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Endoscopic diagnosis of cytomegalovirus gastritis after allogeneic hematopoietic stem cell transplantation

World Journal of Gastroenterology 2010年第23期16卷 2907-2912页

作者： Yasuo Kakugawa Masahiro Kami Takahisa Matsuda Yutaka saito Sung-Won Kim Takahiro Fukuda Shin-ichiro Mori Tadakazu Shimoda Ryuji Tanosaki daizo saito Division of Endoscopy National Cancer Center Hospital(Japan) Division of Exploratory Research Institute of Medical ScienceUniversity of Tokyo Division of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital(Japan) Clinical Laboratory Division National Cancer Center Hospital(Japan)

AIM:To clarify the endoscopic and clinical findings of cytomegalovirus(CMV) gastritis after allogeneic hematopoietic stem cell transplantation(allo-SCT).METHODS:Between 1999 and 2005,523 patients underwent allo-SCT at our hospital,and 115 of these patients with gastrointestinal symptoms underwent ***:CMV gastritis was diagnosed pathologically in seven patients(1.3%) with the other 108 patients serving as *** of the seven patients developed positive CMV antigenemia,and five complained of abdominal *** of abdominal pain preceded CMV antigenemia in four of the f ive *** examination showed oozing(n=2),erosion(n=6),and redness(n=5) in the seven patients with CMV gastritis,while the control patients showed oozing(n=3),erosion(n=24),and redness(n=100).Erosion and oozing were more frequently documented in patients with CMV gastritis compared with the controls,and the differences were statistically significant(P=0.0012 and 0.029,respectively).CMV inclusion bodies were documented in 12 of 14 biopsy specimens obtained from erosive lesions,while they were identif ied in 4 of 15 biopsy specimens obtained from lesions other than erosions(P=0.0025).CONCLUSION:This study suggests that erosion and oozing,as well as abdominal pain,are useful indicators in the diagnosis of CMV gastritis following allo-SCT.

关键词： Cytomegalovirus gastritis Hematopoietic stem cell transplantation Cytomegalovirus antigenemia Esophagogastroduodenoscopy Graft-versus-host disease

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Chemotherapy for Advanced Gastric Cancer in Japan

Chemotherapy for Advanced Gastric Cancer in Japan

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2000全国肿瘤学术大会

作者： Kei Muro Kuniaki Shirao daizo saito National Cancer Center Hospital National Cancer Center Hospital National Cancer Center Hospital

＜正＞Recent chemotherapy regimens against advanced gastric cancer（AGC）have been reported to show high response ***,because the survival benefit of these regimens has not yet been demonstrated,the establishment of stan- dard therapy and the developments of new and active agents or chemotherapy regimens are much needed. In Japan,the Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group（JCOG）conducted a randomized phase Ⅲ trial to compare the survivals of 5FU+CDDP（FP）or UFT+MMC（UFTM）with that of 5FU alone as first-line chemotherapy in patients with AGC（JCOG 9205）.From 1992 to 1997,280 patients with AGC from 36 in-

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Endoscopic Mucosal Resection for Early Gastric Cancer National Cancer Center Hospital

Endoscopic Mucosal Resection for Early Gastric Cancer Nation...

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2000全国肿瘤学术大会

作者： Tetsuya Inui Hiroyuki Ono Takuji Gotoda daizo saito

＜正＞Endoscopic mucosal resection（EMR）is widely accepted in Japan as a curative treatment for early gastric cancer （EGC）,which has low probability of lymph nodes ***,the standard EMR indication for EGC is defined generally as follows:（1）intestinal cancer,（2）superficial cancer less than 20 mm in size,and（3）mucosal cancer without ulcerative *** quality of life after surgery,however,the expansion of EMR indication to EGC should be discussed.

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A Review of Skin Banking Guidelines and Standards Worldwide:Towards the Harmonization of Guidelines for Skin Banking in Therapeutic Applications for the Regions under the Asia Pacific Burn Association(APBA)

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Burns & Trauma 2020年第1期8卷 82-93页

作者： Wee Ling Heng Qi Wei Wang Renuka Sornarajah Jacynthe Tremblay Nandita Melati Putri Suzina Sheikh Ab Hamid Pornthep Pungrasmi Hsian-Jenn Wang Dong Chul Kim daizo saito Nhu Lam Nguyen Wan Azman Wan Sulaiman Aditya Wardhana Vinita Puri Hajime Matsumura Niann-Tzyy Dai Rajeev BAhuja Gaoxing Luo Weifeng He Si Jack Chong Alvin Wen Choong Chua Transplant Tissue Centre Singhealth Duke-NUS Transplant CentreSingapore Heart Valve and Tissue Bank Lady Ridgeway Hospital for ChildrenDr Danister De Silva MawathaColomboSri Lanka Jacynthe Tremblay Consultation QuebecCanada Burn Unit Faculty of MedicineCipto Mangunkusumo General HospitalJakartaIndonesia Otorhinolaryngology-Head and Neck Surgery School of Medical SciencesHealth CampusUniversiti Sains MalaysiaKelantanMalaysia Plastic and Reconstructive Surgery Division King Chulalongkorn Memorial HospitalBangkokThailand Plastic and Reconstructive Surgery Taipei Medical UniversityTaipeiChinese Taipei Plastic and Reconstructive Surgery Bundang Jesaeng HospitalSeongnamSouth Korea Division of Traumatology Research InstituteNational Defence Medical CollegeSaitamaJapan Vietnam National Burn Hospital HanoiVietnam Reconstructive Sciences Programme School of Medical SciencesHealth CampusUniversiti Sains MalaysiaKelantanMalaysia Department of Plastic Surgery King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical CollegeMumbaiIndia Department of Plastic and Reconstructive Surgery Tokyo Medical UniversityTokyoJapan Division of Plastic and Reconstructive Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei Plastic and Aesthetic Surgery Sir Ganga Ram HospitalNew DelhiIndia Institute of Burn Research Southwest HospitalArmy Medical UniversityChongqingChina Department of Plastic Reconstructive and Aesthetic SurgerySingapore General HospitalSingapore Musculoskeletal Sciences Academic Clinical Programme Duke-NUS Medical SchoolSingapore

Currently,there are no harmonized guidelines which govern skin banking in the Asia Pacific ***,skin banks are either unregulated or rely on their nation’s legislation or international accreditation to uphold their quality standards.A new set of skin banking guidelines was devel-oped through a comprehensive review and collation of best international practices for the Asia Pacific Burn Association(APBA)members,from donor screening and testing,to skin recovery,processing,storage and distribution,and quality *** regulatory requirements reviewed include the European directives,Australia’s Therapeutic Goods Administration and Sin-gapore’s tissue banking *** technical and quality management recommendations are referenced from the American Association of Tissue Banks(AATB),the United States Food and Drug Administration standards and guidance documents,various relevant European guides,Japanese Society of Tissue Transplantation guidelines and the Asia Pacific Association of Surgical Tissue *** mainly from the AATB standards,the new Asia Pacific Burn Association Guidelines for Skin Banking in Therapeutic Applications offer a comprehensive manual,address-ing:governance and contracts;staff responsibilities;quality management;facilities,equipment and supplies management;donor consent and testing;and recommendations of good practices pertaining to skin recovery,processing,storage and *** complementing current generic regulations,they provide technical specifications of major aspects unaddressed in most *** inaugural set of new regional skin banking guidelines would be a start for regional members of the APBA to adopt,and will hopefully culminate in a set of standards so that,in the long run,skin allografts from this region can be of similar quality,which can simplify import process and facilitate the exchange of allografts between members.

关键词： Skin banking Skin allografts Skin transplantation Tissue banking Tissue donation

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