune response dominate in severe SARS-CoV-2 infection,probably driven by an uncontrolled secretion of inflammatory cytokines by *** findings unveil a unique immunological profile in COVID-19 patients that will help to design effective stage-specific treatments for this potentially deadly disease.

关键词： C0VID-19 NK cells TIM-3 IL6 Monocytes

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Isolation,characterization and identification of plant growth-promoting rhizobacteria from the rhizosphere of Acacia mangium at sandy BRIS soil

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Frontiers of Agricultural Science and Engineering 2024年第3期11卷 499-513页

作者： Zakiah MUSTAPHA Radziah OTHMAN Nik Nurnaeimah NIK MUHAMMAD NASIR Dhiya dalila ZAWAWI Mohd Khairi CHE LAH Hafizan JUAHIR School of Agriculture Science and Biotechnology Faculty of Bioresources and Food IndustryUniversiti Sultan Zainal AbidinBesut Campus22200 BesutTerengganuMalaysia Department of Land Management Faculty of AgricultureUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Faculty of Plantation and Agrotechnology Universiti Technologi MARA Cawangan Pahang26400 JengkaPahangMalaysia

This study has isolated,characterized,and identified potential plant growthpromoting rhizobacteria(PGPR)with multiple PGP characteristics(N_(2)-fixation,P-and K-solubilization,IAA,and siderophores production)from the rhizosphere BRIS soil of Acacia mangium.A total of 24 pure colonies were isolated and only 8 colonies were selected for further evaluation of the growth rate in 5%organic molasses medium supplemented with 2%KNO_(3).Based on the biochemical,potential PGP characteristics and growth performance,3 superior PGPR strains were selected and identified as Paraburkholderia unamae(UA1),Bacillus amyloliquefaciens(UA6),and Enterobacter asburiae(UAA2)by partial sequencing of the 16S rRNA *** selected bacterial strains either in single or mixed(UA1+UA6+􀀁UAA2)cultures have shown a significant biochemical estimation of the PGP *** strain has its own PGPR traits superiority with UA1 showing the best PGP characteristic followed by UA6 and *** use of mixed bacterial strains was beneficial as it showed the best performance in N_(2)-fixation,siderophores production,and significant effect on corn phenology,growth and yield compared to using a single *** types of microbes showed potential to be used as biofertilizer and should be exploited more.

关键词： Biofertilizer corn organic molasses medium PGP characteristic phytohormone potassium nitrate siderophores

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Forward–Backward SDEs Driven by Levy Process in Stopping Time Duration

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Communications in Mathematics and Statistics 2017年第2期5卷 141-157页

作者： dalila Guerdouh Nabil Khelfallah Laboratoire de Mathematiques Appliquees Universite de BiskraB.P14507000 BiskraAlgeria

As the first part in the present paper,we study a class of backward stochastic differential equation(BSDE,for short)driven by Teugels martingales associated with some Levy processes having moment of all orders and an independent Brownian *** obtain an existence and uniqueness result for this type of BSDEs when the final time is allowed to be *** the second part,we prove,under a monotonicity condition,an existence and uniqueness result for fully coupled forward-backward stochastic differential equation(FBSDE,for short)driven by Teugels martingales in stopping time *** an illustration of our theoretical results,we deal with a portfolio selection in Levy-type market.

关键词： backward stochastic differential equations Teugels martingale Levyprocess Stopping time

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Study on textile waste generation in the undifferentiated municipal solid waste stream in Guimarães,Portugal

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Waste Disposal and Sustainable Energy 2023年第2期5卷 189-203页

作者： Alona Perebynos dalila Sepúlveda Carlos Ribeiro Landscape Laboratory Rua da Ponte RomanaCreixomil4835-095GuimarãesPortugal Environmental and Public Space Division Environmental and Sustainability DepartmentGuimarães City CouncilLargo Cónego JoséMaria Gomes4804-534GuimarãesPortugal

Guimarães is a middle sized city and municipality located in northern *** municipality has committed to reducing the annual amount of undifferentiated municipal solid waste(MSW)from 371 kg/capita in 2021 to 120 kg/capita by 2030 under the Zero Waste Cities Certification *** the municipality of Guimarães,one of the constant fractions of MSW composition is textile waste(TW),which the revised EU Waste Framework Directive requires separate collection by 1 January ***,two indicators of TW generation were analysed to identify waste collection routes with a high level of textile waste generation for the priority implementation of separate collection:TW composition in the undifferentiated MSW stream and TW generation per *** statistical analysis methods were used to process the source data of TW composition in the undifferentiated MSW *** analysis was applied to the data set on TW generation per capita,considering the area typology(urban,rural or mixed)of collection *** was considered that 39%of the industrial sector of Guimarães consists of textile and clothing production and represents small-and medium-sized enterprises,which can affect TW generation in the undifferentiated MSW ***-comparative research was used to define the correlation between TW generation per capita and the economic activity of the textile and clothing industry in the *** a result,applying a multi-disciplinary approach,a project of the Textile Waste Generation Map was presented.

关键词： Textile waste Municipal solid waste Waste generation indicators Waste management Circular economy

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Water yield and biomass production for on a eucalypt-dominated Mediterranean catchment under different climate scenarios

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林业研究:英文版 2023年第5期34卷 1263-1278页

作者： Joao Rocha Ana Quintela dalila Serpa Jan Jacob Keizer Sérgio Fabres RAIZ-Forest and Paper Research Institute Quinta de S.FranciscoRua JoséEstevao(EN 230-1)3800–783 EixoAveiroPortugal Department of Environment and Planning Centre of Environmental and Marine Studies(CESAM)University of AveiroCampus Universitário de Santiago3810–193 AveiroPortugal

Worldwide,forests are vital in the regulation of the water cycle regulation and in water balance *** of ecohydrological responses of production forests is essential to support management strategies,especially where water is already *** climatological patterns are expected to impact thermopluviometric regimes,water cycle components,hydrological responses,and plant physiology,evapotranspiration rates,crop productivity and land management *** work(1)assessed the impacts of different predicted climate conditions on water yield;(2)inferred the impacts of climate change on biomass production on eucalypt-to-eucalypt succes *** this end,the widely accepted Soil and Water Assessment Tool(SWAT)was run with the RCA,HIRHAM5 and RACMO climate models for two emission scenarios(RCP 4.5 and8.5).Three 12-year periods were considered to simulate tree growth under coppice *** results revealed an overall reduction in streamflow and water yield in the catchment in line with the projected reduction in total annual ***,HIRHAM5 and RACMO models forecast a slight shift in seasonal streamflow of up to 2 months(for2024-2048)in line with the projected increase in precipitation from May to *** biomass production,the extreme climate model(RCA)and severe emis sion scenario(RCP 8.5)predicted a decrease up to 46%.However,in the less extreme and more-correlated(with actual catchment climate conditions)climate models(RACMO and HIRHAM5)and in the less extreme emission scenario(RCP 4.5),biomass production increased(up to 20%),and the growth cycle was slightly *** was proven to be a valuable tool to assess climate change impacts on a eucalypt-dominated catchment and is a suitable decision-support tool for forest managers.

关键词： Climate scenarios Forested catchments Forest ecohydrological modelling Eucalypt biomass production SWAT model

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Design and testing of a centralized protection scheme for micro-grids

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Journal of Central South University 2015年第10期22卷 3876-3887页

作者： Sohrab Mirsaeidi dalila Mat Said Mohammad Wazir Mustafa Mohammad Hafiz Habibuddin Kimia Ghaffari Centre of Electrical Energy Systems (CEES) Faculty of Electrical Engineering (FKE)Universiti Teknologi Malaysia (UTM) Young Researchers and Elites Club Saveh Branch Islamic Azad University

Micro-grids comprise low voltage distribution systems with distributed energy resources(DERs) and controllable loads which can operate connected to the medium voltage grid or islanded in a controlled coordinated way. This concept aims to move from "connect and forget" philosophy towards a full integration of DERs. Micro-grids can provide numerous economic and environmental benefits for end-customers, utilities and society. However, their implementation poses great technical challenges, such as a new philosophy in design of protection systems. In this work, a micro-grid protection scheme is presented based on positive-sequence component using phasor measurement units(PMUs) and a central protection unit(CPU). The salient feature of the proposed scheme in comparison with the previous works is that it has the ability to protect both radial and looped micro-grids against different types of faults with the capability of single-phase tripping. Furthermore, since the CPU is capable of updating its pickup values(upstream and downstream equivalent positive-sequence impedances of each line) after the first change in the micro-grid configuration(such as transferring from grid-connected to islanded mode and or disconnection of a line, bus, or DER either in grid-connected mode or in islanded mode), it can protect micro-grid against subsequent faults. Finally, in order to verify the effectiveness of the suggested scheme and the CPU, several simulations have been undertaken by using DIg SILENT Power Factory and MATLAB software packages.

关键词： micro-grid protection grid-connected mode islanded mode positive-sequence component

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Geochemical Record of the Cenomanian-Turonian Anoxic Event in Tunisia:Is it Correlative and Isochronous to the Biotic Signal?

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Acta Geologica Sinica(English Edition) 2011年第6期85卷 1310-1335页

作者： Mohamed SOUA dalila ZAGHBIB-TURKI Hela BEN JEMIA Jalel SMAOUI Amel BOUKADI Exploration and Studies Department Entreprise Tunisienne d'Activités Pétrolières(ETAP) Charguia Ⅱ2035 Tunisia Département of Geology Faculty of sciences of Tunis University of Tunis El Manar1068 Tunisia Petroleum Research and Development Center(CRDP-ETAP) Charguia Ⅱ 2035 Tunisia

In Tunisia, five Bahloul spaced sections, Bargou, Jerisa, Guern Halfaya, Kherij and Gafsa were analyzed for biostratigraphy （foraminifera and radiolarians） and major and trace elements. This high-resolution biostratigraphic and chemostratigraphic integrated analyses for the Late Cenomanian-Early Turonian Bahloul Formation provide new insight into the palaeoceanographic evolution of the southern Tethyan margin. Relative low abundance of related terrigenous Ti/Ai and K/ Al ratios and enrichment of some productivity proxies such as Ba, Cu, and Ni （organic matter related trace elements） suggests that the Bahloul, deposited during a relatively short period （0.5 Ma）, was of relatively elevated primary productivity and minimal detrital input. While higher D＊ values concurrent with lower Ti/AI ratios are interpreted as caused by enhanced fluvial material contribution, due to more humid climate during the OAE-2. Enhanced humidity triggered probably fluvial influxes, resulted in a sluggish water circulation and consequent anoxic/euxinic conditions favoring the preservation of organic matter at the bottom. Enrichments in redox-sensitive trace metals U, V, and Mo in the Bahloul Formation deposits and redox indices, such as V/（V＋Ni）, U/Th, V/Cr, and Ni/Co, indicate that oxygen-restricted conditions prevailed during the Late Cenomanian to earliest Turonian times and correlate well with relative abundances of some foraminiferal and radiolarian paleo- environmental relevant indicators. High Ba~ values and Uauth may indicate anoxic conditions at least at the water-sediment interface during the Bahloul Formation deposition and provide information about low to moderate sulfate-reduction reactions.

关键词： Bahloul Formation Foraminifera chemostratigraphy OAE-2

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Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 208-216页

作者： Moussa Labsi Lila Khelifi dalila Mezioug Imene Soufli Chafia Touil-Boukoffa Laboratory of Cellular and Molecular Biology Department of BiologyUniversity of Sciences and Technology Houari Boumediene

Objective: To investigate the effect of pomegranate peel aqueous extract (PGE) on the development of secondary experimental echinococcosis and on the viability of Echinococcus granulosus protoscoleces, and the immunomodulatory properties of PGE. Methods: Swiss mice were inoculated intraperitoneally with viable protoscoleces. Then, PGE was orally administered daily during cystic echinococcosis development. Cyst development and hepatic damage were macroscopically and histologically analyzed. The production of nitric oxide and TNF-alpha was assessed in plasma and the hepatic expression of iNOS, TNF-alpha, NF-kappa B and CD68 was examined. Moreover, protoscoleces were cultured and treated with different concentrations of PGE. Results: It was observed that in vitro treatment of protoscoleces caused a significant decrease in viability in a PGE-dose-dependent manner. In vivo, after treatment of cystic echinococcosis infected mice with PGE, a significant decrease in nitric oxide levels (P<0.000 1) and TNF-alpha levels (P<0.001) was observed. This decline was strongly related to the inhibition of cyst development (rate of hydatid cyst growth inhibition=63.08%) and a decrease in CD68 expression in both the pericystic layer of hepatic hydatid cysts and liver tissue (P<0.000 1). A significant diminution of iNOS, TNF-alpha and NF-kappa B expression was also observed in liver tissue of treated mice (P<0.000 I). Conclusions: Our results indicate an antihydatic scolicidal effect and immunomodulatory properties of PGE, suggesting its potential therapeutic role against Echinococcus granulosus infection.

关键词： Pomegranate peel aqueous extract Tumor necrosis factor-alpha iNOS Nuclear factor-kappa B

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Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract:In vitro and in vivo study

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Asian Pacific Journal of Tropical Medicine 2019年第3期12卷 106-116页

作者： Nahla Deghbar dalila Mezioug Touri Kahina Yacine-Miloud Medjdoub Chafia Touil-Boukoffa Cytokines and NO Synthases-Immunity and Pathogeny team Laboratory of Cellular and Molecular Biology Faculty of Biological Sciences University of Sciences and Technology Houari Boumediene Department of Thoracic Surgery Mustapha Pacha Hospital

Objective: To evaluate the in vitro and in vivo effect of the Algerian propolis ethanolic extract(EEP) against Echinococcus granulosus(E. granulosus) infection. Methods: In vitro scolicidal activity of EEP was investigated on the protoscolices of hydatid cyst. This in vitro study was conducted by using an in vivo assay. BALB/c mice were inoculated with E. granulosus and treated with propolis for three months. Hydatid cysts development was assessed. Nitric oxide(NO), tumor necrosis factor alpha(TNF-α) production and inducible NO synthase, NF-κB, and TNF-α spleen expression were estimated by Griess method and immunofluorescence ***: Our study revealed that EEP has a high scolicidal activity against E. granulosus. Oral administration of EEP decreased TNF-α, NF-κB and inducible NO synthase expression in the spleen tissues in the CE+EEP group, in comparison with the CE group. Concomitantly, EEP treatment caused an important systemic decrease in NO and TNF-α levels. These findings are associated with the reduction of CE development. Conclusions: This is the first report demonstrating with interest the antihydatic and immunomodulatory effects of the Algerian EEP, suggesting its therapeutic potential for the hydatid disease treatment.

关键词： Cystic echinococcosis Algerian propolis Antihydatic effect Immunomodulatory effect

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Future Hybrid of Photovoltaic and Fuel Cell for Langkawi SkyCab

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Journal of Electronic Science and Technology 2019年第4期17卷 348-356页

作者： Siti Maherah bt Hussin Zainal Salam Norzanah Rosmin Md Pauzi Abdullah dalila Mat Said Madihah binti Md Rasid the School of Electrical Engineering Universiti Teknologi Malaysia

Langkawi SkyCab has the highest energy demand in Langkawi Island and the demand keeps increasing year by *** study proposed alternatives energy of a hybrid photovoltaic(PV)and fuel cell system for the SkyCab’s *** best sizing and configurations were chosen based on Homer simulation software.A comparative study was done between a conventional system and other hybrid *** results revealed that the proposed system had reduced the cost as well as CO2 emission almost by 39%and 79%,*** hybrid PV and fuel cell system is aligned with the Malaysian government’s goals of reducing carbon emissions 40%by the year 2030.

关键词： Fuel cell Homer software Langkawi SkyCab photovoltaic.

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