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Oxidative stress-elevated high gamma glutamyl transferase levels, and aging, intake of tropical food plants, migration and visual disability in Central Africans

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 493-498页

作者： Benjamin Longo-Mbenza Mose Mvitu Muaka Etienne Mokondjimobe dalida kibokela ndembe Doris Tulomba Mona Baudouin Buassabu-bu-Tsumbu Faculty of Health Sciences Walter Sisulu UniversityMthatha 5117 Eastern Cape South Africa Department of Ophthalmology University of KinshasaKinshasa Democratic Republic of the Congo Faculty of Health Sciences University of Marien NgouabiBrazzaville Democratic Republic of the Congo Department of Neuropsychiatry University of KinshasaKinshasa Democratic Republic of the Congo Biostatistics Unit Lomo Medical Center and Heart of Africa Center of CardiologyKinshasa Democratic Republic of the Congo Department of Basic Sciences Division of Biochemistry University of KinshasaKinshasa Democratic Republic of the Congo

·AIM:To investigate the independent pathogenic role of high serum gamma-glutamyl transferase (GGT) levels, sociodemographic data, dietary and environmental risk factors for visual disability (VD). ·METHODS:This was a case-control study, run in 200 black Congolese patients managed in Saint Joseph Hospital Ophthalmology Division from Kinshasa town. Logistic regression model was used to identify determinants of VD (n = 58) among sex, age, cigarette smoking, alcohol abuse, rural-urban migration, education levels, aging ≥60 years, intake of red Beans, Safou fruit and Taro leaves, lipid profile, residence, socioeconomic status, and GGT. ·RESULTS:After adjusting for confounding factors, we identified migration (OR=3.7 95% CI:1.2-11.3; P =0.023), low education level (OR=3.1 95% CI 1.1-8.5; P =0.026), no intake of Safou fruit (OR=34.2 95% CI 11.5-102; P < 0.0001), age ≥60 years (OR=2.5 95% CI 1.01-6.5; P = 0.049), and serum GGT ≥10U/L (OR=3.6 95% CI 1.3-9.6; P = 0.012) as the significant and independent determinants of VD. ·CONCLUSION:VD appears as a major public health problem in Central Africa to be prevented or delayed by control of migration, lifestyle changes, antioxidant supplements, appropriate diet, nutrition education, and blocking of oxidative stress.

关键词： oxidative stress serum gamma-glutamyl transferase intake of tropical food plants aging vision loss

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Retinopathy in non diabetics, diabetic retinopathy and oxidative stress: a new phenotype in Central Africa?

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 293-301页

作者： Benjamin Longo-Mbenza Moise Mvitu Muaka Wayiza Masamba Lucien Muizila Kini Igor Longo Phemba dalida kibokela ndembe Doris Tulomba Mona Walter Sisulu University Faculty of Health Sciences Walter Sisulu University Department of Ophthalmology University of Kinshasa Department of Chemistry and Chemical Technology Walter Sisulu University Department of Family Medicine Umtata General HospitalWalter Sisulu University School of International Studies Wendzou Medical College Department of Neuropsychiatry University of Kinshasa Biostatistics Unit Lomo Medical Center and Heart of Africa Center of Cardiology

AIM:To evaluate the rates of retinopathy without diabetes and diabetic retinopathy(DR),associated with some markers of oxidative stress,antioxidants and cardiometabolic risk ***:We determined the prevalence of DR in 150type 2 diabetes mellitus(T2DM)patients,that of retinopathy in 50 non diabetics,the levels of body mass index(BMI),waist circumference(WC),blood pressure,lipids,8-isoprostane,8-hydroxydeoxyguanosine(8-oHdG),gamma-glutamyl transferase(GGT),oxidized low density lipoprotein(LDL)(OxLDL),thiobarbituric acid reacting substances(TBARS),reduced glutathione(GSH),superoxide dismutase(SOD),uric acid,creatinine,albumin,total antioxidant status(TAOS),zinc,selenium,magnesium,vitamin C,vitamin D,vitamin E,glucose,apolipoprotein B(ApoB).RESULTS:The prevalences of DR at 53y and Rtp at62y were 44%(n=66)and 10%(n=5),*** levels of 8-isoprostane,8-OHdG,TBARS,SOD,and OxLDL were in *** lowest levels of vitamin D,vitamin C,TAOS,and vitamin E were in *** the casecontrol study discriminant analysis,the levels of vitamin C,vitamin D,ApoB,8-OHdG,creatinine,Zn,vitamin E,and WC distinguished significantly non-diabetics without DR(controls),T2DM patients without DR and T2DM patients with ***:Anticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type *** of oxidative stress and abdominal obesity is *** in vitamin C,D,and E should be recommended as complement therapies of T2DM.

关键词： anticipation apolipoprotein B diabetic retinopathy oxidative stress discriminant analysis Africa

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Role of Mediterranean diet, tropical vegetables rich in antioxidants, and sunlight exposure in blindness, cataract and glaucoma among African type 2 diabetics

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International Journal of Ophthalmology(English edition) 2012年第2期5卷 231-237页

作者： Mvitu Muaka Mose Longo-Mbenza Benjamin Tulomba Mona Doris kibokela ndembe dalida Nge Okwe Augustin University of Kinshasa Department of Ophthalmology Walter Sisulu University Faculty of Health Sciences South Africa Biostatistics Unit Lomo Medical Center and Heart of Africa Center of Cardiology Kinshasa DR Congo

AIM: To assess whether regular Mediterranean diet and regular intake of vegetables may reduce the risk of blindness, cataract, and glaucoma in these type 2 diabetics. · METHODS: A cross-sectional design was carried out among known black diabetics admitted at the diabetic clinics of Kinshasa, between October 2008 and March 2009. The Mediterranean-style dietary score (MSDPS) was used to characterize a Mediterranean-style dietary pattern in the study population using the Harvard semi quantitative FFQ adapted for Africa. · RESULTS: Five hundred Type 2 diabetic patients were included in this study (48% of males; 40% aged ≥60 years). There was a significant association between blindness, cataract and aging; between blindness (P <0.05), cataract (P<0.05), glaucoma (P <0.05), and physical inactivity; between blindness (P<0.05), cataract (P <0.0001), glaucoma (P <0.01) and high SES, and a very significant association between blindness (P <0.0001), cataract (P <0.0001), glaucoma (P <0.0001) and exposure to sunlight. There was also a significant association between blindness, glaucoma, and male sex. Regular intake of Mediterranean diet, Brassica Rapa, beans, Abelmoschus, Musa acuminata reduced significantly the risk of blindness, cataract and glaucoma. · CONCLUSION: Regular intake of Mediterranean diet, Brassica Rapa, beans, Abelmoschus, and Musa acuminata may significantly reduce the risk of blindness or its major causes among type 2 diabetes mellitus in Africa.

关键词： type 2 diabetes mellitus Mediterranean diet blindness cataract Africa

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