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聚氨酯缔合增稠剂流变性能的影响因素研究

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中国涂料 2017年第4期32卷 25-30页

作者：张东阳王木立马智俊营飞 daliborVukadinovic Tenter 中海油常州涂料化工研究院有限公司江苏常州213016 德国雷曼弗斯公司德国汉堡

研究了增稠剂疏水端基的大小、结构对流变性能以及流变性质的影响,探索了增稠剂分子量与分子量分布状态对流变性能的影响,并研究了不同增稠剂加量条件下,流变曲线的变化。

关键词：聚氨酯缔合增稠剂疏水端基流变性能分子量

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A candidate identification questionnaire for postmenopausal osteoporosis patients switched from daily or weekly bisphosphonate to once-monthly ibandronate: An open, prospective, multicenter study—BONCURE study

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Health 2013年第7期5卷 30-40页

作者： Yesim Gokce Kutsal Nurten Eskiyurt Jale Irdesel Vesile Sepici Hatice Ugurlu Yesim Kirazli Fusun Ardic Mirko Korsic Tonko Vlak Mane Grlickov Snezana Markovic Temelkova Miroslav Lazarov Nada Pilipovic Vera Popovic Aleksandar Dimic Branka Kovacev Dorina Ruci Argjend Tafaj Elma Kucukalic-Selimovic Dijana Avdic Hajrija Seleskovic Snjezana Pejicic Bulent Butun Gulseren Akyuz Lale Cerrahoglu Omer Faruk Sendur Peyman Yalcin Sema Oncel Merih Saridogan Tunay Sarpel Mehmet Tosun Kazim Senel Savas Gursoy Ferhan Canturk Huseyin Demir Blazenka Miskic dalibor Krpan Franjo Skreb Simeon Grazio Zeljka Crncevic-Orlic Fatih Ozdener Hakan Oncel Clinic for Orthopaedic Surgery Clinical Centre Vodnjansk Skopje Macedonia Clinic of Endocrinology Diabetes and Metabolic Disorders Skopje Macedonia Clinic of Rheumatology Clinical Centre Skopje Macedonia Clinical Center of Vojvodina Novi Sad Serbia Clinical Center Banja Luka Bosnia and Herzegovina Clinical Hospital Centre Split Croatia Department of PMR Cerrahpasa School of Medicine Istanbul University Istanbul Turkey Department of PMR Clinical Hospital Center Rijeka Rijeka Croatia Department of PMR Dr. Josip Bencevic General Hospital Slavonski Brod Croatia Department of PMR Istanbul School of Medicine Istanbul University Istanbul Turkey Department of PMR Polyclinic for Internal Medicine Zagreb Croatia Department of PMR School of Medicine Adnan Menderes University Aydin Turkey Department of PMR School of Medicine Akdeniz University Ankara Turkey Department of PMR School of Medicine Ankara University Ankara Turkey Department of PMR School of Medicine Ataturk University Erzurum Turkey Department of PMR School of Medicine Celal Bayar University Manisa Turkey Department of PMR School of Medicine Cukurova University Adana Turkey Department of PMR School of Medicine Dokuz Eylul University Izmir Turkey Department of PMR School of Medicine Ege University Izmir Turkey Department of PMR School of Medicine Erciyes University Kayseri Turkey Department of PMR School of Medicine Gazi University Ankara Turkey Department of PMR School of Medicine Gaziantep University Gaziantep Turkey Department of PMR School of Medicine Hacettepe University Ankara Turkey Department of PMR School of Medicine Karadeniz Technical University Trabzon Turkey Department of PMR School of Medicine Marmara University Istanbul Turkey Department of PMR School of Medicine Ondokuz Mayis University Samsun Turkey Department of PMR School of Medicine Pamukkale University Denizli Turkey Department of PMR School of Medicine Selcuk University Konya Turkey Department

A candidate identification questionnaire (CIQ) was tested to determine its predictive value for patient-reported satisfaction in patients switched from once-weekly or once-daily treatment with a bisphosphonate to once-monthly dosing. This was a prospective, open-label, multicenter international study in patients with postmenopausal osteoporosis who had been receiving once-daily or once-weekly alendronate or risendronate for at least 3 months. Patients completed a CIQ, then commenced 150 mg monthly ibandronate for 6 months. Patients completed the Osteoporosis Patient Satisfaction Questionnaire (OPSAT-QTM) at baseline for 6 months. Scores were converted to composite satisfaction scores (CSS, scale 0-100). Totally 677 patients completed a CIQ, 645 were enrolled in the treatment phase and comprised the intent-to-treat (ITT) population, and 630 completed the study. In the ITT population, 68.1% patients answered “yes” to one or more CIQ questions. OPSAT-Q scores increased for the convenience, quality of life and overall satisfaction domains (p scores for the side effects domains were significant (p < 0.001) in the CIQ “yes” group, but not for the degree of bother (decrease in mean of 0.1 points, p = 0.50) or duration (no change, p = 0.84) of non-gastrointestinal side effects. Of 638 patients who completed the preference questionnaire, 93.0% of patients preferred the once-monthly dosing schedule and 563 patients (90.7%) found it more convenient. The most common adverse events were dyspepsia (1.9%), nausea (1.1%), and upper abdominal pain (0.9%). Patients are likely to prefer treatment with monthly ibandronate to a weekly or monthly bisphosphonate irrespective of their stated preference before switching treatment.

关键词： Bisphosphonate Compliance Ibandronate Postmenopausal Osteoporosis

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