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Putrescine Modulates Cadmium Fixation Ability of Cell Wall to Decrease Cadmium Accumulation in Rice,a Process Might Depend on Nitric Oxide

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Rice science 2024年第3期31卷 237-240,I0002-I0007页

作者： WANG Haoyu LI Su yang Jibo HUANG Jing ZHU Xiaofang SHEN Renfang ZENG dali College of Advanced Agricultural Sciences Zhejiang A&F UniversityHangzhou 311300China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of ScienceNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China

Although putrescine(PUT)has been linked to plants'responses to cadmium(Cd)stress,the exact mechanism is still elusive.In the current investigation,the endogenous PUT concentration in rice roots was enhanced by Cd stress.Exogenous PUT increased root cell wall hemicellulose levels,which in turn increased its Cd binding capacity,concurrently decreasing the transcription level of genes such as OsNRAMP1 and OsCd1 that are responsible for root Cd absorption.As a result。

关键词： absorption roots cadmium

Multi-scale analysis of carbon mineralization in lime-treated soils considering soil mineralogy

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2296-2309页

作者： Dhanalakshmi Padmaraj Chinchu Cherian dali Naidu Arnepalli Department of Civil Engineering Indian Institute of Technology MadrasChennai600036India University of Northern British Columbia Prince GeorgeBCV2N4Z9Canada

Mineral carbonation is emerging as a reliable CO_(2) capture technology that can mitigate climate change.In lime-treated clayey soils,mineral carbonation occurs through the carbonation of free lime and cementitious products derived from pozzolanic reactions.The kinetics of the reactions in lime-treated clayey soils are variable and depend primarily on soil mineralogy.The present study demonstrates the role of soil mineralogy in CO_(2) capture and the subsequent changes caused by carbon mineralization in terms of the unconfined compressive strength(UCS)of lime-treated soils during their service life.Three clayey soils(kaolin,bentonite,and silty clay)with different mineralogical characteristics were treated with 4%lime content,and the samples were cured in a controlled environment for 7 d,90 d,180 d,and 365 d.After the specified curing periods,the samples were exposed to CO_(2) in a carbonation cell for 7 d.The non-carbonated samples purged with N2 gas were used as a benchmark to compare the mechanical,chemical-mineralogical,and microstructure changes caused by carbonation reactions.Experimental investigations indicated that exposure to CO_(2) resulted in an average increase of 10%in the UCS of limetreated bentonite,whereas the strength of lime-treated kaolin and silty clay was reduced by an average of 35%.The chemical and microstructural analyses revealed that the precipitated carbonates effectively filled the macropores of the treated bentonite,compared to the inadequate cementation caused by pozzolanic reactions,resulting in strength enhancement.In contrast,strength loss in lime-treated kaolin and silty clay was attributed to the carbonation of cementitious phases and partly to the tensile stress induced by carbonate precipitation.In terms of carbon mineralization prospects,lime-treated kaolin exhibited maximum carbonation due to the higher availability of unreacted lime.The results suggest that,in addition to the increase in compressive strength,adequate calcium-bearing phases and macropores determine the effic

关键词： Clays Mineralogy Carbon capture Lime Strength Pore structure

The First-in-Human Whole-Body Dynamic Pharmacokinetics Study of Aptamer

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Research 2024年第1期2023卷 119-130页

作者： Ding Ding Haitao Zhao dali Wei Qinglai yang Cai yang Ruowen Wang Yumei Chen Lianghua Li Shuxian An Qian Xia Gang Huang Jianjun Liu Zeyu Xiao Weihong Tan Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of Medicineand College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Nuclear Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Center for Molecular Imaging Probes Cancer Research InstituteUniversity of South ChinaHengyangHunan 421001China The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhouZhejiang 310022China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai200127China

Serving as targeting ligands,aptamers have shown promise in precision medicine.However,the lack of knowledge of the biosafety and metabolism patterns in the human body largely impeded aptamers’clinical translation.To bridge this gap,here we report the first-in-human pharmacokinetics study of protein tyrosine kinase 7 targeted SGC8 aptamer via in vivo PET tracking of gallium-68(^(68)Ga)radiolabeled aptamers.The specificity and binding affinity of a radiolabeled aptamer,named ^(68)Ga[Ga]-NOTA-SGC8,were maintained as proven in vitro.Further preclinical biosafety and biodistribution evaluation confirmed that aptamers have no biotoxicity,potential mutation risks,or genotoxicity at high dosage(40 mg/kg).Based on this result,a first-in-human clinical trial was approved and carried out to evaluate the circulation and metabolism profiles,as well as biosafety,of the radiolabeled SGC8 aptamer in the human body.Taking advantage of the cutting-edge total-body PET,the aptamers’distribution pattern in the human body was acquired in a dynamic fashion.

关键词： metabolism dosage Whole

WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling

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International Journal of Oral Science 2024年第1期16卷 85-96页

作者： Qingling Huang Yi Xiao Ting Lan Youguang Lu Li Huang dali Zheng Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFujian Medical UniversityFuzhouChina Fujian Key Laboratory of Oral Diseases School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Preventive Dentistry School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Dentistry The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina

Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3 was observed, which positively correlated with tumor progression.These findings underscore the significance of WNT7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/STAT3 pathway as a promising strategy for precise treatment of HNSCC.

关键词： WNT squamous tumorigenesis

Revealing the Solution Structure of Pd(OAc)_(2) with Halide Additives

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Chinese Journal of Chemistry 2022年第8期40卷 895-901页

作者： Liwei Wang dali yang Hesham Alhumade Hong Yi Xiaotian Qi Aiwen Lei Institute for Advanced Studies(IAS) College of Chemistry and Molecular SciencesEngineering Research Center of Organosilicon Compounds&Materials(Ministry of Education)Wuhan UniversityWuhanHubei 430072China King Abdulaziz University JeddahSaudi Arabia Department of Chemical andMaterials Engineering Facultyof EngineeringCenter of Research Excellence in Renewable Energy andPowerSystemsKingAbdulaziz UniversityJeddah21589Saudi Arabia

Mechanistic studies of the palladium catalyst activation with halide additives are of great importance to palladium catalysis.In this work,XAFS spectroscopy and cyclic voltammetry were utilized to study real structures of Pd(OAc)2 in solution with different inorgan-ic halogen additives.XAFS results demonstrate that Pd maintained+2 in the presence of excessive LiCl,LiBr,ZnCl_(2),ZnBr_(2),and Nal.Fitting results of EXAFS spectra revealed that the Pd's first shell is replaced by halogen partially or completely depending on the hal-ogen species.DFT calculations were conducted to identify the most reliable solvated structures.The combined experimental and computational studies elucidate the critical role of inorganic halide additives in Pd chemistry.

关键词： Palladium Structure Halides X-ray absorption spectroscopy(XAS) Density functional calculation

Multi-Scale Pore Structure Heterogeneity in Tuff Reservoirs Investigated with Multi-Experimental Method and Fractal Dimensions in Chang 7 Formation,Southern Ordos Basin

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Journal of Earth Science 2024年第2期35卷 666-686页

作者： Hao Lu Qing Li dali Yue Dongdong Xia Shenghe Wu Lang Wen Yu He State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China College of Geosciences China University of PetroleumBeijing102249China Petroleum Exploration and Development Institute of SINOPEC Beijing100083China

The tight tuff reservoir is an unusual type of unconventional reservoir with strong heterogeneity.However,there is a lack of research on the microscopic pore structure that causes the heterogeneity of tuff reservoirs.Using the Chang 7 Formation in Ordos Basin,China as a case study,carbon-dioxide gas adsorption,nitrogen gas adsorption and high-pressure mercury injection are integrated to investigate the multi-scale pore structure characteristics of tuff reservoirs.Meanwhile,the fractal dimension is introduced to characterize the complexity of pore structure in tuff reservoirs.By this multi-experimental method,the quantitative characterizations of the full-range pore size distribution of four tuff types were obtained and compared in the size ranges of micropores,mesopores and macropores.Fractal dimension curves derived from full-range pores are divided into six segments as D1,D2,D3,D4,D5 and D6 corresponding to fractal characteristics of micropores,smaller mesopores,larger mesopores,smaller macropores,medium macropores and larger macropores,respectively.The macropore volume,average macropore radius and fractal dimension D5 significantly control petrophysical properties.The larger macropore volume,average macropore radius and D5 correspond to favorable pore structure and good reservoir quality,which provides new indexes for the tuff reservoir evaluation.This study enriches the understanding of the heterogeneity of pore structures and contributes to unconventional oil and gas exploration and development.

关键词： tuff reservoir pore structure carbon-dioxide gas adsorption nitrogen gas adsorption high-pressure mercury injection fractal dimension petroleum geology

Coupled multiphysical model for investigation of influence factors in the application of microbially induced calcite precipitation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2232-2249页

作者： Xuerui Wang Pavan Kumar Bhukya dali Naidu Arnepalli Shuang Chen Gesellschaft für Anlagen-und Reaktorsicherheit(GRS)GGmbH Braunschweig38122Germany Department of Civil Engineering Indian Institute of Technology MadrasChennai600036India Federal Institute for Geosciences and Natural Resources(BGR) Hannover30655Germany

The study presents a comprehensive coupled thermo-bio-chemo-hydraulic(T-BCH)modeling framework for stabilizing soils using microbially induced calcite precipitation(MICP).The numerical model considers relevant multiphysics involved in MICP,such as bacterial ureolytic activities,biochemical reactions,multiphase and multicomponent transport,and alteration of the porosity and permeability.The model incorporates multiphysical coupling effects through well-established constitutive relations that connect parameters and variables from different physical fields.It was implemented in the open-source finite element code OpenGeoSys(OGS),and a semi-staggered solution strategy was designed to solve the couplings,allowing for flexible model settings.Therefore,the developed model can be easily adapted to simulate MICP applications in different scenarios.The numerical model was employed to analyze the effect of various factors,including temperature,injection strategies,and application scales.Besides,a TBCH modeling study was conducted on the laboratory-scale domain to analyze the effects of temperature on urease activity and precipitated calcium carbonate.To understand the scale dependency of MICP treatment,a large-scale heterogeneous domain was subjected to variable biochemical injection strategies.The simulations conducted at the field-scale guided the selection of an injection strategy to achieve the desired type and amount of precipitation.Additionally,the study emphasized the potential of numerical models as reliable tools for optimizing future developments in field-scale MICP treatment.The present study demonstrates the potential of this numerical framework for designing and optimizing the MICP applications in laboratory-,prototype-,and field-scale scenarios.

关键词： Multiphysics Microbially induced calcite precipitation(MICP) Coupled thermo-bio-chemo-hydraulic(TBCH) model OpenGeoSys(OGS) Influence factors

Chiral phonon activated spin Seebeck effect in chiral materials

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 149-155页

作者： Xiao Li Jinxin Zhong Jinluo Cheng Hao Chen Huiqian Wang Jun Liu dali Sun Lifa Zhang Jun Zhou Phonon Engineering Research Center of Jiangsu Province Center for Quantum Transport and Thermal Energy ScienceSchool of Physics and TechnologyNanjing Normal UniversityNanjing 210023China Center for Phononics and Thermal Energy Science China-EU Joint Lab for NanophononicsSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of ScienceChangchun 130033China Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleigh NC 27606USA Department of Physics North Carolina State UniversityRaleigh NC 27695USA Organic and Carbon Electronics Laboratories(ORaCEL) North Carolina State UniversityRaleigh NC 27606USA

Efficient generation of spin polarization is very important for spintronics and quantum computation. In chiral materials without magnetic order nor spin-orbit coupling, we find a new spin selectivity effect—chiral phonon activated spin Seebeck(CPASS)effect. Starting with the nonequilibrium distribution of chiral phonons under a temperature gradient, the CPASS coefficients are computed based on the Boltzmann transport theory. With both the phonon-drag and band transport contributions, the spin accumulations generated by the CPASS effect exhibit quadratic dependence on the temperature gradient. The strength of the CPASS effect and the relative magnitude of both contributions are tunable by the chemical potential modulation. The CPASS effect, which gives a promising explanation on the traditional chiral-induced spin selectivity effect, provides opportunities for the exploration of advanced spintronic devices based on chiral materials even in the absence of any magnetic order and spin-orbit coupling.

关键词： spin Seebeck effect chiral phonon phonon-drag contribution efficient spin generation

Study on Clogging Mechanism and Water Sediment Movement Mechanism of Patch-Type Drip Irrigation Emitters

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排灌机械工程学报 2024年

作者： ZHU Ximao YU Liming WANG Dan WANG Changman WU dali YCIC Ecological Environment Engineering Co. LTD 4. Yanshan Manyue Berry Agriculture Co. LTD Faculty of Modern Agriculture Engineering Kunming University of Science and Technology Research Institute of Highway Ministry of Transport Key Laboratory of Environmental Protection Technology on Road

As one of the key components of drip irrigation technology， the existence of sediment particles seriously affects the service life of emitters and restricts the popularization of drip irrigation technology. In this paper， two kinds of patch drip irrigation emitters are used as research object， and the anti-clogging performance experiment is carried out in the laboratory. The dynamic changes in emitters’ clogging characteristics (Dra， Cu) were statistically analyzed. The movement mechanism of emitter clogging and discharging sediment was studied. The effects of emitter structure and position factors on emitter clogging were analyzed. The results show that: (1) The pressure-compensated emitter has better anti-clogging performance， and its service life is 227.8% of the labyrinth channel emitter. (2) Single structural factor can not evaluate the anti-clogging performance of emitters. All factors causing emitter clogging should be considered comprehensively. (3) All emitters have sensitive clogging sediment inside， but only when sediment content is high can it easily cause blockage. The results show that when the sensitive sediment content is 5.46% and 5.54%， it does not affect the clogging characteristics of the emitters. (4) The discharge of sediment V90 from the emitter is affected by the accumulation effect of clogged sediment. The experimental results show that the emitter can discharge up to 50% of the accumulated clogged sediment without clogging. In comparison， the emitter with clogging can only discharge up to 25% of the accumulated clogged sediment. These results could provide references for the application and promotion of drip irrigation technology.

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