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Single-cell RNA sequencing analysis of the retina under acute high intraocular pressure

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Neural Regeneration Research 2024年第11期19卷 2522-2531页

作者： Shaojun wang Siti Tong Xin Jin Na Li Pingxiu Dang Yang Sui Ying Liu dajiang wang Division of Ophthalmology The Third Medical Center of PLA General HospitalBeijingChina Department of Ophthalmology Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

High intraocular pressure causes retinal ganglion cell injury in primary and secondary glaucoma diseases,yet the molecular landscape characteristics of retinal cells under high intraocular pressure remain *** models of acute hypertension ocular pressure were established by injection of cross-linked hyaluronic acid hydrogel(Healaflow■).Single-cell RNA sequencing was then used to describe the cellular composition and molecular profile of the retina following high intraocular *** results identified a total of 12 cell types,namely retinal pigment epithelial cells,rod-photoreceptor cells,bipolar cells,Müller cells,microglia,cone-photoreceptor cells,retinal ganglion cells,endothelial cells,retinal progenitor cells,oligodendrocytes,pericytes,and *** single-cell RNA sequencing analysis of the retina under acute high intraocular pressure revealed obvious changes in the proportions of various retinal cells,with ganglion cells decreased by 23%.Hematoxylin and eosin staining and TUNEL staining confirmed the damage to retinal ganglion cells under high intraocular *** extracted data from retinal ganglion cells and analyzed the retinal ganglion cell cluster with the most distinct *** found upregulation of the B3gat2 gene,which is associated with neuronal migration and adhesion,and downregulation of the Tsc22d gene,which participates in inhibition of *** study is the first to reveal molecular changes and intercellular interactions in the retina under high intraocular *** data contribute to understanding of the molecular mechanism of retinal injury induced by high intraocular pressure and will benefit the development of novel therapies.

关键词： apoptosis axon degeneration high intraocular pressure microglia ocular hypertension photoreceptor cells retina retinal degeneration retinal ganglion cells single-cell RNA sequencing

Identification of S-RNase genotype and analysis of its origin and evolutionary patterns in Malus plants

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Journal of Integrative Agriculture 2024年第4期23卷 1205-1221页

作者： Zhao Liu Yuan Gao Kun wang Jianrong Feng Simiao Sun Xiang Lu Lin wang Wen Tian Guangyi wang Zichen Li Qingshan Li Lianwen Li dajiang wang Research Institute of Pomology Chinese Academy of Agricultural Sciences/Key Laboratory of Horticultural Crops Germplasm Resources UtilizationMinistry of Agriculture and Rural AffairsXingcheng 125100China College of Agriculture Shihezi University/Key Laboratory of Special Fruits and Vegetables Cultivation Physiology and Germplasm Resources Utilization of Xinjiang Production and Construction CorpsShihezi 832000China

Identification of the S genotype of Malus plants will greatly promote the discovery of new genes,the cultivation and production of apple,the breeding of new varieties,and the origin and evolution of self-incompatibility in Malus *** this experiment,88 Malus germplasm resources,such as Aihuahong,Xishuhaitang,and Reguanzi,were used as *** gene-specific primer combinations were used in the genotype *** amplification using leaf DNA produced a single S-RNase gene fragment in all *** results revealed that 70 of the identified materials obtained a complete S-RNase genotype,while only one S-RNase gene was found in 18 of *** homology comparison and analysis,13 S-RNase genotypes were obtained:S_(1)S_(2)(Aihuahong,etc.),S_(1)S_(28)(Xixian Haitang,etc.),S_(1)S_(51)(Hebei Pingdinghaitang),S_(1)S_(3)(Xiangyangcun Daguo,etc.),S_(2)S_(3)(Zhaiyehaitang,etc.),S_(3)S_(51)(Xishan 1),S_(3)S_(28)(Huangselihaerde,etc.),S_(2)S_(28)(Honghaitang,etc.),S_(4)S_(28)(Bo 11),S_(7)S_(28)(Jiuquan Shaguo),S_(10)S_e(Dongchengguan 13),S_(10)S_(21)(Dongxiangjiao)and S_(3)S_(51)(Xiongyue Haitang).Simultaneously,the frequency of the S gene in the tested materials was *** findings revealed that different S genes had varying frequencies in Malus resources,as well as varying frequencies between intraspecific and interspecific.S_(3) had the highest frequency of 68.18%,followed by S_(1)(42.04%).In addition,the phylogenetic tree and origin evolution analysis revealed that the S gene differentiation was completed prior to the formation of various apple species,that cultivated species also evolved new S genes,and that the S_(50) gene is the oldest S allele in Malus *** S_(1),S_(29),and S_(33) genes in apple-cultivated species,on the other hand,may have originated in ***,***,and ***,*** addition to ***,*** and *** may have also played a role in the origin and evolution of some Chine

关键词： Malus S-RNase genotype self-incompatibility origin and evolution

Mechanisms and applications of antitumor immunotherapy of responsive drug-loaded nanoparticles in breast cancer

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BIOCELL 2023年第7期47卷 1483-1498页

作者： LETIAN JIN HETING CHEN QI RUAN RUI LIU YIFENG FAN XIUFANG XU dajiang wang JIAHUI LU School of Medical Imaging Hangzhou Medical CollegeHangzhou310053China

During the chemotherapy of tumors,the cytotoxic effect of drugs is vital to kill tumor cells,and the delivery of a chemotherapeutic agent is of great importance for optimal therapeutic *** high in vivo clearance rate and low delivery efficiency of conventional chemotherapeutic agents affect the therapeutic *** recent years,the responsive drug delivery nanosystem has received increasing concern owing to its excellent biocompatibility,stable delivery performance,and controlled drug release *** lucidly explain the cytocidal and immunotherapeutic effects of such responsive nanosystems in breast cancer,this review discusses the various stimuli and responses of drug-loaded liposomal *** light/magnetic response of drug-loaded bionic membranes nanosystems and the heat/magnetic response of drug-loaded iron oxide nanosystems are also *** cancer cell-killing efficacy and antitumor immunotherapeutic effects are also scrutinized.

关键词： Responsive nanoparticles Antitumor immunotherapy Breast cancer

Xinjiang Girl World Super Model

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Women of China 1999年第1期 4-5页

作者： wang dajiang

Leading Chinese model Yue Mei won thetitle of World Super Model at the ’98 WorldSuper Model Competition held in FranceSeptember 6 - 17. Yue, a university studentfrom the Xinjiang Uygur AutonomousRegion, had won the top title at ’98 ChinaSuper Model Competition held in Beijingone month *** that, she underwentone month’s professional modeling trainingwith the New Silk Road ModelingManagement Company before setting off forthe world competition. In France, Yueimpressed the judges with her strikingfeatures, and display of oriental elegance

关键词： World Xinjiang Girl World Super Model

Auxiliary Fault Location on Commercial Equipment Based on Supervised Machine Learning

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ZTE Communications 2022年第S1期20卷 7-15页

作者： ZHAO Zipiao ZHAO Yongli YAN Boyuan wang dajiang State Key Laboratory of Information Photonics and Optical Communictions Beijing University of Posts and TelecomunicationsBeijing 100876China ZTE Corporation Shenzhen 518057China

As the fundamental infrastructure of the Internet,the optical network carries a great amount of Internet *** would be great financial losses if some faults ***,fault location is very important for the operation and maintenance in optical *** to complex relationships among each network element in topology level,each board in network element level,and each component in board level,the con-crete fault location is hard for traditional *** recent years,machine learning,es-pecially deep learning,has been applied to many complex problems,because machine learning can find potential non-linear mapping from some inputs to the *** this paper,we introduce supervised machine learning to propose a complete process for fault ***,we use data preprocessing,data annotation,and data augmenta-tion in order to process original collected data to build a high-quality ***,two machine learning algorithms(convolutional neural networks and deep neural networks)are applied on the *** evaluation on commercial optical networks shows that this process helps improve the quality of dataset,and two algorithms perform well on fault location.

关键词： optical network fault location supervised machine learning

A Quantum Key Re-Transmission Mechanism for QKD-Based Optical Networks

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ZTE Communications 2018年第3期16卷 52-58页

作者： wang Hua ZHAO Yongli wang dajiang wang Jiayu wang Zhenyu State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications100876China Skill Transfer Management Department ZTE CorporationBeijing 100000China

Due to the vulnerability of fibers in optical networks, physical- layer attacks targeting photon splitting, such as eavesdrop- ping, can potentially lead to large information and revenue loss. To enhance the existing security approaches of optical networks, a new promising technology, quantum key distribu- tion （QKD）, can securely encrypt services in optical networks, which has been a hotspot of research in recent years for its characteristic that can let clients know whether infomlation transmission has been eavesdropped or not. In this paper, we apply QKD to provide secret keys for optical networks and then introduce the architecture of QKD based optical net- work. As for the secret keys generated by QKD in optical net- works, we propose a re-transmission mechanism by analyzing the security risks in QKD-based optical networks. Numerical results indicate that the proposed re-transmission mechanism can provide strong protection degree with enhanced attack protection. Finally, we illustrated some future challenges in QKD-based optical networks.

关键词： optical networks security QKD re-transmission

Software Defined Optical Networks and Its Innovation Environment

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ZTE Communications 2016年第4期14卷 50-57页

作者： LI Yajie ZHAO Yongli ZHANG Jie wang dajiang wang Jiayu Beijing University of Posts and Telecommunications Beijing 100876China ZTE Corporation Shenzhen 518057China

Software defined optical networks （SDONs） integrate software defined technology with optical communication networks and represent the promising development trend of future optical networks. The key technologies for SDONs include software-defined optical transmission, switching, and networking. The main features include control and transport separation, hard-ware universalization, protocol standardization, controllable optical network, and flexible optical network applications. This paper introduces software defined optical networks and its innovation environment, in terms of network architecture, protocol extension solution, experiment platform and typical applications. Batch testing has been conducted to evaluate the performance of this SDON testbed. The results show that the SDON testbed has good scalability in different sizes. Meanwhile, we notice that controller output bandwidth has great influence on lightpath setup delay.

关键词： optical networks software defined networking innovation en-vironment

Adaptability Analysis of Fluctuating Traffic for IP Switching and Optical Switching

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ZTE Communications 2021年第1期19卷 82-90页

作者： LIAN Meng GU Rentao JI Yuefeng wang dajiang LI Hongbiao Beijing Laboratory of Advanced Information Network Beijing University of Posts and TelecommunicationsBeijing 100876China Wireline Product Planning Department ZTE CorporationShenzhen 518057China

The technological development of smart devices and Internet of Things(IoT)has brought ever-larger bandwidth and fluctuating traffic to existing *** analy⁃sis of network capital expenditure(CAPEX)is extremely important and plays a fundamen⁃tal role in further network *** this paper,an adaptability analysis is raised for IP switching and optical transport network(OTN)switching in CAPEX when the service bandwidth is fluctuating *** paper establishes a multi-layer network architec⁃ture through Clos network model and discusses impacts of maximum allowable blocking rate and service bandwidth standard deviation on CAPEX of IP network and OTN network to find CAPEX demarcation point in different *** simulation results show,when the bandwidth deviation mean rate is 0.3 and the maximum allowable blocking rate is 0.01,the hardware cost of OTN switching will exceed IP switching as the average band⁃width is greater than 6100 Mbit/*** the service bandwidth fluctuation is severe,the hardware cost of OTN switching will increase and exceed IP switching as the single port rate is allowed in optical *** increasing of maximum allowable blocking rate can decrease hardware cost of OTN ***,it is found that Flex Ethernet(FlexE)can be used to decrease CAPEX of OTN switching greatly at this time.

关键词： bandwidth fluctuating CAPEX OTN switching IP switching FlexE

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以就业为导向的高校创业教育探究

高等工程教育研究 2016年第4期64卷 52-56页

作者：王大将温州大学瓯江学院创业就业工作部温州大学创业学院

文章提出以就业为导向的高校创业教育新观点,分析了专业教育、职业教育、就业教育与创业教育之间的关系,阐述了高校以就业为导向开展创业教育的必要性,并指出了当前高校创业教育仍存在的诸多问题,探究了以就业为导向的高校创业教育发展... 详细信息

文章提出以就业为导向的高校创业教育新观点,分析了专业教育、职业教育、就业教育与创业教育之间的关系,阐述了高校以就业为导向开展创业教育的必要性,并指出了当前高校创业教育仍存在的诸多问题,探究了以就业为导向的高校创业教育发展路径。

关键词：就业创业教育问题路径