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Synthetic high-density lipoprotein(sHDL):a bioinspired nanotherapeutics for managing periapical bone inflammation

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International Journal of Oral Science 2024年第3期16卷 460-470页

作者： Renan dal.Fabbro Minzhi Yu Ling Mei Hajime Sasaki Anna Schwendeman Marco C.Bottino Department of Cariology Restorative Sciencesand EndodonticsSchool of DentistryUniversity of MichiganAnn ArborMIUSA Department of Pharmaceutical Sciences College of Pharmacy and Biointerfaces InstituteUniversity of MichiganAnn ArborMIUSA Department of Biomedical engineering College of EngineeringUniversity of MichiganAnn ArborMIUSA

Apical periodontitis(AP)is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apical bone resorption affecting 50%of the worldwide population,with more than 15 million root canals performed annually in the United *** treatment involves cleaning and decontaminating the infected tissue with chemo-mechanical approaches and materials introduced years ago,such as calcium hydroxide,zinc oxide–eugenol,or even formalin ***,we present,for the first time,a nanotherapeutics based on using synthetic highdensity lipoprotein(sHDL)as an innovative and safe strategy to manage dental bone *** application in concentrations ranging from 25μg to 100μg/mL decreases nuclear factor Kappa B(NF-κB)activation promoted by an inflammatory stimulus(lipopolysaccharide,LPS).Moreover,sHDL at 500μg/mL concentration markedly decreases in vitro osteoclastogenesis(Pgly dampens the Toll-Like Receptor signaling pathway facing LPS stimulation,mainly by downregulating at least 3-fold the pro-inflammatory genes,such as Il1b,Il1a,Il6,Ptgs2,and *** vivo,the lipoprotein nanoparticle applied after NaOCl reduced bone resorption volume to(1.3±0.05)mm^(3) and attenuated the inflammatory reaction after treatment to(1090±184)cells compared to non-treated animals that had(2.9±0.6)mm^(3)(P=0.0123)and(2443±931)cells(P=0.004),thus highlighting its promising clinical potential as an alternative therapeutic for managing dental bone inflammation.

关键词： inflammation lipoprotein markedly

A complete reference genome for the soybean ***

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Plant Communications 2024年第2期5卷 19-22页

作者： Yicheng Huang dal.Hoe Koo Yizhou Mao eliot M.Herman Jianwei Zhang Monica A.Schmidt National Key Laboratory of Crop genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Wheat genetics Resource Center Department of Plant PathologyKansas State UniversityManhattanKS 66506USA BIO5 Institute School of Plant SciencesUniversity of ArizonaTucsonAZ 85721USA

Dear editors,Soybeans are a global commodity for their edible protein and vegetable *** global population is predicted to be 9.7 billion by 2050(UN,2022),with a concomitant drastic increase in protein *** already 2.4 billion people suffering from food insecurity(FAO et al.,2023),there is an urgent need to meet future production demands for plant-based proteins.

关键词： commodity soybean urgent

Respiratory protein-driven selectivity during the Permian-Triassic mass extinction

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The Innovation 2024年第3期5卷 122-128页

作者： Haijun Song Yuyang Wu Xu Dai Jacopo dal.Corso Fengyu Wang Yan Feng Daoliang Chu Li Tian Huyue Song William JFoster State Key Laboratory of Biogeology and environmental geology School of Earth SciencesChina University of GeosciencesWuhan 430074China Biogéosciences UMR 6282CNRSUniversitéde Bourgogne21000 DijonFrance Universitat Hamburg Institute for Geology20148 HamburgGermany

extinction selectivity determines the direction of macroevolution,especially during mass extinction;however,its driving mechanisms remain poorly *** investigating the physiological selectivity of marine animals during the Permian-Triassic mass extinction,we found that marine clades with lower O2-carrying capacity hemerythrin proteins and those relying on O2 diffusion experienced significantly greater extinction intensity and body-size reduction than those with higher O2-carrying capacity hemoglobin or hemocyanin *** findings suggest that animals with high O2-carrying capacity obtained the necessary O2 even under hypoxia and compensated for the increased energy requirements caused by ocean acidification,which enabled their survival during the Permian-Triassic mass ***,high O2-carrying capacity may have been crucial for the transition from the Paleozoic to the Modern evolutionary Fauna.

关键词： extinction selectivity finding

Deadwood position matters:Diversity and biomass of saproxylic beetles in a temperate beech forest

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Forest ecosystems 2024年第1期11卷 120-130页

作者： Vaclav Zumr Oto Nakladal.Josef gallo JiríRemes Faculty of Forestry and Wood Sciences Czech University of Life Sciences PragueKamýck a 129Praha 6-Suchdol16500Czech Republic

Deadwood plays a key role for biodiversity in forests.A significant number of beetles from this group are currently listed as endangered in the Red *** addition to other management recommendations,there have been recent efforts to enrich stands with dead wood to promote *** important parameter for forestry enterprises is the optimization of these *** study investigated the abundance,species richness,gamma diversity,conservation value and biomass of saproxylic beetles in natural forests using window traps.A total of 89traps were used for saproxylic beetle monitoring,of which 29 were placed on lying logs,30 on snags and 30 as controls in forest stand space.A total of 35,011 beetles were recorded in 564 species(61 families).Notably,20,515 of these belong to saproxylic beetles(59%)in 311 species(55%),with 62 classified as Red-List species(20%).In the group of'all saproxylic beetles',the results indicate that a diversity and y diversity(q=0)remain consistent across various deadwood types,whileβdiversity showed significant *** differences were found in the Red-List species group,where a diversity and y diversity differed,with higher values observed in *** based total species richness of site was estimated to be 391 species,including 74 Red-Listed *** the sample coverage of the studied stand categories showed that all saproxylic species exhibit a pronounced preference for inhabiting areas featuring lying ***,Red-List species mainly inhabit snags,withβdiversity being more similar to snags and forest stand ***,both the conservation value(weighted average by conservation status)and beetle biomass are significantly highest in snags,whereas stand space shows the lowest values across all measured saproxylic beetle ***,the use of traps set on the poles in forest stand space resulted in an underestimation of the actual stand richness by 20%-25%.Our results support th

关键词： Snags Coleoptera Fagus sylvatica Unmanaged forests Red-list Coarse woody debris

Clinical implications of single cell sequencing for bladder cancer

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Oncology Research 2024年第4期32卷 597-605页

作者： ReZA YADOLLAHVANDMIANDOAB MeHRSA JALALIZADeH FRANCIeLe APAReCIDA VeCHIA DIONATO KeINI BUOSI PATRÍCIA A.F.LeMe LUCIANA S.B.dal.COL CRISTIANe F.gIACOMeLLI ALeX DIAS ASSIS NASIM BASHIRICHeLKASARI LeONARDO OLIVeIRA ReIS UroScience School of Medical SciencesUniversity of CampinasUNICAMPCampinasSao Paulo13083-872Brazil ImmunOncology Pontifical Catholic University of CampinasPUC-CampinasCampinasSao Paulo13087-571Brazil

Bladder cancer(BC)is the 10th most common cancer worldwide,with about 0.5 million reported new cases and about 0.2 million deaths per *** this scoping review,we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA *** searched PubMed,CeNTRAL,embase,and supplemented with manual searches through the Scopus,and Web of Science for published studies until February *** included original studies that used at least one single-cell technology to study bladder ***-one publications were included in the ***-nine studies showed that this technology can identify cell subtypes in the tumor microenvironment that may predict prognosis or response to immune checkpoint inhibition *** studies were able to diagnose BC by identifying neoplastic cells through single-cell sequencing urine *** remaining studies were mainly a preclinical exploration of tumor microenvironment at single cell ***-cell sequencing technology can discriminate heterogeneity in bladder tumor cells and determine the key molecular properties that can lead to the discovery of novel perspectives on cancer *** nascent tool can advance the early diagnosis,prognosis judgment,and targeted therapy of bladder cancer.

关键词： Bladder cancer Urothelial carcinoma Transitional cell carcinoma Single-cell sequencing Tumor heterogeneity Immunotherapy Scoping review Tumor microenvironment

effect of acetyl L-carnitine on human retinal pigment epithelium-19 cells in hypoxic conditions

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国际眼科杂志 2024年第10期24卷 1515-1521页

作者： Ali dal.Onur Catak Murat erdag Mehmet Canleblebici ebru Onalan Ilay Buran Department of Ophthalmology Faculty of MedicineFirat UniversityElazig 23119Turkey Department of Ophthalmology Ata Sokmen Faculty of MedicineMustafa Kemal UniversityHatay 31100Turkey Department of Ophthalmology Kayseri State HospitalKayseri 38200Turkey Department of Medical Biology Faculty of MedicineFirat UniversityElazig 23100Turkey

AIM:To investigate the effect of acetyl-L-carnitine(ALCAR)on cell viability,morphological integrity,and vascular endothelial growth factor(VegF)expression in human retinal pigment epithelium(ARPe-19)cells using a hypoxic ***:In the first set of experiments,the optimal CoCl_(2) dose was determined by exposing ARPe-19 cell cultures to different *** evaluate the effect of ALCAR on cell viability,five groups of ARPe-19 cell culture were established that included a control group,a sham group(200μM CoCl_(2)),and groups that received 1,10 and 100 mM doses of ALCAR combined with 200μM CoCl_(2),*** cell viability was measured by MTT *** morphological characteristics of cells were observed by an inverted phase contrast *** levels of VegF and HIF-1α secretion by ARPe-19 cells were detected by enzyme linked immunosorbent assay(eLISA)***:ARPe-19 cells were exposed to different doses of CoCl_(2) in order to create a hypoxia ***,when exposed to a concentration of 200μM CoCl_(2),a notable decrease in viability to 83% was *** was found to increase the cell viability at 1 mM and 10 mM concentrations,while the highest concentration(100 mM)did not have an added *** cell viability was found to be significantly higher in the groups treated with a concentration of 1 mM and 10 mM ALCAR compared to the Sham group(P=0.041,P=0.019,respectively).The cell viability and morphology remained unaffected by the greatest dose of ALCAR(100 mM).The administration of 10 mM ALCAR demonstrated a statistically significant reduction in the levels of VegF and HIF-1α compared with the Sham group(P=0.013,P=0.033,respectively).CONCLUSION:The findings from the current study indicate that ALCAR could represent a viable therapeutic option with the potential to open up novel treatment pathways for retinal diseases,particular relevance for age-related macular degeneration(AMD).However,to fully elucidate ALCAR’s application

关键词： acetyl-L-carnitine(ALCAR) human retinal pigment epithelium(ARPe-19) vascular endothelial growth factor(VegF) hypoxia-inducible factor 1(HIF-1α)

The Role of the Size effect on the Drying of Refractory Castables—How Its Under-standing Could Narrow the gap between Laboratory Studies and Industrial Reality

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China's Refractories 2024年第2期33卷 35-40页

作者： M.H.MOReIRA H.PeNg S.dal.PONT V.C.PANDOLFeLLI Materials engineering Department Federal University of São Carlos(UFSCar)São Carlos 13565-905Brazil Materials Innovation Elkem Silicon Products DevelopmentKristiansand 4621Norway CNRS Grenoble INP3SRUniversitéGrenoble AlpesGrenoble 38000France

Refractories have unique capabilities such as sustaining their shape and properties at extreme conditions such as the combination of high temperatures and thermal shock,contact with molten metals and slags and in some circumstances resistance to erosion from abrasive *** the large processing output of the heavy industries such as the cement and steel ones which both require high temperature processes,the refractories structures span various meters and weight of several *** the water removal stage of hydraulic bonded castables in industrial sites takes hours(10-60 h)due to the risk of explosive spalling,efforts to mitigate it are commonly *** has provided theoretical understanding of the general aspects of drying and important tools,such as the thermogravimetry analysis(TgA),for the design of refractory compositions with higher explosive spalling ***,the optimization of this process is still far from the industrial reality especially because the actual linings that require the drying are orders of magnitude larger than the samples considered in the laboratory ***,this study proposed the analysis of the sample volume effect on the water removal dynamics through TgA of high alumina castables with calcium aluminate ***φ5 cm×5 cm cylindrical samples were assessed in a laboratory scale equipment whereas macro TgA were carried out considering 20 cm×20 cm×20 cm and 30 cm×30 cm×30 cm cubic ***,the effect of polymeric fibers was also *** was found out that the different thermal gradients within the macro TgA samples resulted in an inflection on the sample’s heating rate and that the mass loss was affected by the volume considered,especially for the composition without *** findings highlight the requirement of carefully taking into consideration the different dimensional sizes and thermal gradients in the samples when analyzing and interpreting the laboratory studies,and

关键词： drying refractory castables size effect thermogravimetry analysis

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贵州青岩中三叠世安尼期琥珀及其意义

地球科学 2024年第4期49卷 1515-1523页

作者：田垚铠楚道亮曹怡然 Jacopo dal.Corso guido Roghi 宋海军田力刘传远贺箫缪雪张世岩舒文超童金南中国地质大学生物地质与环境地质国家重点实验室地球科学学院湖北武汉430074 国家研究委员会地球科学与地质资源研究所意大利帕多瓦351313 贵州地质博物馆贵州贵阳550081

中-晚三叠世是现代型生态系统构建的关键时期,系统研究该时期生物与环境的协同演变过程对揭示生物复苏机制和生态系统重建规律具有重要意义.琥珀是探讨中-晚三叠世植物演化和古气候演变的重要载体.对青岩剖面雷打坡段的琥珀和伴生的植... 详细信息

中-晚三叠世是现代型生态系统构建的关键时期,系统研究该时期生物与环境的协同演变过程对揭示生物复苏机制和生态系统重建规律具有重要意义.琥珀是探讨中-晚三叠世植物演化和古气候演变的重要载体.对青岩剖面雷打坡段的琥珀和伴生的植物化石开展研究,并将全球的中-晚三叠世琥珀的分布与湿润事件进行对比分析.结果发现青岩琥珀是由松柏类植物伏脂杉生产,琥珀的出现与松柏类植物的辐射演化有关.菊石生物地层表明含有琥珀的地层属于中三叠世安尼期Pelsonian亚期.认为琥珀的产出与湿润事件具有对应性,说明湿润事件可能是中-晚三叠世琥珀频繁出现的重要原因.

关键词：中三叠世安尼期琥珀湿润事件贵州青岩地层学

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5g政务专网视频监控覆盖解决方案

长江信息通信 2024年第5期37卷 205-208页

作者：代海刚福建省邮电规划设计院有限公司福建福州350001

5g作为新基建的重点和热点,在新基建中扮演着重要角色,将为国民经济各产业发展和不断地满足人民群众对信息通信的新需求提供有力支撑。我国已经在城市、乡镇、行政村等重要区域建设了大量的5g基站,5g网络覆盖非常广泛,从而衍生出很多行... 详细信息

5g作为新基建的重点和热点,在新基建中扮演着重要角色,将为国民经济各产业发展和不断地满足人民群众对信息通信的新需求提供有力支撑。我国已经在城市、乡镇、行政村等重要区域建设了大量的5g基站,5g网络覆盖非常广泛,从而衍生出很多行业的应用。通过5g政务专网的网络搭建,将会对政府部门、企事业单位的智能化、数字化运用提供更加安全便捷的无线网络接入,所以政务专网就成为了信息行业关注的焦点。因此,进一步推进5g政务专网在视频监控运用也十分重要。基于此,文章重点对5g政务专网在视频监控覆盖应用上进行了研究,为相关人员提供一些支持和参考。

关键词： 5g 政务专网视频监控

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