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Biochemical, Biophysical and Mechanical Characterization of Decellularized Dermal Implants

Materials Sciences and Applications 2017年第12期8卷 873-888页

作者： Frederick H. Silver dale devore Ruchit Shah Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical School Rutgers the State University of New Jersey Piscataway NJ USA DV Consulting Services Chelmsford MA USA Graduate Program in Biomedical Engineering Rutgers the State University of New Jersey Piscataway NJ USA

Allografts have been used in a variety of applications to augment as well as replace tissues throughout the body. A number of steps are involved in selection, harvesting, processing and testing of dermal allografts. Grafts can be obtained that are: free of antibodies to viruses and low in viral titers. Cellular material can be eliminated from the tissue and the product becomes almost exclusively a collagen fiber network. The purpose of this paper is to examine the changes in collagen structure and properties that occur during processing of decellularized dermis. The results indicate that collagen fiber swelling occurs during processing although the product preserves the native collagen banding pattern at the fibrillar structural level. Fiber swelling and decreased collagen deformability of processed dermis, may lead to stress concentration at the implant-tissue interface and up-regulation of mechanotransduction. This may lead to premature mechanical failure due to creation of a chronic inflammatory condition at the implant-tissue interface. It is suggested that all dermal allografts be oriented such that Langer’s lines of the implant match those of the host tissue, and that wound closure by suturing be done under conditions that preserve the normal tension in skin in order to minimize implant-interfacial failure.

关键词： Collagen Dermis Repair Wound Healing Optical Coherence Tomography Vibrational Analysis Resonant Frequency Modulus Langer’s Lines Mechanotransduction

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Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product

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Modern Research in Inflammation 2014年第1期3卷 19-25页

作者： Kevin J. Ruff dale P. devore ESM Technologies LLC Carthage USA Membrell LLC Carthage USA

NEM®?brand eggshell membrane is a novel dietary supplement that has been clinically shown to alleviate arthritis joint pain and stiffness;however the mechanism of action is not well understood. Preliminary evidence from an?in vitro?study of?NEM®?indicated that the mechanism of action may be based on the reduction of pro-inflammatory cytokines.?In vivo?studies were therefore initiated to evaluate the effects of?NEM®?on pro-inflammatory and anti-inflammatory cytokines following oral administration in rats.?NEM®?was administered daily at doses of 6.13 mg/kg bw/day (Study 1), 10.0 mg/kg bw/day (Study 2), or at doses of 0 (control), 26.0 or 52.0 mg/kg bw/day (Study 3) by oral gavage for 7 consecutive days. Inflammation was induced in the Study 3 rats by intraperitoneal injection of lipopolysaccharide. Changes in plasma cytokine levels from baseline following 7 days of oral supplementation with?NEM®?at 6.13 mg/kg bw/ day (Study 1) were statistically significant at Day 8 for IL-2, TIMP-1 and VEGF, at Day 21 for IL-10, and at Day 35 for MCP-1, MCP-3 and TIMP-1, and at 10.0 mg/kg bw/day (Study 2) were statistically significant at Day 8 for VEGF, at Day 21 for MIP-1β, MIP-2 and VEGF, and at Day 35 for MCP-3, MIP-1β, MIP-2 and VEGF. Changes in serum cytokine levels versus control at 26.0 mg/kg bw/day (Study 3) were statistically significant at all time-points for IL-1β?and at 1.5 hours for IL-10, and at 52.0 mg/kg bw/day (Study 3) were statistically significant at 1.5 hours for IFN-γ, IL-1β?and IL-10, and at 3 hours for IL-1β, and at 24 hours for IL-10. Taken together, these studies demonstrate that oral supplementation with?NEM®?can influence both early-phase pro-inflammatory cytokines like IL-1β?and TNF-α?(Study 3), as well as later-phase cytokines like MCP-1, MIP-1α?&?β, RANTES and VEGF (Study 1 & 2). These studies provide a possible basis for the mechanism of action of?NEM®?in vivo.

关键词： Pro-Inflammatory Cytokines Eggshell Membrane

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Viscoelastic Evaluation of Different Hyaluronic Acid Based Fillers Using Vibrational Optical Coherence Tomography

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Materials Sciences and Applications 2019年第5期10卷 423-431页

作者： Frederick H. Silver Ruchit G. Shah Nikita Kelkar Dominick Benedetto dale devore Justin Cohen Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical School Rutgers The State University of New Jersey Piscataway NJ USA OptoVibronex LLC Mt. Bethel Pa USA Graduate Program in Biomedical Engineering Rutgers The State University of New Jersey Piscataway NJ USA Center for Advanced Eye Care Vero Beach FL USA DV Consulting Chelmsford MA USA Glasgold Group Princeton NJ USA

Hylauronic acid (HA) is used as a viscoelastic in Ophthalmology during cataract surgery based on its high viscosity at rest, its ability to shear thin and dissipate energy during phacoemulsification. However, these properties of HA solutions would make them susceptible to migration when used as dermal filler materials. In this study, we apply a new technique termed vibrational optical coherence tomography (VOCT) to compare the physical properties of different HA solutions and fillers used in facial aesthetics. Results presented in this study suggest that HA solutions and HA dermal fillers have markedly different physical properties. HA solutions are highly viscoelastic with high % viscous losses while fillers tend to have lower viscous energy dissipation properties. Clinical observations suggest that the high loss fillers are injected more superficially in the face where tension and internal and external forces are more likely minimized giving tissue of the hands and lips more volume and allowing more natural movement. In contrast, the lower loss gels that are used to lift tissue, generally have a higher G’, and are injected deeper into the face where injection and internal forces are likely to be higher. It is concluded that HA filler gel design can be optimized by use of VOCT to evaluate the % viscous energy loss both in vitro and in vivo.

关键词： Hyaluronic Acid Injectable Filler Dermal Filler Plastic Surgery Cosmetic Surgery Viscoelastic Mechanical Properties Facial Surgery Optical Coherence Tomography Vibrational Optical Coherence Tomography

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